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1821
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1822
Exact Group Sequential Methods for Estimating a Binomial Proportion
Published 2013-01-01“…Illustrative examples are given for applications in clinical trials.…”
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1823
The Impact of Sulforaphane on Sex-Specific Conditions and Hormone Balance: A Comprehensive Review
Published 2025-01-01“…SF has been the subject of thousands of studies and over 125 clinical trials. The many mechanisms of action of SF in mammalian systems have been extensively documented. …”
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1824
Control of atropoisomerism: an access to valuable compounds
Published 2024-03-01“…Atropoisomerism is well-known in biaryls, however this phenomenon is encountered in many pharmaceutically relevant compounds such as heterobiaryl, diarylamines, benzamides and anilides.Currently four FDA-approved drugs are atropostable and many others are in clinical trials. It is also important to note that almost 30% of recent FDA-approved small molecules are “proatropisomeric” and interact with a target in a specific chiral conformation.Given this vivid interest in C–C but also C–N atropisomerically stable compounds, this account will detail the new atropoisomeric strategies we developed and their applications in the synthesis of relevant molecules and ligands.…”
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1825
Application of bone turnover markers in skeletal and extra-skeletal conditions in children and adults
Published 2024-12-01“…Therefore, there is a need for standardized clinical trials on currently available and new BTMs.…”
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1826
Convergence of evolving artificial intelligence and machine learning techniques in precision oncology
Published 2025-01-01“…., digital twins, in order to provide the necessary information to design or expedite the conduct of clinical trials. Currently, many operational and technical challenges exist related to data technology, engineering, and storage; algorithm development and structures; quality and quantity of the data and the analytical pipeline; data sharing and generalizability; and the incorporation of these technologies into the current clinical workflow and reimbursement models.…”
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1827
Peroxisome Proliferator-Activated Receptors and the Heart: Lessons from the Past and Future Directions
Published 2015-01-01“…We also describe the results and lessons learned from important clinical trials on PPAR agonists and discuss the potential future directions for this class of drugs.…”
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1828
Verteporfin Photodynamic Therapy Combined with Intravitreal Ranibizumab for Polypoidal Choroidal Vasculopathy Controversy Concerning Long-Term Followup
Published 2012-01-01“…These data need to be confirmed in large, prospective, and controlled clinical trials which are randomized and carried out over a long period.…”
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1829
PPARγ and Its Role in Cardiovascular Diseases
Published 2017-01-01“…This review aims to discuss the role of PPARγ in the various cardiovascular diseases and summarize the current knowledge on PPARγ agonists from multiple clinical trials. Finally, we also review the new PPARγ agonists under development as potential therapeutics with reduced or no adverse effects.…”
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1830
Dietary Recommendations for the Prevention of Type 2 diabetes: What Are They Based on?
Published 2012-01-01“…In addition we aim to explore the available evidence from both observation studies and clinical trials to determine whether these recommendations are appropriate.…”
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1831
Receptor Tyrosine Kinases and Inhibitors in Lung Cancer
Published 2004-01-01“…The inhibitors against the specific RTKs are in various preclinical and clinical trials, and this will be detailed.…”
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1832
Testosterone Deficiency, Cardiac Health, and Older Men
Published 2014-01-01“…There are recent data to suggest that testosterone replacement therapy may reduce cardiovascular mortality as well as improving multiple surrogate markers for cardiovascular events. Specific clinical trials of testosterone replacement therapy are needed in selected populations but in the meantime we must treat patients based on the best current evidence.…”
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1833
PEEP or No PEEP: That Is Not the Question
Published 1996-01-01“…In the absence of controlled clinical trials, the use of PEEP in acute respiratory distress syndrome needs to be guided by physiological principles that balance the beneficial effects of an increase in functional residual capacity, prevention of alveolar closure, redistribution of lung water and improved ventilation of low ventilation-perfusion areas against the potential harm of alveolar rupture (barotrauma and "volutrauma") and reduction in cardiac output.…”
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1834
The Effects of Hypoxia on the Immune-Modulatory Properties of Bone Marrow-Derived Mesenchymal Stromal Cells
Published 2019-01-01“…Despite the encouraging in vivo data, however, clinical trials delivered ambiguous results. Since one of the typical features of inflamed tissues is decreased oxygenation, the success of cellular therapy in inflammatory pathologies seems to be affected by the impact of oxygen depletion on transplanted cells. …”
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1835
CANDLE syndrome – a narrative review
Published 2024-09-01“…Further research and clinical trials are imperative to enhance understanding and optimise treatment strategies for this rare and debilitating condition.…”
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1836
The Evolution of Radiation Therapy in Metastatic Breast Cancer: From Local Therapy to Systemic Agent
Published 2018-01-01“…In this article, we will review the emerging role of radiation in the treatment of metastatic disease and discuss the current state of the science and clinical trials investigating the combination of radiation and immunotherapy.…”
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1837
Functional Multipotency of Stem Cells: What Do We Need from Them in the Heart?
Published 2012-01-01“…After more than ten years of human research in the field of cardiac regenerative medicine, application of stem cells in different phases of ischemic heart disease has come to age. Randomized clinical trials have demonstrated that stem cell therapy can improve cardiac recovery after the acute phase of myocardial ischemia and in patients with chronic ischemic heart disease, and several efficacy phase III trials with clinical endpoints are on their way. …”
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1838
Intestinal microbiome as effective regulator of enteral and central nervous system activity
Published 2018-08-01“…Accumulated data change the current concept on human microbiome and its potential, however further clinical trials required.…”
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1839
Iron Chelation Therapy in Myelodysplastic Syndromes
Published 2010-01-01“…The usefulness of iron chelation in MDS patients is still under debate, mainly because of the lack of solid prospective clinical trials that should take place in the future. …”
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1840
Recent Advances in Antiviral Therapy for Chronic Hepatitis C
Published 2016-01-01“…This review introduces the characteristics and results of recent clinical trials of several DAAs: NS3/4A protease inhibitors, NS5A inhibitors, and NS5B inhibitors. …”
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