Racial differences in takotsubo cardiomyopathy outcomes in a large nationwide sample by Raja Zaghlol, Amit K. Dey, Sameer Desale, Ana Barac

“…After the adjustment for differences in age, gender, comorbidities (using the enhanced Charlson comorbidity index), hospital location/teaching status, and socio‐economic factors, all differences were significantly attenuated or eliminated. …”
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Comparison of the regional and general anesthesia as a risk factor of perioperative arrhythmia: a two-group observational study by N.M. Semenko, Iu.L. Kuchyn, K.Yu. Bielka, M.S. Frank

“…Regional anesthesia has less hemodynamic effects and is the method of choice in patients with cardiovascular comorbidity. However, given the risk of cardiotoxicity due to the resorptive effect of the local anesthetic, in older patients and with existing risk factors, it is crucial to account for the arrhythmogenic effects of local anesthetics and adjust the dosage accordingly.…”
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Cost analysis of dermal allograft patch utilization in rotator cuff repair by Adrik Z. Da Silva, BS, Joshua Mizels, MD, Christopher E. Clinker, BS, Minkyoung Yoo, PhD, Richard Nelson, PhD, Christopher Joyce, MD, Robert Z. Tashjian, MD, Peter N. Chalmers, MD

“…Via chart review, we collected demographics, medical comorbidities, tear characteristics, and intraoperative repair characteristics. …”
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Association between HOMA2 based beta-cell function or insulin resistance and long-term outcomes in kidney transplant recipients with type 2 diabetes by Mehdi Maanaoui, Florence Debillon, Rémi Lenain, Frédérique Defrance, Marie-Christine Vantyghem, Marine Van Triempont, François Provôt, Mikael Chetboun, Julie Kerr-Conte, Aghiles Hamroun, Marie Frimat, Violeta Raverdy, François Pattou, Marc Hazzan, François Glowacki

“…Abstract Type 2 diabetes (T2D) is a common comorbidity in kidney transplant recipients, representing a significant proportion of the candidate pool. …”
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Depression Paradox in Cardiovascular Outcomes of Adult Patients with Obstructive Sleep Apnea: Insights from 2 Million Nationwide Hospitalizations by Rupak Desai, Sashwath Srikanth, Shaylika Chauhan, Zainab Gandhi, Warda Shahnawaz, Aleen Rahman, Bisharah Rizvi, Akhil Jain

“…OBJECTIVE: Depression is a frequent comorbidity in obstructive sleep apnea (OSA) patients. …”
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Relationship Between Obstructive Sleep Apnea and Enuresis in Children: Current Perspectives and Beyond by Wang Z, Zhang P, Shi R, Yang S, Liu K, Zhou Z, Li Q

“…The benefits of positive airway pressure (PAP) therapy in children with NE remain to be further studied.Conclusion: NE and OSA comorbidity seriously affect the physical and mental health of children. …”
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Impact of re-operation on progression-free survival in patients with recurrent GBM: Experience in a tertiary referral center. by Houssein Darwish, Tasnim Diab, Sarah Kawtharani, Mounir Barake, Bader Ali, Nagham Ramadan, Hiba Fadlallah, Jeannot Kekedjian, Marwan Najjar, Hazem I Assi

“…However, a notable association was observed with Charlson comorbidity index (CCI) ≤3, indicating higher reoperation rates (p = 0.022). …”
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Insulin degludec 100 U/mL for treatment of spontaneous diabetes mellitus in dogs by Jocelyn Mott, Arnon Gal, Antonio Maria Tardo, Alisa Berg, Riley Claude, Alexis Hoelmer, Mei Lun Mui, Avin Arjoonsingh, Chen Gilor

“…Seventy‐nine percent (26/33) of the dogs had comorbidities with 42% (11/26) having more than 1 comorbidity. …”
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The criteria for choice of myocardial revascularization method in patients with stable coronary artery disease in routine clinical practice by O.A. Yepanchintseva, O.J. Zharinov, K.O. Mikhaliev, A.V. Khokhlov, B.M. Todurov

“…In patients with similar coronary artery lesions, the potential criteria for MR method include such characteristics, as severity of symptoms, comorbidity and prior CAD treatment.…”
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The influence of neurovegetative and psychological characteristics of infertile patients with long-term COVID-19 on the effectiveness of assisted reproductive technologies by O.G. Boichuk, I.S. Golovchak, T.V. Kolomiichenko

“…These patients have a higher level of stressogenic load: comorbidity with chronic somatic pathology (58.8%), conflict situations in the family (31.3%), dissatisfaction with their sexual relationships (58.7%), a significantly higher level of fear of COVID -19 (29.73±1.31 points). …”
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Aluminium adjuvants versus placebo or no intervention in vaccine randomised clinical trials: a systematic review with meta-analysis and Trial Sequential Analysis by Christian Gluud, Marija Barbateskovic, Sara Russo Krauss, Janus C Jakobsen, Sesilje Bondo Petersen, Sarah Louise Klingenberg, Snezana Djurisic, Mette Kenfelt, De Zhao Kong

“…Objectives To assess the benefits and harms of aluminium adjuvants versus placebo or no intervention in randomised clinical trials in relation to human vaccine development.Design Systematic review with meta-analysis and trial sequential analysis assessing the certainty of evidence with Grading of Recommendations Assessment, Development and Evaluation (GRADE).Data sources We searched CENTRAL, MEDLINE, Embase, LILACS, BIOSIS, Science Citation Index Expanded and Conference Proceedings Citation Index-Science until 29 June 2021, and Chinese databases until September 2021.Eligibility criteria Randomised clinical trials irrespective of type, status and language of publication, with trial participants of any sex, age, ethnicity, diagnosis, comorbidity and country of residence.Data extraction and synthesis Two independent reviewers extracted data and assessed risk of bias with Cochrane’s RoB tool 1. …”
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The evolving landscape of COVID-19: factors associated with in-hospital COVID-19 related mortality during the 2023–2024 phase of JN.1 subvariant dominance by Drieda Zaçe, Albiana Çekrezi, Christopher Jones, Ludovica Ferrari, Giuseppe De Simone, Elisabetta Teti, Vincenzo Malagnino, Marco Iannetta, Loredana Sarmati, Anna Maria Geretti

