Passive Monitoring of Parkinson Tremor in Daily Life: A Prototypical Network Approach by Luc J. W. Evers, Yordan P. Raykov, Tom M. Heskes, Jesse H. Krijthe, Bastiaan R. Bloem, Max A. Little

“…Objective and continuous monitoring of Parkinson’s disease (PD) tremor in free-living conditions could benefit both individual patient care and clinical trials, by overcoming the snapshot nature of clinical assessments. …”
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Expert advice from ResearchMatch volunteers: Recruitment Innovation Center use cases and innovation by Maeve Tischbein, Sarah K. Cook, Cathy Shyr, Katelyn Benhoff, Amna Baig, Kaysi Quarles, Leslie R. Boone, Loretta M. Byrne, Mariela Rodriguez, Terri Edwards, Consuelo H. Wilkins, Paul A. Harris

“…Involving participants in the design of clinical trials should improve the overall success of a study. …”
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Promising role of voxelotor in managing sickle cell disease in children: a narrative review by Amit Agrawal, Gaurav Jadon, Japna Singh, Dalwinder Janjua

“…The group that received voxelotor also showed a greater decrease in hemolytic markers but a comparable incidence of side effects. Six ongoing clinical trials also sought to ascertain the effectiveness and safety of high-dose voxelotor when administered to children younger than 12 years. …”
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Asbestos Induces Reduction of Tumor Immunity by Naoko Kumagai-Takei, Megumi Maeda, Ying Chen, Hidenori Matsuzaki, Suni Lee, Yasumitsu Nishimura, Junichi Hiratsuka, Takemi Otsuki

“…However, regarding bad prognosis of mesothelioma, medical approaches to ensure the recognition of the biological effects of asbestos and the pathological mechanisms of asbestos-induced carcinogenesis, as well as clinical trials to detect the early stage of mesothelioma, should result in better preventions and the cure of these malignancies. …”
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Efficacy of Nivolumab in a Patient with Metastatic Renal Cell Carcinoma and End-Stage Renal Disease on Dialysis: Case Report and Literature Review by Jawaher Ansari, Muhammad Ali, Ashraf Farrag, Arwa M. Ali, Abdulaziz Alhamad

“…Treatment of patients with metastatic renal cell carcinoma (mRCC) and end-stage renal disease (ESRD) on dialysis poses a therapeutic challenge, particularly as this patient group was excluded from the pivotal clinical trials. In addition, there is uncertainty regarding drug dosing/pharmacokinetics, lack of safety and efficacy data, and potential for increased toxicity when using targeted therapy or immunotherapy for the management of patients with mRCC on dialysis. …”
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Biologics and Small Molecules for Inflammatory Nail Disorders: A Narrative Review by Carrie A. Forman, Shari R. Lipner

“…Conclusion: Many biologics and small molecules are effective in treating nail psoriasis and alopecia areata, with each requiring precautions for adverse events. Clinical trials for use of biologics and small molecules for nail lichen planus and atopic dermatitis have not been published to date.…”
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Sulforaphane as a preventive agent in Oral Cancer- A Systematic Review by M. Parasakthi, Kavitha Sanjeev

“…Conclusion: Based on the analysis of studies included in this systematic review, sulforaphane is found to be effective in prevention of oral cancer. But further clinical trials are necessary to assess the effects of sulforaphane on oral cancer patients.…”
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Identification of musk compounds as inhibitors of the main SARS-CoV-2 protease by molecular docking and molecular dynamics studies by Belhassan Assia, Salgado Guillermo, Mendoza-Huizar Luis Humberto, Zaki Hanane, Chtita Samir, Lakhlifi Tahar, Bouachrine Mohammed, Gerli Candia Lorena, Cardona Wilson

“…The perspectives of this work are as follows: in vitro, in vivo and clinical trials to verify the computational findings.…”
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Brain-targeting drug delivery systems: The state of the art in treatment of glioblastoma by Bo Sun, Rong Li, Ning Ji, Han Liu, Hongxiang Wang, Chao Chen, Long Bai, Jiacan Su, Juxiang Chen

“…This emphasis has driven the exploration and evaluation of diverse technologies for GBM pharmacotherapy, with some already undergoing clinical trials. This review provides a thorough overview of recent advancements and challenges in targeted drug delivery for GBM treatment. …”
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Advanced In Vitro Models for Preclinical Drug Safety: Recent Progress and Prospects by Dileep G. Nair, Ralf Weiskirchen

