Small Pancreas Neuroendocrine Tumors: How Small is Small? by Ming-Huang Chen, Chia Hsun Hsieh, Ching-Yao Yang, Hui-Jen Tsai, Li-Tzong Chen, On Behalf of Taiwan Neuroendocrine Tumor Society

“…Patients with small nonfunctioning PNETs require individualized recommendations for surgery versus active surveillance based on tumor size, radiographic characteristics, and patient characteristics, such as age and comorbidities and also patient references.…”
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A Rare Case of Primary Anterior Mediastinal Yolk Sac Tumor in an Elderly Adult Male by Sammy G. Nakhla, Srinath Sundararajan

“…Chemotherapy followed by adjuvant surgery improves overall response in EGGCTs. However, comorbidities can render treatment with chemotherapy and surgery challenging in elderly patients.…”
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Psychogenic Nonepileptic Seizures (PNES) in the Setting of Trauma and Schizophrenia by Sikander Chohan, Ali Chohan, Muhamid Asif

“…Major depressive disorder and generalized anxiety disorder are common comorbid conditions in these patients. Additionally, previous trauma has been linked as a predisposing factor for the development of PNES. …”
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Hemopericardium and Cardiac Tamponade Secondary to Migrated Inferior Vena Cava Filter by Jeet J. Mehta, Benjamin DeMarco, John P. Vavalle, Khola S. Tahir, Joseph S. Rossi

“…A multidisciplinary meeting resulted in deferring further action against the embedded fractured legs of the filter with consideration of the patient’s age and comorbidities. This case report should alert clinicians to think about hemopericardium as a cause of cardiac tamponade and cardiogenic shock in a patient with a history of an inferior vena cava filter placement.…”
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Endourologic Management of Upper Tract Transitional Cell Carcinoma following Cystectomy and Urinary Diversion by Jeffrey John Tomaszewski, Marc Christopher Smaldone, Michael Cecil Ost

“…With advances in endoscopic equipment and improvements in technique, conservative endourologic management via a retrograde or antegrade approach is technically feasible with acceptable outcomes in patients with bilateral disease, solitary renal units, chronic renal insufficiency, or significant medical comorbidities. Contemporary studies have expanded the utility of these techniques to include low-grade, low-volume disease in patients with a normal contralateral kidney. …”
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Usefulness of a personalized algorithm‐based discharge checklist in patients hospitalized for acute heart failure by Florent Allain, Virginie Loizeau, Laure Chaufourier, Maya Hallouche, Laurence Herrou, Amir Hodzic, Katrien Blanchart, Annette Belin, Alain Manrique, Paul Milliez, Rémi Sabatier, Damien Legallois

“…In addition, the management of HF comorbidities was significantly improved by PCL with a better referral to follow‐up programme. …”
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The trajectory of changes in cognitive frailty and factors influencing it in elderly patients with cerebral infarction by Shengnan Xu, Qin Liang, Li Zhang, Shihua Liu

