A multi-stakeholder collaborative approach to awareness, education and support needed in the haemophilia gene therapy patient journey – a report on insights from a European patient... by O’Mahony Brian, Fletcher Simon, Baarslag Manuel, Khair Kate, Breederveld Daan, Jansen Nathalie, Pembroke Luke, Pinachyan Karen, Sivasubramaniyam Sujan

“…The participants were 11 age-diverse men with severe haemophilia A or B, including six who had received gene therapy in phase 1-3 clinical trials. Two were members of a national patient organisation or a patient organisation leader. …”
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Development and Evaluation of a Mental Health Chatbot Using ChatGPT 4.0: Mixed Methods User Experience Study With Korean Users by Boyoung Kang, Munpyo Hong

“…Future studies should include larger-scale clinical trials, enhanced risk detection features, and integration with existing health care systems to fully realize its potential in supporting mental well-being across different linguistic and cultural contexts.…”
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The LIFTMOR-M (Lifting Intervention For Training Muscle and Osteoporosis Rehabilitation for Men) trial: protocol for a semirandomised controlled trial of supervised targeted exerci... by Benjamin K Weeks, Belinda R Beck, Amy T Harding, Steven L Watson

“…The study has been granted ethical approval from the Griffith University Human Research Ethics Committee (Protocol number AHS/07/14/HREC).Trial registration number Australian New Zealand Clinical Trials Registry (www.anzctr.org.au)ANZCTR12616000344493; Pre-results.…”
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TROPION-Breast04: a randomized phase III study of neoadjuvant datopotamab deruxtecan (Dato-DXd) plus durvalumab followed by adjuvant durvalumab versus standard of care in patients... by Heather L. McArthur, Sara M. Tolaney, Rebecca Dent, Peter Schmid, Jamil Asselah, Qiang Liu, Jane Lowe Meisel, Naoki Niikura, Yeon Hee Park, Gustavo Werutsky, Giampaolo Bianchini, Jay C. Andersen, Robert Kozarski, Nana Rokutanda, Barbara Pistilli, Sibylle Loibl

“…Trial registration: ClinicalTrials.gov identifier: NCT06112379.…”
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Long-Term Safety and Effectiveness of Dimethyl Fumarate in Patients with Multiple Sclerosis Treated in Routine Medical Practice: Final Analysis of the ESTEEM Study by Krupa Shah Pandey, Kathryn Giles, Konstantin Balashov, Richard Macdonell, Jörg Windsheimer, Mikel Martinez, Ivan Božin, Stephanie Raynaud, Matthew Scaramozza, Oksana Mokliatchouk, Zhaonan Sun, Nicholas Belviso, Yayoi Sato, Xiaochen Lin, Annette Okai

“…Trial Registration ClinicalTrials.gov Identifier NCT02047097.…”
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Genetically predicted causal link between the plasma lipidome and pancreatic diseases: a bidirectional Mendelian randomization study by Liaoyi Lin, Yingbao Huang, Songzan Qian, Lifang Chen, Houzhang Sun

“…Some lipid classes showed significant effects both in the FinnGen consortium and UK Biobank datasets.ConclusionsThe findings of this study indicate a potential genetic predisposition linking the plasma lipidome to pancreatic diseases and good prospects for future pancreatic disease clinical trials.…”
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The Usefulness of the Pressure Algometer in the Diagnosis and Treatment of Orofacial Pain Patients: A Systematic Review by Agata Kamińska, Bartosz Dalewski, Ewa Sobolewska

“…Importantly, however, additional factors should be considered in the future for the evaluation of the PPT, including body symmetry and posture, hormone levels and the menstrual phase in women, and the use of medications and its influence on the PPT. Further clinical trials should also be performed on the PPT, examining head and neck pain patients, with more precise study design and larger samples.…”
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Viral and immune dynamics of genital human papillomavirus infections in young women with high temporal resolution. by Nicolas Tessandier, Baptiste Elie, Vanina Boué, Christian Selinger, Massilva Rahmoun, Claire Bernat, Sophie Grasset, Soraya Groc, Anne-Sophie Bedin, Thomas Beneteau, Marine Bonneau, Christelle Graf, Nathalie Jacobs, Tsukushi Kamiya, Marion Kerioui, Julie Lajoie, Imène Melki, Jean-Luc Prétet, Bastien Reyné, Géraldine Schlecht-Louf, Mircea T Sofonea, Olivier Supplisson, Chris Wymant, Vincent Foulongne, Jérémie Guedj, Christophe Hirtz, Marie-Christine Picot, Jacques Reynes, Vincent Tribout, Édouard Tuaillon, Tim Waterboer, Michel Segondy, Ignacio G Bravo, Nathalie Boulle, Carmen Lía Murall, Samuel Alizon

“…Trial Registration: This trial was registered is registered at ClinicalTrials.gov under the ID NCT02946346. This study has been approved by the Comité de Protection des Personnes (CPP) Sud Méditerranée I (reference number 2016-A00712-49); by the Comité Consultatif sur le Traitement de l'Information en matière de Recherche dans le domaine de la Santé (reference number 16.504); by the Commission Nationale Informatique et Libertés (reference number MMS/ABD/ AR1612278, decision number DR-2016-488), by the Agence Nationale de Sécurité du Médicament et des Produits de Santé (reference 20160072000007).…”
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The newborn behavioural observations (NBO) system embedded in routine postpartum care in at-risk families in Iceland: a randomised controlled trial by Lisbeth Valla, Kari Slinning, Tore Wentzel-Larsen, Gun-Mette Røsand, Stefanía Birna Arnardóttir

