The Role of Pentacyclic Triterpenoids in Non-Small Cell Lung Cancer: The Mechanisms of Action and Therapeutic Potential by Young-Shin Lee, Ryuk Jun Kwon, Hye Sun Lee, Jae Heun Chung, Yun Seong Kim, Han-Sol Jeong, Su-Jung Park, Seung Yeon Lee, Taehwa Kim, Seong Hoon Yoon

“…However, despite promising preclinical data, rigorous clinical trials are needed to verify their safety and efficacy. …”
Get full text

Selection of In Vivo Relevant Dissolution Test Parameters for the Development of Cannabidiol Formulations with Enhanced Oral Bioavailability by Nathan Koch, Quentin Bourcy, Olivier Jennotte, Patrice Chiap, Anna Lechanteur, Jean-Michel Cardot, Brigitte Evrard

“…<b>Background:</b> Cannabidiol (CBD) shows interesting therapeutic properties but has yet to demonstrate its full potential in clinical trials partly due to its low solubility in physiologic media. …”
Get full text

Health Status Measurement Instruments in Chronic Obstructive Pulmonary Disease by Yves Lacasse, Eric Wong, Gordon Guyatt, Roger S Goldstein

“…Generic questionnaires should not be used alone in clinical trials as evaluative instruments because of their inability to detect change over time. …”
Get full text

Bioactive molecules from soybeans (Glycine max) with anti-type 2 diabetes activity: a systematic review by Adekunle Babajide Rowaiye, Lorretha Chinonye Emenyonu, Ezinne Janefrances Nwonu, Okiemute Ajiroghene Okpalefe, Joseph Akwoba Ogugua, Victor Oluwatoyin Akinseye, Gordon Chukwuma Ibeanu

“…Both in vivo and in vitro experiments, and human clinical trials have proven a marked efficacy of these bioactive molecules in suppressing the key enzyme biomarkers that modulate T2D pathogenesis. …”
Get full text

How effective is undergraduate palliative care teaching for medical students? A systematic literature review by Jason W Boland, Jane Gibbins, Megan E L Brown, Gabrielle M Finn, Angelique Duenas

“…Screening, data extraction and quality assessment (mixed methods and Cochrane risk of bias tool) were performed in duplicate.Data sources Embase, MEDLINE, PsycINFO, Web of Science, ClinicalTrials.gov, Cochrane and grey literature in August 2019. …”
Get full text

Anti-Inflammatory and Antimicrobial Actions of Vitamin D in Combating TB/HIV by Anna K. Coussens, Adrian R. Martineau, Robert J. Wilkinson

“…Adjunct vitamin D therapy during treatment of active TB may therefore reduce lung pathology and TB morbidity, accelerate resolution of cavitation and thereby decrease the chance of transmission, improve lung function following therapy, prevent relapse, and prevent IRIS in those initiating ARVs. Future clinical trials of vitamin D for TB prevention and treatment must be designed to detect the most appropriate primary endpoint, which in some cases should be anti-inflammatory and not antimicrobial.…”
Get full text

The Nrf-2/HO-1 Signaling Axis: A Ray of Hope in Cardiovascular Diseases by Xueyan Zhang, Yihan Yu, Hanyu Lei, Yufeng Cai, Jie Shen, Ping Zhu, Qingnan He, Mingyi Zhao

“…Research has demonstrated the clinical application of Nrf2/HO-1 in pediatric cardiovascular disease; further clinical trials will help elucidate the potential of the Nrf2/HO-1 signaling axis.…”
Get full text

Nanoparticle Therapy Is a Promising Approach in the Management and Prevention of Many Diseases: Does It Help in Curing Alzheimer Disease? by Lamyaa M. Kassem, Nada A. Ibrahim, S. Ayesha Farhana

“…Neurotrophic factors when integrated with the nanotechnological approaches can pass the BBB merely, representing a significant challenging track. Clinical trials proved that levodopa nanoparticles cause little motor complications which is a considerable drawback in treating Parkinson’s disease with levodopa. …”
Get full text

Suhexiang pill for acute ischemic stroke in real-world practice setting (SUNRISE): protocol of a multicenter registry by Xinxing Lai, Xuejiao Xiong, Qi Jia, Tingting Liu, Zhaowen Yang, Chi Zhang, Lingbo Kong, Kegang Cao, Ting Dong, Caixia Fang, Jianwen Ge, Li Dong, Zhitao Zong, Sisi Chen, Yuhong Ma, Xue Bai, Dahua Wu, Yao Xie, Mingyan Zhang, Yilong Wang, Guohui Jiang, Daqiao Song, Yanping Wang, Chunyan Gui, Qingwen Geng, Ying Gao, for the SUNRISE study investigators

“…Study registration This study was registered with the ClinicalTrials.gov (URL: https://clinicaltrials.gov/ , Unique identifier: NCT05833932).…”
Get full text

