Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose? by Marka Crittenden, Sandra Demaria, C Norman Coleman, Jonathan Schoenfeld, Arta Monjazeb, Samir Khleif, Seema Gupta, Andrew Sikora, Zachary Morris, Chandan Guha, Stephen Shiao, Silvia Chiara Formenti, Bhadrasain Vikram, Mansoor M Ahmed

“…Divergence of approaches and findings between preclinical studies and clinical trials highlights the need for evaluating the design of future clinical studies with particular emphasis on radiation dose and fractionation, immune biomarkers and selecting appropriate end points for combination radiation/immune modulator trials, recognizing that direct effect on the tumor and potential abscopal effect may well be different. …”
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Steroid use for established bronchopulmonary dysplasia: study protocol for a systematic review and meta-analysis by Roy K Philip, Joanna Seliga-Siwecka, Eduardo Villamor, Maria Pierro, Niazy Al Assaf, Sabina Strashun, Roberto Chioma, Kinga Zielińska, Krzysztof Włodarczyk

“…Observational studies and non-randomised and randomised clinical trials will be analysed separately. We will combine OR with 95% CI for dichotomous outcomes and the mean difference (95% CI) for continuous outcomes. …”
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Effectiveness of a comic book intervention on mental health literacy among adolescents and youth in Burkina Faso: a randomized controlled trial protocol by Irene Brandt, Sylvain Some, Ourohiré Millogo, Oumar Sourabié, Jacob Burns, Sachin Shinde, Matthias Haucke, Nathan Sivewright, Christine Neumann, Shraddha Bajaria, Katian Napon, Clarisse Dah, Marina Taonda, Jason T. Siegel, Mary Mwanyika Sando, Till Bärnighausen, Ali Sié, Shuyan Liu

“…Trial registration This trial has been registered on the German Clinical Trials Register (DRKS), with the registration number DRKS00034242.…”
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Vagal Blocking Improves Glycemic Control and Elevated Blood Pressure in Obese Subjects with Type 2 Diabetes Mellitus by S. Shikora, J. Toouli, M. F. Herrera, B. Kulseng, H. Zulewski, R. Brancatisano, L. Kow, J. P. Pantoja, G. Johnsen, A. Brancatisano, K. S. Tweden, M. B. Knudson, C. J. Billington

“…This trial is registered with ClinicalTrials.gov NCT00555958.…”
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Local application of sodium thiosulfate as an otoprotectant for cisplatin-exposed patients – A narrative literature review to explore the potential benefit for children with cancer... by Nienke Streefkerk, Amirhossein Masroor, James I. Geller, Martine van Grotel, Marc Ansari, Eric Bouffet, Archie Bleyer, Brice Fresnau, Michael Sullivan, Alwin D.R. Huitema, Alexander E. Hoetink, Per Kogner, Rudolf Maibach, Allison F. O’Neill, Vassilios Papadakis, Kaukab M. Rajput, Gareth J. Veal, Penelope R. Brock, Annelot J.M. Meijer, Marry M. van den Heuvel-Eibrink

“…Preclinical studies in guinea pigs showed a significant protective effect on outer hair cell loss or hearing function. However, two clinical trials in adults did not show convincing evidence of otoprotection, by locally administered STS. …”
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Rationale and design for the thoracic Paravertebral Adjunctive Dexamethasone Palmitate Reducing chronic pain After cardiac surgery (PANDORA) trial: a parallel-group, double-blinded... by Jing Zhao, Hui Zhang, Ziyu Zheng, Baobao Gao, Lini Wang, Chong Lei, Hailong Dong, Taoyuan Zhang, Jiao Gao, Lihong Hou

“…Results will be submitted for publication in peer-reviewed journals and presented at academic meetings.Trial registration number ClinicalTrials.gov, NCT05920967.…”
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Lupus activity in lupus nephritis patients with end-stage renal disease treated with hemodialysis by Caroline Samy Morad, Shams ElDoha Galal Zaiema, Eman Ahmed Hafez, Mohammed Maher Mohammed Mohammed Mansour, Amr Elsayed Mohammed Abd-Allah Khalil, Shaymaa Gamal Arafa Hassan

