Bimatoprost Intracameral Implant (Durysta®): A New Era in Glaucoma Management Through Sustained-Release Innovation by Vagiakis I, Papadopoulou EP, Amaxilati E, Tsiropoulos GN, Konstas AG, Panos GD

“…This review evaluates its pharmacology, efficacy, and safety, using data from pivotal clinical trials and recent real-world studies. The implant achieves IOP reductions comparable to topical prostaglandin analogs, with benefits for patient adherence and fewer common side effects. …”
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Clinical implications of Delphian lymph node metastasis in papillary thyroid carcinoma: a single-institution study, systemic review and meta-analysis by Bin Wang, Xing-zhu Wen, Wei Zhang, Ming Qiu

“…Trial registration The clinical study was retrospectively registered to UMIN clinical trials registry (the registry number: UMIN000033835).…”
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Systemic reviews and meta-analysis of the use of midodrine in hepatorenal syndrome by Prem Balaji Reddy Lankapothu, Shrinidhi B., Satish Kumar M., Magesh Kumar S.

“…However, significant, well-designed clinical trials are needed to determine optimal dosage, duration, and pharmacological side effects. …”
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Biological Evaluation of Platinum(II) Sulfonamido Complexes: Synthesis, Characterization, Cytotoxicity, and Biological Imaging by Charini Maladeniya, Taniya Darshani, Sameera R. Samarakoon, Frank R. Fronczek, W. M. C. Sameera, Inoka C. Perera, Theshini Perera

“…Platinum-based compounds are actively used in clinical trials as anticancer agents. In this study, two novel platinum complexes, (C1 = [PtCl2(N(SO2quin)dpa)], C2 = [PtCl2(N(SO2azobenz)dpa)]) containing quinoline and azobenzene appended dipicolylamine sulfonamide ligands were synthesized in good yield. …”
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Intra-articular corticosteroids for treatment of temporomandibular joint internal disorders: protocol for systematic review and network meta-analysis by Aurelio Tobias, Daniela Torres, Carlos Zaror, Verónica Iturriaga

“…There are several studies on minimally invasive therapy for internal TMJ disorders; however, none compares the effectiveness of the different intra-articular corticosteroids to each other.The purpose of this study is to evaluate the effectiveness of the different intra-articular corticosteroids for the treatment of internal disorders of the TMJ and compare them to each other or to other minimally invasive therapies.Methods and analysis A systematic search will be carried out up to December 2019 in the electronic databases: Medline, Cochrane Library, EMBASE, SCOPUS and LILACS.Randomised clinical trials evaluating patients with internal disorders of the TMJ, with intra-articular corticosteroid therapy and comparing these to each other and/or to other minimally invasive therapy will be included. …”
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Treatment for neovascular age-related macular degeneration: reasonable expectations of physicians and patients by A.B. Durasov

“…Treatment outcomes are not always in line with the results of randomized clinical trials and do not meet the expectations for therapy whose success is assessed differently by patients and physicians. …”
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Polygenic risk score for acute rejection based on donor-recipient non-HLA genotype mismatch. by Rui Cao, David P Schladt, Casey Dorr, Arthur J Matas, William S Oetting, Pamala A Jacobson, Ajay Israni, Jinbo Chen, Weihua Guan

“…Trial registry: Deterioration of Kidney Allograft Function Genomics (NCT00270712) and Genomics of Kidney Transplantation (NCT01714440) are registered on ClinicalTrials.gov.…”
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Species Differences in the Biotransformation of Aflatoxin B1: Primary Determinants of Relative Carcinogenic Potency in Different Animal Species by David L. Eaton, David E. Williams, Roger A. Coulombe

“…John Groopman has played a leading role in every step of the way—from initial laboratory studies on specific AFB1 metabolites to the application of molecular biomarkers in epidemiological studies associating dietary AFB1 exposure with liver cancer, and the design and conduct of chemoprevention clinical trials to reduce cancer risk from unavoidable aflatoxin exposures by alteration of specific AFB1 biotransformation pathways. …”
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Effects of a Distributed Form of Constraint-Induced Movement Therapy for Clinical Application: The Keys Treatment Protocol by Sarah dos Anjos, Mary Bowman, David Morris

“…These findings support its feasibility and potential for outpatient stroke rehabilitation (ClinicalTrials.gov Registration: NCT05311384).…”
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Immunotherapy versus targeted therapy in management of recurrent squamous cell carcinoma of oral tongue by Nadimul Hoda, Aastha Moza, K.P. Amith, K.S. Sabitha

