Clinical Characteristics of COVID-19 in Neonates and Infants Younger Than 3 Months by Fatemeh Varshoei, Mohammad Sadegh Rezai, Roya Farhadi, Azin Hajialibeig, Saeid Mohammadi, Masoud Moradi, Fatemeh Hosseinzadeh

“…Demographic data such as age, sex, comorbidity, clinical characteristics and symptoms, medications, and laboratory test results were extracted from the patient’s medical records. …”
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A Digital Tool for Clinical Evidence–Driven Guideline Development by Studying Properties of Trial Eligible and Ineligible Populations: Development and Usability Study by Shahzad Mumtaz, Megan McMinn, Christian Cole, Chuang Gao, Christopher Hall, Magalie Guignard-Duff, Huayi Huang, David A McAllister, Daniel R Morales, Emily Jefferson, Bruce Guthrie

“…ResultsThe tool supports 128 chronic health conditions as index conditions and 161 conditions as comorbidities (33 in addition to the 128 index conditions). …”
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Exploring the shared gene signatures and mechanism among three autoimmune diseases by bulk RNA sequencing integrated with single-cell RNA sequencing analysis by Xiaofang Liu, Bin Li, Yuxi Lin, Xueying Ma, Yingying Liu, Lili Ma, Xiaomeng Ma, Xia Wang, Nanjing Li, Xiaoyun Liu, Xiaohong Chen

“…BackgroundEmerging evidence underscores the comorbidity mechanisms among autoimmune diseases (AIDs), with innovative technologies such as single-cell RNA sequencing (scRNA-seq) significantly advancing the explorations in this field. …”
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Clostridium difficile-associated disease in versatile hospital patient population and risk factors for its development by Ya. N. Yarushina, G. B. Kolotova, V. A. Rudnov, V. A. Bagin

“…Predictors of C. difficile-associated diarrhea risk were following: the age over 65 years (OR=3.43; 95%CI 1.06-11.08; р=0.0409), Charlson comorbidity index over 2 points (OR=2,92, 95%CI 1.33-6.44; р=0.0114), presence of anemia (OR=4,35, 95%CI 1.98-9.54; р=0.0003), admission to intensive care unit with staying for more than 1 day (OR=10.59; 95%CI 2.35-47.69; р=0.0002) and in surgical departments (OR=2.46; 95%CI 1.16-5.20; р=0.0276), surgical intervention (OR=3.06; 95%CI 1.33-7.04; р=0.0120), hospital stay for 5 days (OR=3.87; 95%CI 1.87-8.01; р=0.0004), chronic dialysis at chronic renal failure (OR=8.56; 95% of CI 1,05-69,69; р=0,0210), installation of an urethral catheter (OR=3,43; 95% of CI 1.06-11.08; р=0.0409), proton pump inhibitors (PPI) therapy for over 7 days (OR=7.76; 95% CI 1.69-35.53; р=0.0032), antibacterial therapy for over 5 days (OR=4.10; 95%CI 1.93-8.68; р=0.0003), more than one course} of antibacterial treatment (OR=5.31; 95% CI 1.12-25.03; р=0.0365), ceftriaxone therapy (OR=3.21; 95%CI 1.51-6.82; р=0.0036). …”
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Systematic review and meta‐analysis of the pelvic organ prolapse and vaginal prolapse among the global population by Tharanga Mudalige, Vindya Pathiraja, Gayathri Delanerolle, Heitor Cavalini, Shuqi Wu, Julie Taylor, Om Kurmi, Kathryn Elliot, Sharron Hinchliff, Carol Atkinson, Kristina Potocnik, Paula Briggs, Lucky Saraswat, Helen Felicity Kemp, George Eleje, Toh Teck Hock, Cristina Laguna Benetti‐Pinto, Irfan Muhammad, Rabia Kareem, Yassine Bouchareb, Peter Phiri, Ruishu Zhang, Yunfei Weng, Ieera Aggarwal, Jian Qing Shi, Ashish Shetty, Ian Litchfield, Nirmala Rathnayake, Sohier Elneil

“…The review highlighted a lack of diversity in terms of ethnicity, age and comorbidity status, which are essential to fully understanding the impact of POP. …”
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Preventable hospitalizations through ED: does the number of hospital beds matter under the global budget in a single-payer system in Taiwan? by Hsueh-Fen Chen, Hsueh-Fen Chen, Hsueh-Fen Chen, Hui-Min Hsieh, Hui-Min Hsieh, Hui-Min Hsieh, Wei-Shan Chang

