Successful Regulatory T Cell-Based Therapy Relies on Inhibition of T Cell Effector Function and Enrichment of FOXP3+ Cells in a Humanized Mouse Model of Skin Inflammation by S. Landman, V. L. de Oliveira, M. Peppelman, E. Fasse, E. van Rijssen, S. C. Bauland, P. van Erp, I. Joosten, H. J. P. M. Koenen

“…Background. Recent clinical trials using regulatory T cells (Treg) support the therapeutic potential of Treg-based therapy in transplantation and autoinflammatory diseases. …”
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Comparison of Different Invasive Devices for the Treatment of Urinary Incontinence after Radical Prostatectomy by Stefano Salciccia, Pietro Viscuso, Giulio Bevilacqua, Antonio Tufano, Paolo Casale, Ettore De Berardinis, Giovanni Battista Di Pierro, Susanna Cattarino, Alessandro Gentilucci, Francesca Lourdes Lia, Di Giulio Ivan, Davide Rosati, Francesco Del Giudice, Alessandro Sciarra, Gianna Mariotti

“…Evidence synthesis. 36 clinical trials were selected. At baseline, in the different populations, mean number of pad-day varied from 1.1 to 8.8, 24-hour pad weight varied extremely from 17.3 g to 747.0 g, and mean ICIQ-UI-SF questionnaire score varied from 4.8 to 18.6. …”
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Indocyanine Green Fluorescence Plus Blue Dye for Sentinel Lymph Node Biopsy in Patients Undergoing Neoadjuvant Chemotherapy for Breast Cancer: A Multicenter, Prospective Cohort Stu... by Miao Liu, Yang Yang, Bin Hua, Rui Feng, Tianyu Xu, Mengyuan Wang, Xiaowei Qi, Yingming Cao, Bo Zhou, Fuzhong Tong, Peng Liu, Hongjun Liu, Lin Cheng, Houpu Yang, Fei Xie, Siyuan Wang, Chaobin Wang, Yuan Peng, Danhua Shen, Lei Chen, Jun Jiang, Shu Wang

“…Trial Registration ClinicalTrials.gov (https://www.clinicaltrials.gov/), NCT02869815…”
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Pathogenesis-directed therapy of methylphenidate-induced oxidative heart damage in rats by Izzet Emir, Seval Bulut, Bahadır Suleyman, Renad Mammadov, Nurinisa Yucel, Betul Cicek, Gulce Naz Yazici, Durdu Altuner, Murat Gunay, Halis Suleyman

“…ATP, melatonin, and metirozin applications were effective to different degrees in preventing histopathological changes.ConclusionThis study may guide clinical trials using ATP and melatonin to prevent methylphenidate-induced myocardial injury.…”
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The Application of Traditional Chinese Medicine-Derived Formulations in Cancer Immunotherapy: A Review by Li Y, Li C, Fan J, Liu Y, Xu Y, Pang G

“…Various TCM herbs and compounds, their active ingredients, and their application in cancer prevention and treatment were analyzed through an integrated review of preclinical studies, clinical trials, and molecular mechanistic investigations.Results: TCM formulations contribute to cancer therapy by modulating the body’s internal environment to improve immune defense. …”
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Survival and risk factors for metastatic colorectal cancer patients with a history of prior malignancy by Yiwen Qiu, Nida Cao, Dan Meng, Jian Yuan, Yingjie Zhu

“…Therefore, we advocate for active standardized treatment for these patients and propose expanding the range of prior malignancies included in clinical trials based on publication timelines, primary tumour locations, and genetic testing results. …”
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Adult validation of a self-administered tablet audiometer by Mark Bastianelli, Amy E. Mark, Arran McAfee, David Schramm, Renée Lefrançois, Matthew Bromwich

“…Trial registration ClinicalTrials.gov Identifier: NCT02761798. Registered April, 2016 < https://clinicaltrials.gov/ct2/show/NCT02761798>…”
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Outcomes of combined liver-lung transplant in pediatric patients with cystic fibrosis: An ISHLT transplant registry study by Renita Wilson, BS, J. Asher Jenkins, MD, Juan Maria Farina, MD, Blake Langlais, MS, Bashar Aqel, MD, Ashraf Omar, MD, Jonathan D’Cunha, MD PhD, Pedro Reck dos Santos, MD PhD

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Cardiovascular Therapy Benefits of Novel Antidiabetic Drugs in Patients With Type 2 Diabetes Mellitus Complicated With Cardiovascular Disease: A Network Meta‐Analysis by Saixian Shi, Xiaofeng Li, Ye Chen, Jiahao Li, Yan Dai

“…Methods Conduct a comprehensive search of all relevant literature from PubMed, Embase, Web of Science, Cochrane Library, and Clinical Trials.gov from their establishment until December 13, 2023, and select randomized controlled trials (RCTs) that meet the pre‐established inclusion and exclusion criteria. …”
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A Review of the Therapeutic Potential of Ginseng and Its Bioactive Components in Nonalcoholic Fatty Liver Disease by Hao L, Li S, Li C, Zhang Z, Hu X, Yan H

