Innovative immunotherapies and emerging treatments in type 1 diabetes management by Malek Zarei, Mohammad Abbas Sheikholeslami, Masoud Mozaffari, Yassar Mortada

“…Antigen-dependent strategies focus on inducing immune tolerance to specific beta cell antigens, with mixed results from clinical trials involving autoantigen vaccines like GAD65. …”
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Diagnosis of Peripheral Lung Lesions via Conventional Flexible Bronchoscopy with Multiplanar CT Planning by Marianne Anastasia De Roza, Kien Hong Quah, Cheong Kiat Tay, Weiquan Toh, HuiHua Li, Ganesh Kalyanasundaram, Devanand Anantham

“…This trial is registered with ClinicalTrials.gov Identifier: NCT01374542.…”
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The Impact of Zinc Supplementation on the Course of Infections by Justyna Woźniak, Ewelina Kopczyńska, Piotr Kulej, Wiktor Biesiada, Justyna Weronika Kmieć, Anna-Mariia Chernysh, Aleksandra Dusińska, Jakub Waszczyński, Kamila Fuczyło, Karolina Stankevič

“…Materials and Methods: The study utilized a comprehensive approach, combining literature reviews, clinical trials, experimental studies, and microbiota analyses to investigate zinc's role in immune function, infection management, and antimicrobial resistance. …”
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Sequential exploratory mixed-method research of an eHealth intervention on blood pressure, sleep quality and physical activity in obstructive sleep apnoea: rationale and methodolog... by Manuel Sánchez-de-la-Torre, Ferran Barbé, Oriol Martínez-Navarro, Francisco José Verdejo-Amengual, Fran Valenzuela-Pascual, Joan Blanco-Blanco, Rabie Adel El Arab, Esther Rubinat-Arnaldo, Maria Masbernat-Almenara, Francesc Rubí‑Carnacea, Blanca Manuel Martí

“…Results will be published in a peer-reviewed journal.Trial registration number ClinicalTrials.gov Identifier: NCT05380726.…”
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Effect of Physical Exercise on Telomere Length: Umbrella Review and Meta-Analysis by Juan Luis Sánchez-González, Juan Luis Sánchez-Rodríguez, Rogelio González-Sarmiento, Víctor Navarro-López, Raúl Juárez-Vela, Jesús Pérez, Javier Martín-Vallejo

“…We selected systematic reviews and meta-analyses of randomized and nonrandomized controlled clinical trials evaluating the effect of physical exercise on TL. …”
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Inflammatory Markers and Obstructive Sleep Apnea in Obese Children: The NANOS Study by Alex Gileles-Hillel, María Luz Alonso-Álvarez, Leila Kheirandish-Gozal, Eduard Peris, José Aurelio Cordero-Guevara, Joaquin Terán-Santos, Mónica Gonzalez Martinez, María José Jurado-Luque, Jaime Corral-Peñafiel, Joaquin Duran-Cantolla, David Gozal

“…This trial is registered with ClinicalTrials.gov NCT01322763.…”
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Ecuadorian University Students’ Perception and Attitude Regarding Vaccination against COVID-19 by Lexter Mihalache, Jhonatan Miguel Siguencia Muñoz, Álvaro Paúl Moina Veloz

“…<br /><strong>Results:</strong> before the intervention it was found that 43.3 % of the students were against vaccination, where the main causes were skepticism due to infodemic and biased information (33.7 %), and fear about safety of the vaccine due to the short duration of clinical trials (22.1 %). After the intervention, it was found that 84 % of the students supported vaccination, results that showed a statistically significant variation. …”
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Effects of a supplement associating Lactobacillus strains and proanthocyanidin-rich plant extracts against recurrent uncomplicated, urinary tract infections: A prospective, control... by Samira Ait Abdellah, Anne Leblanc, Quentin Dauchet, Claude Blondeau, Jean Marc Bohbot

