A conceptual model for advanced/metastatic gastric or gastroesophageal junction cancer: a review of qualitative studies and results from patient interviews by France Ginchereau Sowell, Thom de Milliano, Keri J. S. Brady, Ginamarie Foglia, Medha Sasane, Samira Bensfia, Matthew Reaney

“…Interviews also help understand patients’ perspectives on clinical trials.…”
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The need for evidence-based, outcome-focused medical imaging research for cancer management by Jiazheng Wang, Richard L. Hesketh, John C. Gore, Kevin M. Brindle

“…We argue there remain compelling needs for better designs of clinical trials, imaging protocol standards, quantification methods, efficient translation pathways and patient engagement.…”
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Maintenance Therapy for Inflammatory Bowel Disease: What Really Works by Lloyd R Sutherland

“…Therapies that have been shown in randomized, controlled, double-blind clinical trials to either lengthen the time of remission or improve the odds of staying in remission during a set time interval are required.…”
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Should the Food and Drug Administration Limit Placebo-Controlled Trials? by Max Goodman, Connor Pedersen

“…Open Access Journal of Clinical Trials. 2018;Volume 10:19-28. doi:10.2147/oajct.s156054; Mezher M. …”
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Review of the Impact and Burden of Urinary Urgency on Adults with Overactive Bladder by Adrian Wagg, A. Lenore Ackerman, H. Henry Lai, Diane K. Newman

“…However, urgency has been understudied in clinical trials, potentially owing to inherent difficulties in its assessment. …”
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Glucocorticoids and Preterm Hypoxic-Ischemic Brain Injury: The Good and the Bad by Laura Bennet, Joanne O. Davidson, Miriam Koome, Alistair Jan Gunn

“…Fetuses at risk of premature delivery are now routinely exposed to maternal treatment with synthetic glucocorticoids. In randomized clinical trials, these substantially reduce acute neonatal systemic morbidity, and mortality, after premature birth and reduce intraventricular hemorrhage. …”
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Progress in personalized immunotherapy for patients with brain metastasis by Lalit Patel, Nikola Kolundzic, Malak Abedalthagafi

“…This review explores the immune landscape of brain metastases, current therapies, clinical trials, and the need for personalized, biomarker-driven approaches to optimize outcomes.…”
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Association of age, race, and ethnicity with access, response, and toxicities from CAR-T therapy in children and adults with B-cell malignancies: a review by Marco Ruella, Guido Ghilardi, Zainul S. Hasanali, Sandra P. Susanibar-Adaniya, Lena E. Winestone, Alfred L. Garfall

“…We also review the representation of age, racial, and ethnic groups in key CAR-T clinical trials. We focus on B-cell acute lymphoblastic leukemia, B-cell non-Hodgkin’s lymphoma, and multiple myeloma.…”
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Novel Generalized Divergence Measure on Intuitionistic Fuzzy Sets and Its Application by Priya Arora, V. P. Tomar

“…In that case, we have devised a method to choose the best treatment for the patients based on the results of clinical trials.…”
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Think Stop before Going 'Off-Label' by Gerald Y Minuk

“…Only after careful and extensive review of all available safety and efficacy data derived from preclinical and clinical trials will a regulatory body approve the licensing of a drug for a specific medical condition ('indication'). …”
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Vedolizumab for inflammatory bowel diseasesI by Igor L. Khalif, M. V. Shapina

“…The results received in clinical trials were confirmed by clinical data in the different countries. …”
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Lymphatic filariasis in Zambia: A scoping review protocol. by Hugh Shirley, Adrienne Orriols, Dylan Hogan, Kingford Chimfwembe, Alinaswe Balya, Kaala Sibbuku, Janelle Lardizabal, Sophie Tillotson, Philip Espinola Coombs, Richard Wamai

“…In consultation with a research librarian, these guidelines will be applied to a literature search of articles from peer-reviewed journals, or government and international regulatory bodies using PubMed, Embase, Web of Science, Cochrane CENTRAL, WHO ICTRP, Pan African Clinical Trials Registry, and ClinicalTrials.gov. Each record will be screened at the abstract and full-text level by two independent reviewers, and results reported via summary statistics.…”
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Role of phytochemicals in cardiovascular disease management: Insights into mechanisms, efficacy, and clinical application by Esther Ugo Alum

“…The review analyzes findings from clinical trials, epidemiological studies, and preclinical research to explain how these phytochemicals are effective in preventing and treating cardiovascular diseases. …”
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Apremilast generic for the treatment of active psoriatic arthritis: A single-center real-life experience from India by Sanjiv Amin, Aneesa Kapadia, Dhiraj Dhoot, Hanmant Barkate

