Description and biomechanical evaluation of the modified laparoscopic-assisted percutaneous gastropexy technique in dogs by Dong Woo Kim, Ho Hyun Kwak, Ho Hyun Kwak, Junhyung Kim, Heung Myong Woo

“…However, further clinical trials are warranted to further validate this technique and confirm its effectiveness.…”
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Impact of multimorbidity on long-term outcomes in older adults with non-ST elevation acute coronary syndrome in the North East of England: a multi-centre cohort study of patients u... by Chris Wilkinson, Vijay Kunadian, Benjamin Beska, Abdulla A Damluji, Hanna Ratcovich, Greg B Mills

“…For each additional CCI comorbidity, on average, there was a 20% increased risk of the primary composite endpoint at 5 years (aHR 1.20 (1.09 to 1.33), p<0.001).Conclusions In older adults with NSTE-ACS referred for coronary angiography, the presence of multimorbidity is associated with an increased risk of long-term adverse cardiovascular events, driven by a higher risk of all-cause mortality.Trial registration number NCT01933581; ClinicalTrials.gov.…”
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Role of Epidural Electrode Stimulation in Three Patients with Incomplete AIS D Spinal Cord Injury by Yu-Chen Chen, Xiang-Ling Huang, Hung-Yu Cheng, Ciou-Chan Wu, Ming-Yung Wu, Lian-Cing Yan, Shin-Yuan Chen, Sheng-Tzung Tsai, Shinn-Zong Lin

“…These findings may facilitate stable walking in subjects with chronic incomplete SCI, but larger clinical trials are warranted. <b>Clinical</b> trial: NCT05433064.…”
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Opioid-free versus opioid-based anesthesia in laparoscopic sleeve gastrectomy: a single-center, randomized, controlled trial by Hanane Barakat, Linda Gholmieh, Jessy Abou Nader, Vanda Yazbeck Karam, Obey Albaini, Mohamad El Helou, Rony Al Nawwar

“…Trial registration ClinicalTrials.gov (NCT03507634); first trial registration date: 12/04/2018; first posted date: 25/04/2018.…”
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Eating disorders in weight-related therapy (EDIT): Protocol for a systematic review with individual participant data meta-analysis of eating disorder risk in behavioural weight man... by Hiba Jebeile, Natalie B Lister, Sol Libesman, Kylie E Hunter, Caitlin M McMaster, Brittany J Johnson, Louise A Baur, Susan J Paxton, Sarah P Garnett, Amy L Ahern, Denise E Wilfley, Sarah Maguire, Amanda Sainsbury, Katharine Steinbeck, Lisa Askie, Caroline Braet, Andrew J Hill, Dasha Nicholls, Rebecca A Jones, Genevieve Dammery, Alicia M Grunseit, Kelly Cooper, Theodore K Kyle, Faith A Heeren, Fiona Quigley, Rachel D Barnes, Melanie K Bean, Kristine Beaulieu, Maxine Bonham, Kerri N Boutelle, Braulio Henrique Magnani Branco, Simona Calugi, Michelle I Cardel, Kelly Carpenter, Hoi Lun Cheng, Riccardo Dalle Grave, Yngvild S Danielsen, Marcelo Demarzo, Aimee Dordevic, Dawn M Eichen, Andrea B Goldschmidt, Anja Hilbert, Katrijn Houben, Mara Lofrano do Prado, Corby K Martin, Anne McTiernan, Janell L Mensinger, Carly Pacanowski, Wagner Luiz do Prado, Sofia M Ramalho, Hollie A Raynor, Elizabeth Rieger, Eric Robinson, Vera Salvo, Nancy E Sherwood, Sharon A Simpson, Hanna F Skjakodegard, Evelyn Smith, Stephanie Partridge, Marian Tanofsky-Kraff, Rachael W Taylor, Annelies Van Eyck, Krista A Varady, Alaina P Vidmar, Victoria Whitelock, Jack Yanovski, Anna L Seidler, Eating Disorders In weight-related Therapy (EDIT) Collaboration

“…We systematically searched four databases up to March 2022 and clinical trials registries to May 2022 to identify randomised controlled trials of weight management interventions conducted in adolescents or adults with overweight or obesity that measured eating disorder risk at pre- and post-intervention or follow-up. …”
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The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta‐Analysis by Umar Akram, Obaid Ur Rehman, Eeshal Fatima, Zain Ali Nadeem, Omer Usman, Waqas Rasheed, Ramsha Ali, Khawaja Abdul Rehman, Abdulqadir J. Nashwan

