Survey of willingness to participate in clinical trials and influencing factors among cancer and non-cancer patients by Teck Long King, Shirin Hui Tan, Shirley Siang Ning Tan, Wei Hong Lai, Mohamad Adam Bujang, Pei Jye Voon

“…Abstract Despite the expanding landscape of clinical trials, there is a lack of study concerning Malaysian patients’ participation and perspectives. …”
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Simulation of clinical trials of oral treprostinil in pulmonary arterial hypertension using a virtual population by Andrew E. Stine, Jignesh Parmar, Amy K. Smith, Zachary Cummins, Narasimha Rao Pillalamarri, R. Joseph Bender

“…We generated a virtual population that spanned the range of clinical observations and then calibrated virtual patient-specific weights to match clinical trials. We then used this virtual population to predict the results of clinical trials on the basis of disease severity, dosing regimen, time since diagnosis, and co-administered background therapies. …”
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Efficacy of Memantine, Donepezil, or Their Association in Moderate-Severe Alzheimer’s Disease: A Review of Clinical Trials by Ivana Molino, Luisa Colucci, Angiola M. Fasanaro, Enea Traini, Francesco Amenta

“…This paper has reviewed evidence from clinical trials of the effectiveness of memantine, donepezil, or the two drugs in association in managing moderate-severe AD. …”
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Recent Advances in Dipeptidyl-Peptidase-4 Inhibition Therapy: Lessons from the Bench and Clinical Trials by Jixin Zhong, Quan Gong, Aditya Goud, Srividya Srinivasamaharaj, Sanjay Rajagopalan

“…Further, a signal of heart failure hospitalization in a recent large scale clinical trial SAVOR-TIMI 53 has called into question the safety of these agents and their utility in the treatment of cardiovascular disease. …”
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The Effect of the Platelet Administration for the Patients with Liver Dysfunction after Liver Resection: Preliminary Clinical Trial by Hui Xu, Yu-Mei Li, Yongxiang Yi, Yun-Wen Zheng, Nobuhiro Ohkohchi

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Associations of Serum Urate and Cardiovascular Events in a Clinical Trial of Interleukin-1β Blockade by Nicholas H. Adamstein, MD, Jean G. MacFadyen, BA, Brittany N. Weber, MD, PhD, Peter Libby, MD, Daniel H. Solomon, MD, MPH, Paul M Ridker, MD, MPH

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Toxicity Associated with Pembrolizumab Monotherapy in Patients with Gastrointestinal Cancers: A Systematic Review of Clinical Trials by Nikolas Naleid, Amit Mahipal, Sakti Chakrabarti

“…<b>Methods:</b> A comprehensive search of PubMed/MEDLINE was performed to identify clinical trials investigating pembrolizumab monotherapy in GI cancer patients. …”
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Evaluating Mirror Therapy Protocols in Phantom Limb Pain Clinical Trials: A Scoping Review by Limakatso K, McGowan E, Ortiz-Catalan M

“…Establishing a standardized treatment protocol could enhance the reliability and reproducibility of treatment outcomes in future studies and ensure a meaningful comparison between mirror therapy and other treatments in clinical trials and meta-analyses.Keywords: amputation, phantom limb pain, mirror therapy, rehabilitation…”
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Assessing patient risk, benefit and outcomes in drug development: an observational study of regorafenib clinical trials by Matt Vassar, Vinay Prasad, Ryan McIntire, Alyson Haslam, Brody Dennis, Chance Bratten, Griffin K Hughes, Andriana M Peña, Chase Ladd, Brooke Gardner, William Nowlin, Reagan Livingston, Jordan Tuia

“…To regenerate what they’ve spent, drug manufacturers may attempt to repurpose their medications for new indications via clinical trials. To fully understand the risk/benefits in comparison to a drug’s efficacy, a pooled analysis must be completed.Methods We screened PubMed, Embase, Cochrane (CENTRAL) and ClinicalTrials.gov for trials of regorafenib used to treat solid cancers. …”
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Effectiveness of a training program for the acquisition of motor milestones in infants: a randomized clinical trial by Luis Fernández-Sola, Beatriz Cano-Díez, Yessica Pons-Solaz, Begoña Vera-Egido, Sergio Moreno-González

