CRISPR screen reveals modifiers of rAAV production including known rAAV infection genes playing an unexpected role in vector production by Emily E. O’Driscoll, Sakshi Arora, Jonathan F. Lang, Beverly L. Davidson, Ophir Shalem

“…Food and Drug Administration-approved AAV-mediated gene therapies already on the market and numerous more in clinical trials. However, manufacturing rAAV vectors is an expensive, timely, and labor-intensive process that limits the commercial use of AAV-mediated gene therapies. …”
Get full text

The Efficacy and Mechanism of Chinese Herbal Medicine on Diabetic Kidney Disease by Zhenzhen Lu, Yifei Zhong, Wangyi Liu, Ling Xiang, Yueyi Deng

“…We will summarize the progress of Chinese herbal medicine (CHM) in the treatment of DKD from two aspects. In clinical trials, the Chinese herbal formulas were efficacy and safety confirmed by the randomized controlled trials. …”
Get full text

Extensive Use of Interventional Therapies Improves Survival in Unresectable or Recurrent Intrahepatic Cholangiocarcinoma by Ricarda Seidensticker, Max Seidensticker, Kathleen Doegen, Konrad Mohnike, Kerstin Schütte, Patrick Stübs, Erika Kettner, Maciej Pech, Holger Amthauer, Jens Ricke

“…This trial is registered with German Clinical Trials Registry (Deutsche Register Klinischer Studien), DRKS-ID: DRKS00006237.…”
Get full text

Sedentary Behaviour and Physical Activity of People with Stroke in Rehabilitation Hospitals by Anna Sjöholm, Monica Skarin, Leonid Churilov, Michael Nilsson, Julie Bernhardt, Thomas Lindén

“…Interventions to promote reduced sedentary time could help improve outcome and these should be tested in clinical trials.…”
Get full text

In Vivo PET Imaging of the Activated Immune Environment in a Small Animal Model of Inflammatory Arthritis by Benjamin L. Franc MD, MS, Sam Goth PhD, John MacKenzie MD, Xiaojuan Li PhD, Joseph Blecha MS, Tina Lam MS, Salma Jivan BS, Randall A. Hawkins MD, PhD, Henry VanBrocklin PhD

“…Further development of this technique is warranted and could offer a tool to explore the temporal link between activated T cells and RA as well as to monitor immune-mediated therapies for RA in clinical trials.…”
Get full text

Preliminary Evidence for Feasibility, Use, and Acceptability of Individualized Texting for Adherence Building for Antiretroviral Adherence and Substance Use Assessment among HIV-In... by David J. Moore, Jessica L. Montoya, Kaitlin Blackstone, Alexandra Rooney, Ben Gouaux, Shereen Georges, Colin A. Depp, J. Hampton Atkinson, The TMARC Group

“…This trial is registered with ClinicalTrials.gov NCT01317277.…”
Get full text

The comparison of biodistribution of glutathione PEGylated nanoliposomal doxorubicin formulations prepared by pre‐insertion and post‐insertion methods for brain delivery in normal... by Amin Mehrabian, Saba Dadpour, Mohammad Mashreghi, Javad Zarqi, Anis Askarizadeh, Ali Badiee, Leila Arabi, Seyedeh Alia Moosavian, Mahmoud Reza Jaafari

“…Here, the 5% pre‐inserted PEG2000‐GSH PEGylated liposomal doxorubicin was conducted according to 2B3‐101 being tested in clinical trials. In addition, PEGylated nanoliposomal doxorubicin connected to the spacer‐GSH targeting ligand (GSGGCE) and the PEG3400 was conducted using post‐insertion method. …”
Get full text

Global scenario of silica-associated diseases: A review on emerging pathophysiology of silicosis and potential therapeutic regimes by Prasad Sherekar, Sanvidhan G. Suke, Archana Dhok, Srikant Malegaonkar, Shrikrishna A. Dhale

“…The preclinical findings open the doors to clinical trials for operational and regenerative nanoformulations, which eventually create a positive change in medical practice. …”
Get full text

Knowledge, attitudes, and perceptions of a group of Egyptian dental students toward artificial intelligence: a cross-sectional study by Marwa Elchaghaby, Reem Wahby

“…Trial registration This study has been registered in clinical trials. gov with an identifier: NCT06348758.…”
Get full text

Adjuntive nicergoline therapy for severe persistent corneal epithelial defects. by Valeria Oliva-Biénzobas, Enrique O. Graue-Hernandez, Guillermo Raul Vera-Duarte, Jesus Cabral-Macías, Juan Serna-Ojeda, Victor Boullosa, Arturo Ramirez-Miranda, Vishal Jhanji, Victor L. Perez, Alejandro Navas

“…Further studies and clinical trials must be conducted to prove safety and efficacy as a treatment for persistent corneal epithelium defects in humans.…”
Get full text

Photobiomodulation in ocular therapy: current status and future perspectives by Hasan Chichan, Iftkhar Hamzah Aldujaly, Konstantinos Michalakis, Levent Kanal

