Stem Cell Applications in Tendon Disorders: A Clinical Perspective by Mark Young

“…Even though cellular therapies offer some potential in treating tendon disorders, there have been few published clinical trials to determine the ideal cell source, the number of cells to administer, or the optimal bioscaffold for clinical use.…”
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CXC Chemokines in the Pathogenesis of Pulmonary Disease and Pharmacological Relevance by Kayode Komolafe, Maricica Pacurari

“…Furthermore, encouraging preclinical data has necessitated the progression of a few of these drugs into clinical trials in order to make the most effective use of interventions in the development of viable targeted therapeutics. …”
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The Genus <i>Chiliadenus</i>: A Comprehensive Review of Taxonomic Aspects, Traditional Uses, Phytochemistry and Pharmacological Activities by Lucinda Villaescusa Castillo, Francisco Zaragozá García, Cristina Zaragozá Arnáez

“…However, the lack of comparative studies among <i>Chiliadenus</i> species and the scarcity of in vivo studies and clinical trials hinder the full realization of its therapeutic potential. …”
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Targeted Anticancer Immunotoxins and Cytotoxic Agents with Direct Killing Moieties by Koji Kawakami, Oumi Nakajima, Ryuichi Morishita, Ryozo Nagai

“…Such targetable agents, including RFB4(dsFv)-PE38 (BL22), IL13-PE38QQR, and Tf-CRM107, are being tested in clinical trials. Several agents using unique technology such as a cleavable adapter or immunoliposomes with antibodies are also in the preclinical stage. …”
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Role of Bile Acids in Dysbiosis and Treatment of Nonalcoholic Fatty Liver Disease by Caihua Wang, Chunpeng Zhu, Liming Shao, Jun Ye, Yimin Shen, Yuezhong Ren

“…During the past decade, stimulation of bile acid receptors with their agonists has been extensively explored for the treatment of NAFLD in both animal models and clinical trials. Early evidence has suggested the potential of bile acid receptor agonists in NAFLD management, but their long-term safety and effectiveness need further clarification.…”
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Perspectives for Clinical Translation of Adipose Stromal/Stem Cells by Mimmi Patrikoski, Bettina Mannerström, Susanna Miettinen

“…Moreover, the current status of clinical trials applying ASCs and the patent landscape in the field of ASC research are presented. …”
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Usefulness of Therapeutic Laser for Pain Management in Orthodontic Treatment by Karen Daniela Villavicencio Córdova, Katherim Anahí Cortez Campaña, Pamela Jeanneth Salinas Villacis

“…Of the total selected, 13 were bibliographic review articles, 20 clinical trials and 1 case report. It was determined that the recommended wavelength for a favorable and relieving result to exist, in the areas of pain where the laser is applied, is 810 nm (nanometers) and that the laser sessions can be applied daily or intermittently. with a maximum irradiation of 10 seconds in each area of pain. …”
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Exercise Induced Adipokine Changes and the Metabolic Syndrome by Saeid Golbidi, Ismail Laher

“…In this paper we briefly describe the pathophysiologic role of four important adipokines (adiponectin, leptin, TNF-α, and IL-6) in the metabolic syndrome and review some of the clinical trials that monitored these adipokines as a clinical outcome before and after exercise.…”
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The mRNA-1647 vaccine: A promising step toward the prevention of cytomegalovirus infection (CMV) by Adewunmi Akingbola, Abiodun Adegbesan, Olajumoke Adewole, Kolade Adegoke, Akpevwe Emmanuella Benson, Paul Ayomide Jombo, Sandra Uchechukwu Eboson, Victor Oluwasola, Ademola Aiyenuro

“…We have reviewed results from Phase 1 and 2 clinical trials of the mRNA-1647 vaccine, demonstrating robust immune responses in both seronegative and seropositive participants. …”
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Targeting the Heart of Mycobacterium: Advances in Anti-Tubercular Agents Disrupting Cell Wall Biosynthesis by Ahmad Diab, Henry Dickerson, Othman Al Musaimi

