Sexual Differences in response to Mid- or Low-Premixed Insulin Analogue in Patients with Type 2 Diabetes by Bing-li Liu, Xiao-mei Liu, Yi-fei Ren, Yi-Xuan Sun, Meng-hui Luo, Lei Ye, Jian-hua Ma, Feng-fei Li

“…This trial is registered with ClinicalTrials.gov ChiCTR-IPR-15007340.…”
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Use of virtual reality in port implantation to reduce perioperative anxiety and pain: protocol for a randomised controlled pilot trial at a single German university hospital (VIP-t... by Christoph W Michalski, Felix J Hüttner, Colette Dörr-Harim, Sandra Graf, Hannah Feldmann, Lisa S Hunold, Kira C Steinkraus, Nadir Nasir

“…The results will be submitted to a peer-reviewed journal in the field and will be presented at applicable conferences to ensure rigorous evaluation and access for the academic community.Trial registration number German Clinical Trials Register: DRKS00028508; registration date 15 March 2022; Universal Trial Number: U1111-1275-4995.…”
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Preservation of Bilateral Corticospinal Projections from Injured Hemisphere After Perinatal Stroke by Cameron P. Casey, Ellen N. Sutter, Alina Grimaldo, Kellie M. Collins, Jose Guerrero-Gonzalez, Ryan M. McAdams, Douglas C. Dean, Bernadette T. Gillick

“…These results underscore the potential for neural plasticity after perinatal brain injury. Clinical Trials Registration: NCT05013736.…”
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Effectiveness of nurse-led care in patients with rheumatoid arthritis: a systematic review and meta-analysis by Dan Liu, Li Liu, Lin Yang, Ting Wen, Peng Xiang, Guifang Pi

“…Objectives This study sought to assess the effectiveness of nurse-led care (NLC) in patients with rheumatoid arthritis (RA).Methods We conducted a comprehensive search of the Cochrane Library, Web of Science, PubMed, Embase, CINAHL, ClinicalTrials.gov databases and the references from relevant literature published prior to May 2023. …”
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Exendin-4 Exacerbates Burn-Induced Morbidity in Mice by Activation of the Sympathetic Nervous System by Xiao-Jing Ji, Ji-Wei Hao, Guang-Lei Li, Ning Dong, Xin-Qi Wang, Min Zhou, Qing-Hong Zhang, Yong-Ming Yao

“…Although glucagon-like peptide 1- (GLP-1-) based therapy of hyperglycemia in burn injury has shown great potential in clinical trials, its safety is seldom evaluated. We hypothesize that exendin-4, a GLP-1 analogue, might affect the immune response via the activation of the sympathetic nervous system in burn injury. …”
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Clinical validation of an individualized auto-adaptative serious game for combined cognitive and upper limb motor robotic rehabilitation after stroke by Ioannis Doumas, Thierry Lejeune, Martin Edwards, Gaëtan Stoquart, Yves Vandermeeren, Bruno Dehez, Stephanie Dehem

“…Registry number This study was registered at ClinicalTrials.gov (NCT02543424).…”
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Adrenal aldosterone synthase (CYP11B2) histopathology and its association with disease-induced sudden death: a cross-sectional studyResearch in context by Antero Ylänen, Juhani Isojärvi, Antti Virtanen, Helena Leijon, Tiina Vesterinen, Aapo L. Aro, Heini Huhtala, Eeva Kokko, Ilkka Pörsti, Marianna Viukari, Pasi I. Nevalainen, Niina Matikainen

