Treatment of the dry form of age-related macular degeneration: the studied present and promising future by N.G. Glazko, O.A. Kanaeva, M.H. Rabadanova

“…The article presents an analysis of modern views concerning the current therapy possibilities for the dry form of AMD, including the use of nutraceuticals, consisting of lutein, zeaxanthin, mesoseaxanthin, as well as an overview of the directions of development and clinical trials. The use of lutein- and zeaxanthin-containing compounds can be recommended for prevention both the AMD progression and the presence of risk factors for its development, especially in persons over 50 years of age, as well as in the presence of high visual workload. …”
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Nebulised 3% hypertonic saline versus 0.9% saline for treating patients hospitalised with acute bronchiolitis: protocol for a randomised, double-blind, multicentre trial by Sara Szupieńko, Aleksandra Buczek, Henryk Szymański

“…The findings of the study will be submitted to a peer-reviewed journal, and abstracts will be submitted to relevant national and international conferences.Trial registration number ClinicalTrials.gov Registry (NCT06069336).…”
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Safety and validity of extracorporeal fenestration and in situ fenestration in patients with aortic disease involving the left subclavian artery: a prospective, single-center, rand... by Xiaojian Jia, Jingjin Wu, Caiyou Ding, Yanbo Lou

“…Trial registration ClinicalTrials.gov NCT06256757. Registered on February 5, 2024. https://clinicaltrials.gov/study/NCT06256757 .…”
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Why is the New York Times Writing so Much about Alzheimer's Disease Therapies? by Tamas Bartfai

“…However, it is now clear that companies and researchers alike are losing hope in finding an efficacious therapy rapidly that works in ad patients who are already cognitively impaired, and that people who staked their scientific and professional career on finding a cure for ad based on the amyloid hypothesis are shaken by the series of failed clinical trials within a short period of time. It is emerging that we may start to treat ad far too late to be able to make any significant slowing of the disease or postponing the onset of the symptoms of the disease. …”
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An exploration of clinically meaningful definitions of cough bouts by Kimberley J. Holt, Rachel J. Dockry, Kevin McGuinness, Emma Barrett, Jaclyn A. Smith

“…Rationale The measurement of cough frequency is widely used in clinical trials, typically expressed as the number of explosive cough sounds per hour. …”
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Anti-vascular Endothelial Growth Factor Outpatient Treatment Patterns in Patients with Exudative Age-related Macular Degeneration from a Japanese Hospital Claims Database by Tomohiro Iida, Aya Narimatsu, Kenji Adachi, Edward CY Wang

“…**Conclusion:** In a real-world setting in Japan, anti-VEGF PRN injections are administered less frequently than in clinical trials, and with time between monitoring and re-injection visits. …”
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Pain Assessment Following Open Hemorrhoidectomy Under Local Anesthesia Versus Saddle Block: A Multicenter Randomized Controlled Trial. by Sikakulya, Franck Katembo, Ssebuufu, Robinson, Okedi, Xaviour Francis, Baluku, Moris, Lule, Herman, Kiyaka, Sonye Magugu, Kyamanywa, Patrick

“…Trial registration Pan African Clinical Trials Registry, PACTR202110667430356. Registered on 8th October, 2021.…”
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Combining a WT1 Vaccine (Galinpepimut-S) With Checkpoint Inhibition (Nivolumab) in Patients With WT1–Expressing Diffuse Pleural Mesothelioma: A Phase 1 Study by Prashasti Agrawal, MD, Michael Offin, MD, Victoria Lai, MD, Michelle S. Ginsberg, MD, Prasad S. Adusumilli, MD, FACS, Valerie W. Rusch, MD, Jennifer L. Sauter, MD, Teresa Ho, BS, Phillip Wong, PhD, Marjorie G. Zauderer, MD