“…Its efficacy and safety have been established in the landmark clinical trials; however, there is still a dearth of its real-world experience in the management of PsA in India. …”
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Application of Mild Therapeutic Hypothermia on Stroke: A Systematic Review and Meta-Analysis by Shaheen E. Lakhan, Fabricio Pamplona

“…Seven parallel-controlled clinical trials were included in the meta-analysis. Sample sizes ranged from 18 to 62 patients, yielding a total of 288. …”
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Study protocol for Video Images about Decisions to Improve Ethical Outcomes with Palliative Care Educators (VIDEO-PCE): a pragmatic stepped wedge cluster randomised trial of older... by Joshua R Lakin, Na Wang, Howard J Cabral, Michael K Paasche-Orlow, Charlotta Lindvall, Angelo Volandes, Aretha Delight Davis, Michael R Winter, Edward T Moseley, Lori Henault, Sophia N Zupanc, Sophiya Das, Kate Sciacca, Edith A Burns, Maria T Carney, Jennifer Itty, Santiago Lopez, Kaitlin Emmert, Narda J Martin, Sherene Lambert, Jennifer Polo, Shreya Sanghani, Julianne N Dugas, Michele Gomez, Shira Gabry-Kalikow, Alexandra Dobie, Meredith Amshoff, Traci Cucinotta, Milton Joel, Lisa B Caruso, Ana Maria Ramirez, Kathleen Salerno, Qausarat Ogunneye

“…This trial is registered at ClinicalTrials.gov.Trial registration number NCT04857060; ClinicalTrials.gov…”
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Prediction of Survival Outcomes in Patients with Glioma Using Magnetic Resonance Imaging (MRI): A Systematic Review and Meta-Analysis by Mingfang Hu, Jinge Li, Zhangyu Li, Jian Shen

“…Methods: Review of the literature included the following databases: WHO International Clinical Trials Registry Platform; Google Scholar; Web of Science; PubMed; SIGLE; NYAM; Scopus; Randomized controlled trial (RCT); Virtual Health Library (VHL); Cochrane Collaboration; EMBASE; and Clinical Trials. …”
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Protocol for the systematic review of age and sex in preclinical models of age-correlated diseases [version 2; peer review: 2 approved] by Céline Heinl, Ines Schadock, Maximilian Wurm, Paul Lucas Wildner, Daniel Butzke, Bettina Bert, Alexandra Bannach-Brown, Matthias Steinfath, Kai Diederich

“…We compare the results with the age and sex of patients in clinical trials focusing on Alzheimer's disease, stroke, type 2 diabetes mellitus, ischemic heart disease, and chronic obstructive pulmonary disease. …”
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Clinical Significance of ErbB Receptor Family in Urothelial Carcinoma of the Bladder: A Systematic Review and Meta-Analysis by Yuh-Shyan Tsai, Hong-Lin Cheng, Tzong-Shin Tzai, Nan-Haw Chow

“…Using published evidence, we examined the clinical value and the updated results of clinical trials targeting ErbB receptor family members. …”
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Expert Consensus on Molecular Tumor Boards in Taiwan: Joint Position Paper by the Taiwan Oncology Society and the Taiwan Society of Pathology by Ming-Huang Chen, Wan-Shan Li, Bin-Chi Liao, Chiao-En Wu, Chien-Feng Li, Chia-Hsun Hsieh, Feng-Che Kuan, Huey-En Tzeng, Jen-Fan Hang, Nai-Jung Chiang, Tse-Ching Chen, Tom Wei-Wu Chen, John Wen-Cheng Chang, Yao-Yu Hsieh, Yen-Lin Chen, Yi-Chen Yeh, Yi-Hsin Liang, Yu-Li Su, Chiung-Ru Lai, James Chih-Hsin Yang

“…Results: The joint statement proposes key recommendations: (1) MTB discussions encompass diverse molecular analyses including next-generation sequencing (NGS), RNA sequencing, whole-exon sequencing, and whole-genomic sequencing addressing relevant genomic changes, tumor mutation burden, microsatellite instability, and specific biomarkers for certain cancers. (2) MTB meetings should involve multidisciplinary participants who receive regular updates on NGS-related clinical trials. (3) Prioritize discussing cases with unique clinical needs, gene alterations lacking treatments, untreatable neoplasms, or oncogenes unresponsive to targeted therapies. (4) Base MTB discussions on comprehensive patient data, including genetics, pathology, timing of specimen collection, and NGS outcomes. (5) MTBs offer treatment recommendations: standard therapies, off-label use, clinical trials, genetic counseling, and multidisciplinary reviews. (6) MTB effectiveness can be gauged by member composition, case reviews, treatment suggestions, and patient outcomes. …”
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