Riboflavin- and Hypericin-Mediated Antimicrobial Photodynamic Therapy as Alternative Treatments for Oral Candidiasis: A Systematic Review by Maciej Łopaciński, Jakub Fiegler-Rudol, Wojciech Niemczyk, Dariusz Skaba, Rafał Wiench

“…<b>Conclusions</b>: Riboflavin- and hypericin-mediated aPDT present promising, biocompatible alternatives for managing antifungal resistance in Candida infections. Further clinical trials and standardized protocols are essential to optimize outcomes and confirm efficacy in broader clinical settings.…”
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Adipose-Derived Cells (Stromal Vascular Fraction) Transplanted for Orthopedical or Neurological Purposes: Are They Safe Enough? by Katarzyna Siennicka, Aleksandra Zolocinska, Karolina Stepien, Natalia Lubina-Dabrowska, Marzena Maciagowska, Ewa Zolocinska, Anna Slysz, Renata Piusinska-Macoch, Slawomir Mazur, Urszula Zdanowicz, Robert Smigielski, Adam Stepien, Zygmunt Pojda

“…Although mesenchymal stem cells are used in numerous clinical trials, the safety of their application is still a matter of concern. …”
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Assessment of smartphone-based active distraction in association with audioanalgesia for overcoming airotor-related anxiety in children: a randomized controlled trial by Kritika Bali, Radhika Ailawadi, Y. M. Karuna, N. Srikant, Ashwin Rao, P. Anupama Nayak, Charisma Thimmaiah

“…Trial Registration Registered in the Clinical Trials Registry India (CTRI/2024/07/070160) dated 08/07/2024.…”
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<i>Cordyceps militaris</i>-Derived Bioactive Gels: Therapeutic and Anti-Aging Applications in Dermatology by Trung Quang Nguyen, Thinh Van Pham, Yusuf Andriana, Minh Ngoc Truong

“…Emphasis is placed on the necessity of clinical trials and standardization to establish the safety, efficacy, and reproducibility of such applications. …”
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Calpain 2 regulates IL-1α secretion and inhibits tumor development via modulating calpain 1 expression in the tumor microenvironment by Zuhairah Binte Hanafi, Yu Mei, Huey Yee Teo, Ying Zhu, Chew Chin Yong Lionel, Jing Wen Chiu, Jinhua Lu, Haiyan Liu

“…Tumor-promoting inflammation significantly impacts cancer progression, and targeting inflammatory cytokines has emerged as a promising therapeutic approach in clinical trials. Interleukin (IL)-1α, a member of the IL-1 cytokine family, plays a crucial role in both inflammation and carcinogenesis. …”
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Ferric Carboxymaltose as Treatment in Women with Iron-Deficiency Anemia by Melvin H. Seid, Angelia D. Butcher, Ashwin Chatwani

“…This trial is registered with ClinicalTrials.gov, NCT00548860.…”
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Practical Recommendations of Scientific Society for the Study of Human Microbiome and the Russian Gastroenterological Association on Use of Probiotics, Prebiotics, Synbiotics and F... by V. T. Ivashkin, I. V. Maev, D. I. Abdulganieva, S. A. Alekseenko, A. V. Gorelov, I. N. Zakharova, O. Yu. Zolnikova, N. Yu. Ivashkina, N. V. Korochanskaya, S. N. Mammayev, E. A. Poluektova, A. S. Trukhmanov, D. V. Usenko, Yu. P. Uspensky, V. V. Tsukanov, O. S. Shifrin, I. V. Berezhnaya, K. V. Ivashkin, T. L. Lapina, R. V. Maslennikov, S. V. Nikolaeva, N. G. Sugyan, A. I. Ulyanin

“…The clinical efficacy of probiotics, prebiotics, synbiotics and fortified functional foods depends on the prebiotic and strain properties and is verified in appropriate comparative clinical trials. Not all probiotics registered in Russia as BAFAs, drugs and FFPs have a strain identity, which provides no warranty of the clinical effect expected. …”
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Case report: Near-complete response to neratinib-based treatment in HR-positive HER2-amplified metastatic breast cancer refractory to trastuzumab deruxtecan by Ünal Metin Tokat, Ashkan Adibi, Ashkan Adibi, Esranur Aydın, Şevval Nur Bilgiç, Eylül Özgü, Onur Tutar, Mutlu Demiray

“…Furthermore, we demonstrated that triplet combination could induce a remarkable response in the T-DXd–refractory setting, which could be explored in future clinical trials in HR+ and HER2-activated (by RNA or protein overexpression, amplification, and mutation) patients. …”
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Feasibility and Efficacy of S-Adenosyl-L-methionine in Patients with HBV-Related HCC with Different BCLC Stages by Tao Guo, Yukun He, Weijie Ma, Zhisu Liu, Quanyan Liu

“…And the efficacy of SAMe therapy should be further explored in randomized prospective clinical trials.…”
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Fibronectin and Cyclic Strain Improve Cardiac Progenitor Cell Regenerative Potential In Vitro by Kristin M. French, Joshua T. Maxwell, Srishti Bhutani, Shohini Ghosh-Choudhary, Marcos J. Fierro, Todd D. Johnson, Karen L. Christman, W. Robert Taylor, Michael E. Davis

