Obtaining patient phenotypes in SARS-CoV-2 pneumonia, and their association with clinical severity and mortality by Fernando García-García, Dae-Jin Lee, Mónica Nieves-Ermecheo, Olaia Bronte, Pedro Pablo España, José María Quintana, Rosario Menéndez, Antoni Torres, Luis Alberto Ruiz Iturriaga, Isabel Urrutia, COVID-19 & Air Pollution Working Group

“…We collected a broad spectrum of variables to describe exhaustively each case: patient demographics, comorbidities, symptoms, physiological status, baseline examinations (blood analytics, arterial gas test), etc. …”
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Obsessive-compulsive personality disorder increases cognitive inflexibility in people with coronary artery disease by Agne Stanyte, Naomi A. Fineberg, Julija Gecaite-Stonciene, Aurelija Podlipskyte, Julius Neverauskas, Alicja Juskiene, Vesta Steibliene, Nijole Kazukauskiene, Julius Burkauskas

“…Background: Cardiovascular diseases such as coronary artery disease (CAD) have a high prevalence of psychiatric comorbidities, that may impact clinically relevant outcomes (e.g., cognitive impairment and executive dysfunction). …”
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Clinical characteristics, outcomes, and costs of COVID-19 patients in Thai hospitels: a comparative analysis based on chest X-ray findings by Naruemit Sayabovorn, Pochamana Phisalprapa, Weerachai Srivanichakorn, Thanet Chaisathaphol, Chaiwat Washirasaksiri, Tullaya Sitasuwan, Chonticha Auesomwang, Chayanis Kositamongkol, Pongpol Nimitpunya, Teerapat Attachitwatin, Methee Chayakulkeeree, Pakpoom Phoompoung, Cherdchai Nopmaneejumruslers, Tawatchai Taweemonkongsap, Visit Vamvanij, Rungsima Tinmanee

“…Conclusions Compared with patients with normal baseline chest X-rays, COVID-19 patients with abnormal chest X-rays admitted to hospitels presented higher comorbidity rates, greater severe disease risk, and increased hospital referral rates. …”
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Pulmonary artery catheter use in acute myocardial infarction‐cardiogenic shock by Saraschandra Vallabhajosyula, Aditi Shankar, Sri Harsha Patlolla, Abhiram Prasad, Malcolm R. Bell, Jacob C. Jentzer, Shilpkumar Arora, Saarwaani Vallabhajosyula, Bernard J. Gersh, Allan S. Jaffe, David R. Holmes Jr, Shannon M. Dunlay, Gregory W. Barsness

“…Younger age, male sex, white race, higher comorbidity, noncardiac organ failure, use of mechanical circulatory support, and noncardiac support were independent predictors of PAC use. …”
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Status and annual change of vulnerability among middle-aged and elderly people with cardiometabolic multimorbidity in a division of Xinjiang Production and Construction Corps, 2017... by Ziqi WANG, Jieting CHEN, Mei ZHANG, Mingxia JING

“…The contribution rate of each vulnerability dimension was calculated to explore the vulnerability level and its hierarchical changes in different comorbidity combinations. The obstacle degree model was introduced to identify the influencing factors of vulnerability. …”
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Prevalence of potential drug‒drug interactions and associated factors among elderly patients in Ethiopia: a systematic review and meta-analysis by Tekletsadik Tekleslassie Alemayehu, Yilkal Abebaw Wassie, Abaynesh Fentahun Bekalu, Addisu Afrassa Tegegne, Wondim Ayenew, Gebresilassie Tadesse, Demis Getachew, Abebaw Setegn Yazie, Bisrat Birke Teketelew, Mekonnen Derese Mekete, Setegn Fentahun, Tesfaye Birhanu Abebe, Tefera Minwagaw, Gebremariam Wulie Geremew

