Geographical Differences in the Safety and Efficacy of Tofacitinib Versus TNFi: A Post Hoc Analysis of ORAL Surveillance by Bogdan Batko, Slawomir Jeka, Piotr Wiland, Agnieszka Zielińska, Maria Stopińska-Polaszewska, Marcin Stajszczyk, Magdalena Kosydar-Piechna, Mary Jane Cadatal, Jose L. Rivas

“…Conclusions Differences in safety outcomes were driven by the presence of baseline risk factors; North America and Poland demonstrated a higher proportion of patients with some baseline CV risk factors/comorbidities versus Other countries. Trial Registration NCT02092467 (ClinicalTrials.gov).…”
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Exploration of pulse wave analysis under reactive hyperemia and close to an arteriovenous fistula: a comparative analysis by Veit Busch, Sandra Müller, Joachim Streis, Timm H. Westhoff, Thomas Felderhoff, Felix S. Seibert, Stefan Reuter, Niklas Mueller

“…., healthy individuals and two collectives of patients with kidney disease and different levels of comorbidities): First, under reactive hyperemia in order to assess endothelial function. …”
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Do coping strategies mediate the effects of childhood adversities and traumata on clinical high-risk of psychosis, depression, and social phobia? A cross-sectional study on patient... by Zhixiong Chang, Naweed Osman, Carolin Martha Doll, Theresa Katharina Lichtenstein, Marlene Rosen, Eva Meisenzahl, Hanna Kadel, Joseph Kambeitz, Kai Vogeley, Frauke Schultze-Lutter

“…Abstract Background Childhood adversities and traumata (CAT) increase the risk for various mental disorders, including the clinical high-risk of psychosis (CHR-P) state and its main comorbidities, i.e., depression, and social phobia. However, these relations are likely mediated by personal coping behaviors. …”
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Evaluation of the effects of thyroid functions on frailty in geriatric patients using the Edmonton, SOF and FRAIL Scales by Galip Can Uyar, Mustafa Kemal Kılıç

“…Additionally, factors such as age, sex, education, thyroid medication use, and comorbidities influenced frailty status. Incorporating thyroid function tests into frailty assessments could enhance early identification and targeted interventions for at-risk older adults, particularly when age-specific thresholds are applied.…”
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Testing the Feasibility, Acceptability, and Potential Efficacy of an Innovative Digital Mental Health Care Delivery Model Designed to Increase Access to Care: Open Trial of the Dig... by Natalia Macrynikola, Kelly Chen, Erlend Lane, Nic Nguyen, Jennifer Pinto, Shirley Yen, John Torous

“…Potential efficacy was assessed by calculating pre-post change in symptoms of depression (Patient Health Questionnaire-9; PHQ-9), anxiety (7-item Generalized Anxiety Disorder; GAD-7), and comorbid depression and anxiety (Patient Health Questionnaire Anxiety and Depression Scale; PHQ-ADS), as well as rates of clinically meaningful improvement and remission. …”
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Nissen-Sleeve procedure versus laparoscopic Roux-en-Y gastric bypass in patients with morbid obesity and gastro-oesophageal reflux disease: protocol for a non-inferiority randomise... by Jan A Apers, Martin Dunkelgrun, Ivonne Leeuwenburgh, Judith W H 't Hart, Bo J Noordman, Laser U Biter

“…Secondary outcome measures are long-term GORD improvement; failure rate of procedure; health-related quality of live; weight loss; proton pump inhibitor use; postoperative complications <30 days and >30 days; length of hospital stay; duration of primary surgery; effect on comorbidities; presence and grade of oesophagitis (grade A–D) and/or presence of Barrett’s oesophagus and cost-effectiveness.Ethics and dissemination The protocol was approved by the Medical Research Ethics Committees United (MEC-U), Nieuwegein, on 15 September 2021. …”
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Oxygen Requirement and Associated Risk Factors in Post-COVID-19 Patients Admitted to a Tertiary Care Center: A Cross-Sectional Study by Bishnu Deep Pathak, Binit Upadhaya Regmi, Sushil Joshi, Bishal Dhakal, Suhail Sapkota, Kanchan Bishwakarma, Ashim Bhandari, Seejan Pathak, Shriya Sharma, Aakriti Adhikari, Nabin Simkhada, Dhan Shrestha

“…The nonparametric statistical tests were applied to determine the association between the duration of post-COVID-19 oxygen therapy and several other risk factors such as age, gender, comorbidities, smoking status, exposure to firewood, COVID-19 vaccination, and severity of COVID-19. …”
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Gluten-Free Diet Adherence Evaluation in Adults with Long-Standing Celiac Disease by Marek K. Kowalski, Danuta Domżał-Magrowska, Piotr Szcześniak, Magdalena Bulska, Daria Orszulak-Michalak, Ewa Małecka-Wojciesko

