Exploring TNFR1: from discovery to targeted therapy development by Yingying Li, Ruiwei Ye, Haorui Dai, Jiayi Lin, Yue Cheng, Yonghong Zhou, Yiming Lu

“…This review emphasizes the emerging field of targeted therapies aimed at selectively modulating TNFR1 activity, identifying promising therapeutic strategies that exploit TNFR1 as a drug target through an evaluation of current clinical trials and preclinical studies. In conclusion, this study contributes novel insights into the biological functions of TNFR1 and presents potential therapeutic strategies for clinical application, thereby having substantial scientific and clinical significance.…”
Get full text

Therapies for Mitochondrial Disorders by Kayli Sousa Smyth, Anne Mulvihill

“…Obstacles towards discovering effective therapies include the rarity of MTDS, its pathogenic complexity and lack of clinical trials. Despite the lack of current curative therapies for MTDS, emerging therapies promise exciting and clinically meaningful therapies in the future.…”
Get full text

Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA): A Targeted Antioxidant Strategy to Counter Oxidative Stress in Retinopathy by Marco Zeppieri, Caterina Gagliano, Fabiana D’Esposito, Mutali Musa, Irene Gattazzo, Maria Sole Zanella, Federico Bernardo Rossi, Alessandro Galan, Silvia Babighian

“…Several studies have shown that a higher intake of omega-3 fatty acids is associated with a lower risk of developing diabetic retinopathy and age-related macular degeneration (AMD). Reviewing clinical trials and observational studies that support the protective role of omega-3s in retinal disorders is essential. …”
Get full text

Infliximab Dose Reduction Sustains the Clinical Treatment Effect in Active HLAB27 Positive Ankylosing Spondylitis: A Two-Year Pilot Study by Boel Mörck, Rille Pullerits, Mats Geijer, Tomas Bremell, Helena Forsblad-d'Elia

“…This trial is registered with ClinicalTrials.gov NCT01850121.…”
Get full text

Is Thymoglobulin or Rituximab the Cause of This Serum Sickness? A Case Report of Serum Sickness Dilemma and Literature Review by Amarpreet Sandhu, Antonia Harford, Pooja Singh, Eduardo Alas

“…There are not any evidence-based guidelines or published clinical trials to help guide therapy for antibody-induced serum sickness; however, we successfully treated our case with three doses of Methylprednisone 500 mg intravenously. …”
Get full text

Oral Administration of Lactobacillus plantarum 299v Reduces Cortisol Levels in Human Saliva during Examination Induced Stress: A Randomized, Double-Blind Controlled Trial by Hannah Andersson, Cecilia Tullberg, Siv Ahrné, Kristina Hamberg, Irini Lazou Ahrén, Göran Molin, Mikael Sonesson, Åsa Håkansson

“…The registration number of the study is NCT02974894, and the study is registered at ClinicalTrials.gov.…”
Get full text

Traditional Uses, Bioactive Compounds, and Pharmacological Investigations of Calendula arvensis L.: A Comprehensive Review by Aya Khouchlaa, Aicha El Baaboua, Hamza El Moudden, Fatima Lakhdar, Saad Bakrim, Naoual El Menyiy, Omar Belmehdi, Hicham Harhar, Nasreddine El Omari, Abdelaali Balahbib, Moon Nyeo Park, Gokhan Zengin, Bonglee Kim, Abdelhakim Bouyahya

“…Nevertheless, pharmacokinetic validation and toxicological examinations are required to detect any possible toxicity for future clinical trials.…”
Get full text

Disease-Specific Target Gene Expression Profiling of Molecular Imaging Probes: Database Development and Clinical Validation by Lawrence Wing-Chi Chan, Connie Hiu-Ching Ngo, Fengfeng Wang, Moss Y. Zhao, Mengying Zhao, Helen Ka-Wai Law, Sze Chuen Cesar Wong, Benjamin Yat-Ming Yung

“…Validated with the in vitro study, the expression profiles of disease-associated targets can indicate the eligibility of patients for clinical trials of the treatment probe. A Web search tool of the DIPP database is available at http://www.polyu.edu.hk/bmi/dipp/ .…”
Get full text

Current AAV-mediated gene therapy in sensorineural hearing loss by Jieyu Qi, Xiaolong Fu, Liyan Zhang, Fangzhi Tan, Nianci Li, Qiuhan Sun, Xiaojie Hu, Zuhong He, Ming Xia, Renjie Chai

“…It is currently possible to regenerate hair cells to treat sensorineural hearing loss by FX-322, a small molecule drug in clinical trials. With the development of genetic engineering technology, gene therapy has brought a promising treatment strategy for many previously intractable diseases. …”
Get full text

Advances in the Study of Bioactive Compounds and Nutraceutical Properties of Goji Berry (<i>Lycium barbarum</i> L.) by Xin Shi, Xiaojing Wang, Yuhong Zheng, Li Fu