“…Differences in physiology between humans and animals or cell lines contribute to the failure of many drug programs during clinical trials. The use of advanced in vitro systems that closely mimic human physiology, such as organ-on-a-chip models like gut–liver-on-a-chip, can be crucial in improving drug efficacy while minimizing toxicity. …”
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Defective homologous recombination and genomic instability predict increased responsiveness to carbon ion radiotherapy in pancreatic cancer by Brock J. Sishc, Janapriya Saha, Elizabeth M. Alves, Lianghao Ding, Huiming Lu, Shih-Ya Wang, Katy L. Swancutt, James H. Nicholson, Angelica Facoetti, Arnold Pompos, Mario Ciocca, Todd A. Aguilera, Michael D. Story, Anthony J. Davis

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is notably resistant to conventional chemotherapy and radiation treatment. However, clinical trials indicate that carbon ion radiotherapy (CIRT) with concurrent gemcitabine is effective for unresectable locally advanced PDAC. …”
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Lipopeptide adjuvants for antibiotics and vaccines: the future step in the fight against multidrug-resistant and extensively drug-resistant pathogens by Chloé O. Sebilleau, Steven J. Sucheck

“…Findings discussed in this review could be applied to the development of safer, more effective adjuvants, that could expand the use or repurpose current antibiotics or improve vaccination results in future clinical trials.…”
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Efficacy of different preoperative antiseptics in preventing a risk of surgical site infections: a systematic review and meta‑analysis of randomized controlled trials by Lutao Yang, Shunxin Liao, Qing Cao, Sanjay Rastogi

“…Results: This meta-analysis included 10 587 surgical patients from 18 randomized clinical trials to determine the effectiveness of chlorhexidine in alcohol (CHA; 0.5%, 2%–2.5%, and 4%) with aqueous or alcoholic iodine in preventing postoperative SSIs. …”
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Extended Peritoneal Dialysis and Renal Recovery in HIV-Infected Patients with Prolonged AKI: A Report of 2 Cases by Donlawat Saengpanit, Pongpratch Puapatanakul, Piyaporn Towannang, Talerngsak Kanjanabuch

“…Its efficacy in providing fluid and small solute removal has also been demonstrated in clinical trials and is equivalent to hemodialysis (HD). …”
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Brain-Derived Neurotrophic Factor and Nerve Growth Factor Therapeutics for Brain Injury: The Current Translational Challenges in Preclinical and Clinical Research by Serena-Kaye Sims, Brynna Wilken-Resman, Crystal J. Smith, Ashley Mitchell, Lilly McGonegal, Catrina Sims-Robinson

“…However, the translation of these studies into clinical trials has been limited. Preclinical experiments have largely failed to result in significant impacts in clinical research. …”
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Baseline shock index and baroreflex function in older adults by Kenneth M. Madden, Boris Feldman, Graydon S. Meneilly

“…Autonomic dysfunction is associated with lower SI in older adults, potentially masking circulatory instability.ClinicalTrials.gov ID NCT01914133…”
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The Potential Role of Liver Transplantation as a Treatment Option in Colorectal Liver Metastases by Pål-Dag Line, Morten Hagness, Svein Dueland

“…There is an increasing interest in liver transplantation in these patients in the transplant community, and currently 4 clinical trials are active and are recruiting.…”
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Results comparison of cervical cancer early detection using cerviray ® with VIA test by Ali Budi Harsono, Hadi Susiarno, Dodi Suardi, Kemala Isnainiasih Mantilidewi, Viko Duvadilan Wibowo, Yudi Mulyana Hidayat

“…Trial registration Clinical Trials.gov Identifier NCT06518070 Retrospectively registered.…”
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Icatibant for Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema in Intubated Patients: Case Series and Literature Review by Erin K. Yeung, Haritha Saikumar, Jose Castaneda-Nerio, Sandra G. Adams, Mark Wong

“…The suggested benefit of icatibant in intubated ACEI-induced angioedema patients should be verified by randomized clinical trials and cost-benefit analyses should be performed at individual institutions.…”
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Transformative advancements in immune checkpoint inhibitor therapy for Oropharyngeal Squamous Cell Carcinoma (OPSCC) by Iadalin Ryntathiang, Mukesh Kumar Dharmalingam Jothinathan

“…Furthermore, current clinical trials are exploring innovative combinations of ICIs and treatment sequences in order to enhance patient outcomes. …”
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