“…Our analysis consisted of both the forms of therapies where in immunotherapy precedes targeted therapy in terms of confirmed clinical trials. Conclusion: This newer modality of the cancer treatment forms the fourth pillar supporting surgery, chemotherapy, and radiotherapy. …”
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Dual Role of Bacteria in Carcinoma: Stimulation and Inhibition by Suad A Al-Hilu, Wisam H Al-Shujairi

“…Finally, we provide past and ongoing clinical trials that include bacteria targeting tumors.…”
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Can a low-threshold check-up motivate older adults to schedule a dental visit? Study protocol for a randomized controlled trial by Aster De Vleeschauwer, Louise Poppe, Roos Colman, Barbara Janssens

“…Trial registration ClinicalTrials.gov NCT06341959. Registered on 25 April 2024.…”
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In-hospital versus after-discharge complete revascularization in patients with ST segment elevation myocardial infarction and multivessel disease. REVIVA-ST trial. by Eva Rumiz, Ernesto Valero, Carmen Fernandez, Juan Vicente Vilar, Mauricio Pellicer, Andres Cubillos, Alberto Berenguer, Lorenzo Facila, Joan Vaño, Julio Nuñez

“…<h4>Trial registration</h4>ClinicalTrials.gov number: NCT04743154.…”
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Neuromyelitis optica spectrum disorder: epidemiology, pathogenesis, diagnosis, treatment, and prognosis by J. Čemerkaitė, I. Kaukėnaitė, R. Liutkevičienė

“…Recent results of randomised clinical trials with monoclonal anti- bodies such as inebilizumab, satralizumab, tocilizumab, and eculizumab have proved their efficacy and safety in maintenance treatment of NMOSD. …”
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Immunoinformatics design of a novel multiepitope vaccine candidate against non-typhoidal salmonellosis caused by Salmonella Kentucky using outer membrane proteins A, C, and F. by Elayoni E Igomu, Paul H Mamman, Jibril Adamu, Maryam Muhammad, Abubarkar O Woziri, Manasa Y Sugun, John A Benshak, Kingsley C Anyika, Rhoda Sam-Gyang, David O Ehizibolo

“…Despite these promising in-silico findings, further validation through preclinical and clinical trials is required to confirm the vaccine's efficacy and safety.…”
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Abnormal Esophageal Scintigraphy Associates With a Distinct Clinical Phenotype in Patients With Systemic Sclerosis by Antonio D. Salas, Lisa R. Yanek, Laura K. Hummers, Ami A. Shah, Zsuzsanna H. McMahan

“…University of California Los Angeles Scleroderma Clinical Trials Consortium Gastrointestinal Tract (GIT) 2.0 scores measured GI symptoms, Medsger scores measured physician‐assessed SSc disease severity, and the Composite Autonomic Symptom Score 31 survey evaluated dysautonomia symptoms. …”
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Electronic patient-reported outcome measures using mobile health technology in rheumatology: A scoping review. by Jaclyn Shelton, Sierra Casey, Nathan Puhl, Jeanette Buckingham, Elaine Yacyshyn

“…A total of 39 (56%) studies directly evaluated the feasibility of ePROMs in clinical practice, 19 (27%) were clinical trials that used ePROMs as study endpoints, 9 (13%) were focus groups or surveys on smartphone application development, and 3 (4%) did not fit into one defined category.…”
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‘Obviously, because it’s a tear it won’t necessarily mend itself’: a qualitative study of patient experiences and expectations of treatment for a meniscal tear by Charles E Hutchinson, Nicholas Parsons, Imran Ahmed, Andrew James Price, Andrew Metcalfe, Sophie Staniszewska, Chetan Khatri, Fatema G Dhaif

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Promising Therapeutic Functions of Bone Marrow Mesenchymal Stem Cells Derived-Exosome in Asthma by Jia-Ying Yuan, Xiang-Yun Wang, Zhi-Ying Tong, Yu-Chao Dong, Jia-Yi Zhao, Yi Zhang, Yan Shang

“…However, BMMSC-Exo still lacked more clinical trials for evaluating the effects on asthma, and the technology of extraction and purification still needs to be improved for wide use. …”
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How pragmatic are randomised controlled trials evaluating minimally invasive surgery for oesophageal cancer? A methodological review of trial design using the Pragmatic-Explanatory... by Natalie S Blencowe, Jane Blazeby, Sian Cousins, Katy Chalmers

“…Abstracts, pilot and feasibility studies, and systematic reviews were excluded.Sources of evidence Three sequential searches of Ovid MEDLINE, Embase and CENTRAL electronic databases and clinical trials registry databases.Charting methods Two independent reviewers screened the articles and used appropriate, validated tools (Pragmatic-Explanatory Continuum Indicator Summary-2 (PRECIS-2) and Risk of Bias 2) to assess study quality. …”
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