Acute effects of physical exercise on cognitive function and neurotrophins in patients with type 1 diabetes: A systematic review by Emanuele Zanardo, Giulia Quinto, Francesca Battista, Federica Duregon, Marco Vecchiato, Chiara Bergia, Kirk Erickson, Andrea Ermolao, Daniel Neunhaeuserer

“…Two studies were non-randomized clinical trials, the others were crossover trials. Selected studies performed different exercise intervention protocols, evaluating both high and moderate intensity training. …”
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The Potential Applications of Stem Cell Conditioned Medium Secretome in Knee Cartilage Regeneration: A Systematic Review by I Gusti Ngurah Wien Aryana, Febyan Febyan, Nyoman Gede Grenata Nanda Ustriyana

“…Further research and clinical trials are needed to refine these approaches for practical application.…”
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Neurovascular bundle sparing in hypofractionated radiotherapy maintained with realistic treatment uncertainties by Roel C. Kwakernaak, Victor J. Brand, Jesús Rojo-Santiago, Femke E. Froklage, Mischa S. Hoogeman, Steven J.M. Habraken, Maaike T.W. Milder

“…The clinical impact of the achieved sparing is subject of ongoing clinical trials.…”
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What are the perceived influences on asthma self-management at the workplace? A qualitative study by Adrian Loerbroks, Katherina Heinrichs, Patricia Vu-Eickmann, Stefan Hummel, Jalal Gholami

“…Support by colleagues, line managers, and the employer, for example, practical, emotional, or structural support, was perceived to exert effects on symptom prevention, acute symptom management, and communication (ie, self-disclosure of one’s condition).Conclusions Perceived JDL and social support were experienced as influencing successful implementation of asthma SMB at the workplace.Trial registration number German Clinical Trials Register no: DRKS00011309.…”
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Extracellular Vesicles Derived from Human Umbilical Mesenchymal Stem Cells Transfected with miR-7704 Improved Damaged Cartilage and Reduced Matrix Metallopeptidase 13 by Kun-Chi Wu, Hui-I Yang, Yu-Hsun Chang, Raymond Yuh-Shyan Chiang, Dah-Ching Ding

“…Further investigations should focus on optimizing dosage, understanding mechanisms, ensuring safety and efficacy, developing advanced delivery systems, and conducting early-phase clinical trials to establish the therapeutic potential of HUCMSC-derived EVs for OA management.…”
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Impact of social media on triggering nonsuicidal self-injury in adolescents: a comparative ambulatory assessment study by Andreas Goreis, Dorothy Chang, Diana Klinger, Heidi-Elisabeth Zesch, Bettina Pfeffer, Sofia-Marie Oehlke, Ulrich W. Ebner-Priemer, Laurence Claes, Paul L. Plener, Oswald D. Kothgassner

“…Trial registration This study has been registered at the German Clinical Trials Register (ID: DRKS00025905, https://drks.de/search/en/trial/DRKS00025905 ).…”
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Effect of optimized food-based recommendations on nutrient intakes, hemoglobin levels, and memory performance of adolescent girls in East Java, Indonesia by Dini Suciyanti, Risatianti Kolopaking, Annasari Mustafa, Sugeng Iwan, Fiastuti Witjaksono, Umi Fahmida

“…Trial registration The study was registered on ClinicalTrials.gov (ID No: NCT03946475).…”
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Adipose-Derived Stromal Cells for Treatment of Patients with Chronic Ischemic Heart Disease (MyStromalCell Trial): A Randomized Placebo-Controlled Study by Abbas Ali Qayyum, Anders Bruun Mathiasen, Naja Dam Mygind, Jørgen Tobias Kühl, Erik Jørgensen, Steffen Helqvist, Jens Jørgen Elberg, Klaus Fuglsang Kofoed, Niels Groove Vejlstrup, Anne Fischer-Nielsen, Mandana Haack-Sørensen, Annette Ekblond, Jens Kastrup

“…This trial is registered with ClinicalTrials.gov NCT01449032.…”
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The effect of blue-blocking intraocular lenses on circadian biological rhythm: protocol for a randomised controlled trial (CLOCK-IOL colour study) by Taiji Hasegawa, Kenji Obayashi, Kimie Miyata, Tetsuo Ueda, Norio Kurumatani, Keigo Saeki, Nahoko Ogata, Hiroki Tsujinaka, Mariko Yamashita, Tomo Nishi, Nobuhiro Tone, Naonori Masuda, Yutarou Mizusawa, Masahiro Okamoto, Shinji Maruoka, Masashi Kojima, Toyoaki Matsuura

“…The findings of this study will be communicated to healthcare professionals, participants and the public through peer-reviewed publications, scientific conferences and the University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR) home page.Trial registration number UMIN000014680.…”
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Intermittent Fasting: Weighing the Benefits and Drawbacks for Health and Longevity – A Comprehensive Literature Review by Marta Wojtczak, Michał Pniak, Paweł Miklis, Maciej Mawlichanów, Aleksandra Ciesielska, Aleksandra Sieradzka, Krzysztof Szerej, Alicja Kot, Natalia Myśliwiec, Adrian Różycki

“…Materials and Methods: This study reviews existing literature, including clinical trials, meta-analyses, and observational studies. …”
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L-Dopa Pharmacokinetic Profile with Effervescent Melevodopa/Carbidopa versus Standard-Release Levodopa/Carbidopa Tablets in Parkinson’s Disease: A Randomised Study by Fabrizio Stocchi, Laura Vacca, Paola Grassini, Stephen Pawsey, Holly Whale, Stefano Marconi, Margherita Torti

