The survival of B cells is compromised in kidney disease by Doureradjou Peroumal, Chetan V. Jawale, Wonseok Choi, Hossein Rahimi, Danielle Antos, De-dong Li, Shuxia Wang, Godhev K. Manakkat Vijay, Isha Mehta, Raymond West, Muthusamy Thangaraju, Thomas D. Nolin, Jishnu Das, John F. Alcorn, Partha S. Biswas

“…However, the recent SARS-CoV-2 pandemic has shown that pre-existing comorbid conditions including kidney disease account for compromised humoral immunity to infections. …”
Get full text

The effect of rehabilitation on remission following detoxification treatment in alcohol and substance use disorders: A pilot study by Mustafa Danisman, Gamze Zengin Ispir, Kubra Sezer Katar, Zehra Ucar Hasanli, Ziya Bilgin

“…In the treatment of ASUD, in addition to pharmacological treatment and the treatment of comorbid psychiatric disorders, the inclusion of rehabilitation in the treatment processes is also essential because of the high relapse rates after detoxification treatment. …”
Get full text

Impaired inflammatory resolution with severe SARS-CoV-2 infection in leptin knock out obese hamster by Ren-Di Jiang, Yun-Zhe Luo, Hao-Feng Lin, Xiao-Shuang Zheng, Wen-Tao Zeng, Mei-Qin Liu, Hao-Hao Deng, Qi Wang, Ya-Na Lai, Ying Chen, Zi-Shuo Guo, Ya Zeng, Qian-Chun Gong, Chen Qiu, Mei Dong, Xi Wang, Zi-Yi Wang, Li-Na Ji, Pan-Pan Hou, Qian Li, Xu-Rui Shen, Bei Li, Yun Gao, Ai-Hua Zhang, Ting-Ting Jiang, Ai-Min Shi, Peng Zhou, Xin-Hua Lin, Zi-Qing Deng, Jian-Min Li, Zheng-Li Shi

“…Summary: Comorbidities, such as obesity, increase the risk of severe COVID-19. …”
Get full text

TNM-Like Classification: A New Proposed Method for Heart Failure Staging by Francesco Fedele, Maria Chiara Gatto, Alessandra D’Ambrosi, Massimo Mancone

“…The involvement of different systems is variably related to age and others comorbidities. The severity of organ damage is often proportional to the duration of heart failure. …”
Get full text

Evaluation of Role of Prognostic Factors on Hearing Outcome in Unilateral Idiopathic Sudden Onset Sensorineural Hearing Loss by Namrata Yadav, Priti Lal, Rohit Bharadwaj, Kuldeep Yadav

“…Material and methods: This prospective observational study was conducted with the primary aim of analyzing the role of various possible prognostic factors on the outcome of idiopathic SSNHL including demographic (Age, gender), audio-vestibular (Pre-treatment hearing loss in the affected ear, hearing in the contralateral ear, time elapse between onset of hearing loss and start of treatment, type of hearing loss in term of frequencies affected), presence of tinnitus / vertigo and Comorbidities (Diabetes, Hypothyroidism & Deranged lipid profile/ dyslipidemia). …”
Get full text

Medical Management of Glaucoma in the 21st Century from a Canadian Perspective by Paul Harasymowycz, Catherine Birt, Patrick Gooi, Lisa Heckler, Cindy Hutnik, Delan Jinapriya, Lesya Shuba, David Yan, Radmila Day

“…Selection of therapeutic approaches for glaucoma should be based on careful ocular examination, patient medical history, presence of comorbidities, and awareness of concomitant systemic therapies. …”
Get full text

Extent of Surgery and Implications of Transection Margin Status after Resection of IPMNs by Marina Paini, Stefano Crippa, Filippo Scopelliti, Andrea Baldoni, Alberto Manzoni, Giulio Belfiori, Stefano Partelli, Massimo Falconi

“…Preoperative and intraoperative evaluation of malignant potential of IPMN and of patient’s comorbidities is of paramount importance to balance potential complications of surgery with tumors’ risk of being or becoming malignant; the decision about the extent of pancreatic resection and the eventual total pancreatectomy needs to be determined on individual basis. …”
Get full text

Health-related quality of life in hypertensive patients with chronic kidney disease in low and middle-income countries by Wening Wulandari, Neily Zakiyah, Cherry Rahayu, Irma M. Puspitasari, Auliya A. Suwantika

“…Various factors, including physical limitations, comorbidities, psychological barriers, logistical challenges, and social support, can influence HRQoL. …”
Get full text

Systematic dissection of pleiotropic loci and critical regulons in excitatory neurons and microglia relevant to neuropsychiatric and ocular diseases by Yunlong Ma, Dingping Jiang, Jingjing Li, Gongwei Zheng, Yao Deng, Xuanxuan Gou, Shuaishuai Gao, Cheng Chen, Yijun Zhou, Yaru Zhang, Chunyu Deng, Yinghao Yao, Haijun Han, Jianzhong Su

“…Polygenic enrichment analysis further identified 15 pleiotropic regulons in excitatory neurons and 16 in microglia that were linked to comorbid conditions. Functionally, excitatory neuron-specific regulons were involved in axon guidance and synaptic activity, while microglia-specific regulons were associated with immune response and cell activation. …”
Get full text

Patient and Physician Perspectives of Diabetic Retinopathy and Diabetic Macular Edema Diagnosis, Treatment and Progression: A Podcast Article by Daniel Newman, Bernadette Warren, Randall Barker, Charles C. Wykoff, Stela Vujosevic