“…This trial was registered at ClinicalTrials.gov (NCT05446779). Findings: Adrenal histopathology revealed changes in 31 (7.7%) subjects of the cohort. …”
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Radiological abnormalities persist following COVID-19 and correlate with impaired health-related quality of life: a prospective cohort study of hospitalised patients by Rhian M Touyz, Ninian N Lang, Kevin G Blyth, Naveed Sattar, Patrick B Mark, Stefan Siebert, Colin Berry, Iain McInnes, Giles Roditi, Neil Basu, David Corcoran, Kenneth Mangion, Alex McConnachie, David Carrick, Jaclyn Carberry, Stuart Watkins, Paul Welsh, Sabrina Nordin, Katherine Scott, Christian Delles, Bernard Kelly, Fraser Goldie, John GF Cleland, Sharon Kean, Peter Kellman, David J Lowe, Andrew J Morrow, Antonia Ho, Rosemary Woodward, Tracey Hopkins, Ryan Wereski, Massimo Palmarini, Alasdair McIntosh, Campbell Rogers, Ammani Brown, Catherine Bagot, Kathryn Scott, Robert Sykes, Colin Church, Claire Rooney, Nicola Ryan, Clare Orange, Dirk Husmeier, Xiaoyu Luo, PETER W MACFARLANE, Heerajnarain Bulluck, Iain Findlay, Evonne McLennan, Michael Briscoe, Oliver Peck, Alastair J Rankin, Gruschen Veldtman, Varun Sharma, Kathryn McLaren, Elaine Butler, Sarah Mullen, Andrew Morrow, Patrick Mark, Daniel Doherty, Alexander Payne, Jennifer S Lees, Kaitlin J Mayne, Louise Inglis, Anna Kamdar, Hannah Bayes, Vivienne B Gibson, Lynsey Gillespie, Douglas Grieve, Pauline Hall Barrientos, Christopher McGinley, Connor Mckee, Sarah Allwood-Spiers, Sarah Weeden, Laura Knox, Lynn Abel, David Stobo, Andrew Dougherty, Liam Peng, David Barrie Stobo, Sylvia Wright, Stephen Dobbin, Keith Gillis, Sarah A Spiers, Ian Fergus, Kirsty Fallon, Lesley Gilmour, Chloe Cowan, Jurgen Van-Melckebeke, Kim Moran-Jones, Debra Stuart, Maureen Travers, Laura Dymock, Fiona Savage, Nicola Tynan, Sau Lee Chang, Mhairi Dupre, Lindsey Norton, George Bruce, Rosario Gonzalez-Lopez, Rebecca Stace, Dionne Russell, Jean Watt, Shahid Latif, Nick Hill, Amy Collinsworth, Ross McGeoch Vera Lennie, Robin P Weir

“…We present a prospective, observational, multicentre cohort study using multimodality imaging to describe the pulmonary sequelae of patients hospitalised with COVID-19, predictors of persistent abnormal radiology and implications on health status.Methods In survivors of COVID-19, we performed convalescent CT pulmonary angiogram and high-resolution CT imaging as part of the CISCO-19 study (ClinicalTrials.gov ID NCT04403607). This included serial blood biomarkers and patient-reported outcomes 28–60 days following discharge from hospital.Results Of the COVID-19 cohort, 88 (56%) patients of the COVID-19 cohort (n = 159; mean age, 55 years; 43% female) had persisting radiological abnormalities at 28–60 days postdischarge. …”
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Different Approaches to requesting Consent for Routine data linkage in Neonatal follow-up (ACORN): protocol for a 2×2 factorial randomised trial by Jane E Harding, Barry Milne, Jenny Rogers, Greg Gamble, Jane Marie Alsweiler, Christopher McKinlay, Gavin Brown, Aakash Bajirao Rajay, Caroline Anne Crowther, Nike Franke, Trecia Wouldes

“…Dissemination will be via peer-reviewed publications, scientific meetings, educational sessions and public fora.Trial registration number ACTRN12621000571875 (Australian New Zealand Clinical Trials Registry).…”
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Surgical resection, radiotherapy and percutaneous thermal ablation for treatment of stage 1 non-small cell lung cancer: protocol for a systematic review and network meta-analysis by Arun Chockalingam, Menelaos Konstantinidis, Brandon Koo, John Timothy Moon, Andrew Tran, Sahar Nourouzpour, Emily Lawson, Kathleen Fox, Peiman Habibollahi, Bruno Odisio, Mohammed Loya, Ali Bassir, Nariman Nezami

“…We will conduct a meta-analysis, reviewing literature investigating these therapies in adult patients diagnosed with stage 1 NSCLC, with neither hilar nor mediastinal nodal involvement, confirmed either through cytology or histology regardless of type.Methods and analysis We will search electronic databases (MEDLINE, Embase, Web of Science, Scopus, ClinicalTrials.gov, Cochrane) from their inception to January 2021 to identify randomised controlled trials (RCTs), cluster RCTs and cohort studies comparing survival and clinical outcomes between any two interventions (lobectomy, wedge resection, video-assisted thoracoscopic surgery/robot-assisted thoracoscopic surgery, radiofrequency ablation, microwave ablation, cryoablation and consolidated radiation therapies (external beam radiation therapy, stereotactic body radiation therapy, and 3D conformal radiation therapy). …”
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Active case detection and treatment of malaria in pregnancy using LAMP technology (LAMPREG): a pragmatic randomised diagnostic outcomes trial—study protocol by Mekonnen Teferi, Claire Kamaliddin, Hiwot Tilahun, Rediet Fikru Gebresenbet, Zelalem Mekonnen Bekele, Banchamlak Tegegne, Delenasaw Yewhalaw, Abebe Genetu Bayih, Dylan R Pillai, Filmona Mekuria, Getaneh Alemu, Beka Raya, Omar Abdullah, Taye Teka, James Cheaveau, Ruth Legese, Hiwot Asmerom, Ermias Hundito, Ebrahim Nursefa, Samuel Ayele

