Molecular Signatures of Human Chronic Atrial Fibrillation in Primary Mitral Regurgitation by Günseli Çubukçuoğlu Deniz, Serkan Durdu, Yeşim Doğan, Esra Erdemli, Hilal Özdağ, Ahmet Ruchan Akar

“…This trial is registered with ClinicalTrials.gov identifier: NCT00970034.…”
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Treating self-harm behaviors in prisons: implementation of the STEPPS program by Rosa Lorente-Català, Irene Jaén, Xavier Buscà-Huertas, Berta Framis, Azucena García-Palacios

“…Trial Registration NCT06297460 (ClinicalTrials.gov, retrospectively registered, 2022/01/01).…”
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A pilot study on the effects of olfactory stimulation with white musk aromatic oil on psychophysiological activity: a crossover study by Fadilla Zennifa, Taisuke Nakashima, Yanli Xu, Saki Koshio, Erika Tomimatsu, Akiko Isa, Katsuya Satake, Fumi Kishida, Kuniyoshi Shimizu

“…This experiment has been registered to UMIN Clinical Trials Registry with register ID : UMIN000051972 on 24/08/2023.…”
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Planned, ongoing and completed tuberculosis treatment trials in Brazil, Russia, India, China and South Africa: a 2019 cross-sectional descriptive analysis by Tamara Kredo, Duduzile Edith Ndwandwe, Lindi Mathebula, Lovemore Mapahla, Dilyara Nurkhametova, Liliya Eugenevna Ziganshina, Mikateko Mazinu, Esme Jordan

“…We included only registered clinical trials conducted wholly in BRICS countries or with at least one recruitment centre in one of the BRICS countries that were investigating TB treatment.Results The search of the WHO-ICTRP yielded 408 trials and additional 32 trials were identified from the Russian registry. …”
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The Impact of Astaxanthin Supplementation on the Lipid Profile by Filip Arczewski, Michalina Wójcikiewicz, Witold Czyż, Julia Kacperczyk, Karol Dziedzic, Marta Chuncia, Maciej Wojszczyk, Damian Zys, Piotr Pasek, Julia Ryniecka, Wiktor Czaja, Michał Krzciuk

“…Consequently, there is a need for larger, well-standardized clinical trials to accurately assess the efficacy and safety of astaxanthin as a therapeutic agent for lipid modulation and the prevention of metabolic disorders. …”
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Jet Injection of Naked mRNA Encoding the RBD of the SARS-CoV-2 Spike Protein Induces a High Level of a Specific Immune Response in Mice by Denis N. Kisakov, Larisa I. Karpenko, Lyubov A. Kisakova, Sergey V. Sharabrin, Mariya B. Borgoyakova, Ekaterina V. Starostina, Oleg S. Taranov, Elena K. Ivleva, Oleg V. Pyankov, Anna V. Zaykovskaya, Elena V. Dmitrienko, Vladimir A. Yakovlev, Elena V. Tigeeva, Irina Alekseevna Bauer, Svetlana I. Krasnikova, Nadezhda B. Rudometova, Andrey P. Rudometov, Artemiy A. Sergeev, Alexander A. Ilyichev

“…<b>Background:</b> Although mRNA vaccines encapsulated in lipid nanoparticles (LNPs) have demonstrated a safety profile with minimal serious adverse events in clinical trials, there is opportunity to further reduce mRNA reactogenicity. …”
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Vitamin D Supplementation Ameliorates Metabolic Dysfunction in Patients with PCOS: A SystematicReview of RCTs and Insight into the Underlying Mechanism by Shan Guo, Reshef Tal, Haoyu Jiang, Tao Yuan, Ying Liu

“…Literature research was conducted in Pubmed, Embase, Web of Science, Clinical Trials, and Cochrane Library to identify relevant randomized controlled trials (RCTs) up to March 2020. …”
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Macrophage Activities in Myocardial Infarction and Heart Failure by Sophia Esi Duncan, Shan Gao, Michael Sarhene, Joel Wake Coffie, Deng Linhua, Xingru Bao, Zhang Jing, Sheng Li, Rui Guo, Jing Su, Guanwei Fan

“…Also, though inflammation is as a result of adverse HF in patients, but despite the fact that broad immunosuppression therapeutic target has been used in various clinical trials, no positive results have showed up, but rather, the focus on proinflammatory cytokines has proved more benefits in patients with HF. …”
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Cross-Cultural Adaptation and Validation of “Malocclusion Impact Questionnaire” into Moroccan Arabic by Farid Bourzgui, Samir Diouny, Hadam Mkhantar, Zineb Serhier, Mohamed Bennani Othmani

“…The Moroccan Arabic version of the MIQ was found to be reliable, whereas it has unacceptable validity according to ICON, and hence, it is unlikely to be a useful measure in orthodontic clinical trials for Moroccan adolescents.…”
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Multidisciplinary stakeholder engagement in a type 2 diabetes comparative effectiveness study utilizing real-world data by Elizabeth H. Golembiewski, Mindy M. Mickelson, Juan P. Brito, Victor M. Montori, Rozalina G. McCoy