“…However, despite the significant efficacy of ginseng in human NAFLD treatment, the number and quality of clinical studies remain limited, with a lack of large-scale, multicenter clinical trials to confirm these effects. Moreover, the pharmacokinetic properties of different ginsenosides, optimal therapeutic dosages, and the safety of long-term use require further investigation. …”
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Asthma Biologics Across the T2 Spectrum of Inflammation in Severe Asthma: Biomarkers and Mechanism of Action by Lindsley AW, Lugogo N, Reeh KAG, Spahn J, Parnes JR

“…This review discusses inflammatory pathways that contribute to asthma, quantitatively outlines effects of available biologics on biomarkers, and summarizes data and challenges from clinical trials that address non-T2 mechanisms of asthma.Keywords: thymic stromal lymphopoietin, TSLP, T2 inflammation, asthma, biologics, biomarker, anti-TSLP…”
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A Review of Needle Navigation Technologies in Minimally Invasive Cardiovascular Surgeries—Toward a More Effective and Easy-to-Apply Process by Katharina Steeg, Gabriele Anja Krombach, Michael Horst Friebe

“…Animal studies, case reports, clinical trials, or laboratory experiments were excluded to focus on actively deployed techniques in clinical practice. …”
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The effects of training female students in emotion regulation techniques on their social problem-solving skills and social anxiety: a randomized controlled trial by Ashraf Akbari, Camellia Torabizadeh, Narjes Nick, Giti Setoodeh, Parvin Ghaemmaghami

“…Trial registration The present study was registered under the code IRCT20220413054521N1 (Registration date: 27/02/2024) in the Iranian Registry of Clinical Trials.…”
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Barriers and facilitators of loaded self-managed exercises and physical activity in people with patellofemoral pain: understanding the feasibility of delivering a multicentred rand... by Michael Skovdal Rathleff, Phillipa Logan, Marcus Bateman, Benjamin E Smith, Fiona Moffatt, Paul Hendrick, James Selfe, Toby O Smith

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Efficacy of acupuncture for primary osteoporosis: a systematic review and meta-analysis of randomized controlled trials by Tianyi Ma, Tiantian Zhang, Le Zhang, Haoming Zhao, Ke Liu, Jianjun Kuang, Liang Ou

“…Methods We searched for potentially relevant studies in PubMed, Web of Science, Embase, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, China Biology Medicine disc, Wanfang database and ClinicalTrials.gov up to December 20, 2024. Randomized controlled trials investigating treatment of POP for which acupuncture was administered as a stand-alone treatment or combined with conventional medicine compared to conventional medicine or placebo, were included. …”
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Focus group-supported development and psychometric exploration of an instrument to assess perceived physical exertion in nursing students by Eva Lorenz, Eva Grüne, Johanna Popp, Klaus Pfeifer, Johannes Carl

“…Trail registration Clinical trials NCT05817396.…”
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The effect of the APOE4 genotype on physiological and cognitive health in randomised controlled trials with an exercise intervention: a systematic review and meta-analysis by Felicity S. E. Spencer, Richard J. Elsworthy, Leigh Breen, Jon R. B. Bishop, Connor Dunleavy, Sarah Aldred

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Effectiveness of a Dyadic Technology–Enhanced Home-Based Horticultural Therapy on Psychosocial Well-Being Among People With Dementia and Their Family Caregivers: Multimethods Pilot... by Patrick Pui Kin Kor, Justina Yat Wa Liu, Arkers Kwan Ching Wong, Alex Pak Lik Tsang, Han Zhi Tan, Daphne Sze Ki Cheung, Humphrey Kwong Wai Leung, Frances Kam Yuet Wong

“…Trial RegistrationClinicalTrials.gov NCT05577975; https://clinicaltrials.gov/study/NCT05577975…”
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Barriers to healthcare professionals screening, recognizing, and managing delirium in the adult patients receiving specialist palliative care: a mixed-methods systematic review by Fang Qian, Danyang Yao, Huanhuan Shi, Tao-Hsin Tung, Dongjun Bi

“…Literature was sourced from PubMed, Web of Science, Embase, CINAHL, The Cochrane Library, and Clinical Trials databases from their inception to November 16, 2024, without language restrictions. …”
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Optimizing Xenograft Models for Breast Cancer: A Comparative Analysis of Cell-Derived and Patient-Derived Implantation Techniques in Pre-Clinical Research by Khairani AF, Harmonia S, Chou Y, Alfarafisa NM, Ramadhanti J

“…To optimize xenograft models and support the development of breast cancer drugs, selecting a suitable transplantation technique is essential to attaining the best results.Methods: This scoping review used PRISMA-Scr methodology to summarize findings from eleven articles published between 2012 and 2024 on pre-clinical trials related to xenograft models for breast cancer considering PDX began traction after 2010. …”
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