“…Results Among 122 individuals (median age 76 years, 58.2% males, median comorbidity index 5), 114/122 (93.4%) had received ≥ 1 SARS-CoV-2 vaccination, with a median of 23 months elapsed since the last dose. …”
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Low-Dose Ketamine Infusion for Perioperative Pain Management in Patients Undergoing Laparoscopic Gastric Bypass: A Prospective Randomized Controlled Trial by Mitchell T. Seman, Shawn H. Malan, Matthew R. Buras, Richard J. Butterfield, Kristi L. Harold, James A. Madura, David M. Rosenfeld, Andrew W. Gorlin

“…Obesity is a common comorbidity seen in the perioperative setting and is associated with many diseases including cardiovascular disease and obstructive sleep apnea. …”
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Reference values for the 1-minute sit-to-stand test to assess functional capacity and short-term mortality in people with idiopathic pulmonary fibrosis and fibrotic connective tiss... by Meng-Yun Tsai, Kuo-Tung Huang, Chiann-Yi Hsu, Yi-Hsuan Yu, Pin-Kuei Fu

“…Assessments included the 1MSTS, 6MWT, pulmonary function test (PFT), GAP score, mMRC scale, and Charlson Comorbidity Index (CCI). The association between 1MSTS repetitions and other variables was calculated using Spearman’s rho. …”
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Increased Mortality After Lower Extremity Amputation in a Danish Nationwide Cohort: The Mediating Role of Postoperative Complications by Brix ATH, Petersen TG, Nymark T, Schmal H, Lindberg-Larsen M, Rubin KH

“…Windsløws vej 4, Odense, 5000, Denmark, Tel +45 3027 2862, Email anna.trier.heiberg.brix@rsyd.dkObjective: Patients who undergo major lower extremity amputation (MLEA) have the highest postoperative mortality among orthopedic patient groups. The comorbidity profile for MLEA patients is often extensive and associated with elevated postoperative mortality. …”
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Antidepressant- and Anxiolytic-like Effects in Mice of Alkaloids from Aerial Parts of <i>Argemone platyceras</i> Link & Otto by Mayra Beatriz Gómez-Patiño, Rosa Estrada-Reyes, Héctor Hugo Hernández-Mendoza, Ángela Suarez-Rojas, Daniel Arrieta-Baez

“…<b>Conclusions:</b> The easy and standardized AlkExt analyzed in pharmaceuticals assays in this study strongly suggest its therapeutic potential to treat the comorbidity of anxiety and depression disorders and support further investigations in people with these diseases.…”
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Association between selective serotonin reuptake inhibitors use and blood transfusion risk in older adults after hip fracture: a cohort study by Héloïse Gobillot-Morisson, Bastien Genet, Corinne Frère, Judith Cohen-Bittan, Mathieu Raux, Marie-Eva Rollet, Anthony Meziere, Jacques Boddaert, Lorène Zerah, Sara Thietart

“…Conclusions Among older comorbid adults undergoing hip fracture surgery, the use of SSRIs was not associated with an increased risk of perioperative RBC transfusion.…”
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Survival in patients with CKD 3–5 after 12 months of exercise training – a post-hoc analysis of the RENEXC trial by Sara Denguir, Matthias Hellberg, Martin Almquist, Naomi Clyne

“…Univariate and multivariate Cox regression analyses were used and adjusted for age, sex, comorbidity, time on dialysis and time with a kidney transplant. …”
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Post-COVID-19 laryngo-tracheal sequelae: a comprehensive study at a tertiary care centre by Karthik P., Rupa Mehta, Ranganath T. G., Ajoy K. Behra, Atul Jindal, Himanshi Grover

“…Majority of our patients had history of hospital admission which was predominant (87.1%) over home isolation (10.3%). Most common comorbidity was diabetes mellitus (DM) (62.4%) along with hypertension. …”
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Admission outcomes and their associated factors among children admitted to the paediatric emergency unit within 24 hours of Dilla University Referral Hospital, Ethiopia, 2023: a cr... by Binyam Tariku Seboka, Tomas Yeheyis, Yihenew Ayehu Dessie, Samuel Jigso Dube, Abel Desalegn Demeke, Mekdes Mekonnen Feleke, Abdo Hajo Jarso, Asresu Feleke Bati, Etaferaw Udo, Selam Tadele Markos, Chalachew Kassaw, Amdehiwot Aynalem Debebe, Ephrem Geja Gechere

“…Children presented with diarrhoea (adjusted OR (AOR) =2.92, 95% CI 1.46 to 5.84), severe respiratory distress (AOR=5.08, 95% CI 2.49 to 10.35), coma (AOR=3.71, 95% CI 1.24 to 11.13), comorbidity (AOR=3.33, 95% CI 1.49 to 7.41) and delay to seek healthcare (AOR=1.99, 95% CI 1.03 to 3.83) were significantly associated factors with emergency unit mortality, whereas pneumonia (AOR=1.76, 95% CI 1.16 to 2.65) and severe acute malnutrition (AOR=3.46, 95% CI 2.06 to 5.81) were significantly associated factors with intrahospital unit/ward transfer.Conclusion The magnitude of mortality, transfer to the ward and discharge against medical advice were relatively higher. …”
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