Generation Victoria (GenV): protocol for a longitudinal birth cohort of Victorian children and their parents by Elizabeth K. Hughes, William Siero, Alisha Gülenç, Susan A. Clifford, Tony Frugier, Simon M. Hall, Jatender Mohal, Kathryn North, Natasha Zaritski, Sharon Goldfeld, Richard Saffery, Melissa Wake

“…Trial registration ClinicalTrials.gov: NCT05394363; retrospectively registered 23 May 2022 (8 months into recruitment).…”
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Comparison of handheld rebound tonometry with Goldmann applanation tonometry in children with glaucoma: a cohort study by Catey Bunce, Peng Tee Khaw, John Brookes, Maria Papadopoulos, Amanda Lewis, Poornima Rai, Renata Puertas, Annegret Hella Dahlmann-Noor, Shenille Tabasa-Lim, Ahmed El-Karmouty, Mustafa Kadhim, Nicholas Kloster Wride, Dawn Grosvenor

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Development of a machine learning-based prediction model for extremely rapid decline in estimated glomerular filtration rate in patients with chronic kidney disease: a retrospectiv... by Shingo Fukuma, Yukio Yuzawa, Daijo Inaguma, Hiroki Hayashi, Ryosuke Yanagiya, Akira Koseki, Toshiya Iwamori, Michiharu Kudo

“…The random forest model identified haemoglobin, albumin and C reactive protein as important characteristics.Conclusions The random forest model could be useful in identifying patients with extremely rapid eGFR decline.Trial registration UMIN 000037476; This study was registered with the UMIN Clinical Trials Registry.…”
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Balanced crystalloid versus saline for resuscitation in pediatric septic shock: a systematic review and meta-analysis by Barkhá Vijendra, Ana Beatriz Bertol, Mylena Maria Guedes de Almeida, Pedro Henrique Aquino Gil de Freitas, Áurea Maria Salomão Simão, Bianca Lisa de Faria

“…Results We included 12,231 patients from 8 studies, of which 4 were randomized clinical trials (RCTs). BS was used to treat septic shock in 2,460 (20.1%) patients. …”
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Efficacy & safety of brolucizumab 6.0 mg versus 3.6 mg in diabetic macular edema by Sanjay Kumar Mishra, Pradeep Kumar, Amrita Joshi, Aman Saraf, Abhijeet Awasthi, Supriya Dhar, Khaleel M, Atul Kumar, Vipin Rana, Ravi D

“…Trial registration Study was registered with Clinical trials registry of India (CTRI ref no. CTRI/2023/06/054105), registered on 14 Nov 2022.…”
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Pharmacological Vitamin C-induced high H2O2 generation mediates apoptotic cell death by caspase 3/7 activation in breast cancer tumor spheroids by Ali Mussa, Mahasin Hamid, Khalid Hajissa, Ahmad Hafiz Murtadha, Mohammad A. I. Al-Hatamleh, Noor Fatmawati Mokhtar, Vuk Uskoković, Magdalena Plebanski, Rohimah Mohamud, Rosline Hassan

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A novel technique of blindly positioning bronchial blockers for one-lung ventilation: a prospective, randomized, crossover study by Seihee Min, Susie Yoon, Jiwon Han, Jeong-Hwa Seo, Jae-Hyon Bahk

“…Trial registration This study was registered in ClinicalTrials.gov (NCT02981537) on December 05, 2016.…”
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Efficacy and Acceptability of a Mobile App for Monitoring the Clinical Status of Patients With Chronic Obstructive Pulmonary Disease Receiving Home Oxygen Therapy: Randomized Contr... by Anisbed Naranjo-Rojas, Luis Ángel Perula-de Torres, Freiser Eccehomo Cruz-Mosquera, Guillermo Molina-Recio

“…Trial RegistrationClinicalTrials NCT04820790; https://clinicaltrials.gov/study/NCT04820790 International Registered Report Identifier (IRRID)RR2-https://doi.org/10.1186/s12875-021-01450-8…”
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Geographical Differences in the Safety and Efficacy of Tofacitinib Versus TNFi: A Post Hoc Analysis of ORAL Surveillance by Bogdan Batko, Slawomir Jeka, Piotr Wiland, Agnieszka Zielińska, Maria Stopińska-Polaszewska, Marcin Stajszczyk, Magdalena Kosydar-Piechna, Mary Jane Cadatal, Jose L. Rivas

“…Trial Registration NCT02092467 (ClinicalTrials.gov).…”
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Enhanced antitumor activity of combined hepatic arterial infusion chemotherapy with Lenvatinib and PD-1 inhibitors in unresectable hepatocellular carcinoma: a meta-analysis by Lingling Zhao, Cheng Xu, Jiewen Deng, Yang Ni