“…The study is registered on the ClinicalTrials.gov site under the identifier NCT04987164." …”
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Validity of the German Version of the Continuous-Scale Physical Functional Performance 10 Test by Irene Härdi, Stephanie A. Bridenbaugh, M. Elaine Cress, Reto W. Kressig

“…This trial is registered with ClinicalTrials.gov NCT01539200.…”
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Mechanical HIFU and immune checkpoint inhibition: toward clinical implementation by Vera Mekers, Mirjam de Visser, Karijn Suijkerbuijk, Clemens Bos, Chrit Moonen, Roel Deckers, Gosse Adema

“…Further, we will highlight essential questions that should be addressed in future clinical trials exploring the combination of M-HIFU and ICI in the clinical setting.Conclusion: Overall, this review offers guidance for the clinical implementation of combining M-HIFU with ICI and highlights key questions that remain to be addressed in first clinical studies.…”
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Attenuation and Immunogenicity of a Live High Pathogenic PRRSV Vaccine Candidate with a 32-Amino Acid Deletion in the nsp2 Protein by Wenhui Lu, Baoli Sun, Jianyue Mo, Xiduo Zeng, Guanqun Zhang, Lianxiang Wang, Qingfeng Zhou, Ling Zhu, Zhili Li, Qingmei Xie, Yinzuo Bi, Jingyun Ma

“…Following PRRSV experimental challenge, pigs inoculated with a single dose of QY1 P100 developed no significant clinic symptoms and well tolerated lethal challenge, while QY1 P80 group still developed mild fever in the clinic trial after challenge. Thus, we concluded that QY1 P100 was a promising and highly attenuated PRRSV vaccine candidate.…”
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Prognostic Role of Platelet-to-Lymphocyte Ratio in Hepatocellular Carcinoma with Different BCLC Stages: A Systematic Review and Meta-Analysis by Wan-fu Lin, Mao-feng Zhong, Yu-ren Zhang, Huan Wang, He-tong Zhao, Bin-bin Cheng, Chang-quan Ling

“…Five electronic databases were searched for clinical trials focusing on the role of PLR in the prognosis of HCC. …”
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Applying Focal Therapy to Lesions Detected via Magnetic Resonance Imaging: Delivering Cancer Ablation Beyond the Visibility Phenomenon by Clement Orczyk, Teresa Marsden, Francesco Giganti, Joseph M. Norris, Santosh Waigankar, Louise Dickinson, Shonit Punwani, Alex Kirkham, Alex Freeman, Aiman Haider, Caroline M. Moore, Arnauld Villers, Clare Allen, Mark Emberton

“…Focal therapy (FT) is a promising approach with a low side-effect profile for treating magnetic resonance imaging (MRI)-visible PC within a limited framework of guideline recommendations or clinical trials. On the basis of accumulated clinical and research experience, we present a systematic approach to FT indications for ablation of visible targets that includes imaging findings, margin delineation, and energy selection. …”
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Performance of Size 1 I-Gel Compared with Size 1 ProSeal Laryngeal Mask in Anesthetized Infants and Neonates by Gulay Erdogan Kayhan, Zekine Begec, Mukadder Sanli, Ender Gedik, Mahmut Durmus

“…This trial is registered with: ClinicalTrials.gov NCT01704118.…”
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Efficacy and Tolerability of Intravenous Ferric Carboxymaltose in Patients with Iron Deficiency at a Hospital Outpatient Clinic: A Retrospective Cohort Study of Real-World Clinical... by António Robalo Nunes, Ana Palricas Costa, Sara Lemos Rocha, Ana Garcia de Oliveira

“…Although its use has been extensively studied in clinical trials, real-world evidence regarding FCM treatment is scarce. …”
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Exosomes in neuron-glia communication: A review on neurodegeneration by Naeimeh Akbari-Gharalari, Sina Khodakarimi, Farshad Nezhadshahmohammad, Mohammad Karimipour, Abbas Ebrahimi-Kalan, Jiagian Wu

