The Intersection of Epigenetics and Senolytics in Mechanisms of Aging and Therapeutic Approaches by Daiana Burdusel, Thorsten R. Doeppner, Roxana Surugiu, Dirk M. Hermann, Denissa Greta Olaru, Aurel Popa-Wagner

“…This narrative review underscores the need for continued research into the molecular mechanisms underlying these interactions and suggests future directions for therapeutic development, including clinical trials, biomarker discovery, and combination therapies that synergistically target aging processes.…”
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Minimally Invasive Technique for PMMA Augmentation of Fenestrated Screws by Jan-Helge Klingler, Christoph Scholz, Evangelos Kogias, Ronen Sircar, Marie T. Krüger, Florian Volz, Christian Scheiwe, Ulrich Hubbe

“…This trial is registered with German Clinical Trials DRKS00006726.…”
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68Ga-NOTA-RM26 PET/CT in the evaluation of glioma: a pilot prospective study by Yilin Li, Rongxi Wang, Jingci Chen, Zhaohui Zhu, Yu Wang, Wenbin Ma

“…Trial registration ClinicalTrials.gov: NCT06412952. Registered 26 April 2024, https://clinicaltrials.gov/study/NCT06412952…”
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Circulating Cytokines and Growth Factors in Pediatric Pulmonary Hypertension by Mark Duncan, Brandie D. Wagner, Keri Murray, Jenna Allen, Kelley Colvin, Frank J. Accurso, D. Dunbar Ivy

“…If confirmed in additional cohorts, measurement of these proteins could aid patient care and design of clinical trials by identifying patients at risk for adverse events. …”
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Efficacy of non-invasive ventilation and oxygen therapy on immunocompromised patients with acute hypoxaemic respiratory failure: protocol for a systematic review and meta-analysis... by Juhong Shi, Gang Liu, Meng Wang, Tao Wang, Yi Li, Yi Yang, Xuezhong Yu, Huadong Zhu, Yong Ma, Zongru Li, Lixi Zhang, Kun He, Jianqiang He

“…The use of non-invasive ventilation (NIV) or oxygen therapy among these patients remains controversial, according to the inconsistent results of several randomised clinical trials (RCTs). This meta-analysis aims to evaluate whether NIV or oxygen therapy is the more appropriate initial oxygenation strategy for the immunocompromised patients with acute respiratory failure.Method We will search all the RCTs that compared the efficacy of NIV and oxygen therapy on immunocompromised adult patients with acute hypoxaemic respiratory failure on the major databases (Cochrane Library, MEDLINE, EMBASE, Web of Science and others), conference proceedings and grey literature. …”
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The Impact of Antibiotics on the Development of Colorectal Cancer – A Review of Current Insights and Directions for Future Research by Karol Zagórski, Mateusz Kozik, Nina Skalska-Dziobek, Weronika Małagocka, Karolina Chybowska, Maria Naruszewicz, Przemysław Cetnarowski

“…Systematic reviews, meta-analyses, clinical trials and observational studies were included if they were relevant and provided data on the influence of antibiotics on CRC.   …”
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BEST PROSTHESIS FOR UNICOMPARTMENTAL KNEE ARTHROSIS: FIXED OR MOBILE? by Fabrício Luz Cardoso, Deusimar Cristian dos Santos Gomez, Fabrício Roberto Severino, Patrícia Maria Moraes de Barros de Fucs

“…A systematic keyword search was executed in the PubMed, EMBASE, and Cochrane databases, employing a filter for randomized clinical trials and without language limitations. The search yielded 113 articles from March 28, 2024, including 83 from PubMed, 12 from EMBASE, and 18 from the Cochrane Library. …”
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The Role of Adipose-Derived Stem Cells in Breast Cancer Progression and Metastasis by Riccardo Schweizer, Wakako Tsuji, Vijay S. Gorantla, Kacey G. Marra, J. Peter Rubin, Jan A. Plock

“…A trend towards potential promotion of both breast cancer growth and invasion by ADSCs found in basic science studies was indeed not confirmed in clinical trials. Whether experimental findings eventually correlate with or will be predictive of clinical outcomes remains unclear. …”
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Caffeine as an Active Molecule in Cosmetic Products for Hair Loss: Its Mechanisms of Action in the Context of Hair Physiology and Pathology by Ewelina Szendzielorz, Radoslaw Spiewak

“…Nevertheless, the metabolic activity of caffeine and its ability to enter and accumulate in the hair follicles combined with the results of available clinical trials seem to indicate that caffeine could indeed prove as an effective and safe option in the management of hair loss.…”
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Continuous Inhibition of Sonic Hedgehog Signaling Leads to Differentiation of Human-Induced Pluripotent Stem Cells into Functional Insulin-Producing β Cells by Song Lee, Jae Hyun Joo, Ju Yun Oh, Eun Ha Seo, Yang Hee Kim, Eunsung Jun, In Kyong Shim, Song Cheol Kim

