The impact of vitamin E supplementation on sperm analysis in varicocelectomy patients: a triple-blind randomized controlled trial by Kasra Saeedian, Saeed Davaryar, Maryam Emadzadeh, Alireza Akhavan Rezayat

“…Trial registration This study is registered at the Iranian Registry of Clinical Trials (IRCT20200911048689N1). Registered on October 10, 2020.…”
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Meta-Analysis and Systematic Review of the Role of Appendectomy in the Pathogenesis of Colorectal Cancer by M.I. A. Nezhad, N. P. Yabandeh

“…Our systematic investigation utilized sources including the Cochrane Library, Embase, PubMed, ClinicalTrials.gov, and Web of Science, covering research up to February 1, 2023. …”
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A Protective Role of Canonical Wnt/β-Catenin Pathway in Pathogenic Bacteria-Induced Inflammatory Responses by Zhongjia Jiang, Weiping Zhou, Xing Tian, Peng Zou, Ning Li, Chunmeng Zhang, Yanting Li, Guangyan Liu

“…This review gathers the recent efforts to elucidate the mechanistic details through how Wnt/β-catenin signaling modulates anti-inflammatory responses in response to bacterial infection and its interactions with other inflammatory signals, which warrants further study for the development of specific interventions for the treatment of inflammatory diseases. Further clinical trials from different disease settings are required.…”
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Electronic Cigarettes: Ally or an Enemy in Combating Tobacco-Use-Associated Diseases - An Integrative Review by Hunny Sharma, Manisha Ruikar

“…Methods: This integrative review includes findings from Randomized and non-randomized clinical trials, and laboratory-based Human studies; published in the English language in the last four years. …”
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The combination treatment of RC48 and STAT3 inhibitor acts as a promising therapeutic strategy for basal bladder cancer by Jingxian Li, Kun Shan, Wei Huang, Qiang Su, Yuanjiong Qi, Zhihong Zhang, Jianqiang Zhu, E. Du

“…In summary, these findings provide a theoretical foundation for subsequent clinical trials combining RC48 and ART in MIBC based on molecular subtypes.…”
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Helicobacter pylori Management: How to Improve the Therapeutic Confusion in Practice by Nicholas J Talley

“…Eradication regimens are less successful in practice than in clinical trials. Furthermore, a sizable proportion of patients with peptic ulcer remain symptomatic despite cure of the ulcer diathesis, which may undermine confidence. …”
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Therapeutic Approaches in COVID-19 Patients: The Role of the Renin-Angiotensin System by Farzaneh Ketabchi, Sina Jamzad

“…The benefits of bradykinin inhibitors (BKs) have been reported in some COVID-19 clinical trials. Furthermore, the effects of cyclooxygenase (COX) inhibitors on ACE2 cleavage and prevention of viral entry into host cells have been reported in COVID-19 patients. …”
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Bupropion Mediated Effects on Depression, Attention Deficit Hyperactivity Disorder, and Smoking Cessation by Austin Clark, Brendan Tate, Bretton Urban, Ryan Schroeder, Sonja Gennuso, Shahab Ahmadzadeh, David McGregor, Brook Girma, Sahar Shekoohi, Alan D. Kaye

“…In the case of ADHD, the evidence for efficacy is mixed with poorly conducted randomized clinical trials, small sample sizes, and a lack of long-term assessments. …”
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Ethnomedicinal, Pharmacological, and Phytochemical Overview of Diplazium esculentum by Abhishek Singh

“…Evaluation of the safety profile through animal studies and clinical trials underscores its potential as a safe therapeutic agent albeit with considerations for dosage and administration. …”
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Real-world pharmacovigilance analysis unveils the toxicity profile of amivantamab targeting EGFR exon 20 insertion mutations in non-small cell lung cancer by Jing Zhang, Wenjie Li

“…Abstract Background While clinical trials have demonstrated enduring responses to amivantamab among advanced non-small cell lung cancer (NSCLC) patients bearing EGFR exon 20 insertion mutations, the associated toxicity profile in real-world scenarios remains elusive. …”
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Key features and guidelines for the application of microbial alpha diversity metrics by Ignacio Cassol, Mauro Ibañez, Juan Pablo Bustamante

“…These guidelines enable further detailed analysis by each author according to their specific interests and clinical trials. Several practical examples are provided to illustrate how these recommendations improve the quality and depth of information obtained, facilitating better interpretation when working with microbiome data. …”
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Real-life effectiveness and safety of baricitinib in 17 Japanese patients with alopecia areata: a 60-week single center study by Akihiko Uchiyama, Takeshi Araki, Keiji Kosaka, Sei-Ichiro Motegi