“…Trial registration ClinicalTrials.gov ID NCT04693494. Registered December 28, 2020, retrospectively registered. https://clinicaltrials.gov/study/NCT04693494 .…”
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Improving patient satisfaction based on service quality in clinical trials: A cross-sectional study. by Go-Eun Lee, Sue Kim, Sang Hui Chu, Jeong-Ho Seok, So Yoon Kim, Sanghee Kim

“…<h4>Objective</h4>This study examined the experiences and perceptions of clinical trial participants in terms of service quality and identified the factors that impact participant satisfaction in clinical trials.…”
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Two Oral Midazolam Preparations in Pediatric Dental Patients: A Prospective Randomised Clinical Trial by Katayoun Salem, Shaqayegh Kamranzadeh, Maryam Kousha, Shahnaz Shaeghi, Fatemeh AbdollahGorgi

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Development, implementation, and evaluation of an innovative clinical trial operations training program for Africa (ClinOps) by Dawit Asmamaw Ejigu, Abebaw Fekadu, Jeremy Whitty, Tsegahun Manyazewal, Pamela Nebeta, Almari Conradie, Brenda Okech, Alice Neequaye, Sinéad Whitty, Jennifer Lehrman, Renee Holt, Rahel Birhane, Mahnaz Vahedi, Helen Demarest, Eyasu Makonnen

Subjects: “…Clinical trial…”
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Efficacy of Robotic-Assisted Prostatectomy in Localized Prostate Cancer: A Systematic Review of Clinical Trials by Carolina Sandoval Salinas, Andrés L. González Rangel, Juan G. Cataño Cataño, Juan C. Fuentes Pachón, Juan S. Castillo Londoño

“…Databases MEDLINE, EMBASE, LILACS, and CENTRAL were searched for randomized clinical trials that directly compared two or more radical prostatectomy approaches. …”
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The use of paracetamol during pregnancy: A qualitative study and possible strategies for a clinical trial. by Cathrine Vedel, Ditte Staub Jørgensen, David Møbjerg Kristensen, Olav Bjørn Petersen, Gorm Greisen

“…It highlights the urgent need for a clinical trial, and the aim of the presented qualitative pilot study on APAP use during pregnancy is the feasibility of a large-scale randomized controlled trial (RCT). …”
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Double-Blind Clinical Trial of Arginine Supplementation in the Treatment of Adult Patients with Sickle Cell Anaemia by Renata M. N. Eleutério, Francisco O. Nascimento, Tamara G. Araújo, Marilena F. Castro, Tarcísio P. Almeida Filho, Pedro A. Maia Filho, José Eleutério, Darcielle B. D. Elias, Romélia P. G. Lemes

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Antifungal Efficacy of Ganoderma lucidum and Clotrimazole for Treatment of Denture Stomatitis: A Randomized Clinical Trial by Fahimeh Pakravan, Afsaneh Yegdaneh, Somayeh Taymouri, Shiva Rahimi, Negin Ghahremani

“…Materials and Methods: This double-blind randomized clinical trial was conducted on 50 patients with DS types I and II assigned to two groups (N=25). …”
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Extracorporeal Ultrasound-Guided High Intensity Focused Ultrasound: Implications from the Present Clinical Trials by Tinghe Yu, Xiao Fu

“…These implied that HIFU should be applied as an alternative at most occasions. The present clinical trials had defects making against the understating of HIFU.…”
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Heterogeneity of Treatment Effects of Laser Epilation on Pilonidal Disease Recurrence: A Randomized Clinical Trial by Katherine C. Bergus, MD, MPH, Carley Lutz, BS, Jennifer Cooper, PhD, Lindsey Asti, PhD, MPH, Lindsay Gil, MD, MPH, Cory Criss, MD, Katherine J. Deans, MD, MHSc, Peter C. Minneci, MD, MHSc

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Effect of Humulus lupulus L. (Hop) on Postmenopausal Sexual Dysfunction: A Randomized Clinical Trial by Zahra Vahedpoorfard, Samira Ferdosi, Habibollah Rahimi, Hossein Motedayyen

“…In the current randomized clinical trial, study populations consisted of 63 postmenopausal women who were randomly categorized into two groups. …”
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