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Concomitant abdominal organ transplantation alongside lung transplantation: An ISHLT transplant database analysis by Renita Wilson, BS, J. Asher Jenkins, MD, Juan Maria Farina, MD, Blake Langlais, MS, Bashar Aqel, MD, Ashraf Omar, MD, Jonathan D’Cunha, MD, PhD, Pedro Reck dos Santos, MD, PhD

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Low dose DNA methyltransferase inhibitors potentiate PARP inhibitors in homologous recombination repair deficient tumors by Romain Pacaud, Scott Thomas, Sibapriya Chaudhuri, Ann Lazar, Luika A. Timmerman, Pamela N. Munster

“…While this approach attenuated tumor cell proliferation in preclinical studies, subsequent clinical trials revealed little benefit. We hypothesized that benefit for this drug combination would only be specific to HRR deficient tumors, due to their inability to enact high fidelity DNA repair with subsequent cell death. …”
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Procedural sedative effect of remimazolam in ICU patients on invasive mechanical ventilation: a randomised, prospective study by Youli Tian, Jintong Li, Minggen Jin, YiHua Piao, Jisheng Sheng, Zhixiong Mei, Qingsong Cui, Lilin Li

“…Large sample-size randomised clinical trials are warranted.…”
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ESTRO guidelines for developing questionnaires in survey-based radiation oncology research by Amanda Webster, Lotte S. Fog, Emma Hall, Peter S.N. van Rossum, Daan Nevens, Pierre Montay-Gruel, Pierfrancesco Franco, Elizabeth Joyce, Nuria Jornet, Catharine H. Clark, Jenny Bertholet

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A Clinical Monitoring Program of COVID-19 Outpatients: A Prospective Cohort Study by Hossein Kasiri, Cyrus Mahjub, Mohammadreza Mazaeri, Fahimeh Naderi-Behdani, Aliyeh Bazi, Monireh Ghazaeian, Sahar Fallah

“…While a high portion of COVID-19 patients have mild symptoms, a limited number of clinical trials have evaluated the clinical course of this large group of patients. …”
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Impact of non-invasive oxygen reserve index versus standard SpO2 monitoring on peripheral oxygen saturation during endotracheal intubation in the intensive care unit: Protocol for... by Hugo Hille, Aurélie Le Thuaut, Pierre Asfar, Quentin Quelven, Emmanuelle Mercier, Anthony Le Meur, Jean-Pierre Quenot, Virginie Lemiale, Grégoire Muller, Martin Cour, Alexis Ferré, Asael Berge, Anaïs Curtiaud, Maxime Touron, Gaetan Plantefeve, Jean-Charles Chakarian, Jean-Damien Ricard, Gwenhael Colin, Arthur Orieux, Patrick Girardie, Mathieu Jozwiak, Manon Rouaud, Camille Juhel, Jean Reignier, Jean-Baptiste Lascarrou, CRICS-TRIGGERSEP Network

“…Trial registration: Registered on ClinicalTrials.gov (NCT05867875) on April 27, 2023.…”
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Are psychological attitudes towards vaccination an expression of personality? A cross-sectional study on COVID-19 vaccination in France by Gaëlle Lièvre, Jonathan Sicsic, Simon Galmiche, Tiffany Charmet, Arnaud Fontanet, Judith Mueller

“…The study is registered with ClinicalTrials.gov under the identifier NCT04607941.…”
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Idiopathic pulmonary fibrosis is a risk factor for cardiovascular disease: potential role of KL-6 and systemic inflammation by Mohamed F. AbdelGhany, Waleed GamalEldin Khaleel, Asmaa Omar Ahmed, Ahmad BaheyElden Ahmed, Lamees M. Bakkar

“…Trial registration ClinicalTrials.gov. NCT06539962.…”
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The impact of the COVID-19 pandemic on the research activity and working experience of clinical academics, with a focus on gender and ethnicity: a qualitative study in the UK by Carmen Soto, Jessica Elizabeth Morgan, Paul Crampton, Paul Alexander Tiffin, Gabrielle M Finn, Amelia Kehoe, Ellie Taylor, John AG Buchanan, Abisola Olatokunbo Balogun

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