“…Beyond these, six promising molecules currently in Phase II clinical trials are designed to target arabinan synthesis pathways, sutezolid, TBA 7371, OPC-167832, SQ109, and both benzothiazinone derivatives BTZ043 and PBTZ169, highlighting advancements in the development of cell wall-targeting therapies.…”
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Beneficial Effects of Dietary Nitrate on Endothelial Function and Blood Pressure Levels by Jenifer d’El-Rei, Ana Rosa Cunha, Michelle Trindade, Mario Fritsch Neves

“…The increased levels of nitrite by nitrate intake seem to have beneficial effects in many of the physiological and clinical settings. Several clinical trials are being conducted to determine the broad therapeutic potential of increasing the bioavailability of nitrite in human health and disease, including studies related to vascular aging. …”
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Infrapatellar Fat Pad Stem Cells: From Developmental Biology to Cell Therapy by Ronaldo J. F. C. do Amaral, Henrique V. Almeida, Daniel J. Kelly, Fergal J. O’Brien, Cathal J. Kearney

“…We conclude with a perspective for future clinical trials using IFP stem cells.…”
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Designing a Long Acting Erythropoietin by Fusing Three Carboxyl-Terminal Peptides of Human Chorionic Gonadotropin β Subunit to the N-Terminal and C-Terminal Coding Sequence by Fuad Fares, Avri Havron, Eyal Fima

“…The therapeutic efficacy of EPO-CTP analog needs to be established in higher animals and in human clinical trials.…”
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Assessment of Negative Symptoms in Schizophrenia: From the Consensus Conference-Derived Scales to Remote Digital Phenotyping by Armida Mucci, Stefan Leucht, Giulia M. Giordano, Luigi Giuliani, Sophia Wehr, Lucia Weigel, Silvana Galderisi

“…However, psychometric validation of these scales is still in progress, and they are not yet recommended by regulatory agencies, thus limiting their use in clinical trials and settings. Complementing these traditional methods, remote digital phenotyping offers a novel approach by leveraging smartphones and wearable technology to capture real-time, high-resolution clinical data. …”
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The Organotypic Longitudinal Spinal Cord Slice Culture for Stem Cell Study by Joanna Sypecka, Sylwia Koniusz, Maria Kawalec, Anna Sarnowska

“…The urgent need for an appropriate in vitro model for spinal cord regeneration results from a greater number of clinical trials concerning regenerative medicine in the spinal cord injury and from still insufficient knowledge of the molecular mechanisms involved in the neuroreparative processes. …”
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Potential renoprotective effects and possible underlying mechanisms of angiotensin receptor-neprilysin inhibitors in cardiorenal syndrome by Md. Moshiur Rahman, Md. Moshiur Rahman, Asadur Rahman, Akira Nishiyama

“…In particular, we present a comprehensive summary of the latest advancements and findings from clinical trials, studies, and meta-analyses on the impact of ARNIs in maintaining or improving renal function. …”
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Promising New Treatments for Psoriasis by Sarah Dubois Declercq, Roxane Pouliot

“…This review describes new psoriasis treatments, which are on the market or currently in clinical trials that are being used to treat moderate-to-severe plaque psoriasis. …”
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Current Trends in Targeted Therapies for Glioblastoma Multiforme by Fumiharu Ohka, Atsushi Natsume, Toshihiko Wakabayashi

“…In this paper, we review up-to-date clinical trials of GBM treatments in order to overcome these 4 hurdles and to aim at more therapeutical effect than conventional therapies that are ongoing or are about to launch in clinical settings and discuss future perspectives.…”
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Antitumor Responses of Invariant Natural Killer T Cells by Jennie B. Altman, Adriana D. Benavides, Rupali Das, Hamid Bassiri

“…Finally, we review the successes and failures of clinical trials employing iNKT cell-based immunotherapies and explore the future prospects for the use of such strategies.…”
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Systematic Review of the Relationship between Acute and Late Gastrointestinal Toxicity after Radiotherapy for Prostate Cancer by Matthew Sean Peach, Timothy N. Showalter, Nitin Ohri

“…While numerous strategies to prevent gastrointestinal injury have been studied, clinical trials concentrating on late toxicity have been difficult to carry out. …”
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