Riesgo de preeclampsia y suplementación de vitamina C y E: revisión sistemática y metanálisis by María Teresa Perdomo Rebaza, Víctor Juan Vera-Ponce, Jenny Raquel Torres-Malca, Jesús Enrique Talavera, Fiorella E. Zuzunaga-Montoya, Jhony A. De La Cruz-Vargas

“…Se realizó una búsqueda en las bases de datos pubmed/medline, SCOPUS, Web of Science, Cochrane Library, EMBASE, y Clinical Trials. El riesgo de sesgo de los ensayos clínicos aleatorios se evaluó mediante la herramienta Cochrane versión 2. …”
Get full text

Hyperuricemia-induced complications: dysfunctional macrophages serve as a potential bridge by Wenyi Gu, Wenyi Gu, Jiajing Zhao, Yu Xu, Yu Xu, Yu Xu

“…In this review, we summarize the underlying mechanisms of hyperuricemia, focusing on the effects of macrophages, therapeutic approaches, and clinical trials addressing hyperuricemia-caused dysfunction. …”
Get full text

A single-site randomized controlled trial of partner navigation to HCV treatment for people who inject drugs: a study protocol for the You’re Empowered for Treatment Initiation (YE... by Meghan D. Morris, Judy Y. Tan, Claire C. McDonell, Maia Scarpetta, Tiffany N. Nguyen, Jennifer C. Price, Torsten B. Neilands

“…Trial registration ClinicalTrials.gov NCT06179498. Registered on December 22, 2023.…”
Get full text

A Feasibility Randomised Controlled Trial of the New Orleans Intervention for Infant Mental Health: A Study Protocol by Rachel Pritchett, Bridie Fitzpatrick, Nicholas Watson, Richard Cotmore, Philip Wilson, Graham Bryce, Julia Donaldson, Kathleen Boyd, Charles Zeanah, John Norrie, Julie Taylor, Julie Larrieu, Martina Messow, Matt Forde, Fiona Turner, Susan Irving, Helen Minnis

“…This trial is registered with ClinicalTrials.gov (NC01485510).…”
Get full text

The Stability-Indicating Ultra High-Performance Liquid Chromatography with Diode Array Detector and Tandem Mass Spectrometry Method Applied for the Forced Degradation Study of Ritl... by Jelena Kovačić, Daniela Amidžić Klarić, Nikša Turk, Željko Krznarić, Emma Riordan, Ana Mornar

“…Background/Objectives: Janus kinase inhibitors open new horizons for small-molecule drugs in treating inflammatory bowel disease, with ritlecitinib demonstrating significant efficacy in clinical trials for ulcerative colitis and Crohn’s disease. …”
Get full text

Gestational Weight Gain: Results from the Delta Healthy Sprouts Comparative Impact Trial by Jessica L. Thomson, Lisa M. Tussing-Humphreys, Melissa H. Goodman, Sarah E. Olender

“…This trial is registered with ClinicalTrials.gov NCT01746394, registered 4 December 2012.…”
Get full text

Patients with Acromegaly Presenting with Colon Cancer: A Case Series by Murray B. Gordon, Samer Nakhle, William H. Ludlam

“…We performed a retrospective analysis of the incidental diagnoses of colon cancer from the ACCESS trial (ClinicalTrials.gov identifier: NCT01995734). Colon cancer was identified in 2 patients (4.5%). …”
Get full text

Effect of intermittent urethral catheter clamping combined with active urination training (ICCAUT) strategy on postoperative urinary dysfunction after radical rectal cancer surgery... by Yuchen Guo, Quan Wang, Tingting He, Sen Liang, Yunan Guan, Jianan Sun, Haiyan Hu

“…All primary and secondary outcomes will be reported in peer-reviewed publications and at conference presentations.Trial registration number The trial was registered at ClinicalTrials.gov website, NCT06241703.…”
Get full text

Dual Inhibition of CDK4/6 and CDK7 Suppresses Triple‐Negative Breast Cancer Progression via Epigenetic Modulation of SREBP1‐Regulated Cholesterol Metabolism by Yilan Yang, Jiatao Liao, Zhe Pan, Jin Meng, Li Zhang, Wei Shi, Xiaofang Wang, Xiaomeng Zhang, Zhirui Zhou, Jurui Luo, Xingxing Chen, Zhaozhi Yang, Xin Mei, Jinli Ma, Zhen Zhang, Yi‐Zhou Jiang, Zhi‐Min Shao, Fei Xavier Chen, Xiaoli Yu, Xiaomao Guo

“…This suggests a new treatment approach for TNBC by simultaneously targeting CDK4/6 and CDK7, warranting additional clinical trials.…”
Get full text

PNPO‐Mediated Oxidation of DVL3 Promotes Multiple Myeloma Malignancy and Osteoclastogenesis by Activating the Wnt/β‐Catenin Pathway by Zhendong Deng, Shanliang Sun, Nian Zhou, Yumeng Peng, Long Cheng, Xichao Yu, Yuxia Yuan, Mengjie Guo, Min Xu, Yuexin Cheng, Fan Zhou, Nianguang Li, Ye Yang, Chunyan Gu

“…Eltrombopag inhibited the growth of MM cells and reduced bone lesions by disrupting the interaction between PNPO and DVL3, as supported by preliminary clinical trials. The study highlights the importance of PNPO as a high‐risk gene in the development of MM and suggests that Eltrombopag may be a promising treatment option.…”
Get full text