“…All survey participants provided data concerning current gastrointestinal and systemic symptoms, bowel habits, comorbidities, dietary habits, physical activity, and socioeconomic conditions. …”
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Relationship between alcohol use and overactive bladder disease: a cross-sectional study of the NHANES 2005–2016 by Yixin Zhang, Weijun Qin

“…These findings suggest that higher alcohol consumption, when appropriate, is associated with a lower risk of OAB compared to nondrinkers and the lowest quartile of alcohol consumption quantity group, even after adjusting for age, sex, race, and comorbidities.ConclusionIn conclusion, our findings revealed a significant association between alcohol consumption and the incidence of OAB in the study population. …”
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Elocalcitol, a fluorinated vitamin D derivative, prevents high-fat diet-induced obesity via SCAP downregulation and miR-146a-associated mechanisms by Monika Jürgenson, Keerthana Chithanathan, Aivar Orav, Külli Jaako, Janeli Viil, Mithu Guha, Kalev Kask, Alexander Zharkovsky

“…Therapeutic weight management remains one of the options for the treatment of excess weight and associated comorbidities. In this study, the therapeutic potential of elocalcitol, a fluorinated derivative of vitamin D, was studied on the model of high-fat diet (HFD)-induced obesity in mice.ResultsIt was demonstrated that co-administration of elocalcitol in the doses 15 ug/kg (i.p.) twice a week for 16 weeks prevented body weight gain by approximately 15%. …”
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Korean patients with hereditary cancer: a prospective multicentre cohort study protocol exploring psychosocial and health outcomes by Boyoung Park, Sun-young Kong, Dongju Won, Jong Eun Park, Jun-Kyu Kim, Mi-Ae Jang, Jung-Sook Ha, Kyoung-Bo Kim

“…The survey consists of 342 items across 5 domains: comorbidities (96), health behaviours (80), QoL (41), unmet needs (75) and mental health (50). …”
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Dyslipidemia and metabolic syndrome in childhood-onset systemic lupus erythematosus: is it time to screen? by Sirin Nuntasri, Sirirat Charuvanij, Kraisoon Lomjansook, Puthita Saengpanit, Kwanjai Chotipanang, Maynart Sukharomana

“…Lipid profile assessment in early adolescents is recommended to identify metabolic comorbidities in cSLE.…”
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Value of triglyceride glucose-body mass index in predicting nonalcoholic fatty liver disease in individuals with type 2 diabetes mellitus by Xiaoyi Qian, Wenwen Wu, Boyang Chen, Simin Zhang, Chunmei Xiao, Long Chen, Jun Chen, Jun Chen, Lingli Ke, Meian He, Xiulou Li, Xiulou Li, Xiulou Li

“…The ROC curve was used to assess the predictive efficacy of the TyG-BMI index for NAFLD in T2DM patients.ResultsBMI predicted the development of NAFLD in T2DM patients with an area under the receiver operating characteristic (ROC) curve of 0.792 (95% CI 0.757-0.828), and the optimal cutoff value was 25.22, with 72.2% sensitivity and 71.6% specificity; The area under the receiver operating characteristic (ROC) curve of the TyG index to predict the development of NAFLD in patients with T2DM was 0.755 (95% CI 0.716-0.794), and the optimal cutoff value was 8. 945, with a sensitivity of 80.1% and a specificity of 59.2%; The area under the receiver operating characteristic (ROC) curve of TyG-BMI index to predict the development of NAFLD in T2DM patients was 0.852, (95% CI 0.822-0.882), and the optimal cutoff value was 227.385, with a sensitivity and specificity of 80.1% and 59.2%, respectively.ConclusionsThe TyG-BMI index is a significant predictor of comorbid NAFLD in T2DM patients and provides better screening performance than BMI alone. …”
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Predictors of Colorectal Cancer Screening and Screening Modalities among Patients seen at Federally Qualified Health Centers Funded by the United States Health Resources and Servic... by Megan R.M. Aaronson, Nadereh Pourat, Connie Lu, Jayraan Badiee, Helen Yu-Lefler, Benjamin Picillo, Hank Hoang, Folasade P. May

