Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia-Radiotherapy (H... by Sergio Mingo Barba, Adela Ademaj, Dietmar Marder, Oliver Riesterer, Marco Lattuada, Rudolf M. Füchslin, Alke Petri-Fink, Stephan Scheidegger

“…This approach can be used to optimize HT treatments, design clinical trials, and interpret patient data.…”
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Survival after Locoregional Treatments for Hepatocellular Carcinoma: A Cohort Study in Real-World Patients by Simona Signoriello, Annalisa Annunziata, Nicola Lama, Giuseppe Signoriello, Paolo Chiodini, Ilario De Sio, Bruno Daniele, Giovanni G. Di Costanzo, Fulvio Calise, Graziano Olivieri, Vincenzo Castaldo, Rosario Lanzetta, Guido Piai, Giampiero Marone, Mario Visconti, Mario Fusco, Massimo Di Maio, Francesco Perrone, Ciro Gallo, Giovanni B. Gaeta

“…Adequately powered randomized clinical trials are still needed to definitely assess relative effectiveness of locoregional HCC treatment.…”
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Prevalence and Determinants of Peripheral Microvascular Endothelial Dysfunction in Rheumatoid Arthritis Patients: A Multicenter Cross-Sectional Study by Gian Luca Erre, Matteo Piga, Anna Laura Fedele, Silvia Mura, Alessandra Piras, Maria Luisa Cadoni, Ignazio Cangemi, Martina Dessi, Gabriele Di Sante, Barbara Tolusso, Elisa Gremese, Alberto Cauli, Arduino Aleksander Mangoni, Pier Sergio Saba, Ciriaco Carru, Gianfranco Ferraccioli, Alessandro Mathieu, Giuseppe Passiu

“…Data from 874 RA patients enrolled in the EDRA study (Endothelial Dysfunction Evaluation for Coronary Heart Disease Risk Estimation in Rheumatoid Arthritis—ClinicalTrials.gov: NCT02341066) were analyzed. Log-transformed reactive hyperemia index (Ln-RHI) was evaluated by peripheral arterial tonometry (PAT) using the EndoPAT2000 device: values of Ln-RHI < 0.51 were considered indicative of peripheral ED. …”
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Evaluating a multicomponent intervention for managing kidney outcomes among patients with moderate or advanced chronic kidney disease (CKD): protocol for the Strategies for Kidney... by Tazeen Hasan Jafar, Ngiap Chuan Tan, Mihir Gandhi, Sungwon Yoon, Eric Finkelstein, Peter Moey Kirm Seng, Ruiheng Ong, Anandan Gerard Thiagarajah, Bing Long Lee, Ka Chi To, Aminath Shiwaza Moosa

“…Trial registration ClinicalTrials.gov NCT05295368. Registered on March 25, 2022.…”
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The REpeated ASSEssment of SurvivorS in intracerebral haemorrhage: protocol for a multicentre, prospective observational study by Daniel Woo, Richard Thompson, Carl D Langefeld, Nichol McBee, Daniel Hanley, Matthew L Flaherty, Lauren Sansing, Karen Lane, Lee A Gilkerson, Achala Vagal, Nathan Walborn, Wendy Ziai, Noeleen Ostapkovich, Kevin Triene, Timothy David Howard

“…The findings of the study will be published in academic peer-reviewed journals.Trial registration number NCT05611918; ClinicalTrials.gov; registered on 23 May 2023.…”
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Myocarditis in malaria—current evidence and future directions: a literature review by Gbolahan Olatunji, Emmanuel Kokori, Ikponmwosa Jude Ogieuhi, Olumide Akinmoju, Oluwatobi Omoworare, Doyin Olatunji, David Timilehin Isarinade, God-dowell O. Odukudu, Israel Charles Abraham, Samuel Owolabi, Jamil Nasrallah, Emmanuel Egbunu, Babafemi Oluwadarasimi Jaiyeoba, Ismaila Ajayi Yusuf, Olawale Olanisa, Nicholas Aderinto