“…Trial registration ClinicalTrials.gov ID NCT04739332, Registered 02/01/2021.…”
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A systematic review and meta-analysis of randomized controlled trials for physical activity among colorectal cancer survivors: directions for future research by Jiayu Mao, Xiaoke Qiu, Yi Zhang, Can Wang, Xueli Yang, Qiuping Li

“…However, further high-quality clinical trials are needed to determine the optimal timing, duration, and delivery methods of PA interventions to maximize their effectiveness in this population.…”
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Assessment of Geriatric Problems and Risk Factors for Delirium in Surgical Medicine: Protocol for Multidisciplinary Prospective Clinical Study by Henriette Louise Möllmann, Eman Alhammadi, Soufian Boulghoudan, Julian Kuhlmann, Anica Mevissen, Philipp Olbrich, Louisa Rahm, Helmut Frohnhofen

“…Trial RegistrationGerman Clinical Trials Registry DRKS00028614; https://www.drks.de/search/de/trial/DRKS00028614 International Registered Report Identifier (IRRID)DERR1-10.2196/59203…”
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Efficacy and Safety of Mesenchymal Stem Cells in Treatment of Complex Perianal Fistulas: A Meta-Analysis by Fang Cheng, Zhong Huang, Zhi Li

“…PubMed and Embase databases were searched for published randomized clinical trials (RCTs) that reported local MSC therapy for complex perianal fistulas. …”
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Aldosterone Blockade in Acute Myocardial Infarction: A Systematic Review and Meta-Analysis by Qiao Chen, Die Zhao, Jie Sun, Chengzhi Lu

“…Articles were identified through PubMed, Embase, Cochrane Library, Ovid (Medline1946-2021), and ClinicalTrials.gov databases from their inception to December 31, 2020. …”
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Eligibility for faricimab in a real-world diabetic macular oedema population: a cross-sectional study by Helena Norberg, Inger Westborg, Ayat Al-Najjar

“…A secondary selection of eligible individuals was conducted using the same criteria, except for BCVA, which ranged from 25 to 77 letters according to national guidelines (treatment practice).Main outcome measures Characteristics at the initial visit of the two eligible SMR populations were compared with baseline data from the clinical trials, respectively.Results In total, 3777 individuals with DMO were selected from SMR. …”
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The development and pilot testing of a behavioral activation-based treatment for depressed mood and multiple health behavior change in patients with recent acute coronary syndrome. by Emily C Gathright, Katherine Diaz Vickery, Woubeshet Ayenew, Matthew C Whited, Melissa Adkins-Hempel, Michelle Chrastek, Jill K Carter, Rochelle K Rosen, Wen-Chih Wu, Andrew M Busch

“…<h4>Trial registration</h4>ClinicalTrials.gov Identifier: NCT04158219.…”
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Effectiveness of Traditional Chinese Medicine in Psychological Rehabilitation After Lung Cancer Surgery: Systematic Review and Meta-Analysis protocol by Luchang Cao PhD, Zilin Wang MM, Xinmiao Wang PhD, Guanghui Zhu PhD, Ying Zhang PhD, Jie Li PhD

“…Methods: This study will systematically search the following databases: PubMed, Cochrane Library, EMBASE, Web of Science, ClinicalTrials.gov, China National Knowledge Infrastructure, Wanfang database, VIP database, and Chinese BioMedical Literature database. …”
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Effect of invasive acupuncture on awakening quality after general anesthesia: systematic review and meta-analysis by Fan-dong Bu, Shang-kun Si, Shang-kun Si, Shang-kun Si, Dong-bin Zhang, Yong-liang Chi

“…To explore this, we reviewed relevant randomized trials and conducted a meta-analysis.ObjectiveThis systematic review was conducted to explore the effect of perioperative application of invasive acupuncture on the quality of postoperative awakening after general anesthesia.MethodsBy searching PubMed, Embase, Cochrane Clinical Trials Center, China Knowledge Network (CNKI), China Biomedical Database (CBM), Wanfang Medical Database, Weipu Database, to include randomized controlled trials of invasive acupuncture applied perioperatively. …”
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Efficacy of Olmesartan/Amlodipine Single‐Pill Combination on 24‐h Mean Systolic Blood Pressure Measured by Ambulatory Monitoring in Non‐Responders to Valsartan or Candesartan Monot... by Woo‐Baek Chung, Sang‐Hyun Ihm, Yun‐Seok Choi, Ho‐Joong Youn

“…Trial Registration: ClinicalTrials.gov identifier: NCT01713920…”
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Mixed Comparative Evaluation of a Training Program Dedicated to Cystic Fibrosis Reference Centers: Protocol for the Pilot Implementation of Shared Decision-Making in the Treatment... by Nora Moumjid, Constance Gotte, Sophie Hommey, Stéphanie Poupon Bourdy, Julie Haesebaert, Isabelle Durieu, Quitterie Reynaud

“…Trial RegistrationClinicalTrials.gov NCT04891159; https://clinicaltrials.gov/study/NCT04891159?…”
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Psychological responses to acute exercise in patients with stress-induced exhaustion disorder: a cross-over randomized trial by Jenny Kling, Robert Persson Asplund, Örjan Ekblom, Victoria Blom

“…Trial registration The study was retrospectively registered on 05/30/2024 at Clinical Trials.gov, with trial registration number 2022–04943-01.…”
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