Semantic Modeling for SNPs Associated with Ethnic Disparities in HapMap Samples by HyoYoung Kim, Won Gi Yoo, Junhyung Park, Heebal Kim, Byeong-Chul Kang

“…Entities for the network represented by "Gene," "Pathway," "Disease," "Chemical," "Drug," "ClinicalTrials," "SNP," and relationships between entity-entity were obtained through curation. …”
Get full text

Microbiological Effect of Essential Oils in Combination with Subgingival Ultrasonic Instrumentation and Mouth Rinsing in Chronic Periodontitis Patients by Toshiya Morozumi, Takehiko Kubota, Daisuke Abe, Taro Shimizu, Kaname Nohno, Hiromasa Yoshie

“…This trial is registered with UMIN Clinical Trials Registry UMIN000007484.…”
Get full text

Effect of implant abutment surface treatments on bacterial biofilm composition and structure by Eduardo Anitua, Alia Murias-Freijo, Roberto Tierno, Ricardo Tejero, Mohammad Hamdan Alkhraisat

“…Nevertheless, there is a lack of clinical trials that assess the biofilm formation on TiN abutments in the context of clinical practice. …”
Get full text

A Six-Month Randomized Controlled Trial of Whole Soy and Isoflavones Daidzein on Body Composition in Equol-Producing Postmenopausal Women with Prehypertension by Zhao-min Liu, Suzanne C. Ho, Yu-ming Chen, Jean Woo

“…This trial is registered with ClinicalTrials.gov NCT01270737.…”
Get full text

Direct-Acting Antivirals for the Treatment of Chronic Hepatitis C: Open Issues and Future Perspectives by Hee Bok Chae, Seon Mee Park, Sei Jin Youn

“…Currently, two direct-acting antivirals (DAAs) show well-established efficacy against hepatitis C virus (HCV), namely, first-wave protease inhibitors telaprevir and boceprevir. Most clinical trials have examined DAAs in combination with standard of care (SOC) regimens. …”
Get full text

Impact of Bifidobacterium longum NSP001 on DSS-induced colitis in conventional and humanised mice by Menglin Chen, Hong Yao, Huizi Tan, Wenqi Huang, Quanyong Wu, Shaoping Nie

“…However, differences between human and animal microbiota may confound the data reproducibility from rodent experiments to clinical trials. In this study, the intervention effects of Bifidobacterium longum NSP001 on DSS-induced colitis were investigated using mice colonized with either native or humanised microbiota. …”
Get full text

Pigtail Catheter: A Less Invasive Option for Pleural Drainage in Egyptian Patients with Recurrent Hepatic Hydrothorax by Mohamed Sharaf-Eldin, Adel Salah Bediwy, Abdelrahman Kobtan, Sherief Abd-Elsalam, Ferial El-Kalla, Loai Mansour, Walaa Elkhalawany, Mohamed Elhendawy, Samah Soliman

“…This trial is registered with ClinicalTrials.gov Identifier: NCT02119169.…”
Get full text

Potential Use of Euphorbia hirta for Dengue: A Systematic Review of Scientific Evidence by Sashini D. Perera, Uthpala A. Jayawardena, Chanika D. Jayasinghe

“…Hence, well-controlled clinical trials and contemporary pharmacological approaches including activity guided fractionation and elucidation of the mode of action are encouraged to establish the use of E. hirta for dengue.…”
Get full text

The Efficacy of Conbercept in Polypoidal Choroidal Vasculopathy: A Systematic Review by Yimin Wang, Mengxi Shen, Jinwei Cheng, Xiaodong Sun, Peter K. Kaiser

“…The use of antivascular endothelial growth factor (VEGF) therapy in polypoidal choroidal vasculopathy (PCV), a subtype of neovascular age-related macular degeneration (nAMD), has been well established in randomized clinical trials. This meta-analysis has evaluated the efficacy of a novel anti-VEGF agent, conbercept, in the management of PCV using ranibizumab and aflibercept as the reference agents. …”
Get full text

Improvement of Mouth Functional Disability in Systemic Sclerosis Patients over One Year in a Trial of Fat Transplantation versus Adipose-Derived Stromal Cells by Maria Giuseppina Onesti, Paolo Fioramonti, Sara Carella, Pasquale Fino, Cinzia Marchese, Nicolò Scuderi

“…The present clinical experimentation should be regarded as a starting point for further experimental research and clinical trials.…”
Get full text

Non-Instrumental Pulp Therapy for Deciduous Molars: A Global Bibliometric Analysis of Clinical Studies by Rayza Verônica Soares Carvalho, Marina de Deus Moura de Lima, Cacilda Castelo Branco Lima, Marcoeli Silva de Moura, Caroline Barros Oliveira, Lucia de Fátima Almeida de Deus Moura

“…Japan had the highest number of citations (n=80). Clinical trials were the most common study design (n= 6). …”
Get full text