“…In contrast, other factors, such as female patients and the Charlson comorbidity index, were negatively associated with the likelihood of ED hospitalizations.ConclusionUnder hospital global budgeting with a floating-point value mechanism, increases in hospital beds likely motivate hospitals to admit ED patients with preventable and discretionary conditions. …”
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The IVIG treatment response in autoimmune polyendocrine syndromes type 2 with anti-GAD65 antibody-associated stiff person syndrome: a case report and literature review by Yulong Yang, Hailin Jiang, Wenming Yang, Wenming Yang, Wenming Yang, Han Wang, Han Wang, Meixia Wang, Meixia Wang, Xiang Li, Peng Huang, Shuzhen Fang, Wenjie Hao, Yue Yang, Furong Zhao, Wei He

“…SPS is characterized by axial muscle stiffness, rigidity, and intermittent painful muscle spasms, with a prevalence of one to two in a million, making it an extremely rare neurological disorder. The comorbidity of APS-2 with SPS is even rarer. Most practicing neurologists encounter only one or two cases of APS-2 combined with anti-GAD65 antibody-associated SPS in their careers, resulting in underdiagnosis and undertreatment, leading to severe disability and suffering. …”
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Effects of the Early Start Denver Model on emotional dysregulation and behavior problems in children with Autism spectrum disorder by Wan-Xia Liu, Ling Shan, Chun-Li Li, Yu-Mo Liu, Yang Xue, Yu-Ling OuYang, Fei-Yong Jia

“…Emotional dysregulation and behavior problems represent an important comorbidity, and could be considered as potential treatment targets for treatment for improving emotional stability in ASD.…”
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The clinical features and risk factors of coagulopathy associated with cefoperazone/sulbactam: a nomogram prediction model by Changjing Xu, Junlong Zhu, Kun Tu, Hui Tang, Xinxin Zhou, Qiuyu Li, Kun Chen, Xuping Yang, Yilan Huang

“…The performance of the nomogram was estimated using the concordance index (C-index) and calibration curve.ResultsThe multivariate logistic regression analysis resulted in the following independent risk factors for CD: baseline INR level (OR: 5.768, 95% CI: 0.484∼11.372, p = 0.036), nutritional risk (OR:2.711, 95%CI: 1.495∼4.125, p < 0.001), comorbidity of digestive system (OR:1.287, 95%CI: 0.434∼2.215, p = 0.004), poor food intake (OR:1.261, 95%CI: 0.145∼2.473, p = 0.032), ALB level (OR: −0.132, 95%CI: −0.229∼-0.044, p = 0.005) and GFR< 30 mL/min (OR: 1.925, 95%CI: 0.704∼3.337, p = 0.004). …”
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Green sanctuaries: residential green and garden space and the natural environment mitigate mental disorders risk of diabetic patients by Erxu Xue, Jianhui Zhao, Jingyu Ye, Jingjie Wu, Dandan Chen, Jing Shao, Xue Li, Zhihong Ye

“…Abstract Background The co-occurrence of diabetes and mental disorders is an exceedingly common comorbidity with poor prognosis. We aim to investigate the impact of green space, garden space, and the natural environment on the risk of mental disorders among the population living with diabetes. …”
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Electroacupuncture and Tongbian decoction ameliorate CUMS-induced depression and constipation in mice via TPH2/5-HT pathway of the gut-brain axis by Yi Chen, Peihua Shen, Qi Li, Shun Seng Ong, Yunzhi Qian, Hai Lu, Ming Li, Tianshu Xu

“…Chronic unpredictable mild stress (CUMS) was employed to induce a comorbidity model of depression and constipation in mice, followed by the administration of EA, EA + TB, and fluoxetine (FLX). …”
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Clinical course, management and outcomes of COVID-19 in HIV-infected renal transplant recipients: A case series by L Bertels, K Manning, A Redd, T du Toit, Z Barday, E Muller

“…HIV‐infected kidney transplant recipients with COVID‐19 are at increased risk of acute illness and death owing to their underlying comorbidities and chronic immunosuppression. Objectives. …”
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Mendelian randomization and multiomics comprehensively reveal the causal relationship and potential mechanism between atrial fibrillation and gastric cancer by Zhao Sicheng, Zhao Sicheng, Zhang Jingcheng, Zhang Jingcheng, Zhang Shuo, Zhang Shuo, Lou Jiaheng, Lou Jiaheng, Cai Yan, Cai Yan, Bai Xing, Bai Xing, Jiang Tao, Jiang Tao, Jiang Tao, Zhang Guangji, Zhang Guangji, Zhang Guangji

