Hospitalization outcomes in people living with HIV on Dolutegravir-based regimen in Mwanza, Tanzania: a comparative cohort by Godfrey A. Kisigo, Eric Barongo, Benson Issarow, Cody Cichowitz, Bahati Wajanga, Samuel Kalluvya, Robert N. Peck

“…Conclusion In conclusion, the mortality rate of hospitalized PLWH in Africa remains high in the DTG era. Clinical trials are urgently needed to test novel interventions for improving survival in this high-risk group. …”
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Comparison of diaphragmatic breathing exercises and incentive spirometry on the functional status of heart failure patients: a randomized controlled trial by Amirhossein Nasirmoghadas, Fateme Monjazebi, Malihe Nasiri, Aydin Feyzi, Fariba Borhani

“…Trial registration This study was prospectively registered by the Iranian Registry of Clinical Trials ( https://irct.behdasht.gov.ir/ ) on 14/04/2024 with registration ID: IRCT20240306061197N.…”
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Cosmetic Appeal, HRQoL, and Effectiveness of Simple and Pseudotesticular Techniques of Orchidectomy in Prostate Cancer by Ijeoma N. C. Chibuzo, Augustine O. Takure, Olayiwola B. Shittu, Linus I. Okeke

“…This study is registered with the ClinicalTrials.gov of the National Institute of Health U.S. …”
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Pharmacological pain management in patients with rheumatoid arthritis: a narrative literature review by Natasha Cox, Christian D. Mallen, Ian C. Scott

“…These showed moderate- to high-quality evidence from clinical trials in more contemporary time-periods (mainly 1990s/2000s for synthetic DMARDs and post-2000 for biological/targeted synthetic DMARDs) that, in patients with active RA, short-term glucocorticoids and synthetic, biologic, and targeted synthetic DMARDs have efficacy at reducing pain intensity relative to placebo. …”
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Integrated Management of Cardiovascular–Renal–Hepatic–Metabolic Syndrome: Expanding Roles of SGLT2is, GLP-1RAs, and GIP/GLP-1RAs by Nikolaos Theodorakis, Maria Nikolaou

“…By synthesizing evidence from landmark clinical trials, we highlight the paradigm-shifting potential of these therapies. …”
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Components of cognitive–behavioural therapy for mitigating core symptoms in attention-deficit hyperactivity disorder: a systematic review and network meta-analysis by Sayo Hamatani, Kazuki Matsumoto, Yoshihiko Kunisato, Yoshifumi Mizuno

“…We searched MEDLINE (via PubMed), Embase, PsycINFO, ClinicalTrials.gov and Cochrane Library for literature published up to 31 March 2022. …”
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NS5A replication complex inhibitor daclatasvir in the basis of chronic hepatitis C interferon-free therapy by M. V. Mayevskaya, M. S. Zharkova, V. T. Ivashkin

“…The drug is not registered in Russia yet, its approval in combination to asunaprevir is expected soon.Conclusion. Clinical trials have demonstrated that combination of daclatasvir with other medications possessing direct antiviral action, in particular with asunaprevir, and with pegilated interferon and ribavirin significantly increases treatment response rate at different categories of patients with chronic HCV-infection; that allows to reduce treatment duration of these patientsgroups. …”
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Variation in clinical and patient‐reported outcomes among complex heart failure with preserved ejection fraction phenotypes by Kelsey M. Flint, Sanjiv J. Shah, Eldrin F. Lewis, David P. Kao

“…These differences may inform the design of targeted clinical trials focusing on improvement in outcomes most relevant for specific HFpEF phenotypes.…”
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Ventilator-Associated Pneumonia After Cardiac Arrest and Prevention Strategies: A Narrative Review by Harinivaas Shanmugavel Geetha, Yi Xiang Teo, Sharmitha Ravichandran, Amos Lal

“…The controversy surrounding prophylactic antibiotics persists, but promising new strategies have been proposed; however, they are still awaiting well-designed clinical trials.…”
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PROMETHEUS: Long-Term Exacerbation and Mortality Benefits of Implementing Single-Inhaler Triple Therapy in the US COPD Population by Gerard Criner, Fernando Martinez, Hitesh Gandhi, Norbert Feigler, Bruce Pyenson, Matthew Emery, Umang Gupta, Muthiah Vaduganathan

“…**Discussion:** Widespread SITT adoption may be impeded by competitive pressures from generic treatments and nonadherence, and efficacy observed in clinical trials may not occur in real-world populations. …”
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TAD-SIE: sample size estimation for clinical randomized controlled trials using a Trend-Adaptive Design with a Synthetic-Intervention-Based Estimator by Sayeri Lala, Niraj K. Jha