CRISPR-Cas9 in basic and translational aspects of cancer therapy by Maryam Samareh Salavatipour, Zahra Poursalehi, Negin Hosseini Rouzbahani, Sohaib Mohammadyar, Mohammad Vasei

“…Clinicaltrials.gov, a resource that provides access to information on clinical trials, was also searched in this review. Results: We have defined the basics of this technology and then mentioned some clinical and preclinical studies using this technology in the treatment of a variety of solid tumors as well as hematologic neoplasms. …”
Get full text

Regenerative Medicine for Neurological Disorders by Dong-Hyuk Park, David J. Eve, Yong-Gu Chung, Paul R. Sanberg

“…Finally, the National Institutes of Health guidelines for human stem cell research, clinical trials of commercialized stem cells without larger animal testing, and prohibition of medical tourism were big controversial issues that led to heated discussion.…”
Get full text

Antireflux mucosal valvuloplasty versus proton pump inhibitors for the treatment of patients with gastro-oesophageal reflux disease in a tertiary healthcare centre in China: study... by Xiaofen Lv, Yunqing Zeng, Wenlong Ma, Jiaoyang Lu

“…Study results will be disseminated through peer-reviewed journals and presented at scientific conferences.Trial registration number ClinicalTrials.gov (NCT 06348420).…”
Get full text

Development and application of a clinical core data set for deep brain stimulation in Parkinson’s disease, dystonia or tremor: from data collection to data exchange and data sharin... by Anna-Lena Hofmann, Jonas Widmann, Lilly Brandstetter, Udo Selig, Fabian Haug, Julian Haug, Rüdiger Pryss, Jasper Mecklenburg, Andrea Kreichgauer, Philipp Capetian, Christian J. Hartmann, Christian Niklas, Petra Ritter, Patricia Krause, Alfons Schnitzler, Jens Volkmann, Andrea A. Kühn, Peter Heuschmann, Kirsten Haas

“…Trial registration number ClinicalTrials.gov (DRKS-ID: DRKS00031878).…”
Get full text

Physical and cognitive-based training in healthy older adults: Evidence from a systematic review and meta-analysis by Fatemeh Adelirad, Zeinab Javadivala, Iman Dianat, Aysan Amrahi Tabieh, Vijay Kumar Chattu

“…Methods: For this systematic review and meta-analysis, randomized clinical trials (RCTs) published between 2000 and 6 February 2023 were extracted from several electronic databases, including, ProQuest, PubMed, Scopus, Embase, and Web of Science. …”
Get full text

<i>In Vitro</i> and <i>In Vivo</i> Interventions Reveal the Health Benefits of Levan-Type Exopolysaccharide Produced by a Fish Gut Isolate <i>Lactobacillus reuteri</i> FW2 by Waqar Ahmad, Anam Nasir, Satya Prakash, Azam Hayat, Mujaddad ur Rehman, Shazia Khaliq, Kalsoom Akhtar, Munir Ahmad Anwar, Nayla Munawar

“…It also signifies the need for a further detailed investigation based on clinical trials to include levan in dietary supplements for improved health and well-being.…”
Get full text

Integrated treatment of depression and moderate to severe alcohol use disorder in women shows promise in routine alcohol use disorder care – a pilot study by Anna Persson, Anna Persson, Daniel Wallhed Finn, Alice Broberg, Amanda Westerberg, Åsa Magnusson, Åsa Magnusson, Olof Molander

“…Negative effects were reported in terms of increased adverse emotional experiences.DiscussionThe investigated integrated treatment for co-occurring depression and alcohol use disorder continues to show promise. Randomized clinical trials are needed to evaluate its effectiveness.…”
Get full text

Association between Metformin Use and Cancer Stage at Diagnosis among Elderly Medicare Beneficiaries with Preexisting Type 2 Diabetes Mellitus and Incident Prostate Cancer by Amit D. Raval, Malcolm D. Mattes, Suresh Madhavan, Xiaoyun Pan, Wenhui Wei, Usha Sambamoorthi

“…This is the first epidemiological study to support the role of metformin in reducing the risk of advanced prostate cancer. Randomized clinical trials are needed to confirm the causal link between metformin use and prostate cancer diagnosis stage.…”
Get full text

Meta-Analysis and Evidence Base for the Efficacy of Autologous Bone Marrow Mesenchymal Stem Cells in Knee Cartilage Repair: Methodological Guidelines and Quality Assessment by Mohamed E. Awad, Khaled A. Hussein, Inas Helwa, Mohamed F. Abdelsamid, Alexandra Aguilar-Perez, Ibrahim Mohsen, Monte Hunter, Mark W. Hamrick, Carlos M. Isales, Mohammed Elsalanty, William D. Hill, Sadanand Fulzele

“…The aim of this study is to review all the published clinical trials on autologous bone marrow mesenchymal stem cells (BM-MSCs) in the repair of cartilage lesions of the knee. …”
Get full text

Exploring the Pharmacological Potential of Carrageenan Disaccharides as Antitumor Agents: An In Silico Approach by Ohana Leticia Tavares Silva, Monique Gabriela das Chagas Faustino Alves, Hugo Alexandre Oliveira Rocha

“…These findings offer new insights into the pharmacological properties and mechanisms of action of carrageenan-derived disaccharides, highlighting their potential for further exploration in clinical trials and experimental studies.…”
Get full text