“…[Objective] The trajectory of cognitive frailty in elderly patients with cerebral infarction was analyzed, and the influencing factors were discussed. [ Methods] A total of 100 elderly patients with cerebral infarction hospitalized in Suzhou Hospital of Anhui Medical University from January to September in 2023 were selected for the study.Clinical data were collected on the patients, and cognitive frailty was assessed using the Frailty Screening Scale and the Montreal Cognitive Assessment Questionnaire (MoCA) at the time of admission and 1, 3, 6 months after treatment.Failty score ≥3 scores and MoCA <26 scores were defined as cognitive fraily.Potential categories of cognitive frailty change trajectories were identified by latent category growth modeling, and multifactorial logistic regression analyzed the factors influencing patients' cognitive frailty change trajectories. [ Results] The trajectory of cognitive frailty change in elderly patients with cerebral infarction identified by model fitting can be categorized into a group with a persistently low level of frailty (30 cases), a group with a slow rise in frailty (52 cases), and a group with a persistently high level of frailty (18 cases).Multifactorial logistic regression analysis showed that older age, poor sleep quality, and the number of comorbid chronic diseases > 4 were all risk factors for the development of persistent low levels of cognitive frailty into a slow rise in cognitive decline in elderly patients with cerebral infarction (P<0.05), Higher body mass index and high self-care ability were both protective factors for the development of persistent low levels of cognitive decline into a slow rise in cognitive decline in elderly patients with cerebral infarction (P<0.05).Older age, poor sleep quality and the number of comorbid chronic diseases >4 were risk factors for the progression of persistent low levels of cognitive decline to persistent high levels of cognitive decline in elderly patients with cerebral infarction (P < 0.05), and higher self-care ability were protective factors for the progression of persistent low levels of cognitive decline to persistent high levels of cognitive decline in elderly patients with cerebral infarction (P < 0.05). …”
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Early antibiotics administration reduces mortality in sepsis patients in tertiary care hospital by Suramath Isaranuwatchai, Jirawat Buppanharun, Thamonwan Thongbun, Kaewklao Thavornwattana, Monprach Harnphadungkit, Taweegrit Siripongboonsitti

“…The mean age is 68 years and 49.40% of patients is female. 90.97% of the patients have comorbidities. The most common comorbidities were cancer (68.66%), and hypertension (33.40%). …”
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Predictors and time to poor management outcomes among pediatric patients hospitalized with pneumonia in the Gedeo Zone, southern Ethiopia: a prospective follow-up study by Wagaye Alemu, Mebirat Ademassu, Firehiwot Belayneh, Yabibal Gebeyehu, Getachew Assefa Zenebe, Temesgen Leka Lerango

“…Comorbidities at admission, age, nutritional status, and place of residence were statistically significant predictors of poor management outcomes.…”
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Ankle Arthrodesis: Epidemiology, Etiology, and Complications in Diabetic vs Nondiabetic Patients Using US Nationwide Inpatient Sample Data by Assil Mahamid MD, David Maman MD, Summer Sofer, Mykhail Pavlenko MD, Amr Mansour MD, Marah Hodruj MD, Yaron Berkovich MD, Eyal Behrbalk MD

“…Diabetic patients undergoing AA often face higher risks of complications due to comorbidities such as dyslipidemia and hypertension. …”
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Impact of Oseltamivir and Diabetes Development by Bor-Show Tzang, Chih-Chen Tzang, Pei-Hua Chuang, I-Ying Kuo, Yu-Chun Pan, Pei-Hsun Wu, Tsai-Ching Hsu

“…<b>Conclusions</b>: Oseltamivir is associated with an increased risk of Type 2 diabetes but not Type 1, and related comorbidities.…”
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Incidence and risk factors for mortality of vertebral osteomyelitis: a retrospective analysis using the Japanese diagnosis procedure combination database by Hideo Yasunaga, Hirotaka Chikuda, Kiyohide Fushimi, Hiromasa Horiguchi, Toru Akiyama, Kazuo Saita

“…Dependent variables included patient characteristics (age, sex and comorbidities), procedures (haemodialysis and surgery) and hospital factors (type of hospital and hospital volume).Results Overall, 58.9% of eligible patients were men and the average age was 69.2 years. …”
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Association Between Diabetic Control And Anti-Diabetic Medication Adherence Using 8-Point Morisky Medication Adherence Scale In Local Population Of Khyber Pakhtunkhwa by Fuad Ahmad Siddiqi, Bilal Saeed, Mehmood Hussain, Wasif Anwar, Sidra Riaz, Naveed Abbas

“…Sleep quality, BMI and multiple comorbid conditions were also linked with raised HbA1c. …”
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Protocol for the enhanced management of multimorbid patients with COPD and severe asthma: role of indoor air quality by Emili Vela, Isaac Cano, Josep Roca, Antoni Sisó-Almirall, Carme Hernandez, Ebymar Arismendi, Ramon Farré, Alba Gómez-López, María Figols, Antonio Montilla-Ibarra, Núria Sánchez-Ruano, Benigno Sánchez, Marta Sorribes, Jordi Piera-Jiménez, Jaume Benavent, Jose Fermoso, Rubèn González-Colom