“…A literature search spanning PubMed, Scopus, and Web of Science identified relevant studies up to January 2024, encompassing case reports, cohort studies, clinical trials, and experimental studies. The relationship between severe malaria and myocardial involvement is explored, showcasing elevated biomarkers indicative of myocardial damage. …”
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CDK4/6 inhibitors promote PARP1 degradation and synergize with PARP inhibitors in non-small cell lung cancer by Carlos M Roggero, Anwesha B Ghosh, Anvita Devineni, Shihong Ma, Eliot Blatt, Ganesh V. Raj, Yi Yin

“…Despite widespread deregulation of CDK4/6 activity in non-small cell lung cancer (NSCLC), clinical trials with CDK4/6 inhibitor (CDK4/6i) as a monotherapy have shown poor antitumor activity. …”
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Tetracyclines in Rheumatoid Arthritis: Dual Anti-Inflammatory and Immunomodulatory Roles, Effectiveness, and Safety Insights by Mislav Radić, Andrej Belančić, Hana Đogaš, Marijana Vučković, Andrea Gelemanović, Andrea Faour, Ivan Vlak, Josipa Radić

“…Tetracyclines have demonstrated significant immunomodulatory effects, including the inhibition of pro-inflammatory cytokines and matrix metalloproteinases (MMPs), which are critical in RA pathology. Clinical trials, including double-blind, placebo-controlled studies, have shown efficacy in reducing RA symptoms, particularly in early and refractory cases. …”
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Investigations of Long-Acting Formulations in Children, Adolescents, and Pregnant Women: A Systematic Review by Lynn Bertagnolli, Zhengyi Deng, Melissa Davy-Rothwell, Elaine J. Abrams, Charles Flexner, Ethel D. Weld

“…Special populations, specifically infants, children, young people, and pregnant and postpartum women, could greatly benefit from access to these strategies but are often excluded from clinical trials. We conducted a systematic review of all clinical studies involving the use of a long-acting intramuscular injection or implant in infants, children, young people, and pregnant and postpartum people. …”
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Rituximab-associated adverse events in nephrotic syndrome: A systematic review and meta-analysis by Zixian Yu, Meijin Huang, Yunlong Qin, Xiayin Li, Yueru Zhao, Yuwei Wang, Yumeng Zhang, Anjing Wang, Mei Han, Jin Zhao, Shiren Sun

“…The safety of RTX in NS patients needs to be further confirmed in high-quality clinical trials.…”
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A comprehensive overview of acupuncture therapy over the past 20 years: Machine learning-based bibliometric analysis by Chen Liu, Shuqing Liu, Yu Wang, Xinyi Xia, Yu Zhang, Huili Jiang, Tuya Bao, Xuehong Ma

“…''Comparative Efficacy'', ''Biochemical Analysis'', ''Symptomatic Treatment'', ''Professional Practice'' and ''Clinical Trials'' are hotspots identified by LDA. ''Neurotransmitter'', ''Meta-Analysis'' and ''Literature Review'' have presented as new research hotspots. …”
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Clinically Relevant Solution for the Hypothermic Storage and Transportation of Human Multipotent Mesenchymal Stromal Cells by Yuriy Petrenko, Milada Chudickova, Irena Vackova, Tomas Groh, Eliska Kosnarova, Jitka Cejkova, Karolina Turnovcova, Alexander Petrenko, Eva Sykova, Sarka Kubinova

“…The wide use of human multipotent mesenchymal stromal cells (MSCs) in clinical trials requires a full-scale safety and identity evaluation of the cellular product and subsequent transportation between research/medical centres. …”
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Unlocking the therapeutic mechanism of Caesalpinia sappan: a comprehensive review of its antioxidant and anti-cancer properties, ethnopharmacology, and phytochemistry by Estéfani Alves Asevedo, Estéfani Alves Asevedo, Livia Ramos Santiago, Livia Ramos Santiago, Hyo Jeong Kim, Rony Abdi Syahputra, Moon Nyeo Park, Rosy Iara Maciel Azambuja Ribeiro, Bonglee Kim

“…However, significant challenges remain, including the need to unravel the precise molecular mechanisms underlying its anticancer effects, refine extraction and isolation methods for bioactive compounds, and validate its safety and efficacy through well-designed clinical trials. Particularly noteworthy is C. sappan’s potential in combination therapies, where it may synergistically target multiple cancer pathways, enhance therapeutic outcomes, and mitigate adverse effects. …”
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Interleukin-6 related signaling pathways as the intersection between chronic diseases and sepsis by Jie Yang, Lin Yang, Yanjiao Wang, Lu Huai, Bohan Shi, Di Zhang, Wei Xu, Di Cui

