Serum and urine eosinophil-derived neurotoxin (EDN) levels predict biologic response in severe asthma by Yu Ri Kang, MD, Hyunkyoung Kim, MS, MPH, Chae Eun Lee, BS, Jae-Woo Jung, MD, PhD, Ji-Yong Moon, MD, PhD, So Young Park, MD, MS, Sae-Hoon Kim, MD, PhD, Min-Suk Yang, MD, PhD, Byung Keun Kim, MD, PhD, Jae-Woo Kwon, MD, PhD, Hye-Kyung Park, MD, PhD, Young-Hee Nam, MD, PhD, Young-Joo Cho, MD, PhD, Taehoon Lee, MD, PhD, Ian M. Adcock, MD, PhD, Pank Bhavsar, MD, PhD, Kian Fan Chung, MD, PhD, Tae-Bum Kim, MD, PhD

“…The study protocol is registered at ClinicalTrials.gov (NCT05164939). Results: The findings underscore strong correlations between serum EDN levels, blood eosinophil counts, and treatment responses, with EDN demonstrating comparable predictive capabilities to blood eosinophil counts to determine treatment responses. …”
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The Nasal Route as a Potential Pathway for Delivery of Erythropoietin in the Treatment of Acute Ischemic Stroke in Humans by Julio Cesar García-Rodríguez, Iliana Sosa Teste

“…However, it will be necessary to initiate clinical trials in stroke patients using intranasal delivery in order to obtain the clinical evidence of its neuroprotectant capacity in the treatment of patients with acute stroke and other neurodegenerative disorders. …”
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Early mobilization post-myocardial infarction: A scoping review. by Haroon Munir, Jake Fromowitz, Michael Goldfarb

“…More robust evidence from randomized clinical trials is required to inform clinicians and influence practice.…”
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Biological Evaluation of Garcinia kola Heckel by Abdulrahman Mahmoud Dogara, Saber W. Hamad, Harmand A. Hama, Sarwan W. Bradosty, Soran Kayfi, Sawsan S. Al-Rawi, Abubakar Abdullahi Lema

“…However, the safety and efficacy of G. kola have not been wholly assessed in humans, and further well-designed clinical trials are needed to corroborate preclinical findings. …”
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Prognostic value of circulating Chromogranin A in prostate cancer: a systematic review and meta-analysis by Xiaoying Tang, Zhenyu Liu, Liangdong Song, Huixuan Zhu, Shuai Su, Delin Wang

“…Therefore, we conducted a meta-analysis of the available findings to explore the value of circulating Chromogranin A in the prognosis of prostate cancer.MethodsWe systematically searched the PubMed, Embase, Web of Science, Cochrane Library, and Clinical Trials databases for studies on the relationship between CgA and survival outcomes in prostate cancer from inception until December 2024, and we focused on articles detecting circulating CgA, with the primary endpoints of the studies being overall survival (OS), and progression-free survival (PFS).ResultsOf the 2049 articles retrieved, 10 articles met our inclusion criteria, involving a total of 1445 patients. …”
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Long Coronavirus Disease Symptoms and their Association with Different Risk Factors by Rasha A. F. Jasim

“…So understanding the correlation between appearance of the long COVID-symptoms and these the risk factors presents valuable insights, the conclusions warrant justification through larger clinical trials.…”
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A 3-Month, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Ability of an Extra-Strength Marine Protein Supplement to Promote Hair Growth and Decrease Shedding in... by Glynis Ablon

“…This trial is registered with ClinicalTrials.gov Identifier: NCT02297360.…”
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Special Problems Associated with Surgical Trials in Inflammatory Bowel Disease by Robin S McLeod

“…However, it also appears that there are certain issues that are unique to, or at least occur more frequently in, clinical trials assessing surgical interventions. The issues of special concern in surgical trials can broadly be categorized as methodological and feasibility issues. …”
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The Impact of Polyunsaturated Fatty Acid Supplementation on Inflammatory Markers in Preterm Infants – A Literature Review by Larysa Bielecka

“…Materials and Methods A review of randomized clinical trials (RCTs) published in 2020-2024 regarding the relationship between the supplementation of polyunsaturated fatty acids and the levels of inflammatory markers in preterm infants. …”
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Thymus and activation-regulated chemokine (CCL17) as a clinical biomarker in atopic dermatitis: significance and limitations in the new treatment era by Yoko Kataoka

