Characteristics of patients with undiagnosed stage 3 chronic kidney disease: results from an observational study (REVEAL-CKD) in ChinaResearch in context by Sheng Nie, Shiyu Zhou, Claudia Cabrera, Shan Chen, Mengyun Jia, Shiyu Zhang, Licong Su, Qi Gao, Navdeep Tangri, Fan Fan Hou

“…Age ≥65 years, being female, stage 3A CKD, and the absence of nephrology visit and comorbidities (diabetes, established cardiovascular disease, heart failure, hypertension, or chronic nephritic syndrome) were associated with undiagnosed CKD (P < 0.001). …”
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Indicative features of tissue and microbial sensitization in the pathogenesis of generalized parodontitis associated with rheumatoid arthritis by A.M. Proschenko, N.S. Proschenko, L.L. Reshetnyk, N.A. Zelinskaya, N.V. Chervonna, Т.А. Melnychyk

“…The presence of microbial and tissue sensitization in patients with GP and RA indicates that similar and cross antigens of streptococcal and staphylococcal microorganisms with connective tissue are a potential trigger for the development of both GP and RA, which is a reason to consider GP and RA comorbid diseases with similar pathogenetic mechanisms of development.…”
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Association Between Single-Nucleotide Polymorphisms in <i>Toll-like Receptor 3</i> (<i>tlr3</i>), <i>tlr7</i>, <i>tlr8</i> and <i>tirap</i> Genes with Severe Symptoms in Children P... by Adriana Souza Andrade, Aline Almeida Bentes, Lilian Martins Diniz, Silvia Hees Carvalho, Erna Geessien Kroon, Marco Antonio Campos

“…Studies indicate that comorbidities and genetic factors, such as polymorphisms in immune response genes, can influence the severity of COVID-19. …”
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COVID-19 Pandemic Experiences in Pediatric Intensive Care Unit: An Iranian Referral Hospital-Based Study by Masoud Mohammadpour, Seyed Abbas Hassani, Meisam Sharifzadeh, Leila Tahernia, Setareh Mamishi, Bahareh Yaghmaie, Zeinab Najafi, Farzaneh Beirami, Mehrnoush Afsharipour, Maryam Minuyeefar, Mina Dolatzadeh, Neda Pak, Anahita Majmaa, Zahra Zamani, Shima Mahmoudi

“…There are higher risks of severe COVID-19, PICU admission, and mortality in children with comorbidities.…”
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Periodontal pathogens and obesity in the context of cardiovascular risks across age groups by Georgy Leonov, Yurgita Varaeva, Elena Livantsova, Andrey Vasilyev, Andrey Vasilyev, Olga Vladimirskaya, Tatyana Korotkova, Dmitry Nikityuk, Antonina Starodubova, Antonina Starodubova

“…Obesity, a well-known risk factor for CVDs, is also associated with various comorbidities that may contribute to cardiovascular risk. …”
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Urinary incontinence (UI) in older women in low- and middle-income countries: a rapid review and case study from Burkina Faso by Arthi Kozhumam, Mamadou Bountogo, Dina Goodman Palmer, Carolyn Grieg, Carolyn Grieg, Carolyn Grieg, Maxime Inghels, Maxime Inghels, Sandra Agyapong-Badu, Sandra Agyapong-Badu, Cristina Osborne, Guy Harling, Guy Harling, Guy Harling, Guy Harling, Till Bärnighausen, Till Bärnighausen, Till Bärnighausen, David Rapp, David Rapp, Molly Beestrum, Justine Davies, Justine Davies, Justine Davies, Lisa R. Hirschhorn

“…UI prevalence for LMIC women 40 or older varied greatly (6%–80%), with differences by socio-demographics, gynecological factors (menopausal status, birth outcomes), comorbidities (age, education, obesity, diabetes, hypertension, arthritis), behaviors (smoking status) and survey location. …”
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Epidemiological Analysis of Fungal Infection Disease in Pediatric Population: Focus on Hospitalization from 2007 to 2022 in Veneto Region in Italy by Lorenzo Chiusaroli, Claudia Cozzolino, Silvia Cocchio, Mario Saia, Carlo Giaquinto, Daniele Donà, Vincenzo Baldo

“…Fungal infections (FIs) are widespread globally, affecting both immunocompromised and immunocompetent children, with varying clinical implications based on age and comorbidities. In immunocompromised children, particularly those with hematologic oncological conditions, FI leads to substantially longer hospital stays and increased in-hospital mortality, with reported rates ranging from 15% to 20%. …”
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The incidence of outpatient care within 24 months from SARS-CoV-2 infection in the general population: a multicenter population-based cohort study by Federico Banchelli, Carlo Gagliotti, Angela De Paoli, Rossella Buttazzi, Elena Narne, Enrico Ricchizzi, Silvia Pierobon, Ugo Fedeli, Gisella Pitter, Elisa Fabbri, Michele Tonon, Elisa Gentilotti, Maurizia Rolli, Evelina Tacconelli, Maria Luisa Moro, Francesca Russo, Elena Berti