“…This meta-analysis aims to assess whether the integration of HAIC with lenvatinib and PD-1 inhibitors (referred to as the HAIC-L-P group) leads to better treatment effectiveness and security compared to lenvatinib and PD-1 inhibitors alone (L-P group) in uHCC.MethodsAn exhaustive search of the literature was conducted, including PubMed, the Cochrane Library, Embase, ClinicalTrials.gov, and Web of Science, from the start of each database until September 2024, to ensure a thorough and up-to-date compilation of relevant studies. …”
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Novel CAD/CAM-splint-based navigation protocol enhances intraoperative maxillary position control in orthognathic surgery: a case control study by Felix Schrader, Leonardo Saigo, Norbert Kübler, Majeed Rana, Max Wilkat

“…Trial registration Retrospectively registered with the German Clinical Trials Register (DRKS00034795).…”
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Lifetime quality of life and cost consequences of delays in endovascular treatment for acute ischaemic stroke: a cost-effectiveness analysis from a Singapore healthcare perspective by Mayank Goyal, Weiyi Ni, Deidre Anne De Silva, Yu Li Ng, Kelvin Tan, Wolfgang G Kunz

“…Clinical outcomes and cost data were derived from clinical trials, literature, expert opinion, electronic medical records and community-based surveys from Singapore. …”
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Effect of motivational interviewing to promote advance care planning among palliative care patients in ambulatory care setting: a randomized controlled trial by Helen Yue-Lai Chan, Doris Yin-Ping Leung, Po-Tin Lam, Polly Po-Shan Ko, Raymond Wai-Man Lam, Kin-Shan Chan

“…Trial registration ClinicalTrials.gov Identifier: NCT04162912 (Registered on 14/11//2019).…”
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The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis by Peiye Zhu, Yunrui Jin, Jiya Sun, Xia Zhou

“…A meta-analysis was performed to assess the changes in levels of inflammation and oxidative stress in patients with T2DM.MethodsRelevant literatures before November 6, 2024 were screened through Web of Science,Embase,the Cochrane Library and other sources (ClinicalTrials, ProQuest Dissertations and Theses). The quality of the literature was evaluated according to the Cochrane Handbook of Systematic Reviews. …”
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Evaluating the Effectiveness of a Multimodal Psychotherapy Training Program for Medical Students in China: Protocol for a Randomized Controlled Trial by Tao Pei, Yinan Ding, Jinsong Tang, Yanhui Liao

“…Trial RegistrationClinicalTrials.gov NCT06258460; https://clinicaltrials.gov/ct2/show/NCT06258460 International Registered Report Identifier (IRRID)DERR1-10.2196/58037…”
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Therapeutic potential of Chromolaena odorata, Vernonia amygdalina, and Cymbopogon citratus against pathogenic Bacteria by Udensi Justina Ugochi, Anyanwu Charles Obinna, Emedoh Andrew Emeka, Anyanwu Emilia Oluchi, Danladi Makeri, Pius Theophilus, Ezera Agwu

“…Since the promising findings were based on an in vitro study, we recommend clinical trials to establish safe and effective doses of those plant extracts in humans.…”
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Influence of Extra-Articular Augmentation on Clinical Outcomes and Survival in Patients Undergoing Anterior Cruciate Ligament Reconstruction: A Pseudorandomized Study by Antonio Maestro, Nicolás Rodríguez, Iván Pipa, Carmen Toyos, Lucía Lanuza, Filipe Machado, César Castaño, Santiago Maestro

“…However, there are no clinical trials comparing isolated ACL repairs to those combined with ALL reconstruction. …”
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Effect of a tailor-made hydrotherapy on physical functions in patients after unilateral unicompartmental knee arthroplasty—A feasibility study by Wai-Wang Chau, Mei-Yan Lau, Tsz-Lung Choi, Gloria Yan-Ting Lam, Michael Tim-Yun Ong, Kevin Ki-Wai Ho

“…Trial registration NCT06459960, retrospectively registered on 13.06.2024 (ClinicalTrials.gov).…”
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At-Home Immersive Virtual Reality Exergames to Reduce Cardiometabolic Risk Among Office Workers: Protocol for a Randomized Controlled Trial by Jing Zhao, Akitomo Yasunaga, Andrew T Kaczynski, Hyuntae Park, Yufeng Luo, Jiuling Li, Ai Shibata, Kaori Ishii, Shohei Yano, Koichiro Oka, Mohammad Javad Koohsari

“…Trial RegistrationClinicalTrials.gov NCT06556784; https://clinicaltrials.gov/study/NCT06556784 International Registered Report Identifier (IRRID)PRR1-10.2196/64560…”
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Protocol for the economic evaluation of metacognitive therapy for cardiac rehabilitation participants with symptoms of anxiety and/or depression by Patrick Doherty, David Reeves, Gemma E Shields, Adrian Wells, Lora Capobianco, Anthony Heagerty, Deborah Buck, Linda M Davies

“…The PATHWAY Group MCT study has been prospectively designed to collect comprehensive self-reported resource use and health outcome data, including the EQ-5D, within a randomised controlled trial study design (UK Clinical Trials Gateway). A within-trial economic evaluation and economic model will compare the cost-effectiveness of MCT plus usual care (UC) to UC, from a health and social care perspective in the UK. …”
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