“…This is due to their relatively high rates of comorbidity and polypharmacy, as well as physiological changes that can increase the potential for DDIs and the likelihood of adverse drug reactions. …”
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Utilisation of alcohol-related treatment after a first alcohol use disorder diagnosis in Hamburg, Germany by Jakob Manthey, Kilian Huß, Sven Buth, Ludwig Kraus, Anna Schranz, Carolin Kilian, Jürgen Gallinat, Ingo Schäfer, Bernd Schulte

“…Treatment utilisation was associated with younger age, female sex, unemployment, German nationality, and lower physical comorbidity. Among treatment entrants, nearly half received only brief psychiatric consultation. …”
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Weight-based enoxaparin thromboprophylaxis in young trauma patients: analysis of the CLOTT-1 registry by Sarah Lombardo, Ram Nirula, Elliott R Haut, Scott Brakenridge, Brandon Bruns, Charles E Wade, M Margaret Knudson, Thomas Scalea, Todd W Costantini, Lisa Marie Knowlton, David Spain, Ernest E Moore, Michelle K McNutt, Matthew J Martin, Andrew J Kerwin, George C Velmahos, Bruce Crookes, Marta McCrum, Lucy Kornblith, Mark D Cipolle, Laszlo N Kiraly, David J Milia, Alicia Mohr, Frederick Rogers, Sherry Sixta, Jade Nunez

“…Further studies need to evaluate these findings across a wider age and comorbidity spectrum.Level of evidence Level IV, therapeutic/care management.…”
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The Importance of Discordant Follicle Stimulating Hormone and Inhibin B Levels in Primary Infertile Men: Findings from a Cross-Sectional Study by Fausto Negri, Luca Boeri, Simone Cilio, Edoardo Pozzi, Federico Belladelli, Christian Corsini, Massimiliano Raffo, Giuseppe Fallara, Eugenio Ventimiglia, Luigi Candela, Alessia d’Arma, Francesco Montorsi, Andrea Salonia

“…Healthsignificant comorbidities were scored with Charlson comorbidity index. …”

Abnormal Liver Tests during Hospitalization Predict Mortality in Patients with COVID-19: A Multicenter Study from South America by Domingo Balderramo, Angelo Z. Mattos, Victoria Mulqui, Talita Chiesa, Zuly Plácido-Damián, Jaysoom Abarca, Andrea Bolomo, Yanina Carlino, Isadora Z. Bombassaro, Denusa Wiltgen, Laura Tenorio Castillo, Karina Díaz, Johana Acuña, Estela Manero, Jhon Prieto, Enrique Carrera, Javier Díaz-Ferrer, Jose D. Debes

“…We analyzed demographic and comorbid variables and laboratory tests on admission and during hospitalization. …”
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Post-acute sequelae of hospitalised COVID-19 re-infection compared with hospitalised first-time infection: a population-based retrospective cohort study in Hong Kong by Yin Zhang, Francisco T T Lai, Shirley Chiu Wai Chan, Chak Sing Lau, Xue Li, Eric Yuk Fai Wan, Lung Yi Mak, Celine S L Chui, Ivan F N Hung, Esther Wai Yin Chan, Vincent Ka Chun Yan, Deliang Yang, Carlos Wong, Ian Chi-Kei Wong

“…Subgroup analyses were conducted by age (<65 and ≥65 years), sex, Charlson Comorbidity Index (0–4, ≥5), COVID-19 vaccination (0–1, 2+doses) and hospitalisation status of previous infection.Results 2244 patients with hospitalised COVID-19 re-infection and 58 894 patients with hospitalised first-time COVID-19 infection were included. …”
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Personalized approach in the management of women with heart failure with preserved ejection fraction and carbohydrate metabolism disorders by L.R. Petrovska, I.O. Kostitska, T.R. Petrovskyy, R.V. Petrovskyy

