Overview of Novel Antipsychotic Drugs: State of the Art, New Mechanisms, and Clinical Aspects of Promising Compounds by Letizia Biso, Marco Carli, Marco Scarselli, Biancamaria Longoni

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Effect of Folic Acid Supplementation in Pregnancy on Preeclampsia: The Folic Acid Clinical Trial Study by Shi Wu Wen, Josee Champagne, Ruth Rennicks White, Doug Coyle, William Fraser, Graeme Smith, Dean Fergusson, Mark C. Walker

“…The Effect of Folic Acid Supplementation in Pregnancy on Preeclampsia: the Folic Acid Clinical Trial (FACT) aims to recruit 3,656 high risk women to evaluate a new prevention strategy for PE: supplementation of folic acid throughout pregnancy. …”
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Generalizability of Randomized Clinical Trial Outcomes for Diabetes Control Resulting From Bariatric Surgery by Edward H. Livingston, MD, FACS, AGAF, Hila Zelicha, RD, PhD, Erik P. Dutson, MD, Zhaoping Li, MD, PhD, Matthew L. Maciejewski, PhD, Yijun Chen, MD

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Progression-free survival as a surrogate endpoint in myeloma clinical trials: an evolving paradigm by Charlotte Pawlyn, Fredrik H. Schjesvold, David A. Cairns, L. J. Wei, Faith Davies, Omar Nadeem, Haifaa Abdulhaq, Maria-Victoria Mateos, Jacob Laubach, Katja Weisel, Heinz Ludwig, S. Vincent Rajkumar, Pieter Sonneveld, Graham Jackson, Gareth Morgan, Paul G. Richardson

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RESULTS OF CLINICAL TRIALS OF MEDICAL TREA TMENT OF RENAL CELL CARCINOMA IN 2014–2015 by A. M. Popov, O. B. Karyakin, A. D. Kaprin

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The effect of dexmedetomidine vs. atracurium on intubation condition in children - a randomized clinical trial by Mohammad Alipour, Samira Ghanei, Shahrzad Sheikh, Masoud Ghanei, Ahmad Nemati, Shabnam Niroumand

“…This trial was registered retrospectively in the Iranian Clinical Trials Registry at 2021-24-05 ( https://www.irct.ir/ ), and its registration number is IRCT20201028049177N1.…”
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Exploration of alive-and-ventilator free days as an outcome measure for clinical trials of Resuscitative interventions. by Ari Moskowitz, Xianhong Xie, Michelle Ng Gong, Henry E Wang, Luke Andrea, Yungtai Lo, Mimi Kim, Hospital Airway Resuscitation Trial Investigators

“…<h4>Background</h4>Outcome selection is a critically important aspect of clinical trial design. Alive-and-ventilator free days is an outcome measure commonly used in critical care clinical trials, but has not been fully explored in resuscitation science.…”
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A cost/benefit analysis of clinical trial designs for COVID-19 vaccine candidates. by Donald A Berry, Scott Berry, Peter Hale, Leah Isakov, Andrew W Lo, Kien Wei Siah, Chi Heem Wong

“…We compare and contrast the expected duration and number of infections and deaths averted among several designs for clinical trials of COVID-19 vaccine candidates, including traditional and adaptive randomized clinical trials and human challenge trials. …”
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Initial Clinical Trial of Robot of Endovascular Treatment with Force Feedback and Cooperating of Catheter and Guidewire by Yuhua Jiang, Keyun Liu, Youxiang Li

“…No obvious abnormality was observed in the examination of patients’ check-up, head nuclear magnetism, and blood routine after the digital subtraction angiography. From this clinical trial, it can be observed that the robot system can perform the operation of cerebral angiography. …”
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Endovascular Treatment for Basilar Artery Occlusion: Revisiting Evidence From Randomized Clinical Trials by Sherief Ghozy, Amr Ehab El‐Qushayri, Mohamed Elfil, Alis J. Dicpinigaitis, Krishna Amuluru, Mohammad El‐Ghanem, Chirag D. Gandhi, Fawaz Al‐Mufti