“…The clinicians should be highlight to this kind of diseases and more clinical trials are needed to provide more reliable theoretical basis for health policy formulation.…”
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Definition of sinonasal and otological exacerbation in patients with primary ciliary dyskinesia: an expert consensus by Myrofora Goutaki, Yin Ting Lam, Andreas Anagiotos, Miguel Armengot, Andrea Burgess, Raewyn Campbell, Mathilde Carlier, Nathalie Caversaccio, Neil K. Chadha, Berat Demir, Sinan Ahmed D. Dheyauldeen, Onder Gunaydin, Amanda Harris, Isolde Hayn, Deniz Inal-Ince, Eric Levi, Trini Lopez Fernandez, Jane S. Lucas, Bernard Maitre, Anne-Lise M.L. Poirrier, Lynne Schofield, Kazuhiko Takeuchi, Christine van Gogh, Nikolaus E. Wolter, Jean-François Papon

“…While pulmonary exacerbations in primary ciliary dyskinesia are defined, there is no definition for ear-nose-throat exacerbations, a potential outcome for research and clinical trials. Methods We set up an expert panel of 24 ear-nose-throat specialists, respiratory physicians, other healthcare professionals and patients to develop consensus definitions of sinonasal and otological exacerbations in children and adults with primary ciliary dyskinesia for research settings. …”
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Effectiveness of Space Maintainers in Pediatric Patients: A Systematic Review and Meta-Analysis by MDolores Casaña-Ruiz, Juan Ignacio Aura-Tormos, Laura Marques-Martinez, Esther Garcia-Miralles, Marcelino Perez-Bermejo

“…<b>Results:</b> The total number of patients treated in the studies was 479, with four observational studies and seven randomized clinical trials. Fixed space maintainers, such as band and loop (BL) or lingual arch (LA), are preferred due to their long-term stability and lower risk of loss. …”
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Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (the PROMIZING study): update to the statistical analysis plan for a randomized controlled tri... by Karen J. Bosma, Myriam Lafreniere-Roula, Arlene Jiang, Anna Heath, Yongdong Ouyang, Kaitlyn Wade, Pingzhao Hu, Karen E. A. Burns, Claudio M. Martin, Yoanna Skrobik, Sorcha Mulligan, Kevin E. Thorpe, Laurent Brochard, members of the Canadian Critical Care Trials Group and the REVA Network

“…Trial registration ClinicalTrials.gov Identifier: NCT02447692 prospectively registered May 19, 2015.…”
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Comparative Analysis of Acral Melanoma in Chinese and Caucasian Patients by Kai Huang, Yu Xu, Emmanuel M. Gabriel, Subhasis Misra, Yong Chen, Sanjay P. Bagaria

“…There appears to be no difference in stage-stratified survival between Chinese and Caucasians, supporting the implementation of clinical trials for AM that could include both Chinese and Caucasian patients.…”
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Protocol for a scoping review on rehabilitation among individuals with traumatic brain injury who intersect with the criminal justice system. by Vincy Chan, Maria Jennifer Estrella, Zacharie Beaulieu-Dearman, Jessica Babineau, Angela Colantonio

“…Primary research articles that meet pre-defined inclusion criteria will be identified from electronic databases (MEDLINE® ALL, Embase and Embase Classic, Cochrane CENTRAL Register of Clinical Trials, CINAHL, APA PsycINFO, Applied Social Sciences Index and Abstracts, Criminal Justice Abstracts, Nursing and Allied Health, and Dissertation and These Global), reference lists of included articles, and scoping or systematic reviews. …”
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The pharmacology, toxicology, and detoxification of Aconitum kusnezoffii Reichb., traditional and modern views by Kenneth Happy, Sungyu Yang, Chang Ho Kang, Youngmin Kang

“…While research on this herb is extensive, gaps remain in clinical trials and efficacy studies. Further research is recommended to evaluate the quality of medicinal materials, understanding the herb’s pharmacodynamic substances, and assess long-term toxicity and clinical efficacy. …”
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