“…Stratified analysis revealed that subjects with severe acute COVID-19 had a higher increase in rates (up to IRR = 3.96, 95% CI = 2.89–5.44), as well as patients with no comorbidities (up to IRR = 2.71, 95% CI = 2.60–2.83). …”
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Plasma IL-17A is increased in patients with critical MIS-C and associated to in-hospital mortality by Emmerson C. F. de Farias, Luciana M. P. P. do Nascimento, Manoel J. C. Pavão Junior, Dalila C. A. Pavão, Ana P. S. Pinheiro, Andreza H. O. Pinheiro, Marília C. B. Alves, Kíssila M. M. M. Ferraro, Larisse F. Q. Aires, Luana G. Dias, Mayara M. M. Machado, Michaelle J. D. Serrão, Raphaella R. Gomes, Sara M. P. de Moraes, Gabriela C. L. Pontes, Railana D. F. P. Carvalho, Cristiane T. C. Silva, Carla M. A. das Neves, Joyce C. L. dos Santos, Adriana M. B. de Sousa, Leda L. da Silva, Mary L. F. M. F. de Mello, Patricia B. Carvalho, Renata de B. Braga, Kathia de O. Harada, Maria C. A. Justino, Iran B. Costa, Igor Brasil-Costa, Marta C. Monteiro, Gleice Clemente, Maria Teresa Terreri

“…The ROC (Receiver Operating Characteristic) curve analysis was performed.Results and conclusionsA total of 41 patients out of 109 patients admitted at PICU with suspected MIS-C during the study period were included, of which 33 (80.5%) were male, 9 (22%) were under one year old, and 30 (73.2%) presented comorbidities. Among them, 16 (39%) did not survive. …”
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Reattempt Percutaneous Coronary Intervention of Chronic Total Occlusions after Prior Failures: A Single-Center Analysis of Strategies and Outcomes by Mingqiang Fu, Shufu Chang, Lei Ge, Dong Huang, Kang Yao, Feng Zhang, Qing Qin, Jianying Ma, Juying Qian, Junbo Ge

“…Data on clinical factors (age, sex, comorbidities, left ventricular ejection fraction, history of cigarette usage, and revascularization), angiographic characteristics of CTOs (target lesion, Japanese Chronic Total Occlusion (J-CTO) score, the morphology of CTO lesions, and collateral channel scale), strategies (procedural approach and use of devices), and major adverse events were obtained and analyzed. …”
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Impact of Thrombocytopenia on In-Hospital Outcome in Patients Undergoing Percutaneous Coronary Intervention by Zhongxiu Chen, Zheng Liu, Nan Li, Ran Liu, Miye Wang, Duolao Wang, Chen Li, Kai Li, Fangbo Luo, Yong He

“…Thrombocytopenia was intuitively considered to be associated with higher risk of bleeding and multiple comorbidities after percutaneous coronary intervention (PCI). …”
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Relevance of superoxide dismutase type 1 to lipoid pneumonia: the first retrospective case-control study by Yinan Hu, Yanhong Ren, Yinzhen Han, Zhen Li, Weiqing Meng, Yuhui Qiang, Mengyuan Liu, Huaping Dai

“…Conclusion SOD1 is a potential biomarker for LP, but the smoking status, diabetes comorbidities, and TSA level need to be considered.…”
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Clinical Characteristics, Laboratory Parameters, and Molecular Epidemiology of Neuroinvasive Flavivirus Infections in a Hotspot Region of Eastern Croatia by Dario Sabadi, Kristian Bodulić, Vladimir Savić, Nika Vlahović Vlašić, Maja Bogdanić, Ljiljana Perić, Irena Tabain, Dubravka Lišnjić, Mario Duvnjak, Snježana Židovec-Lepej, Barbara Grubišić, Ilija Rubil, Ljubo Barbić, Luka Švitek, Vladimir Stevanović, Petra Smajić, Bernarda Berišić, Mihaela Zlosa, Ivana Rončević, Tatjana Vilibić-Čavlek

“…A statistically significant age difference was found between WNV patients (median 65 years) and TBEV patients (median 36 years). Comorbidities were more frequently detected in WNV patients (hypertension 56.3 vs. 18.2%; diabetes 31.3 vs. 0%). …”
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Disparities in anxiety and related factors among Chinese older adults across different aged-care models: a comparison of two cross-sectional studies by Xin Zheng, Ziwen Xu, Jiajie Zhao, Sanyuan Hao, Fuqin Xu, Shuo Ding, Guoqing Liu, Shufan Yang, Benjamin Otsen, Wen Zhu, Zhongliang Bai, Jie Yang, Ren Chen