“…Cardiac progenitor cells (CPCs) have rapidly advanced to clinical trials, yet little is known regarding their interaction with the microenvironment. …”
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The Effects of Baclofen for the Treatment of Gastroesophageal Reflux Disease: A Meta-Analysis of Randomized Controlled Trials by Shujie Li, Shengying Shi, Feng Chen, Jingming Lin

“…We systematically searched randomized controlled trials published prior to November 2013 from PubMed, Medline, Embase, ScienceDirect, ClinicalTrials.gov, and the Cochrane Central Register of Randomized Controlled Trials. …”
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Effect of amniotic fluid on hair follicle growth by Gamze Tumentemur, Elif Ganime Aygun, Bulut Yurtsever, Didem Cakirsoy, Ercument Ovali

“…These findings support further evaluation of hAF in clinical trials to validate its potential for hair regeneration therapies.…”
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Acute Toxicity and Neuroprotective Effect of “RJ6601”, a Newly Formulated Instant Soup, in Geriatric Rats by Rujikarn Chaisanam, Jintanaporn Wattanathorn

“…Subchronic toxicity studies and clinical trials are essential to confirm the safety of RJ6601 consumption and its health benefits.…”
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Effect of Isosporiasis Prevention with Toltrazuril on Long-Term Pig Performance by K. Rypula, M. Porowski, J. Kaba, M. Gorczykowski, A. Deniz

“…Animals from Group D were slaughtered 5 days earlier than animals from Group K (day 166 versus day 171). Data from clinical trials suggest treatment of coccidiosis with toltrazuril offering potential for improved animal welfare and yields, however this has remained unproven in field conditions in large swine production facilities. …”
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The Clinical Application and Progress of Mirogabalin on Neuropathic Pain as a Novel Selective Gabapentinoids by Hui Tang, Jing Lu, Yazhuo Duan, Dejun Li

“…Our review was aimed at encompassing the bulk of clinical research on mirogabalin, which included clinical trials, special considerations, coadministration studies, case reports, and cost-effectiveness studies. …”
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The Impact of Creatine Supplementation on Physical Performance, Cognitive Functions, and Safety – A Literature Review by Adam Sobiński, Matylda Czerwonka, Zuzanna Kościuszko, Katarzyna Kurza, Silvia Ciraolo, Julianna Podolec, Agnieszka Kulczycka-Rowicka, Katarzyna Lesiczka-Fedoryj, Joanna Wojda, Anna Walczak

“…Research Materials and Methods: The study is based on clinical trials, meta-analyses, and systematic reviews from the past decade. …”
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Photobiomodulation Therapy for Neurosensory Disturbances in Orthognathic Surgery Patients: A Systematic Review by Aneta Olszewska, Mateusz Wolny, Julia Kensy, Agnieszka Kotela, Agata Czajka-Jakubowska, Jacek Matys

“…However, the development of standardized treatment protocols and the conduct of larger-scale clinical trials are essential to optimize their clinical application.…”
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Protocol for a Randomized Hybrid Type 2 Trial on the Implementation of Group Problem Management Plus (PM+) for Venezuelan Women Refugees and Migrants in Colombia by Manaswi Sangraula, M. Claire Greene, Diany Castellar, Jean Carlos Flechas de la Hoz, Jennifer Diaz, Valeria Merino, Lucy Miller-Suchet, Maria Cristobal, Ana Maria Chamorro Coneo, Luisa Morales, Marcela Venegas, Abel Guerrero Gonzalez, Marilyn DeLuca, Miguel Uribe, Sara A. Romero, Monica Ferrer, Leslie Snider, Lisa A. Marsch, Zelde Espinel, James M. Shultz, Peter Ventevogel, Brandon A. Kohrt, Camilo Ramirez, Annie Bonz, Ana Maria Trejos Herrera, Adam D. Brown

“…Trials Registry: ClinicalTrials.gov identifier: NCT05477355…”
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A Randomised Controlled Trial of Efficacy of Cognitive Rehabilitation in Multiple Sclerosis: A Cognitive, Behavioural, and MRI Study by J. Campbell, D. Langdon, M. Cercignani, W. Rashid

“…This study supports the hypothesis that home-based, computerised, cognitive rehabilitation may be effective in improving cognitive performance in patients with MS. Clinical trials registration is ISRCTN54901925.…”
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Cryotherapy for Primary Treatment of Prostate Cancer: Intermediate Term Results of a Prospective Study from a Single Institution by S. Alvarez Rodríguez, F. Arias Fúnez, C. Bueno Bravo, R. Rodríguez-Patrón Rodríguez, E. Sanz Mayayo, V. Hevia Palacios, F. J. Burgos Revilla

“…Published data about cryotherapy for prostate cancer (PC) treatment are based on case series with a lack of clinical trials and the inexistence of a validated definition of biochemical failure. …”
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