Evaluating the efficacy of multi-incision and tube-dragging therapy combined with laser closure for high horseshoe-shaped anal fistula: Protocol of a prospective, randomized, contr... by Min Yang, Zubing Mei, Qingming Wang, Ye Han, De Zheng

“…Consequently, obtaining more definitive and authoritative evidence through scientifically rigorous clinical trials is of utmost importance in further validating this treatment approach.…”
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Integrated chronic care models for people with comorbid of HIV and non-communicable diseases in Sub-Saharan Africa: A scoping review. by Rumbidzai Chireshe, Tawanda Manyangadze, Keshena Naidoo

“…Data on some short-term benefits of integrated care was available, but evidence was absent on the long-term outcomes. Randomized clinical trials with clearly defined comparator groups and standardized measures of HIV and NCD outcomes are needed to demonstrate non-inferiority of integrated against non-integrated care.…”
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Circulating fibroblast growth factor 21 levels in gestational diabetes mellitus and preeclampsia: a systematic review and meta-analysis by Zhen Cao, Zhiming Deng, Jieyi Lu, Ying Yuan

“…Methods Articles published before April 5, 2024 were searched across four databases: PubMed, Web of Science, Embase, and Cochrane Library, and studies exploring the association of FGF21 levels and GDM or PE were collected. Additionally, ClinicalTrials.gov was also searched for completed and ongoing trials. …”
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Blood from septic patients with necrotising soft tissue infection treated with hyperbaric oxygen reveal different gene expression patterns compared to standard treatment by Julie Vinkel, Alfonso Buil, Ole Hyldegaard

“…Trial registration Biological material was collected during the INFECT study, registered at ClinicalTrials.gov (NCT01790698) 04/02/2013.…”
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Medical researchers' perception of sharing of metadata from case report forms by Alexandra Meidt, Carolin Walter, Christoph U. Lehmann, Martin Dugas

“…Methods We examined CRF data sharing commitments for 1842 interventional trials registered on the German Clinical Trials Registry (DRKS) from January 1, 2020, to December 31, 2021. …”
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Study protocol for a hybrid type 3 effectiveness-implementation trial of a team-based implementation strategy to support educators’ use of a social engagement intervention by Jill Locke, Aksheya Sridhar, Wendy Shih, Stephanie Shire, Andria B. Eisman, Emily Kim, Adora Du, Christine Espeland, Connie Kasari

“…Trial Registration: Clinical Trials ID: NCT06559267 . Date of Registration: August 15, 2024. …”
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Development and validation of a high-throughput qPCR platform for the detection of soil-transmitted helminth infections. by Nils Pilotte, Victor Omballa, Monica Voss, Leah Padgett, Malathi Manuel, Jeanne L Goodman, Tim Littlewood, Zayina Zondervenni Manoharan, Lisette van Lieshout, Jaco J Verweij, Manigandan Sekar, Ajith Kumar Muthukumar, Gretchen Walch, Abriana Warren, Mariyam Sheikh, Andrew Gonzalez, Sean R Galagan, Sitara Swarna Rao Ajjampur, Moudachirou Ibikounlé, Steven A Williams, Doug Rains, Ushashi Dadwal, Judd L Walson

“…Testing the feasibility of such an approach requires large-scale clinical trials, such as the DeWorm3 cluster randomized trial. …”
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Protocol for the impact of machine learning-based clinician decision support algorithims in perioperative care (IMAGINATIVE) in Singapore general hospital : a large prospective ran... by Marcus Ong, Hairil Rizal Abdullah, Ecosse Lamoureux, Elaine Lum, Gek Hsiang Lim, Tan Pei Yi Brenda, Celestine Loh

“…The primary outcome is to evaluate the effectiveness of the Machine Learning Clinical Decision Support (ML-CDS) algorithm in improving perioperative mortality rates when integrated into the clinical workflow.Ethics and dissemination The study has been approved by the SingHealth Centralised Institutional Review Board (CIRB Ref: 2023:2114) and is registered on ClinicalTrials.gov (trial number: NCT05809232). All patients will sign an informed consent form before recruitment and translators will be made available to non-English-speaking participants. …”
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Comparison of three cryotherapy techniques for early post-TKA pain control in terms of efficacy and patient satisfaction: a randomized controlled trial by Keerati Chareancholvanich, Worawut Keesukpunt, Chaturong Pornrattanamaneewong, Rapeepat Narkbunnam, Atthakorn Jarusriwanna

“…Trial registration This study was registered in the Thai Clinical Trials Registry database (no. TCTR20200517002).…”
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Synergistic Antitumor Effects of Anlotinib Combined with Oral 5-Fluorouracil/S-1 via Inhibiting Src/AKT Signaling Pathway in Small-Cell Lung Cancer by Xinhang Xia, Wenhu Pi, Yanli Lan, Xiaomai Wu, Dongqing Lv, Yinnan Meng, Haihua Yang, Wei Wang