“…Selected factors associated with any CRC screening included having five or more health center visits in the past year (aOR = 1.66, 95 %CI = 1.07–2.56), being insured (Medicaid aOR = 2.25, 95 %CI = 1.44–3.54; other insurance aOR = 2.69, 95 %CI = 1.51–4.82), living within 30  minutes of the health center (aOR = 1.93, 95 %CI = 1.15–3.25), having multiple comorbidities (aOR = 1.72, 95 %CI = 1.13–2.63), using telehealth (aOR = 1.52, 95 %CI = 1.02–2.27), and having a flu shot last year (aOR = 1.77, 95 %CI = 1.29–2.45). …”
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The potential benefits of radiotherapy in elderly patients with early-stage triple-negative breast cancer by Zheng Xu, Zheng Xu, Chengdong Qin, Binxiao Cao, Binxiao Cao, Pengcheng Ruan, Pengcheng Ruan, Mianhao Zhang, Mianhao Zhang, Guidong Chen, Guidong Chen

“…Older patients often face multiple comorbidities, complicating treatment decisions. This study will analyze the role of radiotherapy (RT) in early-stage triple-negative breast cancer (TNBC) among elderly patients using the SEER database to assess its impact on survival outcomes.MethodsThe patients aged 70+ with T1-2N0-1M0 TNBC were selected from the SEER database (2010–2015) according to specific inclusion and exclusion criteria. …”
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Predictive modelling and identification of critical variables of mortality risk in COVID-19 patients by Olawande Daramola, Tatenda Duncan Kavu, Maritha J. Kotze, Jeanine L. Marnewick, Oluwafemi A. Sarumi, Boniface Kabaso, Thomas Moser, Karl Stroetmann, Isaac Fwemba, Fisayo Daramola, Martha Nyirenda, Susan J. van Rensburg, Peter S. Nyasulu

“…The study reveals how ML could assist medical practitioners in making informed decisions on handling critically ill COVID-19 patients with comorbidities. It also offers insight into the combined effect of CV, PCA, and SMOTE on the performance of ML models for COVID-19 mortality risk prediction, which has been little explored.…”
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An outbreak within an outbreak: The impact of Infection Prevention and Control strategies on hospital-acquired infections and the occurrence of multi-drug resistant organisms durin... by B Mashigo, A Parker, U Lalla, B W Allwood, M S Moolla, T Lovelock, C F N Koegelenberg

“…Information from the admission database, including the patients’ demographics, comorbidities, laboratory results and length of ICU stay were extracted. …”
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Development of delayed pulmonary toxicities and transcriptional changes in pre-existing interstitial lung disease mice after partial thoracic irradiation by Jiamei Fu, Xinglong Liu, Yuchuan Zhou, Shengnan Zhao, Liang Zeng, Yan Pan, Jianghong Zhang, Kevin M. Prise, Chunlin Shao, Yaping Xu

“…Abstract Background Lung cancer patients with comorbid interstitial lung disease (LC-ILD) have an increased risk of developing severe or even fatal radiation pneumonitis after thoracic radiotherapy. …”
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Benzodiazepine agonist treatment for patients with benzodiazepine dependence undergoing opioid agonist treatment: a study protocol for the randomized controlled trial BMX-BAR by Fatemeh Chalabianloo, Lars Thore Fadnes, Jörg Assmus, Jon Mordal, Kristin K. Solli, Kjetil S. Dale, Christina D. Andersen, Silvia Zavenova, Beathe H. Rønning, Andreas W. Blomkvist, Martin Ryssdal, Wasifa S. J. Butt, Anne Marciuch, Anne G. Ørmen, Christian Ohldieck, Else-Marie Løberg, Kjell Arne Johansson, for the BMX-BAR and NORCATS study group

“…Abstract Background There is a lack of knowledge on effective treatment methods for comorbid benzodiazepine dependence in populations undergoing opioid agonist treatment (OAT). …”
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Long-Term Clinical Outcomes for Non-ST Elevation Acute Coronary Syndrome Patients with High-Risk Angiographic Findings Undergoing Percutaneous Coronary Intervention by Sida Jia, Ce Zhang, Yue Liu, Deshan Yuan, Xueyan Zhao, Runlin Gao, Yuejin Yang, Bo Xu, Zhan Gao, Jinqing Yuan

“…Compared with the LRCA group, patients in the HRCA group had worse baseline characteristics including higher age, more comorbidities, and worse angiographic findings. Patients in the HRCA group had higher incidence of unplanned revascularization (2 years: 9.7% vs. 5.1%, p<0.001; 5 years: 15.4% vs. 10.3%, p<0.001), 2-year MACCE (13.1% vs. 8.8%, p<0.001), and 5-year death/MI/revascularization/stroke (23.0% vs. 18.4%, p=0.001). …”
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