Introducing youth to clinical research: Development and pilot implementation of a children’s activity book by Renee Cadzow, Andy Strohmeier, Erin Carnes, Teresa Quattrin

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Molecular glue degrader for tumor treatment by Yuhan Hu, Yan Yan, Jiehao Wang, Jiangxue Hou, Quande Lin

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Promotion of nitric oxide production: mechanisms, strategies, and possibilities by Marcos Gonzalez, Sarah Clayton, Eric Wauson, Daniel Christian, Quang-Kim Tran

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Validation of the Food Safe Zone questionnaire for families of individuals with Prader-Willi syndrome by Elisabeth M. Dykens, Elizabeth Roof, Hailee Hunt-Hawkins, Theresa V. Strong

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Advances in preclinical and clinical studies of oncolytic virus combination therapy by Wenlong Du, Jintong Na, Liping Zhong, Liping Zhong, Pumin Zhang

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Psoriasis: Unraveling Disease Mechanisms and Advancing Pharmacological and Nanotechnological Treatments by Miao M, Yan J, Sun Y, Liu J, Guo S

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Clinical testing of antiretroviral drugs as future prevention against vaginal and rectal transmission of HIV infection – a review of currently available results by Vysloužil Jakub, Kubová Kateřina, Tkadlečková Veronika Nováková, Vetchý David

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Comparative clinical efficacy of acupuncture combined with manipulation and other non-pharmacological interventions in the treatment of lumbar disc herniation: a prospective, multi... by Fudong Shi, Haibao Wen, Yuzhang Liu, Zuoxu Li, Jiao Jin, Ning Liu, Guojun Wang, Chun Chen, Yadi Feng, Hai Lin, Shimin Zhang

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Evaluating the effects of chlorhexidine and vitamin c mouthwash on oral health in non-surgical periodontal therapy: a randomized controlled clinical trial by Nurdan Ozmeric, Ayaz Enver, Sila Cagri Isler, Ceren Gökmenoğlu, Merve Topaloğlu, Hilal Selamet, Gökçen Altun, Selin Aykol Sayar

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A phase 1 clinical trial of SP16, a first-in-class anti-inflammatory LRP1 agonist, in healthy volunteers. by George F Wohlford, Leo F Buckley, Dinesh Kadariya, Taeshik Park, Juan Guido Chiabrando, Salvatore Carbone, Virginia Mihalick, Matthew S Halquist, Adam Pearcy, Dana Austin, Cohava Gelber, Antonio Abbate, Benjamin Van Tassell

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Peri-implant soft tissue conditioning of immediate posterior implants by CAD-CAM socket sealing abutments: a randomized clinical trial by Mai Mohamed Elgendi, Iman Salah Eldin Hamdy, Hanaa Ibraheem Sallam

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A consort‐guided randomized, blinded, controlled clinical trial on the effects of 6 weeks training on heart rate variability in thoroughbred horses by Emma Santosuosso, Renaud Léguillette, Sierra Shoemaker, Ryan Baumwart, Sierra Temple, Kaneesha Hemmerling, Tessa Kell, Warwick Bayly

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Effectiveness of Frequent Point-of-Care Molecular COVID-19 Surveillance in a Rural Workplace: Nonrandomized Controlled Clinical Trial Among Miners by Akshay Sood, William “Cotton” Jarrell, Xin W Shore, Nestor Sosa, Alisha Parada, Nicholas Edwardson, Alexandra V Yingling, Teah Amirkabirian, Qiuying Cheng, Ivy Hurwitz, Linda S Cook, Shuguang Leng, Orrin B Myers, Douglas J Perkins

“…MethodsIn this nonrandomized controlled clinical trial conducted from February 2021, to March 2022, 169 miners in New Mexico (intervention cohort) and 61 miners in Wyoming (control cohort) were enrolled. …”
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SPIRIT-DEFINE explanation and elaboration: recommendations for enhancing quality and impact of early phase dose-finding clinical trials protocolsResearch in context by Moreno Ursino, Guillermo Villacampa, Jan Rekowski, Munyaradzi Dimairo, Olga Solovyeva, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Thomas R. Jeffry Evans, Elizabeth Garrett-Mayer, Robert M. Golub, Christina Guo, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Adrian Mander, Lynley V. Marshall, James Matcham, Dhrusti Patel, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Mahtab Rouhifard, Lesley Seymour, Yoshiya Tanaka, Christopher J. Weir, Johann de Bono, Christina Yap

“…Summary: Transparent and accurate reporting in early phase dose-finding (EPDF) clinical trials is crucial for informing subsequent larger trials. …”
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Regenerative potential of concentrated growth factor compared to platelet-rich fibrin in treatment of necrotic mature teeth: a randomized clinical trial by Taghreed Salah, Wael Hussein, Heba Abdelkafy

“…The study was registered in the Clinical Trials Registry ( ClinicalTrials.gov ) with identifier number NCT06227533. …”
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Comparison of ropivacaine with ropivacaine–dexamethasone combination for postoperative analgesia in the pectoral nerve block for modified radical mastectomy: A randomized clinical trial by Veena Mathur, Brijesh Kumari, Anand Kumar Verma, Arvind Khare, Deepak Kumar Garg

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The Effect of Free Weight Resistance Training on Cognitive Function Explored Through Eye Tracking: A Randomized Double-Blind Clinical Trial by Cristián Mateluna-Núñez, Romualdo Ibáñez-Orellana, César Campos-Rojas, Andrea Santana-Covarrubias, Rodrigo Fuentes Figueroa, Ricardo Martínez-Flores

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The Effect of Eighteen-Month Metformin Treatment in Obese Adolescents: Comparison of Results Obtained in Daily Practice with Results from a Clinical Trial by Marloes P. van der Aa, Vera Hoving, Ewoudt M. W. van de Garde, Antonius de Boer, Catherijne A. J. Knibbe, Marja M. J. van der Vorst

“…This trial is registered with ClinicalTrials.gov number: NCT01487993.…”
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Study protocol: multi-centre, randomised controlled clinical trial exploring stromal targeting in locally advanced pancreatic cancer; STARPAC2 by Hemant M. Kocher, BCI-STARPAC2 team, BPTB team, Precision-Panc team, Peter Sasieni, Pippa Corrie, Mairéad G. McNamara, Debashis Sarker, Fieke E. M. Froeling, Alan Christie, Roopinder Gillmore, Khurum Khan, David Propper

“…We propose a phase II clinical trial to test whether a combination of standard chemotherapy (gemcitabine & nab-Paclitaxel: GEM-NABP) and repurposing All Trans Retinoic Acid (ATRA) to target the stroma may extend progression-free survival and enable successful surgical resection for patients with laPDAC, since data from phase IB clinical trial demonstrate safety of GEM-NABP-ATRA combination to patients with advanced PDAC with potential therapeutic benefit. …”
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Spirituality-based palliative care education on quality of life, death anxiety, and resilience of heart failure patients: Randomized controlled clinical trial by Roghayeh Balaghi Inaloo, Mostafa Bijani, Leila Nikrouz, Azizallah Dehghan, Abdulhakim Alkamel, Ali Taghinezhad, Zahra Khiyali

“…Methods: This investigation employed a randomized controlled clinical trial design without blinding, incorporating both experimental and control groups. 80 patients who were randomly assigned to intervention and control groups (40 patients per group). …”
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