“…This trial is registered with ClinicalTrials.gov NCT00491998.…”
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Caerin 1.1/1.9-mediated antitumor immunity depends on IFNAR-Stat1 signalling of tumour infiltrating macrophage by autocrine IFNα and is enhanced by CD47 blockade by Junjie Li, Yuandong Luo, Quanlan Fu, Shuxian Tang, Pingping Zhang, Ian H. Frazer, Xiaosong Liu, Tianfang Wang, Guoying Ni

“…These results indicate that F1/F3 may be effective to improve the efficacy of ICB and therapeutic vaccine-based immunotherapy for human epithelial cancers and warrants consideration for clinical trials.…”
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Genistein Implications in Radiotherapy: Kill Two Birds with One Stone by Xiongxiong Liu, Tong Zheng, Yanyu Bao, Ping Li, Ting Zhao, Yan Liu, Hui Wang, Chao Sun

“…Future research should focus on dosage optimization and administration, the exploration of combination therapies, and long-term clinical trials to establish genistein benefits in clinical settings. …”
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Enhancing immunotherapy efficacy with synergistic low-dose radiation in metastatic melanoma: current insights and prospects by Zahid Rafiq, Mingyo Kang, Hampartsoum B. Barsoumian, Gohar S. Manzar, Yun Hu, Carola Leuschner, Ailing Huang, Fatemeh Masrorpour, Weiqin Lu, Nahum Puebla-Osorio, James W. Welsh

“…We meticulously examine the preclinical evidence and ongoing clinical trials, throwing light on the promising prospects of LDRT as a complementary therapy in melanoma treatment. …”
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Exercise training and chronic kidney disease: characterization and bibliometrics of citation classics of clinical intervention trials by Fan Zhang, Shan Liu, Yan Bai, Liuyan Huang, Yifei Zhong, Yi Li

“…This study analyzes citation classics on clinical intervention trials on exercise training and CKD to describe the research landscape and hotspots through bibliometric analysis.Methods To identify clinical trials of exercise training interventions for CKD with more than 100 citations from the Web of Science Core Collection database. …”
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Whole transcriptome analysis of unmutated sporadic ALS patients' peripheral blood reveals phenotype-specific gene expression signature by Francesca Dragoni, Maria Garofalo, Rosalinda Di Gerlando, Bartolo Rizzo, Matteo Bordoni, Eveljn Scarian, Camilla Viola, Veronica Bettoni, Giuseppe Fiamingo, Danilo Tornabene, Lucia Scanu, Orietta Pansarasa, Luca Diamanti, Stella Gagliardi

“…The possibility to cluster ALS patients based on their molecular signature pave the way for future personalized clinical trials and early diagnosis.…”
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Comparison of one-year real-world outcomes between red (670 nm) subthreshold micropulse laser treatment and intravitreal aflibercept injection for treatment-naïve diabetic macular... by Wataru Kikushima, Yukiko Furuhata, Taiyo Shijo, Mizuki Matsumoto, Yoichi Sakurada, Daphne Viel Tsuru, Kenji Kashiwagi

“…These treatment outcomes were equivalent to IVA in real-world settings, which tend to be inferior to clinical trials.…”
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ASA score is an independent predictor of 1-year outcome after moderate-to-severe traumatic brain injury by Olivia Kiwanuka, Philipp Lassarén, Alexander Fletcher-Sandersjöö, Charles Tatter, Jonathan Tjerkaski, David W. Nelson, Eric P. Thelin

“…Logistic regression evaluated the contribution of ASA score to the International Mission for Prognosis and Clinical Trials in Traumatic Brain Injury (IMPACT) core + CT outcome prediction model incorporating age, admission GCS, pupillary reactivity, Marshall CT classification, hypoxia, hypotension, epidural hematoma, and subarachnoid hemorrhage. …”
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State of the art progress of Evolvulus alsinoides in pharmacological activity and plant tissue culture: A potent Chinese medicinal plant by Collince Omondi Awere, Valentine Chikaodili Anadebe, Rakkammal Kasinathan, Pandiyan Muthuramalingam, Ramesh Manikandan

“…Nevertheless, thorough clinical trials and translational research are required to bridge the gap between conventional knowledge and current medical uses. …”
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Effectiveness of the self-fatigue assessment in guiding early postoperative ambulation in gynaecological oncology patients: study protocol for a randomised controlled trial by Bo Chen, Xu Wang, Hong He, Xiaojie Huang, Qian Du, Shaoyong Xu, Xiaomin Qin, Tongting Kang

“…Secondary outcome measures are the time to first bowel movement, the incidence of moderate to severe bloating, the incidence of bowel obstruction or venous thromboembolism, the incidence of adverse events (nausea, vomiting, dizziness), patient satisfaction, sleep quality scores, patient compliance with activities, hospital costs and days in hospital.Ethics and dissemination This study was approved by the Independent Ethics Committee of Xiangyang Central Hospital affiliated with Hubei University of Arts and Sciences and registered with the China Clinical Trials Registry in May 2021. The results of the trial will be disseminated through open access peer-reviewed journals and abstracts will be submitted to relevant national and international conferences.Trial registration number CTR2100046035.…”
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