“…We noted the interactive effect, suggesting that community-dwelling female older adults with an income level of less than 6500 RMB per year and reported chronic disease comorbidities had the highest likelihood of anxiety, and institutionalized female older adults with income sources such as pension, subsidy, family providing, and resident in rural areas have the greatest risk of experiencing anxiety. …”
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Association between Metformin and a Lower Risk of Age-Related Macular Degeneration in Patients with Type 2 Diabetes by Yu-Yen Chen, Ying-Cheng Shen, Yun-Ju Lai, Chun-Yuan Wang, Keng-Hung Lin, Shih-Chao Feng, Chiao-Ying Liang, Li-Chen Wei, Pesus Chou

“…Confounders included for adjustment were age, sex, and comorbidities (hypertension, hyperlipidemia, coronary artery disease, obesity, diabetic retinopathy, chronic kidney disease, and insulin treatment). …”
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Study protocol for the COPE study: COVID-19 in Older PEople: the influence of frailty and multimorbidity on survival. A multicentre, European observational study by Thomas Lee, Sandeep Singh, Phyo Kyaw Myint, Sheila Jones, Ben Carter, Susan Moug, Terry Quinn, Michael Thomas, Emma Bhatti, Angeline Price, Fenella Barlow-Pay, Siobhan Duffy, Lyndsay Pearce, Arturo Vilches-Moraga, Michael Stechman, Philip Braude, Emma Mitchell, Alessia Verduri, Kathryn McCarthy, Jonathan Hewitt, Charlotte Davey, Kiah Lunstone, Alice Cavenagh, Charlotte Silver, Thomas Telford, Rebecca Simmons, Dolcie Paxton, Francis Rickard, Mark Holloway, James Hesford, Tarik Jichi, Norman Galbraith, Jenny Edwards, Carly Bisset, Ross Alexander, Abigail Ingham, Roxanna Short, Aine McGovern, Jemima Collins, Eilidh Bruce, Alice Einarsson, Enrico Clini, Giovanni Guaraldi, Madeline Garcia, Shefali Sangani, Thomas Kneen, George Kyriakopoulos, Denise Tan

“…Introduction This protocol describes an observational study which set out to assess whether frailty and/or multimorbidity correlates with short-term and medium-term outcomes in patients diagnosed with COVID-19 in a European, multicentre setting.Methods and analysis Over a 3-month period we aim to recruit a minimum of 500 patients across 10 hospital sites, collecting baseline data including: patient demographics; presence of comorbidities; relevant blood tests on admission; prescription of ACE inhibitors/angiotensin receptor blockers/non-steroidal anti-inflammatory drugs/immunosuppressants; smoking status; Clinical Frailty Score (CFS); length of hospital stay; mortality and readmission. …”
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Correlation between the white blood cell/platelet ratio and 28-day all-cause mortality in cardiac arrest patients: a retrospective cohort study based on machine learning by Huai Huang, Guangqin Ren, Shanghui Sun, Zhi Li, Yongtian Zheng, Lijuan Dong, Shaoliang Zhu, Xiaosheng Zhu, Wenyu Jiang

“…Key patient characteristics, encompassing demographic data, comorbidities, hematological and biochemical indices, and vital signs, were extracted using PostgreSQL Administration Tool (pgAdmin) software. …”
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Clinical Findings in Diabetes Mellitus Patients with COVID-19 by Ting Guo, Qinxue Shen, Xiaoli Ouyang, Wei Guo, Jinhua Li, Wenlong He, Bo Yu, Chenfang Wu, Zhiguo Zhou, Hong Luo, Hong Peng

“…Diabetes mellitus (DM) is one of the most common comorbidities in patients with coronavirus disease (COVID-19). …”
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Clinical Characteristics of 31 Patients with Chest Pain Variant Asthma by Mao W, Gao Y, Sun W, Li J, Wang J, Wang Z, Zhang L, Huang K

“…Understanding its manifestations, lung function, chest CT features and comorbidities is helpful for diagnosis and evaluation of patients with such symptoms.Keywords: chest pain, atypical asthma, bronchial provocation test, chest computed tomography…”
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Reconstructive trends and complications following parotidectomy: incidence and predictors in 11,057 cases by Cory Donovan Bovenzi, Peter Ciolek, Meghan Crippen, Joseph M. Curry, Howard Krein, Ryan Heffelfinger

“…Preoperative demographics, surgical indications, and common medical comorbidities were collected. CPT codes were used to identify patients who underwent parotidectomy with or without reconstruction. …”
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