“…ObjectiveGastric cancer is a harmful disease, the comorbidity mechanism and causality relationship between this disease and other diseases are worth studying.MethodsUsing a two-sample Mendelian Randomization method, this study revealed the potential causal effect of atrial fibrillation (AF) on gastric cancer (GC) risk by constructing a genetic instrument containing 136 AF associated SNPs. …”
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Evaluation of the ABC pathway in patients with atrial fibrillation: A machine learning cluster analysis by Jingyang Wang, Haiyang Bian, Jiangshan Tan, Jun Zhu, Lulu Wang, Wei Xu, Lei Wei, Xuegong Zhang, Yanmin Yang

“…The clusters include Cluster 1: old patients with the highest prevalence rates of atherosclerotic and/or other comorbidities (n = 964), Cluster 2: valve-comorbidities AF in young females (n = 407), and Cluster 3: low comorbidity patients with paroxysmal AF (n = 644). …”
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Venous thromboembolism incidence and risk factors associated with immune checkpoint inhibitors among patients with advanced non-small cell lung cancer by Chi Nguyen, Alok A Khorana, John Barron, Jennell Palaia, Lisa Rosenblatt, Radhika Pisupati, Ning Huang, Kerrin Gallagher, T Christopher Bond

“…VTE is a common complication of lung cancer, and there is a continued need for awareness of VTE as a comorbidity in this population.…”
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The Effects of Oral Semaglutide on Hepatic Fibrosis in Subjects with Type 2 Diabetes in Real-World Clinical Practice: A Post Hoc Analysis of the Sapporo-Oral SEMA Study by Hiroya Kitsunai, Yuka Shinozaki, Sho Furusawa, Naoyuki Kitao, Miki Ito, Hiroyoshi Kurihara, Chiho Oba-Yamamoto, Jun Takeuchi, Akinobu Nakamura, Yumi Takiyama, Hiroshi Nomoto

“…Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is an important common comorbidity in subjects with type 2 diabetes, and liver fibrosis is a factor directly related to its prognosis. …”
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Factors associated with the revolving door phenomenon in patients with schizophrenia: results from an acute psychiatric hospital in Romania by Vlad Dionisie, Vlad Dionisie, Maria Gabriela Puiu, Maria Gabriela Puiu, Mihnea Costin Manea, Mihnea Costin Manea, Emanuel Moisa, Ana Maria Dumitru, Leila Ibadula, Aliss Madalina Mares, Aliss Madalina Mares, Corina Ioana Varlam, Mirela Manea, Mirela Manea

“…Male gender (p=0.000), younger age (p<0.05), presence of psychiatric comorbidity (p<0.05), substance use disorder (p=0.000) and alcohol use disorder (p<0.01) were associated with the revolving door patients. …”
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Diagnostics and treatment of Clostridium difficile-associated disease: Guidelines of the Russian gastroenterological association by V. T. Ivashkin, N. D. Yushchuk, I. V. Mayev, Tatyana L Lapina, Ye. A. Poluektova, O. S. Shifrin, A. S. Tertychny, A. S. Trukhmanov, A. A. Sheptulin, Ye. K. Baranskaya, O. S. Lyashenko, K. V. Ivashkin

“…Risk factors of C. difficile-associated include antibacterial therapy, hospital admission, elderly age, comorbidity and immunosuppressive treatment. At the present time several laboratory methods for diagnosis of Clostridial infection exist: fecal ELISA test for toxins A and B, PCR, test for C. difficile glutamate dehydrogenase. …”
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Evolving racial/ethnic disparities in AML survival in the novel therapy era by Xin Wang, Phyllis A. Gimotty, Andrew H. Matthews, Ronac Mamtani, Selina M. Luger, Elizabeth O. Hexner, Daria V. Babushok, Shannon R. McCurdy, Noelle V. Frey, Ximena Jordan Bruno, Saar Gill, Mary Ellen Martin, Vikram R. Paralkar, Ivan Maillard, David L. Porter, Alison W. Loren, Alexander E. Perl, Keith W. Pratz, Kelly D. Getz, Catherine Lai

“…After accounting for age and comorbidity, overall survival (OS) was higher in patients in Post era than Pre era (adjusted hazard ratio [aHR], 0.90; 95% confidence interval [CI], 0.83-0.96). …”
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Spine surgery and readmission: Risk factors in lumbar corpectomy patients by Julius Gerstmeyer, MD, Anna Gorbacheva, August Avantaggio, Clifford Pierre, MD, Emre Yilmaz, MD, Thomas A. Schildhauer, MD, Amir Abdul-Jabbar, MD, Rod J Oskouian, MD, Jens R Chapman, MD

“…Demographic information and clinical data, including comorbidities, was extracted. Patients were categorized by their readmission status. …”
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