“…Alopecia areata (AA) is a chronic immune-mediated skin disorder characterized by non-scarring hair loss. Although clinical trials have shown the effectiveness and safety of baricitinib, there are limited reports that have shown real-world evidence of baricitinib in patients with AA. …”
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Advances in CAR T cell therapy: antigen selection, modifications, and current trials for solid tumors by Safwaan H. Khan, Safwaan H. Khan, Yeonjoo Choi, Mysore Veena, Mysore Veena, John K. Lee, John K. Lee, Daniel Sanghoon Shin, Daniel Sanghoon Shin

“…By integrating insights from preclinical models, clinical trials, and innovative engineering approaches, this review addresses advances in CAR T cell therapies and their performance in solid tumors.…”
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Organ preservation, for rectal cancer: general overview of the latest data from phase III randomized trials by Syrine Ben Dhia, Damien Chauviere, Diana Mitrea, Renaud Schiappa, Tanguy Pace Loscos, Emmanuel Chamorey, David Baron

“…Method: We searched for articles and abstracts on randomized clinical trials investigating OP approaches for rectal cancer, including data presented at the LUCARRE Congress held in Nice on November 25, 2023, covering ongoing and recently published trials on rectal preservation. …”
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Evaluation of Inflammatory Markers in a Large Sample of Obstructive Sleep Apnea Patients without Comorbidities by Izolde Bouloukaki, Charalampos Mermigkis, Nikolaos Tzanakis, Eleftherios Kallergis, Violeta Moniaki, Eleni Mauroudi, Sophia E. Schiza

“…This trial is registered with ClinicalTrials.gov number NCT03070769.…”
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Turn TRAIL Into Better Anticancer Therapeutic Through TRAIL Fusion Proteins by Yan Wang, Xin Qian, Yubo Wang, Caiyuan Yu, Li Feng, Xiaoyan Zheng, Yaya Wang, Qiuhong Gong

“…Recombinant soluble TRAIL and agonistic antibodies against TRAIL receptors have demonstrated safety and tolerability in clinical trials. However, they have failed to exhibit expected clinical efficacy. …”
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Second-generation anti-amyloid monoclonal antibodies for Alzheimer’s disease: current landscape and future perspectives by Byeong-Hyeon Kim, Sujin Kim, Yunkwon Nam, Yong Ho Park, Seong Min Shin, Minho Moon

“…First-generation MABs targeting the non-toxic monomeric Aβ, such as solanezumab, bapineuzumab, and crenezumab, failed to demonstrate clinical benefit for AD in clinical trials. In contrast, second-generation MABs, including aducanumab, lecanemab, donanemab, and gantenerumab directed against pathogenic Aβ species and aggregates have shown that reducing Aβ deposition can be an effective strategy to slow cognitive impairment in AD. …”
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MECHANISMS AND CLINICAL PERSPECTIVES OF ALLERGEN-SPECIFIC IMMUNOTHERAPY by Leila Akhvlediani, Marina Izmailovich, Meruyert Gazaliyeva, Anna Skvortsova, Kanan Tanriverdiev

“…Vitamin D, particularly 25(OH)D, plays a pivotal immunomodulatory role, supporting Treg and Breg cell function, and mitigating allergic inflammation. Clinical trials demonstrate that vitamin D supplementation enhances ASIT outcomes, especially in pediatric patients. …”
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Differential Reponses of Hematopoietic Stem and Progenitor Cells to mTOR Inhibition by Aimin Yang, Xia Xiao, Mingfeng Zhao, Amanda C. LaRue, Bradley A. Schulte, Gavin Y. Wang

“…Therefore, targeting of the mTOR pathway is an attractive strategy for cancer treatment and several mTOR inhibitors, including AZD8055 (AZD), a novel dual mTORC1/2 inhibitor, are currently in clinical trials. Although bone marrow (BM) suppression is one of the primary side effects of anticancer drugs, it is not known if pharmacological inhibition of dual mTORC1/2 affects BM hematopoietic stem and progenitor cells (HSPCs) function and plasticity. …”
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Causal relationships between plasma lipidome and diabetic neuropathy: a Mendelian randomization study by Zhaoxiang Wang, Zhong Liu, Qichao Yang, Qichao Yang, Huibo Qiao, Huibo Qiao, Yong Yin, Yong Yin, Zhiyong Zhao, Zhiyong Zhao, Xuejing Shao, Xuejing Shao

“…Sensitivity assessments have confirmed the robustness of these findings, revealing no evidence of heterogeneity or pleiotropy.ConclusionOur research linked certain lipid species with diabetic neuropathy risk, suggesting that targeting lipids could be a therapeutic strategy in clinical trials addressing this condition.…”
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