“…We believe that performing clinical trials and developing new post-HD evidence-based treat-to-target management guidelines for LN patients is now mandatory to improve their clinical outcomes and quality of life.…”
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Pharmacokinetic Evaluation of [C]CEP-32496 in Nude Mice Bearing BRAF Mutation-Induced Melanomas by Cuiping Jiang MMSc, Lin Xie MD, PhD, Yiding Zhang BSc, Masayuki Fujinaga PhD, Wakana Mori MSc, Yusuke Kurihara PhD, Tomoteru Yamasaki PhD, Feng Wang MD, PhD, Ming-Rong Zhang MD, PhD

“…CEP-32496, also known as RXDX-105 or Agerafenib, is a new orally active inhibitor for the mutated v-raf murine sarcoma viral oncogene homolog B1 (BRAF V600E ), which has attracted considerable attention in clinical trials for the treatment of human cancers. Here, we used carbon-11-labeled CEP-32496 ([ 11 C]CEP-32496) as a positron emission tomography (PET) radiotracer to evaluate its pharmacokinetic properties and explore its potential for in vivo imaging. …”
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Double-blind, randomised, placebo-controlled trial to evaluate the effectiveness of late gestation oral melatonin supplementation in reducing induction of labour rates in nulliparo... by Miranda Davies-Tuck, Emily Callander, Mary Sharp, Scott W White, Dorota A Doherty, Jane Warland, Zoe Bradfield, Lesley Kuliukas, Monique Rose, Amber Pettitt, Kylie Ekin, JA Keelan

“…Trial findings will be disseminated through conference presentations and peer-reviewed publications.Trial registration number The trial has been prospectively registered on the Australian New Zealand Clinical Trials Registry as ACTRN12623000502639 on 17/05/2023.…”
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Oridonin: A natural terpenoid having the potential to modulate apoptosis and survival signaling in cancer by Abhishek Chauhan, Hemant Joshi, Divya Kandari, Diwakar Aggarwal, Ritu Chauhan, Hardeep Singh Tuli, Arpit Mehrotra, Abhilasha Sood, Ujjawal Sharma, Darin Mansor Mathkor, Shafiul Haque, Naveen Chandra Joshi, Laurent Dufossé

“…Further research, including clinical trials, is necessary to fully harness its potential as a cancer treatment alternative.…”
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Very first real-world data on zongertinib use in non-small cell lung cancer patients with HER2 mutations: A brief report by Oliver Illini, Anna Sophie Lang-Stöberl, Hannah Fabikan, Christoph Weinlinger, Arschang Valipour, Maximilian J. Hochmair

“…New agents, including zongertinib, a HER2-selective tyrosine kinase inhibitor (TKI), are being investigated in clinical trials. However, published clinical data on the efficacy and safety of zongertinib are limited to data from a single phase I trial including only 36 patients with NSCLC. …”
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Assessing the effectiveness and the feasibility of a group-based treatment for self-stigma in people with mental disorders in routine mental health services in North-East Italy: st... by Antonio Lasalvia, Luca Bodini, Doriana Cristofalo, Veronica Fin, Philip T. Yanos, Chiara Bonetto

“…Trial registration ClinicalTrials.gov; Identifier: NCT06567145.…”
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Is epinephrine still the drug of choice during cardiac arrest in the emergency department of the hospital? A meta-analysis by Hou Min, Dong Su, Kan Qing, Ouyang Meng, Zhang Yun

“…RevMan and MedCalc software were used and statistical parameters such as odds ratio and risk ratio were calculated. Twelve clinical trials with a total of 208,690 cardiac arrest patients from 2000 to 2022 were included, in accordance with the chosen inclusion criteria. …”
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Comparative efficacy and safety of 20 intravenous pharmaceutical intervention for prevention of etomidate-induced myoclonus: a systematic review and Bayesian network meta-analysis by Lu Chen, Lu Chen, Pengxiang Zhou, Pengxiang Zhou, Zhengqian Li, Ziyang Wu, Suodi Zhai, Suodi Zhai

“…ObjectiveTo compare the efficacy and safety of pharmaceutical interventions to prevent etomidate-induced myoclonus (EIM), providing the optimal intervention for clinical practice.MethodsPubMed, Embase, the Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, Chinese National Knowledge Infrastructure, WanFang database, and SinoMed database were searched from the inception to sixth May 2024. …”
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Evaluation of Melongosides as Potential Inhibitors of NS2B-NS3 Activator-Protease of Dengue Virus (Serotype 2) by Using Molecular Docking and Dynamics Simulation Approach by Partha Biswas, Ommay Hany Rumi, Dhrubo Ahmed Khan, Md Nasir Ahmed, Nusratun Nahar, Rownak Jahan, Md Nazmul Hasan Zilani, Tridib K Paul, Anamul Hasan, Tohmina Afroze Bondhon, Khoshnur Jannat, Md Nazmul Hasan, Mohammed Rahmatullah