“…Galinpepimut-S (GPS), a tetravalent, non–human leukocyte antigen–restricted, heteroclitic WT1–specific peptide vaccine was safe and effective in early phase clinical trials and upregulates T-cell suppressive programmed death-ligand 1 in the tumor microenvironment of other malignancies. …”
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Multicentre Harmonisation of a Six-Colour Flow Cytometry Panel for Naïve/Memory T Cell Immunomonitoring by Iole Macchia, Valentina La Sorsa, Irene Ruspantini, Massimo Sanchez, Valentina Tirelli, Maria Carollo, Giorgio Fedele, Pasqualina Leone, Giovanna Schiavoni, Carla Buccione, Paola Rizza, Paola Nisticò, Belinda Palermo, Stefania Morrone, Helena Stabile, Aurelia Rughetti, Marianna Nuti, Ilaria Grazia Zizzari, Cinzia Fionda, Roberta Maggio, Cristina Capuano, Concetta Quintarelli, Matilde Sinibaldi, Chiara Agrati, Rita Casetti, Andrea Rozo Gonzalez, Floriana Iacobone, Angela Gismondi, Filippo Belardelli, Mauro Biffoni, Francesca Urbani

“…Flow cytometry (FCM) methods represent an essential tool for immunomonitoring, and their harmonisation is crucial to obtain comparable data in multicentre clinical trials. The objective of this study was to design a harmonisation workflow able to address the most effective issues contributing to intra- and interoperator variabilities in a multicentre project. …”
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Efficacy and Safety of Sacubitril/Valsartan Versus Amlodipine in Japanese Patients With Essential Hypertension: A Randomized, Multicenter, Open‐Label, Noninferiority Study (PARASOL... by Koichi Yamamoto, Daisuke Yarimizu, Ayano Shimanishi, Shunsuke Eguchi, Kazuma Iekushi, Yoichi Takami, Yoichi Nozato, Kazuomi Kario, Hiromi Rakugi

“…ABSTRACT Sacubitril/valsartan, an angiotensin receptor‐neprilysin inhibitor, has demonstrated a superior blood pressure‐lowering effect compared with renin‐angiotensin system inhibitors in several clinical trials. However, there has been no available evidence on the comparison between sacubitril/valsartan and calcium channel blockers (CCBs), a well‐established class of antihypertensive drugs. …”
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Healthy lifestyle before and during pregnancy to prevent childhood obesity: study protocol for a parallel group randomised trial — the PRE-STORK trial by Tina Vilsbøll, Signe S Torekov, Julie Lyng Forman, Romain Barrès, Andreas Andersen, Filip K Knop, Signe Foghsgaard, Klaus Bønnelykke, Thomas Bergholt, Karoline Kragelund Nielsen, Christina Anne Vinter, Majken Lillholm Pico, Louise Groth Grunnet, Nina Kornerup, Julie Hagstrøm Danielsen, Ronni Eg Sahl, Mette Yun Johansen, Louise Kelstrup, Nida Ghauri, Emilie Grønlund, Lærke Lund

“…All results, whether positive, negative and inconclusive, will be disseminated at national or international scientific meetings and in peer-reviewed scientific journals.Trial registration number ClinicalTrials.gov: NCT05578690 (October 2022).…”
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Preclinical development of a standardized extract of Ilex paraguariensis A.St.-Hil for the treatment of obesity and metabolic syndrome by Sara E.L. Tolouei, Rodrigo Marcon, Fabiana Cardoso Vilela, Cristina Setim Freitas, Melina Heller, Edineia Lemos de Andrade, Sergio José Macedo Júnior, Adara Áurea dos Santos, Ruth Fernandes Rocha, Guilherme Pasetto Fadanni, Naiani Ferreira Marques, Jarbas Mota Siqueira Júnior, João B. Calixto

“…These findings strongly suggest that TI-076 holds great potential for clinical trials aimed at developing a safe phytomedicine for treating obesity and related metabolic diseases.…”
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Effect of multiple counselling contacts along the continuum of care on use of postpartum family planning in a cohort of Ethiopian women: a dose-response analysis by Saifuddin Ahmed, Anne Pfitzer, Firew Ayalew, Gebi Husein Jima, Deborah Sitrin

“…PPFP did not increase with additional contacts without FP information.Conclusions While PPFP conversations immediately after a facility birth generated the greatest chance of affecting use, integrating at every visit in the continuum had more impact.Trial registration number ClinicalTrials.gov, NCT03585361.…”
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Machine learning based on blood test biomarkers predicts fast progression in advanced NSCLC patients treated with immunotherapy by Jie Yang, Jian-Guo Zhou, Benjamin Frey, Hu Ma, Haitao Wang, Markus Hecht, Rainer Fietkau, Udo Gaipl, Xiaofei Chen, Ada Hang-Heng Wong, Fangya Tan, Si-Si He, Gang Shen, Yun-Jia Wang, Wenzhao Zhong