“…However, the previous clinical trials did not provide evidence to support the efficacy of endovascular treatment (EVT) in patients with basilar artery occlusion. …”
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The Effect of Probiotics on Childhood Constipation: A Randomized Controlled Double Blind Clinical Trial by M. Sadeghzadeh, A. Rabieefar, P. Khoshnevisasl, N. Mousavinasab, K. Eftekhari

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Efficacy of yoga for chronic back pain: A comprehensive meta-analysis of clinical trials by M. D. Sangeetha, B. N. Sharath, P. Seema, P. K. Sreenath Menon, M. Shashi Kumar, M. Sathiabalan, R. Nandhini

“…This study aimed to comprehensively assess the efficacy of yoga for CBP through a meta-analysis of clinical trials. A systematic review and meta-analysis were conducted following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. …”
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A policy framework for leveraging generative AI to address enduring challenges in clinical trials by Johnathon Edward Liddicoat, Gabriela Lenarczyk, Mateo Aboy, Timo Minssen, Sebastian Porsdam Mann

“…Can artificial intelligence improve clinical trial design? Despite their importance in medicine, over 40% of trials involve flawed protocols. …”
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Self- versus clinician-collected swabs in anal cancer screening: A clinical trial. by Clare E F Dyer, Fengyi Jin, Jennifer M Roberts, I Mary Poynten, Annabelle Farnsworth, Leon P McNally, Philip H Cunningham, Andrew E Grulich, Richard J Hillman

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Fedratinib for the treatment of myelofibrosis: a critical appraisal of clinical trial and “real-world” data by Adrian Duek, Ilona Leviatan, Osnat Jarchowsky Dolberg, Martin H. Ellis

“…In contrast, recently published real-world data suggest that these responses may not be as robust outside clinical trials. In the context of routine clinical practice spleen responses are documented in only 13–68%, with varying degrees of symptom improvement. …”
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The Effect of Acupuncture along with Conventional Therapies on the Treatment of Allergic Rhinitis: A Clinical Trial by Sayed Mostafa Hashemi, Farhang Mokhtarinejad, Seyed Mojtaba Abtahi Forooshani, Mehran Rezvani Habibabadi

“…Materials and Methods: The present randomized, clinical trial was performed on 51 patients with AR. All patients underwent standard AR treatment under the supervision of a specialist physician. …”
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The phase I RELEASE clinical trial to evaluate the safety of NK cells in COVID-19 by Clara Hernández-Blanco, Karima Al-Akioui-Sanz, Lara Herrera, Cristina Aguirre-Portolés, Daniel Lozano-Ojalvo, Leticia Pérez-Rodriguez, Jordi Cano-Ochando, Pilar Guerra-García, Alejandro Martín-Quirós, José Luis Vicario, Silvia Santos, Miguel Ángel Pérez-Vaquero, Miguel Ángel Vesga, Alberto M. Borobia, Antonio J. Carcas, Antonio Balas, Miguel Ángel Moreno, Rebeca Pérez de Diego, Mercedes Gasior, Bernat Soria, Cristina Eguizabal, Antonio Pérez-Martínez

“…In 2022 a phase I, dose-escalation, single center clinical trial was conducted to evaluate the safety and feasibility of the infusion of CD3−/CD56+ NK cells against moderate/severe cases of COVID-19 (NCT04578210). …”
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The “L-Sandwich” Strategy for True Coronary Bifurcation Lesions: A Randomized Clinical Trial by Quan Guo, Liang Peng, Lixin Rao, Cao Ma, Kang Zhao, Zhenzhou Zhao, Haiyu Tang, Muwei Li

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Frequency of orthostatic hypotension in the Pooled Resource Open-Access ALS Clinical Trials database by C. Quarracino, F. Capani, F. Capani, M. Otero-Losada, G. E. Rodríguez, S. Pérez-Lloret, S. Pérez-Lloret

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A Criterion-based Approach for the Systematic and Transparent Extrapolation of Clinical Trial Survival Data by Gabriel Tremblay, Patrick Haines, Andrew Briggs

“…Often, significant survival effects are found beyond the time period observed in clinical trials, thus, extrapolation of trial results is required for health economic and HTA evaluations. …”
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