“…The progression of heart failure (HF) in individuals with carbohydrate metabolism disorders is one of the many fatal complications among comorbid conditions. It is found that the risk of developing HF in women with diabetes mellitus (DM) is five times higher than in those without it. …”
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Network analysis of suicide ideation and depression–anxiety symptoms among Chinese adolescents by Yan Zhang, Jin Liu, Mei Huang, Liang Li, Yumeng Ju, Bangshan Liu, Shuyin Xu, Xiyu Wei, Wenwen Ou, Mohan Ma, Guanyi Lv, Xiaotian Zhao, Yaqi Qin, Yunjing Li, Siqi Yang, Yimei Lu, Yafei Chen, Junwu Liu

“…Background The co-occurrence of depression and anxiety among adolescents is typically associated with suicide ideation.Aims The study aimed to investigate the symptom-level relationship between suicide ideation and the comorbidity of depression and anxiety.Methods 1501 adolescents aged 12–19 years were assessed using the Patient Health Questionnaire (PHQ-9) and the Generalized Anxiety Disorder Scale, and 716 adolescents who scored ≥5 on both scales were selected as participants. …”
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A Neural Circuit From Paraventricular Nucleus of the Thalamus to the Nucleus Accumbens Mediates Inflammatory Pain in Mice by Xi Liu, Xi Zhang, Dongxu Wang, Ya Cao, Ling Zhang, Zhonghua Li, Qin Zhang, Yu Shen, Xian Lu, Keyu Fan, Mingxia Liu, Jingqiu Wei, Siping Hu, He Liu

“…ABSTRACT Background Pain is a prevalent comorbidity in numerous clinical conditions and causes suffering; however, the mechanism of pain is intricate, and the neural circuitry underlying pain in the brain remains incompletely elucidated. …”
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Investigate of preoperative hope level and analysis of influencing factors in elderly patients with femoral neck fracture (老年股骨颈骨折患者术前希望水平及影响因素分析)... by ZHANG Caixia (张彩侠), LI A Min (李阿敏), PAN Rusheng (潘如胜), LI Ling (李玲), CHE Xia (车侠)

“…The results of multiple stepwise regression analysis showed that age, comorbidity index, economic status, housing status, and self-efficacy were significant predictors of the preoperative hope level of elderly patients with femoral neck fractures (p<0. 05). …”
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Mental health disorder symptom changes among public safety personnel after emotional resilience skills training by R.N. Carleton, S. Sauer-Zavala, T.A. Teckchandani, K.Q. Maguire, L. Jamshidi, R.E. Shields, T.O. Afifi, J. Nisbet, K.L. Andrews, S.H. Stewart, A.J. Fletcher, R. Martin, R.S. MacPhee, J.C. MacDermid, T.M. Keane, A. Brunet, M. McCarron, L.M. Lix, N.A. Jones, G.P. Krätzig, J.P. Neary, G. Anderson, R. Ricciardelli, H. Cramm, J. Sareen, G.J.G. Asmundson

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Changes in laboratory value improvement and mortality rates over the course of the pandemic: an international retrospective cohort study of hospitalised patients infected with SARS... by Ramakanth Kavuluru, Xuan Wang, Paul Avillach, Florence Bourgeois, Kee Yuan Ngiam, Gabriel A Brat, Isaac Kohane, Tianxi Cai, Yuk-Lam Ho, Yuan Luo, Harrison G Zhang, Kelly Cho, Vincent Benoit, Antoine Neuraz, Chuan Hong, Sehi L'Yi, Griffin Weber, Bryce W Q Tan, Alba Gutiérrez-Sacristán, Clara-Lea Bonzel, Nathan P Palmer, Alberto Malovini, Valentina Tibollo, Meghan R Hutch, Molei Liu, Riccardo Bellazzi, Luca Chiovato, Fernando J Sanz Vidorreta, Trang T Le, William Yuan, Bertrand Moal, Michele Morris, David A Hanauer, Sarah Maidlow, Kavishwar Wagholikar, Shawn Murphy, Hossein Estiri, Adeline Makoudjou, Patric Tippmann, Jeffery Klann, Robert W Follett, Nils Gehlenborg, Gilbert S Omenn, Zongqi Xia, Arianna Dagliati, Shyam Visweswaran, Lav P Patel, Danielle L Mowery, Emily R Schriver, Malarkodi Jebathilagam Samayamuthu, Sara Lozano-Zahonero, Daniela Zöller, Amelia L M Tan, Byorn W L Tan, John H Holmes, Petra Schubert, Brett K. Beaulieu-Jones, Miguel Pedrera-Jiménez, Noelia García-Barrio, Pablo Serrano-Balazote, Andrew South