“…ABSTRACT Background and Aim Lubiprostone increases chloride and water secretion in the intestines, and several studies have demonstrated the efficacy of lubiprostone in treating functional constipation. Several new clinical trials have emerged since the previous meta‐analysis conducted in 2020. …”
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Comparative efficacy and safety of first-line neoadjuvant therapy for early-stage non-small cell lung cancer based on immune checkpoint inhibitor therapy: a systematic review and n... by Linfeng Wang, Guangda Zheng, Yue Hu, Ayidana Maolan, Yue Luo, Yue Li, Rui Liu

“…Methods We searched PubMed, EMBASE, Cochrane Library, ClinicalTrials.go and randomised controlled trials (RCTs) from major international conferences for literature related to neoadjuvant immunotherapy combinations published as first-line treatment options for non-small cell lung cancer from the start of the library to 20 February 2024, and performed a systematic review and network meta-analysis. …”
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Clinical Characteristics and Outcomes in Heart Failure Patients with Implantable Pulmonary Artery Pressure Monitors: A Single Centre Irish Experience by Niall Leahy, Cillian O’Brien, Sara Essa Alsubai, Eileen Coen, Darragh Murphy, Faisal Sharif

“…., Chicago, IL, USA) in University Hospital Galway, Ireland, as part of three separate clinical trials—SIRONA 1, SIRONA 2, PROACTIVE HF, was performed. …”
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Unleashing the potential of a low CpG Passer transposon for superior CAR-T cell therapy by Jianyao Zeng, Yan Sun, Yan Sun, Yuan Fang, Xiaodie Wang, Qian Huang, Pingjing Zhang, Meiqi Shao, Pei Wang, Jingbo Cheng, Meng Di, Tao Liu, Qijun Qian, Qijun Qian, Qijun Qian

“…BackgroundTo date, the non-viral vector Chimeric Antigen Receptor (CAR) T cell preparation platform, exemplified by transposons, has demonstrated significant potential in tumor immunotherapy and yielded positive results in multiple clinical trials. Nonetheless, non-methylated CpG sequences within plasmid DNA can elicit an inflammatory response via Toll-like receptor 9 (TLR9) during CAR-T cell preparation, adversely affecting transgene expression. …”
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Timed Bromocriptine-QR Therapy Reduces Progression of Cardiovascular Disease and Dysglycemia in Subjects with Well-Controlled Type 2 Diabetes Mellitus by Bindu Chamarthi, J. Michael Gaziano, Lawrence Blonde, Aaron Vinik, Richard E. Scranton, Michael Ezrokhi, Dean Rutty, Anthony H. Cincotta

“…Methods. 1834 subjects (1219 bromocriptine-QR; 615 placebo) with baseline HbA1c ≤7.0% derived from the Cycloset Safety Trial (this trial is registered with ClinicalTrials.gov Identifier: NCT00377676), a 12-month, randomized, multicenter, placebo-controlled, double-blind study in T2DM, were evaluated. …”
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Effect of video-based trauma-informed care training for nursing staff on seclusion and restraint of psychiatric inpatients: A non-randomized controlled study by Michi Miyake, Megumi Hazumi, Kentaro Usuda, Takahiro Kawashima, Maiko Fukasawa, Hisateru Tachimori, Daisuke Nishi

“…Trial registration: The study was registered in the University Hospital Medical Information Network Clinical Trials Registry on 31 October 2021 (UMIN-CTR ID: UMIN000045879).…”
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Immune Checkpoint Inhibitors +/− Chemotherapy for Patients With NSCLC and Brain Metastases: A Systematic Review and Network Meta‐Analysis by Lauren Julia Brown, Nicholas Yeo, Harriet Gee, Benjamin Y. Kong, Eric Hau, Inês Pires daSilva, Adnan Nagrial

“…This network meta‐analysis suggests combination chemoimmunotherapy offers PFS benefit over ICI monotherapy in BM patients, warranting direct comparisons in clinical trials. Trial Registration: PROSPERO: CRD42024501345…”
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Impact of prior CAR T-cell therapy on mosunetuzumab efficacy in patients with relapsed or refractory B-cell lymphomas by Elise A. Chong, Elicia Penuel, Ellen B. Napier, Rachel K. Lundberg, Lihua E. Budde, Mazyar Shadman, Matthew J. Matasar, Nancy L. Bartlett, Ian W. Flinn, Francesc Bosch, Keith Fay, Andre Goy, Anita Kumar, Loretta J. Nastoupil, Michael C. Wei, Mei Wu, Shen Yin, Joseph A. Fraietta, Emeline R. Chong, Stephen J. Schuster