“…Taken together, melongosides need further attention for more scientific studies as a DENV inhibitory agent, which if proven, in vivo and in clinical trials, can be a useful therapeutic agent against at least DENV-2.…”
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The effects of low-carbohydrate diet on glucose and lipid metabolism in overweight or obese patients with T2DM: a meta-analysis of randomized controlled trials by Wende Tian, Shuyu Cao, Yongxin Guan, Zihao Zhang, Qiyu Liu, Jianqing Ju, Ruixi Xi, Ruina Bai

“…Low-carbohydrate diets have emerged as a potential intervention, yet clinical evidence remains inconclusive.PurposeThis meta-analysis assesses the impact of low-carbohydrate diets on metabolic profiles in overweight or obese T2DM patients, aiming to guide clinical practice.MethodsA systematic review identified randomized clinical trials (RCTs) comparing low-carbohydrate diets to control diets in T2DM patients from PubMed, Embase, and the Cochrane Library databases up to April 2023.ResultsSeventeen RCTs, encompassing 1,197 participants, demonstrated that low-carbohydrate diets significantly improved HbA1c levels and fasting plasma glucose (mean difference [MD] = −0.36, 95% CI −0.44 to −0.29, p < 0.00001; MD = −10.71, 95% CI −14.39 to −7.03, p < 0.00001). …”
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Effectiveness of interventions for the prevention of occupational violence against professionals in health services: a protocol for a systematic review by Caroline Vieira Cláudio Okubo, Renata Cristina Campos Pereira Silveira, Maria José Quina Galdino, Daiane Rubinato Fernandes, Aline Aparecida Oliveira Moreira, Júlia Trevisan Martins

“…The risk of bias of the randomised clinical trials will be evaluated by the Risk of Bias tool from Cochrane, and the risk of bias of the non-randomised intervention studies will be evaluated using the Downs and Black scale. …”
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Efficacy of phototherapy to treat facial ageing when using a red versus an amber LED: a protocol for a randomised controlled trial by Lidiane Rocha Mota, Christiane Pavani, Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Ivone da Silva Duarte, Daniela de Fátima Teixeira da Silva

“…This trial has been registered in the Registro Brasileiro de Ensaios Clínicos (Brazilian Clinical Trials Registry) (REBEC number: RBR-6YFCBM). …”
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Local Anesthesia Versus Saddle Block for Open Hemorrhoidectomy: Cost-Analysis From a Randomized, Double Blind Controlled Trial. by Sikakulya, Franck Katembo, Ssebuufu, Robinson, Okedi, Xaviour Francis, Baluku, Moris, Lule, Herman, Kiyaka, Sonye Magugu, Muhumuza, Joshua, Selamo, Fabrice Molen, Bassara, Godefroy Nyenke, Waziri, Musa Abbas, Kithinji, Stephen Mbae, Mugisho, Munyerenkana Leocadie, Byamungu, Pahari Kagenderezo, Munihire, Jeannot Baanitse, Vahwere, Bienfait Mumbere, Kiswezi, Ahmed, Kyamanywa, Patrick

“…Trial registration Pan African Clinical Trials Registry, PACTR202110667430356. Registered on 08/10/2021.…”
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Real-world outcomes with tisagenlecleucel in aggressive B-cell lymphoma: subgroup analyses from the CIBMTR registry by Frederick L Locke, Grant Schofield, Marcelo Pasquini, Matthew J Frigault, Cameron J Turtle, Stephen Lim, Brian Hill, Samantha Jaglowski, Caron A Jacobson, Gunjan Shah, Daniel J Landsburg, Michael Heim, Stephen Ronan Foley, Ron Ram, Peter A Riedell, Leslie L Popplewell, Ranjan Tiwari, Marta Majdan, Aisha Masood

“…When used in real-world settings, tisagenlecleucel has shown similar efficacy and improved safety compared with previous clinical trials. However, long-term data on real-world outcomes are lacking.Methods Clinical data from a cohort of patients treated with tisagenlecleucel in a real-world setting were captured in the Center for International Blood and Marrow Transplant Research registry. …”
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