“…The secondary outcome was the average rate of change in laboratory values during the first week of hospitalisation.Results Baseline Charlson Comorbidity Index and laboratory values at admission were not significantly different between the first and second waves. …”
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Biologics as well as inhaled anti-asthmatic therapy achieve clinical remission: Evidence from the Severe Asthma Network in Italy (SANI) by Giorgio Walter Canonica, MD, Francesco Blasi, PhD, Pierluigi Paggiaro, MD, Enrico Heffler, PhD, Fulvio Braido, MD, Luisa Brussino, PhD, Giulia Scioscia, PhD, Cristina Cardini, MsC, Chiara Oriecuia, MsC, Isabella Sala, MsC, Vincenzo Bagnardi, PhD, Cecilia Calabrese, PhD, Gianna Camiciottoli, MD, Giovanna Elisiana Carpagnano, PhD, Stefano Centanni, PhD, Angelo Guido Corsico, PhD, Maria Teresa Costantino, MD, Claudia Crimi, PhD, Alice D'Adda, MD, Simona D’Alò, MD, Maria D'Amato, PhD, Corrado D'Andria, MD, Stefano Del Giacco, MD, Fabiano Di Marco, PhD, Nicola Cosimo Facciolongo, MD, Alessandro Farsi, MD, Manuela Latorre, PhD, Manlio Milanese, PhD, Eustachio Nettis, MD, Eleonora Nucera, MD, Giovanni Passalacqua, MD, Girolamo Pelaia, MD, Laura Pini, MD, Luisa Ricciardi, PhD, Fabio Luigi Massimo Ricciardolo, PhD, Luca Richeldi, PhD, Erminia Ridolo, PhD, Pierachille Santus, PhD, Nicola Scichilone, PhD, Gianenrico Senna, MD, Giuseppe Spadaro, MD, Antonio Spanevello, MD, Paolo Tarsia, MD