“…The trial was registered at www.ClinicalTrials.gov as #NCT02500407.…”
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Mental health disorder symptom changes among public safety personnel after emotional resilience skills training by R.N. Carleton, S. Sauer-Zavala, T.A. Teckchandani, K.Q. Maguire, L. Jamshidi, R.E. Shields, T.O. Afifi, J. Nisbet, K.L. Andrews, S.H. Stewart, A.J. Fletcher, R. Martin, R.S. MacPhee, J.C. MacDermid, T.M. Keane, A. Brunet, M. McCarron, L.M. Lix, N.A. Jones, G.P. Krätzig, J.P. Neary, G. Anderson, R. Ricciardelli, H. Cramm, J. Sareen, G.J.G. Asmundson

“…Trial registration: ClinicalTrials.gov, NCT05530642.…”
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Longer disease progression milestone-free time in people with amyotrophic lateral sclerosis treated versus not treated with intravenous edaravone: results from an administrative cl... by James D Berry, Melissa Hagan, Jeffrey Zhang, Ying Liu, Malgorzata Ciepielewska

“…Background: IV edaravone is US FDA approved for the treatment of ALS and was shown in clinical trials to slow the rate of physical functional decline. …”

Web-based interventions for pregnant women with gestational diabetes mellitus: a systematic review and meta-analysis protocol by Ping Xu, Wei Zhang, Xiaojuan Wang, Dan Dan Chen, Pingping Guo, Yin Jin, Zhenzhen Xiang, Minna Mao, Qiong Zheng, Suwen Feng

“…Six electronic databases (PubMed, Web of Science, Cochrane Central Register of Controlled Trials, Embase, CINAHL and PsycINFO) will be comprehensively searched from their inception to 26 January 2022 to identify randomised controlled trials and controlled clinical trials regarding the efficacy of web-based interventions for pregnant women with GDM on glycaemic control, behavioural outcomes, cognitive and attitudinal outcomes, mental health, maternal and neonatal clinical outcomes, and medical service utilisation and costs. …”
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Antimicrobial effect of silver diamine fluoride (SDF) in arresting dentine caries of permanent teeth: A Systematic review [version 1; peer review: 2 approved] by Mamata Hebbal, Albandri Mohammed Alowid, Praveen Jodalli, Shahad Saad Alkait, Ghadeer Ghalab Almutairi, Fatimah Salim Almufarji

“…Future research, including long-term clinical trials, is warranted to elucidate optimal dosage regimens and therapeutic approaches for the routine application of SDF in managing dental caries.…”
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Comparative effects of Health Qigong and closed motor exercise on the physical and mental health of female drug rehabilitation participants: a randomized controlled trial by Guang Yang, Deyu Meng, Shichun He, Meiqi Wei, Man Li, Lu Zhang, Zhendong Pan, Ziheng Wang

“…Trial registration ClinicalTrials.gov NCT06454565. The date of registration is 2024.07.11 (Retrospectively registered).…”
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Development and validation of a prognostic prediction model for elderly gastric cancer patients based on oxidative stress biochemical markers by Xing-Qi Zhang, Ze-Ning Huang, Ju Wu, Chang-Yue Zheng, Xiao-Dong Liu, Ying-Qi Huang, Qi-Yue Chen, Ping Li, Jian-Wei Xie, Chao-Hui Zheng, Jian-Xian Lin, Yan-Bing Zhou, Chang-Ming Huang

“…Trial registration Retrospectively registered at ClinicalTrials.gov (trial registration number: NCT06208046, date of registration: 2024–05-01).…”
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Effect of immunomodulation on cardiac remodelling and outcomes in heart failure: a quantitative synthesis of the literature by Navkaranbir S. Bajaj, Kartik Gupta, Nitin Gharpure, Mike Pate, Lakshay Chopra, Rajat Kalra, Sumanth D. Prabhu

“…Methods and results PubMed, Embase®, Cochrane CENTRAL, and ClinicalTrials.gov were systematically reviewed to identify RCTs that studied the effects of immunomodulation in patients with HFrEF. …”
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