“…In this new era, TARC remains a useful biomarker for more accurate drug selection and the determination of therapeutic efficacy; Currently, in clinical trials of AD, all outcome measurements depend on the clinical score; however the use of a biomarker, such as TARC, as a secondary outcome measure will clarify the characteristics of each drug and the pathophysiological conditions for which it is expected to be effective.…”
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Rimegepant for the treatment of migraine by Amnon A. Berger, Ariel Winnick, Austin H. Carroll, Alexandra Welschmeyer, Nathan Li, Marc Colon, Antonella Paladini, Giovanni F. Ramírez, Jamal Hasoon, Elyse M. Cornett, Jaehong Song, Giustino Varrassi, Adam M. Kaye, Alan D. Kaye, Latha Ganti

“…Rimegepant, a second-generation gepant, has shown efficacy in several clinical trials in treating acute migraine. Ongoing trials are also evaluating its role in migraine prophylaxis, and results are promising. …”
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Comparative efficacy and safety of co-amoxiclav, cefpodoxime proxetil, and levofloxacin in patients with acute uncomplicated bacterial tonsillitis: A prospective, open-label, paral... by Suja Xaviar, K. Girish, B. Jagannath, Saibal Das, Probin Joseph

“…Background: No clinical trials have compared the efficacy and safety of beta-lactam antibiotics and fluoroquinolones in acute uncomplicated bacterial tonsillitis. …”
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Tibial scoring as a predictor for amputation-free survival in critical limb ischemic patients by Yehia K. Sadek, Sameh El Sayed El Emam, Ahmed K. Mohamed

“…Creating novel approaches to pinpoint high-risk patients would allow for targeted treatments and support specialized clinical trials focused on limb preservation. This study’s objective is to evaluate tibial adversity and scoring for risk of lower extremity amputation in critical limb ischemic patients (CLI). …”
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A scoping review protocol on diagnostic strategies to detect occult malignancies in individuals with ischemic stroke. by Jenneke Leentjens, Nicholas L J Chornenki, Janneke Spiegelenberg, Valentina Ly, Dariush Dowlatshahi, Deborah M Siegal

“…Addressing this knowledge gap will help guide the development of future clinical trials on occult cancer screening patients with ischemic stroke.…”
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Dry Swab-Based Nucleic Acid Extraction vs. Spin Column-Based Nucleic Acid Extraction for COVID-19 RT-PCR Testing: A Comparative Study by Mohammed Faraaz Khan, C. Roopa

“…The trial was registered with the Clinical Trials Registry of India (CTRI) with a CTRI registration number of CTRI/2021/12/038792.…”
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Musculoskeletal Adverse Events Associated with PCSK9 Inhibitors: Disproportionality Analysis of the FDA Adverse Event Reporting System by Lingqing Ding, Congqin Chen, Yongkuan Yang, Jie Fang, Longxing Cao, Yige Liu

“…Some studies suggest that potential safety issues about PCSK9 inhibitors have not been sufficiently explored in clinical trials, including musculoskeletal adverse events (MAEs). …”
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Pembrolizumab for the Treatment of Locally Advanced Cutaneous Squamous Cell Carcinoma: Patient Selection and Special Considerations by Stewart M, Geiger JL

“…Pembrolizumab, approved by the FDA in 2020 for recurrent or metastatic cSCC not amenable to curative surgery or radiation, has shown promising results in clinical trials. Immunotherapy is also being explored in neoadjuvant settings, with ongoing trials evaluating its potential to improve outcomes for high-risk patients with recurrent or metastatic disease. …”
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Is there a risk of esketamine misuse in clinical practice? by Carlos Roncero, Milton Merizalde-Torres, Néstor Szerman, Marta Torrens, Pablo Vega, Pilar Andres-Olivera, Francisco Javier Álvarez

“…In 2019, intranasal esketamine gained approval as a promising therapy for those individuals grappling with treatment-resistant depression. Both clinical trials and real-world studies have underscored its efficacy in alleviating and remitting depressive symptoms, with sustained benefits observed for nearly 4.5 years. …”
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Analysis of restoration in atrophic scar by intradermal autologous dermal tissue: a pilot study by Sudhir Singh, Adarsh L. Singh, Deepika Singh

“…It is important to continue conducting research and clinical trials to establish the benefits and limitations of autologous dermal tissue transplantation for depressed scars. …”
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Minimally invasive lateral, posterior, and posterolateral sacroiliac joint fusion for low back pain: a systematic review and meta-analysis by Kai Xu, Ya-Ling Li, Song-Hua Xiao, Yong-Wei Pan

“…Methods The PubMed, Web of Science, Embase, Cochrane Library, and ClinicalTrials.gov databases were comprehensively searched for studies up to 31 August 2024. …”
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