“…However, people with diabetes are often unaware of the importance of DR screening for preserving vision, highlighting the importance of patient education about DR and DR-related ocular and systemic comorbidities. In this podcast, three patients with different stages of DR and two ophthalmologists exchanged their views on diagnosis, treatment, and progression of DR and diabetic macular edema. …”
Get full text

Euglycemic Ketoacidosis in a Patient with Metastatic Non-Small-Cell Lung Adenocarcinoma and Concomitant Pulmonary Embolism by Robert Sean O’Neill, Lauren Tyack, Mary Freeman, Hussein Soudy Hussein

“…Euglycemic ketoacidosis is a recognised side effect secondary to sodium-glucose cotransporter 2 inhibitor use in the treatment of type 2 diabetes mellitus; however, there is scarce evidence to suggest whether preexisting comorbid conditions contribute to the development of this potentially life-threatening complication. …”
Get full text

Anti-SARS-CoV-2 Antibody Level among Renal Transplant Recipients: A Case Report from Nepal by Kamal Ranabhat, Bhuvan Saud, Saroj Adhikari, Suraj Bhattarai, Rojan Adhikari, Bhoj Raj Luitel, Mahesh Raj Sigdel

“…Globally, SARS-CoV-2 has caused significant public health burden, mainly in patients with underlying comorbidities including both communicable and noncommunicable diseases. …”
Get full text

The Gut Microbiome Profile in Obesity: A Systematic Review by Olga Castaner, Albert Goday, Yong-Moon Park, Seung-Hwan Lee, Faidon Magkos, Sue-Anne Toh Ee Shiow, Helmut Schröder

“…Gut microbiome has been identified in the past decade as an important factor involved in obesity, but the magnitude of its contribution to obesity and its related comorbidities is still uncertain. Among the vast quantity of factors attributed to obesity, environmental, dietary, lifestyle, genetic, and others, the microbiome has aroused curiosity, and the scientific community has published many original articles. …”
Get full text

Current Evidence on Atypical Odontalgia: Diagnosis and Clinical Management by Yoshihiro Abiko, Hirofumi Matsuoka, Itsuo Chiba, Akira Toyofuku

“…(iii) Are there any comorbidities of AO? (iv) Is local anesthesia effective for the relief of pain in AO? …”
Get full text

Efficacy and safety of gut microbiome-targeted treatment in patients with depression: a systematic review and meta-analysis by Bo Pan, Yiming Pan, Yu-Song Huang, Meng Yi, Yuwei Hu, Xiaoyu Lian, Hui-Zhong Shi, Mingwei Wang, Guifen Xiang, Wen-Yi Yang, Zhong Liu, Fangfang Xia

“…The efficacy of MTT for depression exhibits variation influenced by geography, patient comorbidities, and duration of administration.…”
Get full text

Immune-related adverse events with PD-1/PD-L1 inhibitors: insights from a real-world cohort of 2523 patients by Ting Yan, Minghui Long, Chaoyi Liu, Jiwen Zhang, Jiwen Zhang, Xingyu Wei, Xingyu Wei, Fei Li, Fei Li, Dehua Liao

“…Significant differences in patient gender, age, Eastern Cooperative Oncology Group (ECOG) Performance Status (PS), comorbidities, PD-1 or PD-L1 inhibitors, and treatment modalities were observed between the irAEs and non-irAEs groups, but not between the multiple irAEs and single irAE groups. …”
Get full text

SARS-CoV-2 infections in pediatric and young adult recipients of chimeric antigen receptor T-cell therapy: an international registry report by Hongyan Liu, Colleen Callahan, Shannon L Maude, Kevin Owen McNerney, Rebecca M Richards, Paibel Aguayo-Hiraldo, Friso G Calkoen, Julie-An Talano, Amy Moskop, Adriana Balduzzi, Jennifer Krajewski, Hema Dave, Anant Vatsayan, Yimei Li, Kara Lynn Davis

“…Patients with two or more comorbidities or aged ≥18 years were more likely to experience significant illness. …”
Get full text

Calciphylaxis: Temporal Artery Calcification Preceding Widespread Skin Lesions and Penile Necrosis by Manzoor A. Shah, Michael W. Roppolo

“…We report a case of 72-year-old Caucasian man with multiple comorbidities and end-stage renal disease on dialysis who presented with temporal artery calcification leading to bilateral loss of vision followed by extensive skin lesions including one on glans penis. …”
Get full text

Psychotic and Substance Use Disorders Among Relatives of Patients with Bipolar Disorder at a Hospital in Kenya by Kimutai Katwa, Benson Gakinya, Irene Chesire, Maloosoy Katwa, Nicodemus Kuboi

“…Studies conducted outside Kenya show that bipolar disorders and psychotic disorders are interlinked by family relations, while alcohol and substance use disorders are their important comorbidities. This study investigated the prevalence and associated factors of psychotic, alcohol and substance use disorders among first-degree relatives (FDR) of patients with bipolar disorders at a referral hospital in Western Kenya. …”
Get full text

Procedural Treatments for Knee Osteoarthritis: A Review of Current Injectable Therapies by Lisa M. Billesberger, Kyle M. Fisher, Yawar J. Qadri, Richard L. Boortz-Marx

“…In addition to pain and disability, osteoarthritis is associated with depression, comorbid conditions such as diabetes, and increased caregiver burden. …”
Get full text