“…Chronic rhinosinusitis with nasal polyps (CRSwNP) comorbidity was associated, though not significantly, with CR achievement in patients treated with biologics. …”
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Prevalence of chronic kidney disease among Chinese adults with diabetes: a nationwide population-based cross-sectional studyResearch in context by Weiping Jia, Rong Yu, Limin Wang, Dalong Zhu, Lixin Guo, Jianping Weng, Hong Li, Mei Zhang, Xiaoqi Ye, Zhiguang Zhou, Dajin Zou, Qiuhe Ji, Xiaohui Guo, Yinan Zhang, Dong Lang, Jiarui Wu, Jing Wu, Xuhong Hou, Xiaohui Guo, Kai Wu, Liming Chen, Demin Liu, Guangyao Song, Linyi Shu, Jing Yang, Yan Wang, Dongmei Li, Qiansha Guo, Ling Li, Na Wu, Yadong Sun, Huifang Cheng, Hongyu Kuang, Huijuan Zhang, Weiping Jia, Xuhong Hou, Dalong Zhu, Jian Zhu, Hong Li, Fenping Zheng, Qiu Zhang, Honglin Hu, Gang Chen, Xingquan Yang, Xiaoyang Lai, Jianping Liu, Li Chen, Ming Dong, Zhigang Zhao, Jian Liu, Guangda Xiang, Junxia Zhang, Zhiguang Zhou, Jian Peng, Jianping Weng, Longyi Zeng, Yuzhen Liang, Guoqiao Li, Kaining Chen, Leweihua Lin, Qifu Li, Qingfeng Cheng, Xingwu Ran, Dawei Chen, Hong Li, Xin Nian, Lihui Yang, Shuyou Meng, Jing Xu, Junhong Long, Jing Liu, Qi Zhang, Qingxiang Dai, Xiaomin Xie, Guirong Bai, Jun Li, Tao Li, Zhong Dong, Tao Zhang, Sijia Liu, Yong Yang, Kun Geng, Wenlong Zheng, Zhihong Li, Hui Wang, Zuojun Wu, Miao Wang, Jixin Sun, Jianwei Zhou, Jun An, Huaqing Shen, Yanfang Li, Zeping Ren, Xiuli Xue, Shaohui Jia, Yongping Zheng, Jiaoxia Li, Yonggang Qian, Ping Ma, Yan Su, Liang Cao, Xuyi Yang, Guowei Pan, Guangzhi Pan, Ling Jin, Quanfu Yu, Yunfei Liu, Yingli Zhu, Zhifang Cheng, Jun Yang, Chundi Jia, Qing Wang, Shichun Yan, Jingyang Huang, Yumei Chi, Li Zhang, Ruifa Pang, Yan Shi, Yan Lu, Yiling Wu, Jie Yu, Chunxiang Wu, Jinyi Zhou, Yunxia Wu, Ning Zhang, Jing Sun, Xiumei Tian, Jieming Zhong, Jingying Chen, Kaixu Xie, Lingjuan Fu, Xiaohua Wang, Yeji Chen, Ling Zeng, Zhenqian Cao, Maomin Yang, Biao Hu, Wenling Zhong, Qingyan Liu, Zhiding Huang, Qingbin Lai, Yuyu Zhang, Liping Zhu, Yujing Zhao, Wuming Tao, Yonghai Tu, Lin Zhou, Xiaolei Guo, Benzheng Chai, Liping Ding, Yuewei Zou, Dongzhi Li, Li Hua, Shixian Feng, Jianli Guo, Wanguang Liu, Qingxiang Li, Yunzhi Zheng, Minli Xu, Lan Zhang, Chunbo Li, Yingchao Wan, Chi Hu, Shengping Xu, Biyun Chen, Huilin Liu, Xiaojia Bian, Wenwei Chen, Honghua Li, Yanjun Xu, Fan Weng, Hong Wu, Weijin Zhang, Liankai Zhu, Jun Meng, Jin Yang, Yongsong Zeng, Gaoke Zhai, Lingfeng Qin, Yi Lu, Zhenwang Fu, Shukuan Wu, Caigang Li, Na Wang, Lianfen Chen, Xianbin Ding, Qi Zhou, Yiling Xie, Rui Chen, Dongsheng Yang, Ying Deng, Youping Hu, Bo Huang, Ping Wang, Peng Cai, Changyan Peng, Xiaofang Chen, Ling Li, Liang Xiao, Chenglin Wang, Chaogang Tan, Daobin Chen, Min Chen, Mingfang Qin, Zhaomin Lei, Jianzhi Qiu, Wei Yu, Yunfei Li, Guoxia Bai, Ying Wang, Lin Qiu, Ning Wang, Xudong Zhao, Ani Yan, Jianfei Liu, Tingcai Wang, Kaihua Hao, Zaihong Zhang, Zhanqi Xian, Tenghuan Ma, Zhihua Xu, Yi Yang, Hongli Wang, Rong Li, Zhonggang Zhao, Caixia Fan, Purhati, Hongjun Xu, Liping Gao

“…Summary: Background: To date, comprehensive data on the distribution of chronic kidney disease (CKD), the most prevalent comorbidity in diabetes, among Chinese adults with diabetes is lacking. …”
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Idiopathic pulmonary fibrosis is a risk factor for cardiovascular disease: potential role of KL-6 and systemic inflammation by Mohamed F. AbdelGhany, Waleed GamalEldin Khaleel, Asmaa Omar Ahmed, Ahmad BaheyElden Ahmed, Lamees M. Bakkar

“…It is characterized by pulmonary and extrapulmonary comorbidities. So far, little is known as regards the prevalence of cardiovascular comorbidities in IPF patients. …”
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