Ethnopharmacology, Biological Evaluation, and Chemical Composition of Ziziphus spina-christi (L.) Desf.: A Review by Mahmoud Dogara Abdulrahman, Ali Muhammad Zakariya, Harmand A. Hama, Saber W. Hamad, Sawsan S. Al-Rawi, Sarwan W. Bradosty, Ahmad H. Ibrahim

“…However, the safety and efficacy of Z. spina have not been wholly assessed in humans, and further well-designed clinical trials are needed to corroborate preclinical findings. …”
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Challenges in Assessing Outcomes among Infants of Pregnant HIV-Positive Women Receiving ART in Uganda by Barbara Castelnuovo, Frank Mubiru, Ivan Kalule, Shadia Nakalema, Agnes Kiragga

“…We report very low documented HIV transmission comparable with those reported in clinical trials settings; however, demonstrating the efficacy of Option B-plus in terms of averted transmission in routine settings is challenging since high proportion of infants do not have documented HIV tests.…”
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Efficacy of Abiraterone and Enzalutamide in Pre- and Postdocetaxel Castration-Resistant Prostate Cancer: A Trial-Level Meta-Analysis by Mike Fang, Mary Nakazawa, Emmanuel S. Antonarakis, Chun Li

“…The results from this comprehensive meta-analysis suggest a survival advantage with the use of first-line enzalutamide over abiraterone in CRPC and highlight the need for prospective clinical trials.…”
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Association between dietary intake of live microbes and chronic obstructive pulmonary disease: a cross-sectional study of NHANES 2007–2012 by Yifeng Xu, Zhaoqi Yan, Liangji Liu

“…Trial registration ClinicalTrials.gov Identifier NCT00005154 First Posted date 26/05/2000(retrospectively registered).…”
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Exploring the associations between the biomechanical and psychological mechanistic pathways of lower back pain development amongst persons with lower-limb amputation: A study proto... by Alexandra Withey, Dario Cazzola, Abby Tabor, Elena Seminati

“…<h4>Trial reference number</h4>The study is registered at IRAS ID: 321729 and at ClinicalTrials.gov: NCT06243549.…”
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Fractional Radiofrequency Microneedling as a Monotherapy in Acne Scar Management: A Systematic Review of Current Evidence by Niaz G, Ajeebi Y, Alshamrani HM, Khalmurad M, Lee K

“…We systematically reviewed all available literature on FRM techniques used for acne scarring by searching the PubMed and EBSCO databases up to July 2024. 16 studies involving 481 patients, comprising six prospective studies, six randomized clinical trials, three retrospective studies, and one comparative trial, were included. …”
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Natural products as anticancer agents and enhancing their efficacy by a mechanism-based precision approach by Stephen Safe

“…Many of the compounds perform poorly in clinical trials due to pharmacokinetic consideration and limited uptake (e.g., curcumin) and these are issues that can be addressed. …”
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Comprehensive analysis of adverse events associated with onasemnogene abeparvovec (Zolgensma) in spinal muscular atrophy patients: insights from FAERS database by Wenwen Zhang, Yizhen Yin, Dan Yang, Mengyuan Liu, Caixia Ye, Ruiling Yan, Ruiman Li

“…Information on its adverse drug reactions is mainly from clinical trials and real-world studies with extensive sample sizes are lacking. …”
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Transient loss of consciousness without cerebral origin following injection of Sinopharm vaccine by Bakhtiar Ebrahimirad, Hero Payandeh

“…Background: The Sinopharm vaccine has been widely administered in Iran during COVID-19 pandemic. Clinical trials have identified several side effects associated with the Sinopharm vaccine, including pain at the injection site, fatigue, headache, and lethargy. …”
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A modern approach to the treatment of acute low back pain: a proposal of a new treatment algorithm by Robert Rupiński, Urszula Grata-Borkowska, Jarosław Drobnik

“…Several randomized clinical trials have demonstrated the efficacy of this method in reducing pain and disability to a degree comparable to high-dose NSAID therapy. …”
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Efficacy and safety of laquinimod versus placebo in relapsing-remitting multiple sclerosis: a systematic review and meta-analysis of randomized controlled trials by Malik Waleed Zeb Khan, Aizaz Ali, Amna Hussain, Safeena Khan, Ammara Tahir, Muhammad Haris Khan, Touba Azeem, Abdul Moeez, Arysha Monis, Aban Masaud Mian, Fazia Khattak, Moosa Ali, Jibran Ikram