“…However, more human clinical trials are needed to confirm these findings. …”
Get full text

Dentin-derived alveolar bone graft for alveolar augmentation: A systematic review by Dedy Agoes Mahendra, Kavanila Bilbalqish, Alexander Patera Nugraha, Arief Cahyanto, Kaushik Sengupta, Kamal Hanna, Asti Meizarini, Ninuk Hariyani

“…The review included both randomized controlled trials (RCT), pilot studies, clinical trials, and retrospective studies reporting on dentin-derived ABG use for alveolar augmentation. …”
Get full text

Liquid biopsy in cancer management: Integrating diagnostics and clinical applications by Shashwat Pandey, Preeti Yadav

“…Further research, clinical trials, and regulatory harmonization will be vital in realizing its full potential in precision cancer care.…”
Get full text

First-Line Helicobacter pylori Eradication with Vonoprazan, Clarithromycin, and Metronidazole in Patients Allergic to Penicillin by Soichiro Sue, Nobumi Suzuki, Wataru Shibata, Tomohiko Sasaki, Hiroaki Yamada, Hiroaki Kaneko, Toshihide Tamura, Tomohiro Ishii, Masaaki Kondo, Shin Maeda

“…This study was registered in the UMIN Clinical Trials Registry as UMIN000016335.…”
Get full text

Direct-Acting Oral Anticoagulants in the Management of Cerebral Venous Sinus Thrombosis—Where Do We Stand? by Nikhil Vojjala, Supriya Peshin, Lakshmi Prasanna Vaishnavi Kattamuri, Rabia Iqbal, Adit Dharia, Jayalekshmi Jayakumar, Rafi Iftekhar, Shagun Singh, Mamtha Balla, Claudia S. Villa Celi, Ramya Ramachandran, Rishab Prabhu, Sumeet K. Yadav, Geetha Krishnamoorthy, Vijendra Singh, Karan Seegobin

“…Ongoing multicentric clinical trials are currently reviewing the role of these agents in both short-term as well as long-term. …”
Get full text

Therapeutic Effects of Milk Thistle (Silybum marianum L.) and Artichoke (Cynara scolymus L.) on Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Rats by Aida Doostkam, Mohammad Fathalipour, Mohammad Hossein Anbardar, Azar Purkhosrow, Hossein Mirkhani

“…Nonetheless, long-term randomized clinical trials are necessary to confirm the observed results.…”
Get full text

New Treatments for Bacterial Keratitis by Raymond L. M. Wong, R. A. Gangwani, Lester W. H. Yu, Jimmy S. M. Lai

“…In vitro studies and prospective clinical trials have shown that fourth-generation fluoroquinolones are better than the older generation fluoroquinolones and are as potent as combined fortified antibiotics against common pathogens that cause bacterial keratitis. …”
Get full text

Understanding the role of the gut microbiome in solid tumor responses to immune checkpoint inhibitors for personalized therapeutic strategies: a review by Mi Young Lim, Seungpyo Hong, Young-Do Nam

“…Moreover, we review studies investigating the possibility of patient outcome prediction using machine learning models based on gut microbiome data before starting ICI therapy and clinical trials exploring whether gut microbiota modulation, for example via fecal microbiota transplantation or live biotherapeutic products, can improve results of ICI therapy in patients with cancer. …”
Get full text

Advances and Challenges in the Research of Integration Methods of Animal Experimental Evidence by ZHENG Qingyong, LI Tengfei, XU Jianguo, ZHOU Yongjia, MA Zhichao, WANG Na, LI Molan, YANG Wenjing, WU Peirun, WANG Haidong, TIAN Jinhui

“…By continuously optimizing original experimental research protocols and evidence integration practices, this work aims to establish a more efficient and scientific environment for the synthesis of evidence from animal experiments, ultimately contributing to clinical trials and human health.…”
Get full text

Drug Repositioning for Gynecologic Tumors: A New Therapeutic Strategy for Cancer by Kouji Banno, Miho Iida, Megumi Yanokura, Haruko Irie, Kenta Masuda, Yusuke Kobayashi, Eiichiro Tominaga, Daisuke Aoki

“…Such drug discovery can be performed at low cost and in the short term based on the results of previous clinical trials. New drugs for gynecologic tumors may be found by drug repositioning. …”
Get full text

Extracellular matrix re-normalization to improve cold tumor penetration by oncolytic viruses by Geofrey F. Soko, Geofrey F. Soko, Benson K. Kosgei, Stephene S. Meena, Stephene S. Meena, Ying Jing Ng, Huihui Liang, Bing Zhang, Qingjun Liu, Tielong Xu, Xinju Hou, Xinju Hou, Ray P. S. Han

“…Additionally, we investigated current clinical trials and challenges associated with translating these strategies into clinical practice to improve patient outcomes.…”
Get full text