“…Furthermore, an exploration of the Clinicaltrials.gov database was undertaken to identify clinical trials related to cellular signaling, utilizing analogous terminology. …”
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Mesothelioma and Radical Surgery 2 (MARS 2): protocol for a multicentre randomised trial comparing (extended) pleurectomy decortication versus no (extended) pleurectomy decorticati... by Liz Darlison, John Edwards, Apostolos Nakas, Nick A Maskell, Wendy Underwood, Chris Rogers, Matthew Callister, David Waller, Richard Milton, Victoria Ashford-Turner, Paul Taylor, Claire Matthews, Victoria Hughes, Kelvin Lau, Alan Kirk, Robert C Rintoul, Elizabeth A Stokes, Kate Ashton, Daisy Elliott, Rosie Harris, Marie Kirwan, Juliette Novasio, Sara Waplington, Eric Lim, Holly Mckeon, Charlotte Jacobs, Laura White, Mary O’Brien, Judith Moore, Louise Li, Nicola Mills, Sanjay Popat, Suzanne Miller, Nadia Yousaf, D A Fennell, Clinton Ali, Andrea Bille, Liz Fuller, Andreea Ionescu, Manjusha Keni, Pek Koh, Talal Mansy, Dakshinamoorthy Muthukumar, Tony Pope, Amy Roy, Riyaz Shah, Jonathan Shamash, Zacharias Tasigiannopoulos, Sarah Treece, Katherine Joyce, Barbara Warnes, Athanasia Gravani, Rachel Brophy, Nicola Farrar, Jane Elliott, Philip Noyes, Louise Nelson, Sara Tenconi, Laura Socci, Hilary Wood, Helena Hanratty, Helena Stanley, Robert Rintoul, Amy Gladwell, Jenny Castedo, Amanda Stone, Charlotte Ingle, Hayley Hewer, Eleanor Aynsley, Andrea Watson, Alison Hassall, Masuma Begum, Christopher Worth, Ellie Piggott, Elizabeth Nadin, Yvonne Summers, Raffaele Califano, Laura Cove-Smith, Matt Evison, Maria Blinston, Amal Ismail, Rachel Chant, Asmita Desai, Ian Morgan, Victoria Lake, Nichola Harris, Simon Hodge, Nadza Tokaca, Adam Januszewski, Avani Athauda, Anisha Ramessur, Emily Grist, Niamh Colman, Michael Flynn, Joan Joyce, Sarah Vaughan, Maria Piga, Derya Sahin, Agnieszka Yongue, Emma Turay, Jaishree Bhosle, Rajiv Kumar, Charlotte Milner-Watts, Jessica Brown, David Walder, Alexandros Georgiou, Xiaorong Wu, Naila Kaudeer, Kroopa Joshi, Michael Davidson, Shelize Khakoo, Bee Ayite, Kathryn Priest, James Dobbyn, Vasanthi Prathapan, Deborah McCrimmon, Natalie Ash, Alison Norton, Bianca Peet, Libby Hennessy, Rosemary Johnson

“…We will submit the results for publication in a peer-reviewed journal.Trial registration numbers ISRCTN—ISRCTN44351742 and ClinicalTrials.gov—NCT02040272.…”
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MTIOT: Identifying HPV subtypes from multiple infection data by Qi Zhao, Tianjun Zhou, Lin Li, Guofan Hong, Luonan Chen

“…This study also underscores the importance of methodological innovation in tackling public health challenges and sets the stage for future clinical trials to validate MTIOT's efficacy in practice.…”
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Biomarkers in Nasopharyngeal Carcinoma (NPC): Clinical relevance and prognostic potential by Madhan Krishnan, Shyamaladevi Babu

“…Despite these advancements, further validation in large-scale clinical trials is required to fully realize their potential. …”
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Promising new drugs and therapeutic approaches for treatment of ovarian cancer—targeting the hallmarks of cancer by Julia Hillmann, Nicolai Maass, Dirk O. Bauerschlag, Inken Flörkemeier

“…For this purpose, we analyzed approvals and current clinical phase III studies (registered at ClinicalTrials.gov (National Library of Medicine, National Institutes of Health; U.S. …”
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