“…The inconclusive results of preventive strategies in patients with chronic obstructive respiratory disorders and comorbidities are explainable by multifactorial but actionable factors.The current protocol (January 2024–December 2025) relies on the hypothesis that intertwined actions in four dimensions: (1) management change, (2) personalisation of the interventions based on early detection/treatment of acute episodes and enhanced management of comorbidities, (3) mature digital support and (4) comprehensive assessment, can effectively overcome most of the limitations shown by previous preventive strategies. …”
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Management Outcomes of Variceal Bleeding in Northern Tanzania: Insights From a Single‐Center Retrospective Analysis by Eliada B. Nziku, Elifuraha W. Mkwizu, Abid M. Sadiq, Fuad H. Said, Doreen T. Eliah, Ibrahim Ali Ibrahim Muhina, Tumaini E. Mirai, Furaha S. Lyamuya, Nyasatu G. Chamba, Elichilia R. Shao, Kajiru G. Kilonzo, Sarah J. Urasa

“…In‐hospital mortality was 8.1%, and factors associated with mortality were a shorter length of stay (p = 0.045), patients without comorbidities (p = 0.041), and grade II esophageal varices (p = 0.043). …”
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Prospective multicentre randomised trial comparing the efficacy and safety of single-anastomosis duodeno–ileal bypass with sleeve gastrectomy (SADI-S) versus Roux-en-Y gastric bypa... by Delphine Maucort-Boulch, Maud Robert, Tigran Poghosyan, Dominique Delaunay, Elise Pelascini, Sylvain Iceta, Adrien Sterkers, Charles Barsamian, Litavan Khamphommala, Sylvie Bin Dorel, Sebastien Czernichow, Emmanuel Disse

“…Key inclusion criteria are obese patients with body mass index (BMI) ≥40 kg/m2 or ≥35 kg/m2 with at least one comorbid condition and candidate to a first bariatric procedure or after failure of sleeve gastrectomy. …”
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A nomogram for predicting mortality risk in geriatric patients with hip fractures complicated by pneumonia: A multicenter study by Kaiming Zhang, Xiangwei Li, Yujia Xiao, Cheng Zhou, Yu Liu, Fan Zhen, Hao Zhang, Mao Nie

“…This study aimed to analyze demographic characteristics, mortality rates, postoperative outcomes, and perioperative comorbidities, identify risk factors for mortality, and develop a nomogram for predicting the prognosis of these patients. …”
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Gender inequalities in prescribing and initiation patterns of guideline-recommended drugs after acute myocardial infarction by Irene López-Ferreruela, Sara Malo, Blanca Obón-Azuara, María José Rabanaque, Adriana Gamba, Sara Castel-Feced, Isabel Aguilar-Palacio

“…Women (27.8% of the study population) were older and had more comorbidities. Of the main guideline-recommended drugs, antiplatelets, lipid modifying agents and beta-blockers, were prescribed less often in women. …”
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Inflammatory biomarkers of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in 563 severe OSA patients before and after surgery by Chung-Wei Lin, Pei-Wen Lin, Li-Wen Chiu, Han-Tan Chai, Chun-Tuan Chang, Michael Friedman, Anna M. Salapatas, Sara Rahavi-Ezabadi, Hsin-Ching Lin

“…The findings could possess clinical importance for severe OSA patients after OSA surgeries in reducing possible OSA-associated cardiovascular comorbidities.…”
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Invasive Aspergillosis in the Intensive Care Unit by Anna Zubovskaia, Jose A. Vazquez

“…The diagnosis and management of invasive aspergillosis in the ICU is particularly challenging, due to the unstable clinical condition of the patients, lack of diagnostic markers, increased risk of further clinical deterioration, multiple comorbidities, and a need for early assessment and treatment. …”
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