“…We aimed to develop a predictive framework based on machine learning (ML) methods to identify FP in advanced NSCLC patients using blood test biomarkers.Methods and analysis We extracted data of 1546 atezolizumab-treated patients from four multicentre clinical trials. In this study, patients from the OAK trial were taken for model training, whereas patients from the other trials were used for independent validations. …”
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High‐risk cytogenetic abnormalities in multiple myeloma: PETHEMA‐GEM experience by Veronica González‐Calle, Paula Rodriguez‐Otero, Maria J. Calasanz, Manuela Guijarro, Joaquin Martínez‐López, Laura Rosiñol, Miguel T. Hernández, Ana I. Teruel, Mercedes Gironella, Albert Oriol, Javier de laRubia, Ana P. González‐Rodríguez, Joan Bargay, Felipe deArriba, Luis Palomera, Marta‐Sonia González‐Pérez, Anna Sureda, Enrique Ocio, Juan J. Lahuerta, Joan Bladé, Jesus F. San Miguel, Maria V. Mateos, Norma C. Gutiérrez

“…The analysis included 1304 patients from four different GEM‐PETHEMA clinical trials. Genetic alterations, such as t(4;14), t(14;16), del(17p), +1q, and del(1p), were investigated using FISH on CD38 purified plasma cells. …”
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Supplementary oxygen efficacy for chronic pulmonary disorders and exertion desaturation by Paraschos Archontakis Barakakis, Adam Wolfe, Andrei Schwartz, Gabriel J. Hernandez Romero, Vipul Gidwani, Shaylika Chauhan, Shinichi Arizono, Ralph J. Panos, Spyridon Fortis

“…We performed a systematic review and meta-analysis of randomised clinical trials (RCTs) to evaluate the efficacy of supplementary oxygen for EID in pulmonary disorders. …”
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The efficacy of internet-based cognitive behavior therapy for psychological health and quality of life among breast cancer patients: a systematic review and meta-analysis by Tang Lin, Yin Ping, Cai Ming Jing, Zhi Xiao Xu, Zhu Ping

“…The quality of the evidence was evaluated at the study level and the outcome level.ResultsIn total, 11 clinical trials on 1,307 patients with BC (ICBT: 671, control: 636) were systematically reviewed. …”
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The impact of particle size of nanostructured lipid carriers on follicular drug delivery: A comprehensive analysis of mouse and human hair follicle penetration by Saman Heydari, Mohammad Barzegar-Jalali, Mostafa Heydari, Afsaneh Radmehr, Ana Cláudia Paiva-Santos, Maryam Kouhsoltani, Hamed Hamishehkar

“…Mouse models are mostly used in clinical trials for dermal, transdermal, and follicular delivery studies. …”
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Prevalence, risk factors, and adverse outcomes of bacterial vaginosis among pregnant women: a systematic review by Neha Sethi, Vallikkannu Narayanan, Rahmah Saaid, Aizura Syafinaz Ahmad Adlan, Soo Tein Ngoi, Cindy Shuan Ju Teh, Mashitah Hamidi, on behalf of WHOW research group

“…PubMed, ScienceDirect, ClinicalTrials.gov and Cochrane database searches were conducted independently by two authors until May 13th, 2023. …”
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Assessing the impact of different donor milk treatments on infant health and growth: a systematic review protocol by Daniel Klotz, Carolyn Smith, Agnieszka Bzikowska-Jura, Marzia Giribaldi, Tanya Cassidy, Laura Cavallarin, Serena Gandino, Karolina Karcz, Chiara Peila, Bartłomiej Walczak, Aleksandra Wesolowska

“…The current systematic review protocol, however, aims to systematically gather and analyse existing data pertaining to the impact of these aforementioned factors on the clinical, health-related and developmental outcomes observed in infants fed with DHM.Methods and analysis We will apply a predefined search strategy including Cochrane Central Register of Controlled Trials, Global Index Medicus, CINAHL on Ebscohost, Medline, Embase, Emcare, Pubmed, Global Health on OVID, Google Scholar, clinicaltrials.gov, the WHO International Trials Registry and Platform and the European Union/European Economic Area Clinical Trials Register. No setting, patient population, date or language restrictions will be applied. …”
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