Retrospective study of factors associated with the clinical severity of covid-19 in older adults in Minas Gerais: structural equation modeling by Flavia Aparecida Dias Marmo, Nayara Gomes Nunes Oliveira, Érica Midori Ikegami, Neilzo Nunes Oliveira, Joilson Meneguci, Darlene Mara dos Santos Tavares

“…In addition to the direct effect, a greater number of risk/comorbidity factors and longer hospitalization time mediated the association between demographic variables and outcomes.…”
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Assessing the impact of long-term inhaled corticosteroid therapy on patients with COVID-19 and coexisting chronic lung disease: A multicenter retrospective cohort study by Adela Pina Belmonte, Manuel Madrazo, Laura Piles, Manuel Rubio-Rivas, Lucía de Jorge Huerta, María Gómez Antúnez, Juan Francisco López Caleya, Francisco Arnalich Fernández, Martin Gericó-Aseguinolaza, Paula Maria Pesqueira Fontan, Nicolás Rhyman, Marina Prieto Dehesa, Juan Luis Romero Cabrera, Gema María García García, Gonzalo García-Casasola, Ane Labirua-Iturburu Ruiz, Francisco Javier Carrasco-Sánchez, Sara Martínez Hernández, Maria de los Reyes Pascual Pérez, José López Castro, José Luis Serrano Carrillo de Albornoz, José F. Varona, Ricardo Gómez-Huelgas, Juan-Miguel Antón-Santos, Carlos Lumbreras-Bermejo

“…Patients with chronic ICS had a longer hospital stay in both asthma and COPD patients (9 vs. 8 days, *p =* 0.031 in asthma patients), (11 vs. 9 days, *p =* 0.018 in COPD patients); although they also had more comorbidity burden. # Conclusions Patients with chronic inhaled corticosteroids had longer hospital stays and more chronic comorbidities, measured by the Charlson comorbidity index, but they did not have more severe disease at admission, evaluated with qSOFA and PSI scores. …”
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Hypnotics' association with mortality or cancer: a matched cohort study by Daniel F Kripke, Lawrence E Kline, Robert D Langer

“…Hazard ratios (HRs) for death were computed from Cox proportional hazards models controlled for risk factors and using up to 116 strata, which exactly matched cases and controls by 12 classes of comorbidity.Results As predicted, patients prescribed any hypnotic had substantially elevated hazards of dying compared to those prescribed no hypnotics. …”
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Pre-existing atrial fibrillation and risk of arterial thromboembolism and death following pneumonia: a population-based cohort study by Reimar Wernich Thomsen, Christian Fynbo Christiansen, Bodil Steen Rasmussen, Lars Hvilsted Rasmussen, Jacob Gamst

“…After adjustment for higher age and comorbidity, the adjusted HR (aHR) with AF was 1.06 (95% CI 0.96 to 1.18). …”
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Sex Disparities in Effects of Cystic Fibrosis-Related Diabetes on Clinical Outcomes: A Matched Study by Robert J Miller, Hugh D Tildesley, Pearce G Wilcox, Hongbin Zhang, Stuart H Kreisman

“…BACKGROUND: Cystic fibrosis-related diabetes (CFRD) is an increasingly prevalent comorbidity factor for patients with cystic fibrosis (CF). …”
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Etiological, Clinical, and Epidemiological Characteristics of Acute Viral Gastroenteritis in an Adult Population in a Tertiary Level Hospital in Spain by Sara Herranz-Ulldemolins, Anna Sellarès-Crous, Miriam J. Álvarez-Martínez, M. Eugenia Valls, Marta Aldea Novo, Anna Vilella Morató, Laura Rodriguez, Mireia Navarro, Roser Vendrell, Josep Barrachina, Miguel J. Martínez, M. Ángeles Marcos

“…Mortality and hospitalization rates were high in patients with higher comorbidity indices, mainly in individuals with immunosuppression. …”
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Cefazolin Alone Versus Cefazolin With Tobramycin or Gentamicin as Intraoperative Antibiotic Prophylaxis for Total Joint Arthroplasty by Meera M. Dhodapkar, MD, MHS, Scott J. Halperin, MD, MHS, Zachary Radford, MD, Lee E. Rubin, MD, FAAOS, FAOA, Jonathan N. Grauer, MD, Mengnai Li, FAAOS, MD, PhD

“…For both THA and TKA, antibiotic subgroups were clinically similar with regard to age, sex, and Elixhauser Comorbidity Index. On univariable and multivariable analysis, no 90-day outcomes varied significantly. …”
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Effect of gestational age on clinical features in necrotizing enterocolitis-associated intestinal perforation by Minming Chen, Wei Feng, Jinping Hou, Xiaohong Die, Zhenhua Guo, Yi Wang

“…Furthermore, we also want to identify the risk factors of poor prognosis for these patients.MethodsThe retrospective study of patients with NEC-IP was conducted with basic information, comorbidity, intraoperative findings, related treatment, and prognosis. …”
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Geographic Socioeconomic Influences on Disease Activity in Rheumatoid Arthritis in an Academic and Safety Net Hospital System by Joseph Kim, Song Zhang, Ang Gao, Donglu Xie, Salahuddin Kazi, David R. Karp, Christie M. Bartels, E. Blair Solow