“…This new strategy may be a promising treatment for SCLC but needs to be confirmed in future clinical trials.…”
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Understanding human papillomavirus vaccine response and efficacy in people living with HIV: A systematic mixed studies review and meta-analysis. by Alvine M Akumbom, Alanna J Bergman, Howard Strickler, Chakra Budhathoki, Manka Nkimbeng, Raeven Grant, Nancy R Reynolds, Kawsar R Talaat

“…This could be influenced by the diversity of eligibility criteria across clinical trials of HPV vaccine efficacy. Precision medicine may offer novel alternatives for evaluating HPV vaccine efficacy in PWH.…”
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Prescribing clarity: mapping the link between antihypertensives and breast cancer by Shadman Newaz, Moontasir Ahmed, Jannat Ara Tina, Talukder Nasif Shahriar, Abdulla Bin Hridoy, Supritom Sarker, Mohammad Zakaria Al-Aziz, Md. Robed Amin

“…Multiple databases were searched for English-language studies of various designs, including clinical trials, cohort studies, and observational studies. …”
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Adapting to ulcerative colitis to try to live a ‘normal’ life: a qualitative study of patients’ experiences in the Midlands region of England by Rachel Cooney, Christel McMullan, Dmitri Nepogodiev, Laura Magill, Thomas D Pinkney, Jonathan M Mathers, Laura L Jones, Shri Pathmakanthan

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Lipoprotein(a) and thromboembolism: current state of knowledge and unsolved issues by Małgorzata Konieczyńska, Joanna Natorska, Michał Ząbczyk, Anetta Undas

“…Targeted Lp(a) lowering therapies are currently being tested in randomized clinical trials and could potentially have clinically relevant antithrombotic effects, evidenced by the reduced risk of thromboembolism. …”
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Effectiveness of Anti-Gravity Treadmill Exercise After Total Knee Arthroplasty: Protocol for a Randomized Controlled Trial by Elina Jääskeläinen, Mikko Manninen, Heikki Hurri, Mikko Rantasalo, Yun Zhou, Hannu Kautiainen, Leena Ristolainen

“…Trial RegistrationClinicalTrials.gov NCT03904030; https://clinicaltrials.gov/study/NCT03904030 International Registered Report Identifier (IRRID)DERR1-10.2196/59935…”
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Winery By-Products In Vitro and In Vivo Effects on Atherothrombotic Markers: Focus on Platelet-Activating Factor by Maria Choleva, Smaragdi Antonopoulou, Elizabeth Fragopoulou

“…Therefore, the purpose of this literature review is to update the existing data concerning the in vitro anti-platelet and anti-inflammatory properties of winery by-product extracts and their possible health effects through controlled clinical trials in humans, specifically focused on their effects on PAF’s actions. …”
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Efficacy and safety of anti-thrombotic therapy after surgical mitral valve repair: a scoping review by Jian Ye, Jenny Chen, Hazal Ece Babadagli, Ricky Turgeon, Erica HZ Wang

“…This scoping review aimed to summarise current evidence on the safety and efficacy of anti-thrombotic therapy after MVr, identify knowledge gaps and propose a future study design.Methods We searched MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Clinicaltrials.gov, the WHO International Clinical Trials Registry Platform and bibliographies of included trials, guidelines and other reviews from inception to 17 September 2024. …”
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Development and feasibility of an mHealth intervention for psychoeducational support of Nigerian women diagnosed with breast cancer undergoing chemotherapy: A pilot randomized cont... by Oluwadamilare Akingbade, Ka Yi Hong, Oluwabukola Sharon Ayo, Adetutu Sefinat Alade, Moshood Akinwumi Lawal, Ibironke Elizabeth Somoye, Victoria Adediran, Olamide Sado, Ka Ming Chow

“…<h4>Trial registration</h4>This manuscript reports a feasibility study preceding the full trial, which was registered with the United States Clinical Trials registry (number NCT05489354).…”
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Bromhexine Hydrochloride Prophylaxis of COVID-19 for Medical Personnel: A Randomized Open-Label Study by Evgeny N. Mikhaylov, Tamara A. Lyubimtseva, Aleksandr D. Vakhrushev, Dmitry Stepanov, Dmitry S. Lebedev, Elena Yu. Vasilieva, Alexandra O. Konradi, Evgeny V. Shlyakhto

“…The prophylactic treatment was not associated with a lower combined primary endpoint rate, a positive swab PCR test, or COVID-19 (ClinicalTrials.gov number, NCT04405999).…”
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Overview of styles, content, learning effects and attitudes of students towards digitally enhanced physiotherapy education – a scoping review by Larissa Pagels, Oskar Schindler, Kerstin Luedtke

“…Studies were included if they reported on any digitally enhanced educational methods in physiotherapy education, involving qualitative studies, clinical trials, observational studies, or case reports published in English or German from 2010 to February 2024. …”
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