“…Abstract Background Phase-3 clinical trials provide the highest level of evidence on drug safety and effectiveness needed for market approval by implementing large randomized controlled trials (RCTs). …”
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Care for post-COVID-19 condition in Germany from the perspectives of patients, informal caregivers and general practitioners: Study protocol for a mixed methods study. by Melanie Brinkmann, Maike Stolz, Annika Herr, Christoph Herrmann-Lingen, Imke Koch, Christiane Müller, Frank Müller, Uta Sekanina, Jona Theodor Stahmeyer, Martina de Zwaan, Christian Krauth, Nils Schneider

“…<h4>Trial registration</h4>The VePoKaP study is registered at the German Clinical Trials Register (DRKS00032846).…”
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Effectiveness of interventions on healthcare professionals’ understanding and use of conscience: a systematic review protocol by Alex Clark, Megan Kennedy, Christina Lamb, Edith Pituskin, Ken Kirkwood, Yolanda Babenko-Mould

“…The objective of this review is to critically analyse the scholarly evidence available to ascertain the effectiveness of interventions that support healthcare professionals to understand and use their conscience in care practice.Methods and analyses At least two reviewers will systematically review 10 interdisciplinary, scholarly databases to examine qualitative, quantitative and mixed-methods studies including clinical trials pertaining to interventions related to conscience for healthcare professionals. …”
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Efficacy of preoperative pulmonary rehabilitation in lung cancer patients: a systematic review and meta-analysis of randomized controlled trials by Yalun Guo, Mengdie Pan, Meidi Xiong, Miao Liu, Na Zhu, Haoxu Dong, Chunhua Zhang

“…Therefore, an updated meta-analysis is needed to integrate the latest published randomized controlled clinical trials (RCT). This updated analysis was performed to identify the clinical effects of preoperative pulmonary rehabilitation on physical rehabilitation (lung function, activity endurance, and dyspnea), psychological rehabilitation, quality of life, length of hospital stay, and postoperative pulmonary complications in patients with lung cancer. …”
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The Multi‐Kinase Inhibitor GZD824 (Olverembatinib) Shows Pre‐Clinical Efficacy in Endometrial Cancer by Dongli Liu, Dylan Glubb, Tracy O'Mara, Caroline E. Ford

“…GZD824, also known as olverembatinib, is a multi‐kinase inhibitor previously investigated in clinical trials for chronic myeloid leukaemia and Ph+ acute lymphoblastic leukaemia as a BCR‐ABL inhibitor. …”
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A comparative longitudinal study between bilateral and unilateral totally extraperitoneal repair among patients with unilateral inguinal hernia at a tertiary care hospital in easte... by Bikash Kumar Sah, Jatin Goel, Vijay Pratap Sah, Bhawani Khanal, Abhijeet Kumar, Rakesh Kumar Gupta

“…Trial registration: ClinicalTrials.gov, identifier NCT06380621.…”
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Novel hormonal agents in men with metastatic castration resistant prostate cancer and reduced performance status: Experiences of a specialized single center by Thomas Büttner, Philipp Lossin, Stefan Latz, Carolin Jacobs, Philipp Krausewitz, Stefan Hauser

“…However, the efficacy of NHA therapy remains uncertain for patients with a compromised general condition, as indicated by an Eastern Cooperative Oncology Group Performance Status (ECOG PS) score of ≥2. Notably, most clinical trials excluded individuals with an ECOG PS ≥2, leaving a gap in our understanding of the potential benefits of NHA therapy for this specific patient cohort. …”
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Evaluation of the Outcomes of Coronectomy Procedure versus Surgical Extraction of Lower Third Molars Which Have a High Risk for Inferior Alveolar Nerve Injury: A Systematic Review by Nedal Abu-Mostafa, Lulwah M. AlRejaie, Fahad A. Almutairi, Ruba A. Alajaji, Maram M. Alkodair, Nourah A. Alzahem

“…A total of 97 articles were identified, and seven studies were finally included for conducting qualitative analysis: 3 randomized clinical trials and 4 clinical controlled trials. Cochrane Collaboration’s tool was used for assessing risk of bias. …”
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Interactive 3D visualisation technique used in pulmonary rehabilitation in chronic obstructive pulmonary disease: A randomised controlled study evaluating quality of life, complian... by Pernilla Sönnerfors, Anna-Karin Nordlin, Maria Nykvist, Ulrika Thunström, Ulrika Einarsson

“…Three-dimensional techniques can be used in PR for COPD as an alternative to conventional techniques. ClinicalTrials.gov (identifier:NCT02802618).…”
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Effects of Pioglitazone on Nonalcoholic Fatty Liver Disease in the Absence of Constitutive Androstane Receptor Expression by Hwa Young Ahn, Hwan Hee Kim, Ji-Yeon Hwang, Changhun Park, Bo Youn Cho, Young Joo Park

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