“…Objective The objective of this study was to analyze the impact of the Area Deprivation Index (ADI) on disease activity and cardiovascular comorbidity in rheumatoid arthritis (RA). Methods A retrospective analysis of adult patients with RA was conducted to highlight differences in academic and safety net hospital clinics. …”
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Charlson syndrome index predicted survival in pancreatic cancer patients received immunotherapy by Nan Zhang, Nan Zhang, Shiyun Chen, Yue Shi, Zhikuan Wang, Ru Jia, Guanghai Dai, Guanghai Dai

“…ObjectiveThe Charlson Comorbidity Index (CCI) is a widely utilized assessment tool for evaluating the mortality rate among patients with chronic diseases and tumors. …”
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The Impact of Preoperative Opioid Use Disorder on Complications and Costs following Primary Total Hip and Knee Arthroplasty by Jacob M. Wilson, Kevin X. Farley, Matthew Aizpuru, Eric R. Wagner, Thomas L. Bradbury, George N. Guild

“…The incidence of OUD was also determined, and the costs associated with this comorbidity were calculated. Results. The incidence of OUD in arthroplasty patients increased 80% over the study period. …”
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Impact of multimorbidity on long-term outcomes in older adults with non-ST elevation acute coronary syndrome in the North East of England: a multi-centre cohort study of patients u... by Chris Wilkinson, Vijay Kunadian, Benjamin Beska, Abdulla A Damluji, Hanna Ratcovich, Greg B Mills

“…Compared with those with few comorbidities (CCI score 3–5), a higher CCI score (≥6) was positively associated with the primary composite outcome (adjusted HR (aHR) 1.64 (95% CI 1.14 to 2.35), p=0.008 adjusted for age and sex), driven by an increased risk of death (aHR 2.20 (1.38 to 3.49), p=0.001). …”
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Risk of depression in glaucoma patients with vision impairment: A nationwide cohort study by Sheng-Min Wang, Younhea Jung, Kyungdo Han, Kyoung Ohn, Hae-young Lopilly Park, Chan Kee Park, Jung Il Moon

“…The impact of glaucoma and vision impairment on new-onset depression was greater in men and in those with less comorbidities.…”
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Association of Pneumatosis Intestinalis With Surgical Outcomes and Mortality: A Matched, Retrospective Cohort Study and Literature Review by Kyle D. Klingbeil, MD, MS, Hila Zelicha, PhD, RD, Yijun Chen, MD, Douglas S. Bell, MD, Edward H. Livingston, MD, FACS, AGAF

“…Patients who did not have PI served as a control group. Patient comorbidity was assessed using Elixhauser comorbidity scores. …”
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Predictors and long-term patterns of medication adherence to glaucoma treatment in Denmark—an observational registry study of 30 100 Danish patients with glaucoma by Miriam Kolko, Rikke Faergemann Hansen, Louise G Dal, Emma Sabelström, Magnus Brandel, Andreas Hoiberg Bentsen, Anne Cathrine Falch-Joergensen

“…Diagnosis-related group fees were applied to estimate healthcare costs.Results High adherence in the first year(s) of treatment was less likely among men (ORfirst year: 0.78, 95% CI: 0.75 to 0.82), younger individuals and among those with a positive Charlson Comorbidity Index (CCI) score (ORfirst year/CCI≥3: 0.71, 95% CI: 0.63 to 0.80). …”
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Investigating Postoperative Urinary Retention: Risk Factors and Postsurgical Outcomes in Total Joint Arthroplasty by Madeleine J.F. Powers, MSIII, Zachary T. Grace, MD, Barrett B. Torre, MD, Dorothy B. Wakefield, MS, Laura Sanzari, MS, BSN, RN, Matthew J. Grosso, MD

“…Variables analyzed included age, sex, alpha-blocker prescription, operative joint, body mass index, American Society of Anesthesiologists score, Charlson Comorbidity Index classification, and anesthesia type. …”
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Retrospective cohort study based on the MIMIC-IV database: analysis of factors influencing all-cause mortality at 30 days, 90 days, 1 year, and 3 years in patients with different t... by Xuehui Fan, Jing Xu, Ruixue Ye, Qiu Zhang, Yulong Wang

“…Multivariable Cox regression analysis revealed that each 1-point increase in the Charlson Comorbidity Index raised the 1-year and 3-year mortality risks by 1.39 times (95% CI: 1.10–1.56) and 1.44 times, respectively. …”
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Medication Belief and Adherence among Patients with Epilepsy by Yirga Legesse Niriayo, Abraham Mamo, Kidu Gidey, Gebre Teklemariam Demoz

“…Low medication necessity belief, high medication concern belief, negative medication belief, comorbidity, and seizure encounter were predictors of medication nonadherence. …”
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Inferior Vena Cava and Renal Vein Thrombosis Associated with Thymic Carcinoma by Vlad Teodor Berbecar, Roxana Jurubita, Marina Paraschiv, Bogdan Obrisca, Bogdan Sorohan, Gener Ismail

“…Thrombosis of large abdominal veins is rare, especially without being associated with any other comorbidity or risk factors.…”
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Headache associated with sexual activity by M. Jokubaitis, K. Ryliškienė

“…The impact of sexual activity on acute attacks of primary headache disorders and the comorbidity of primary headache and sexual dysfunction are also discussed. …”
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