“…Methods An extensive electronic search was conducted across PubMed, Embase, Cochrane Database of Systematic Reviews, and ClinicalTrials.gov to identify suitable studies. Risk of bias was assessed using Cochrane’s Risk of Bias tool. …”
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Decremental response in patients with amyotrophic lateral sclerosis during repetitive nerve stimulation and its relationships with impaired homeostasis by Jinghong Zhang, Yang Li, Qiang Shi

“…Independent factors contributing to decremental response need to be considered in drug development and clinical trials targeting NMJ in patients with ALS.…”
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DNA alterations in ovarian adult granulosa cell tumours: A scoping review protocol. by Sven Karstensen, Karsten Kaiser, Caroline Moos, Tim Svenstrup Poulsen, Kirsten Jochumsen, Claus Høgdall, Finn Lauszus, Estrid Høgdall

“…<h4>Discussion</h4>This scoping review will identify knowledge and gaps in the current understanding of the molecular landscape of aGCT, clinical trials on actionable variations and priorities for future research. …”
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Marginal Strength of Collarless Metal Ceramic Crown by Sikka Swati, R. Chowdhary, P. S. Patil

“…Hence, it may be subjected to more clinical trials.…”
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Post-chemoradiotherapy adjuvant chemotherapy of rectal cancer by E. V. Ledin, A. V. Kochatkov

“…The meta-analysis (2015) of 4 randomized third-phase clinical trials (EORTC 22921, I-CNR-RT, PROCTORSCRIPT, CHRONICLE) demonstrated the lack of significant of 5-fluorouracil-based adjuvant chemotherapy. …”
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Triphenylmethane derivatives have high in vitro and in vivo activity against the main causative agents of cutaneous leishmaniasis. by Renata Celi Carvalho de Souza Pietra, Lucas Fonseca Rodrigues, Eliane Teixeira, Levi Fried, Benjamin Lefkove, Ana Rabello, Jack Arbiser, Lucas Antônio Miranda Ferreira, Ana Paula Fernandes

“…These results demonstrated that TPM present significant anti-leishmanial activities and provide a rationale for human clinical trials of GV and other TPM. TPM are inexpensive and safe, thus using them for treatment of CL may have a major impact on public health.…”
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Role of Opioid Ligands in the Irritable Bowel Syndrome by Enrico Corazziari

“…Fedotozine has been shown to increase the threshold of perception to colonic distension in experimental conditions and to affect favourably symptoms of IBS in clinical trials.…”
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A voice-based algorithm can predict type 2 diabetes status in USA adults: Findings from the Colive Voice study. by Abir Elbéji, Mégane Pizzimenti, Gloria Aguayo, Aurélie Fischer, Hanin Ayadi, Franck Mauvais-Jarvis, Jean-Pierre Riveline, Vladimir Despotovic, Guy Fagherazzi

“…We analyzed pre-specified text recordings from 607 US participants from the Colive Voice study registered on ClinicalTrials.gov (NCT04848623). Using hybrid BYOL-S/CvT embeddings, we constructed gender-specific algorithms to predict T2D status, evaluated through cross-validation based on accuracy, specificity, sensitivity, and Area Under the Curve (AUC). …”
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Childhood trauma and subclinical PTSD symptoms predict adverse effects and worse outcomes across two mindfulness-based programs for active depression. by Nicholas K Canby, Elizabeth A Cosby, Roman Palitsky, Deanna M Kaplan, Josie Lee, Golnoosh Mahdavi, Adrian A Lopez, Roberta E Goldman, Kristina Eichel, Jared R Lindahl, Willoughby B Britton

“…., abuse and neglect) were examined as predictors of depression treatment outcomes and participant attrition using secondary analyses of two MBP clinical trials (N = 52 and 104, respectively). Study 2 also examined meditation-related side effects (MRSE) and MRAE as outcomes and current subclinical and past PTSD symptoms as predictors. …”
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The effectiveness of orthodontic treatment with clear aligners in different thicknesses by Saniye Merve Cengiz, Merve Goymen

“…Trial registration: The trial was registered on https://ClinicalTrials.gov retrospectively with the registration number of NCT06504498, on 16/07/2024.…”
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