“…Notably, these studies differ from traditional clinical trials in their technical complexity and minimal prospective data collection, posing unique challenges for stakeholder involvement. …”
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Advanced progress in the genetic modification of the oncolytic HSV-1 virus by Mi Zhou, Mi Zhou, Mi Zhou, Zhenyu Shen, Zhenyu Shen, Zhenyu Shen

“…Finally, we discuss limitations associated with oncolytic virotherapy at the conclusion of this review. As more clinical trials explore newly engineered therapies, they are likely to yield breakthroughs and promote broader adoption for cancer treatment.…”
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TraxVBF: A hybrid transformer-xLSTM framework for EMG signal processing and assistive technology development in rehabilitation by Seyyed Ali Zendehbad, Athena Sharifi Razavi, Marzieh Allami Sanjani, Zahra Sedaghat, Saleh Lashkari

“…These results indicate that TraxVBF may be a useful tool to improve motor learning and rehabilitation, and longer term clinical trials and multi-sensory biofeedback are needed.…”
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From chaos to order: optimizing fecal microbiota transplantation for enhanced immune checkpoint inhibitors efficacy by Anqi Lin, Aimin Jiang, Lihaoyun Huang, Yu Li, Chunyanx Zhang, Lingxuan Zhu, Weiming Mou, Zaoqu Liu, Jian Zhang, Quan Cheng, Ting Wei, Peng Luo

“…Through a comprehensive synthesis of evidence from clinical trials and preclinical studies, we elucidate the potential benefits and challenges of combining FMT with ICIs across diverse cancer types. …”
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ZBiotics ameliorates T2DM-induced histopathological damage in liver, kidney and adipose tissues by modulating the NOD-like receptor signaling in Wistar rats by Mohammed Esawie, Marwa Matboli, Mariam Sameh Bushra, Amany H. Hasanin, Eman Kamal Habib, Reham Hussein Mohamed, Hebatalla Said Ali

“…ZBiotics is recommended for clinical trials as a separate candidate or as an adjuvant to the conventional T2DM therapy.…”
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Daratumumab for autoimmune diseases: a systematic review by Martin Krusche, Ina Kötter, Lennard Ostendorf, Nikolas Ruffer, Marie-Therese Holzer, Tobias B. Huber

“…Therefore, systematic clinical trials of this therapeutic approach are needed.…”
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Advances in Nucleic Acid Drugs and Gene Therapies based on Animal Models of Duchenne Muscular Dystrophy by LIU Siyu, LAI Yuezhao, GUO Wenting, CHEN Xuejin

“…Preclinical studies in animal models and early-phase clinical trials demonstrate promising efficacy and offer new hope for DMD patients. …”
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Effect of porcine collagen matrix versus rotated pedicle palatal connective tissue flap on the soft-tissue closure after the immediate posterior implantation: study protocol for a... by Wei Zhang, Si Chen, Chenyang Zhang, Shuobo Fang, Zhengjie Dong, Tong Chen, Wanqi Lv, Keyi Hao

“…The project has been registered on the ClinicalTrials.gov website and National Medical Research Registration and Filing Information System. …”
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Laparoscopy Combined with Enhanced Recovery Pathway in Ileocecal Resection for Crohn’s Disease: A Randomized Study by Yibin Zhu, Jianjian Xiang, Wei Liu, Qian Cao, Wei Zhou

“…This study is registered at ClinicalTrials.gov (NCT02777034).…”
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48-Week Outcome after Cessation of Nucleos(t)ide Analogue Treatment in Chronic Hepatitis B Patient and the Associated Factors with Relapse by Wen-xiong Xu, Qian Zhang, Xiang Zhu, Chao-shuang Lin, You-ming Chen, Hong Deng, Yong-yu Mei, Zhi-xin Zhao, Dong-ying Xie, Zhi-liang Gao, Chan Xie, Liang Peng

“…The study was submitted to ClinicalTrials.gov Protocol Registration and Results System with the assigned NCT ID NCT02883647.…”
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Effectiveness of nurse-led volunteer support and technology-driven pain assessment in improving the outcomes of hospitalised older adults: protocol for a cluster randomised control... by Max K Bulsara, Christopher Etherton-Beer, Rosemary Saunders, Kate Crookes, Mustafa Atee, Caroline Bulsara, Beverley Ewens, Olivia Gallagher, Renee M Graham, Karen Gullick, Sue Haydon, Kim-Huong Nguyen, Bev O'Connell, Karla Seaman, Jeff Hughes, Seng Giap Marcus Ang, Debra Scaini

“…Two interventions that have the potential to prevent progression of frailty and improve patient outcomes in hospitalised older adults but have yet to be subject to clinical trials are nurse-led volunteer support and technology-driven assessment of pain.Methods and analysis This single-centre, prospective, non-blinded, cluster randomised controlled trial will compare the efficacy of nurse-led volunteer support, technology-driven pain assessment and the combination of the two interventions to usual care for hospitalised older adults. …”
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