“…Hence the future of photobiomodulation holds significant potential in medicine especially in ocular diseases characterized by progress in research, technology, and clinical trials.…”
Get full text

Therapeutic Potential of Heat Shock Protein 90 Inhibitors, Geldanamycin, and Analog Compounds in Precision Cancer Therapy by Atta Mohammed Alzebari, Amjad Mahmood Qadir, Mahmood Sherzad Rafaat, Abbas Salihi

“…These naturally occurring chemicals play a crucial function in regulating HSP90 activity and can be utilized to develop innovative semi-synthetic or synthetic inhibitors. Over 120 clinical trials have been carried out to evaluate the effectiveness of HSP90 inhibitors as a supplementary therapy for different types of tumor cells. …”
Get full text

Effects of auriculotherapy on blood pressure levels in hypertensive adults and older adults by Victor Hugo Martins Santos, Margani Cadore Weis-Maia, Camila Maria Cenzi, Jaqueline Costa Lima, Camila de Souza dos Santos, Marina Nolli Bittencourt

“…Brazilian Registry of Clinical Trials: RBR-6r8y39d.…”
Get full text

Different Strategies for the Treatment of Age-Related Macular Degeneration in China: An Economic Evaluation by Bin Wu, Jin Li, Houwen Lin, Haixiang Wu

“…Clinical data related to treatments were obtained from published randomized clinical trials. Direct medical costs and resource utilization in the Chinese health care setting were taken into account. …”
Get full text

Beneficial Effects of Palmitoylethanolamide on Expressive Language, Cognition, and Behaviors in Autism: A Report of Two Cases by Nicola Antonucci, Alessandra Cirillo, Dario Siniscalco

“…We propose appropriate double-blind clinical trials to further explore palmitoylethanolamide efficacy and safety.…”
Get full text

Dual anti-CTLA-4 and anti-PD-1 blockade in metastatic basal cell carcinoma by Sandip P. Patel, Eleanor Cano-Linson, Young Kwang Chae, Shiruyeh Schokrpur, Christopher D. Lao, Benjamin C. Powers, Adrienne I. Victor, Adedayo A. Onitilo, Sarah Shin, Naoko Takebe, Sara Threlkel, Christine M. McLeod, Helen X. Chen, Elad Sharon, Megan Othus, Christopher W. Ryan, Charles D. Blanke, Razelle Kurzrock

“…In patients with advanced/metastatic BCC, ipilimumab and nivolumab produced an ORR of 31% and prolonged (>6 months) PFS in 73% of patients, with seven PFS/iPFS of >1 year, including one with prior anti-PD-1. ClinicalTrials.gov ID: NCT02834013 (Registered 7/15/2016; https://clinicaltrials.gov/ct2/show/NCT02834013 ).…”
Get full text

The Evolution of Dendritic Cell Immunotherapy against HIV-1 Infection: Improvements and Outlook by Hager Mohamed, Vandana Miller, Stephen R. Jennings, Brian Wigdahl, Fred C. Krebs

“…The advancements in dendritic cell vaccines in cancers have paved the way for applications of this form of immunotherapy to HIV-1 infection. Clinical trials with patients infected with HIV-1 who are well-suppressed by antiretroviral therapy (ART) were recently performed to assess the efficacy of DC vaccines, with the goal of mounting an HIV-1 antigen-specific T-cell response, ideally to clear infection and eliminate the need for long-term ART. …”
Get full text

The Effects of Noncompliance to Prolia (Denosumab) on the Changes in Bone Mineral Density: A Retrospective Review by Matthew Wong-Pack, Aashish Kalani, Jacob Hordyk, George Ioannidis, Robert Bensen, William G. Bensen, Alexandra Papaioannou, Jonathan D. Adachi, Arthur N. Lau

“…Although denosumab (Prolia) has been shown to be a safe and efficacious therapy for osteoporotic patients in numerous clinical trials, few studies have determined its effectiveness in real world clinical practice. …”
Get full text

Neuroplastic Effects of Combined Computerized Physical and Cognitive Training in Elderly Individuals at Risk for Dementia: An eLORETA Controlled Study on Resting States by Charis Styliadis, Panagiotis Kartsidis, Evangelos Paraskevopoulos, Andreas A. Ioannides, Panagiotis D. Bamidis

“…This trial is registered with ClinicalTrials.gov Identifier NCT02313935.…”
Get full text

Pancreatic Perivascular Epithelial Cell Tumor (PEComa) with Liver Metastasis: a Case Report and Literature Review by Yu. A. Stepanova, Kh. A. Ayvazyan, D. V. Kalinin, O. I. Zhavoronkova, V. S. Shirokov, A. V. Zhao

“…To determine clearer criteria for the diagnosis and differential diagnosis of PEComa, to identify criteria for the malignancy of these tumors, to develop treatment tactics and further dynamic monitoring, a set of statistical data of significant group and randomized clinical trials are needed. Pancreatic PEComas in this group are extremely rare and often have a benign course. …”
Get full text