“…We posit that this method along with further refinement of the differentiation process can be applied to culture IPCs that can be used in clinical trials.…”
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Exploring the application of dietary antioxidant index for disease risk assessment: a comprehensive review by Hossein Pourmontaseri, Sina Bazmi, Matin Sepehrinia, Matin Sepehrinia, Ayda Mostafavi, Reza Arefnezhad, Reza Arefnezhad, Reza Homayounfar, Farhad Vahid

“…However, further prospective observations and clinical trials are warranted to confirm the application of DAI in preventing diseases that have been studied.…”
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Parenterally Administered Norovirus GII.4 Virus-Like Particle Vaccine Formulated with Aluminum Hydroxide or Monophosphoryl Lipid A Adjuvants Induces Systemic but Not Mucosal Immune... by Suvi Heinimäki, Maria Malm, Timo Vesikari, Vesna Blazevic

“…NoV vaccine candidates currently in clinical trials are based on noninfectious highly immunogenic virus-like particles (VLPs) delivered intramuscularly (IM). …”
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The Potential of Virtual Reality for Inducing Neuroplasticity in Children with Amblyopia by María B. Coco-Martin, David P. Piñero, Luis Leal-Vega, Carlos J. Hernández-Rodríguez, Joaquin Adiego, Ainhoa Molina-Martín, Dolores de Fez, Juan F. Arenillas

“…More studies are needed to confirm these promising therapies in controlled randomized clinical trials, with special emphasis on the definition of the most adequate planning for obtaining an effective recovery of the visual and binocular function.…”
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The Role of Coenzyme Q10 in Modern Medicine: Insights into Energy Metabolism and Antioxidant Therapy by Mateusz Górski, Adrianna Załęska, Mateusz Bychowski, Julia Kwaśna, Izabela Kaźmierczyk, Kacper Lenart, Michał Homza, Natalia Zakrzewska, Szymon Bednarek, Joanna Kulicka

“…Methods: This review synthesized findings from clinical trials, meta-analyses, and observational studies. …”
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Determining the Feasibility of Ambulance-Based Randomised Controlled Trials in Patients with Ultra-Acute Stroke: Study Protocol for the “Rapid Intervention with GTN in Hypertensive... by Sandeep Ankolekar, Gillian Sare, Chamila Geeganage, Michael Fuller, Lynn Stokes, Nikola Sprigg, Ruth Parry, A. Niroshan Siriwardena, Philip M. W. Bath

“…Time from acute stroke to enrolment in clinical trials needs to be reduced to improve the chances of finding effective treatments. …”
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The effect of azithromycin treatment on respiratory morbidity in children with down syndrome by Inbal Golan-Tripto, Omer Dor, Noga Arwas, Itai Hazan, Guy Hazan, Aviv Goldbart

“…Conclusion The significant reduction in respiratory LOS suggests the potential benefits of Azithromycin in children with DS, and emphasizes the need for larger clinical trials to determine optimal use and long-term effects in this vulnerable population.…”
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Systematic and comprehensive insights into HIF-1 stabilization under normoxic conditions: implications for cellular adaptation and therapeutic strategies in cancer by Jiayi Zhang, Mingxuan Yao, Shiting Xia, Fancai Zeng, Qiuyu Liu

“…An overview of HIF-1-related drugs that are approved or in clinical trials is summarized, highlighting their potential capacity for targeting HIF-1 in cancer and cardiovascular toxicity related to cancer treatment. …”
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Evaluation of Faecal Microbiota Following Probiotics in Infants of Mothers with Gestational Diabetes Mellitus Trial: Protocol for Double-Blind Placebo-Controlled Randomized Trial by Gayatri Athalye-Jape, Chandra Prakash Rath, Harshad Panchal, Archita Mishra, Dorothy Graham, Sanjay Patole

“…The secondary outcomes will include the quantification of faecal short-chain fatty acids at birth and at four months, as well as growth and developmental assessments at four, twelve, and twenty-four months. (3) Trial registration: This trial protocol is registered (ACTRN12624000930583p) in the Australian Clinical Trials registry (ANZCTR).…”
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Adjuvant Hormonal Therapy in Postmenopausal Women with Breast Cancer: Physician’s Choices by Asim Jamal Shaikh, Shiyam Kumar, Sajjad Raza, Maria Mehboob, Osama Ishtiaq

“…Physicians show disagreement over the choice and duration of hormonal therapy in this patient population. Clinical trials leading to firm recommendations to set standards from which patients benefit the most are needed.…”
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Tirosin Kinase Inhibitors in Chronic Graft versus Host Disease: From Bench to Bedside by Jacopo Olivieri, Sabrina Coluzzi, Imma Attolico, Attilio Olivieri

“…While the exact mechanisms leading to such efficacy are still under investigation, use of TKIs in the context of clinical trials should be promoted, aiming to evaluate the biological changes induced in vivo by TKIs and to assess the long term outcome of these patients. …”
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