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3461
Telemedicine interventions for hypertension management in low- and middle-income countries: A scoping review.
Published 2021-01-01“…However, high-quality clinical trials of sufficient size and duration are needed to establish the impact and role of telemedicine in hypertension care. …”
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3462
Trigeminal neuralgia improvement following Transcutaneous Electrical Nerve Stimulation (TENS): a systematic review and meta-analysis
Published 2025-01-01“…Following selection criteria, five clinical trials involving 101 patients with primary TN and TENS treatment were included. …”
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3463
Repurposing of Drugs for Antibacterial Activities on Selected ESKAPE Bacteria Staphylococcus aureus and Pseudomonas aeruginosa
Published 2020-01-01“…However, de novo synthesis of antibiotics is expensive and time-consuming since the development of a new drug has to go through several clinical trials. Repurposing of old drugs for the treatment of antimicrobial resistant pathogens has been explored as an alternative strategy in the field of antimicrobial drug discovery. …”
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3464
Effectiveness of Combination of Chitosan Gel and Hydroxyapatite from Crabs Shells (Portunus pelagicus) Waste as Bonegraft on Periodontal Network Regeneration through IL-1 and BMP-2...
Published 2022-01-01“…Experimental laboratory research and clinical trials with posttest only control group design. …”
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3465
Effectiveness of PCSK9 inhibitors: A Target Trial Emulation framework based on Real-World Electronic Health Records.
Published 2024-01-01“…Within the TTE framework, the analysis confirmed the association between PCSK9-i and lower risk of events, aligning with findings from randomized clinical trials (RCTs). In our study, PCSK9-i provided protection specifically against all-cause death, expanding upon the evidence from RCTs that had primarily focused on composite CV outcomes.…”
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3466
Epidemiology of transthyretin (ATTR) amyloidosis: a systematic literature review
Published 2025-01-01“…Observational studies, systematic reviews, and meta-analyses were eligible, while reports, commentaries, clinical trials, and non-ATTR amyloidosis studies were excluded. …”
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3467
Advancements in Liposomal Nanomedicines: Innovative Formulations, Therapeutic Applications, and Future Directions in Precision Medicine
Published 2025-01-01“…We explore the evolution of liposomal products currently in clinical trials, emphasizing their potential in addressing diverse medical challenges. …”
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3468
Examining alternative approaches to antibiotic utilisation: A critical evaluation of phage therapy and antimicrobial peptides combination as potential alternatives
Published 2025-03-01“…Our review highlights that both AMPs and bacteriophages have been successfully employed in vitro, in clinical trials, and in patient treatments to eliminate bacterial isolates. …”
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3469
Characterization of Somatic Mutations in Malaysian Luminal Breast Cancer
Published 2018-12-01“…Therefore, it is clinically important to identify actionable mutated genes or pathways implicated in our local breast cancer patients to establish a more defined framework for precision medicine and clinical trials. In this discovery study, a total of nine pairs of newly diagnosed luminal breast cancer cases (>80% tumour content) and their matched normal samples were subjected to exome sequencing. …”
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3470
Effectiveness of couple-based violence prevention education in reducing intimate partner violence during pregnancy in rural Ethiopia: A cluster randomized controlled trial.
Published 2025-01-01“…<h4>Trial registration</h4>The trial is registered on ClinicalTrials.gov under the identifier NCT05856214 on May 4, 2023.…”
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3471
No Effect of Return to Sport Test Batteries with and without Psychological PROs on the Risk of a Second ACL Injury: A Critical Assessment of Four Different Test Batteries
Published 2023-08-01“…There is a need for clinical trials to integrate psychological patient-reported outcomes (PROs) in return to sport batteries assessing patients treated with ACL reconstruction…”
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3472
Patient and provider experiences with active surveillance: A scoping review.
Published 2018-01-01“…<h4>Conclusions</h4>This study revealed a paucity of research on AS communication for DCIS, RCC and CLL, but generated insight on how to optimize AS discussions in the context of routine care or clinical trials from research on AS for prostate cancer. …”
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3473
Edoxaban Monotherapy in Nonvalvular Atrial Fibrillation Patients with Coronary Artery Disease
Published 2022-01-01“…The study was registered with the Japan Registry of Clinical Trials (jRCTs031180119).…”
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3474
Evaluation of Vitrectomy with Planned Foveal Detachment as Surgical Treatment for Refractory Diabetic Macular Edema with or without Vitreomacular Interface Abnormality
Published 2018-01-01“…The study has been registered in Contact ClinicalTrials.gov PRS Identifier: NCT03345056.…”
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3475
A review on phytogenic compounds inhibit coronaviruses associated with respiratory syndrome in human
Published 2024-11-01“…Results: Some of the key compounds showing promising effects for the treatment of coronavirus in humans include scutellarein, silvestrol, tryptanthrin, psychosaponin B2, and lectins such as griffithsin, lycorine, and polyphenolics including quercetin, myristicin, caffeic acid, and isobavachalcone. The conducting clinical trials on humans, in vitro and in vivo tests are required to determine the level of safety, as well as to determine the therapeutic level for each compound. …”
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3476
Spherical implantable collamer lens with postoperative adjunctive LASIK in the treatment of high compound hyperopic astigmatism
Published 2025-01-01“…Trial registration This trial was retrospectively registered on ClinicalTrials.gov with the trial registration number NCT06742541.…”
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3477
Efficacy and safety of hydroxyurea therapy on patients with β-thalassemia: a systematic review and meta-analysis
Published 2025-01-01“…The secondary outcomes were the adverse events incidence rates of HU in β-thalassemia patients.ResultsTwo randomized controlled trials (RCTs) and 25 single-armed observational studies with typically 1,748 individuals were involved in our analysis. All 27 clinical trials were reported with fair quality. HU, in transfusion-dependent β-thalassemia patients, was related to a significant decrease in transfusion requirements [a pooled RR of 0.37 and a pooled good RR of 0.65 (95% CI, 0.53–0.76)]; in transfusion-independent β-thalassemia patients, it was correlated to an excellent raise in Hb levels [a pooled RR of 0.20 (95% CI, 0.08–0.35) and a pooled good RR of 0.53 (95% CI, 0.41–0.65)]. …”
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3478
Determining the Reliability and Validity of the Persian Version of Brief Problem MonitorTM for Ages 18-59 in Students
Published 2024-11-01“…Additionally, factor analysis demonstrated a good fit for the initial three-factor model.Discussion and Conclusion: BPM/18-59 demonstrates appropriate psychometric properties for application in research and clinical trials involving Iranian individuals.…”
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3479
Parodontgel® on Wound Healing and Patient-Reported Outcome Measures (PROMs) after Tunneled Coronally Advanced Flap (TCAF)
Published 2024-01-01“…However, further investigations through randomized clinical trials are required to establish the potential benefits and broader applicability of such healing gel applications in the context of periodontal plastic surgery.…”
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3480
Evaluation of Novel Stereotactic Cannula for Stem Cell Transplantation against Central Nervous System Disease
Published 2020-01-01“…We compared cannulas for cell delivery used in clinical trials, the Pittsburg and Mizuho cannulas, to a newly designed one, MK01, to assess their usability. …”
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