Bottlenecks in the Efficient Use of Advanced Therapy Medicinal Products Based on Mesenchymal Stromal Cells by Natalia Escacena, Elena Quesada-Hernández, Vivian Capilla-Gonzalez, Bernat Soria, Abdelkrim Hmadcha

“…Additionally, hundreds of clinical trials related to the potential benefits of MSCs are in progress. …”
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The Role of Vascular Endothelial Growth Factor in Metastatic Prostate Cancer to the Skeleton by Emma Roberts, Davina A. F. Cossigny, Gerald M. Y. Quan

“…Due to the multifaceted effect VEGF has on tumour angiogenesis, tumour cell proliferation, and bone destruction, therapies targeting the VEGF pathways have shown promising clinical application and are being investigated in clinical trials.…”
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Feasibility, acceptability and preliminary effects of a social network-based, peer-led HIV self-testing intervention among men in two Ugandan fishing communities, 2022 by Joseph KB Matovu, Aisha Twahiri Namwama, Linda Kemigisha, Geoffrey Taasi, Jennipher Nakabugo, Julius Wandabwa, Laura M. Bogart, Nuraan Fakier, Rhoda K. Wanyenze, Peter Olupot-Olupot, Joshua Musinguzi, David Serwadda

“…Trial registration ClinicalTrials.Gov: NCT05685498 (retrospectively registered on January 17, 2023).…”
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Insights from a codesigned dynamic modelling study of child and adolescent obesity in Australia by Alison Hayes, Rebecca Wyse, Anna Lene Seidler, Kylie E Hunter, Rebecca K Golley, Louise A Baur, Anthony D Okely, Kenny Lawson, Jo-An Occhipinti, Louise Freebairn, Simon Keith Chiu, Joseph Carrello, L Kurt Kreuger

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Novel therapy: Combined BRAF and MEK inhibitors for locally advanced BRAF V600L–Positive mucosal melanoma in hypopharynx by Sivakamavalli Jeyachandran

“…Recent case studies and clinical trials have reported promising results, including improved response rates and prolonged progression-free survival in patients with locoregionally advanced, BRAF V600L–positive mucosal melanoma of the hypopharynx. …”
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Long Term Safety of Infliximab by Thomas F Schaible

“…In several placebo controlled, randomized clinical trials and open trials, 771 patients have been given infliximab (a further 192 received placebo). …”
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Cellular MR Imaging by Michel Modo, Mathias Hoehn, Jeff W.M. Bulte

“…Several of these magneto-pharmaceuticals have been FDA-approved or are in late-phase clinical trials. As for prelabeling of cells in vitro, a challenge has been to induce a sufficient uptake of contrast agents into nonphagocytic cells, without affecting normal cellular function. …”
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Clinical Biology and Potential Use of Thrombopoietin by Russell Basser

“…However, one of these agents, interleukin-11, was successfully shown to reduce the incidence of severe thrombocytopenia in patients receiving dose-intensive chemotherapy, and has now received approval from the United States Food and Drug Administration for this purpose. Initial clinical trials of thrombopoietin, the central regulator of megakaryocytopoiesis and thrombopoiesis, and its analogues showed these agents to be the most potent stimulators of thrombopoiesis and to be associated with few adverse effects. …”
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Recent advances in the prevention of secondary ischemic stroke: A narrative review by Yue Qiao, Aminah I. Fayyaz, Yuchuan Ding, Xunming Ji, Wenbo Zhao

“…This review summarizes the latest advancements in the secondary prevention of ischemic stroke over the past 5 years, highlighting the key clinical trials and novel interventions. The optimization of traditional risk factor management and the emergence of novel therapeutic methods have provided more options for clinical practice. …”
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Linezolid and serotonin syndrome by Haytham A. Wali

“…Assessments of the pharmacological mechanisms, large-scale clinical trials, and cohort studies are essential to elucidate risk factors and outcomes. …”
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Belzutifan for the treatment of renal cell carcinoma by Xiancheng Wu, David Lazris, Risa Wong, Scott S. Tykodi

“…Belzutifan has demonstrated activity in clinical trials as a front- and later-line therapy, and in combination with tyrosine kinase inhibitors. …”
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Gut Microbiome in Obsessive Compulsive Disorder: Potential of Probiotics as an Adjuvant Therapy by Grace Yong-En Kong, Vengadesh Letchumanan, Loh Teng-Hern Tan, Jodi Woan-Fei Law

“…In vivo animal studies showed that probiotics can potentially improve OCD symptoms. Nevertheless, clinical trials are required to determine the efficacy of probiotics as an adjuvant therapy to alleviate OCD symptoms. …”
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The Discovery of Novel Experimental Therapies for Inflammatory Arthritis by Charles J. Malemud

“…A few of them have even entered the first phase of human clinical trials.…”
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Adaptive Treatment of Metastatic Prostate Cancer Using Generative Artificial Intelligence by Youcef Derbal

“…As such, the study is expected to help facilitate the design of clinical trials of GenAI-supported cancer treatments.…”
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L-Ornithine L-Aspartate for the Treatment of Sarcopenia in Chronic Liver Disease: The Taming of a Vicious Cycle by Roger F. Butterworth

“…Thus, a vicious cycle occurs whereby hyperammonemia causes severe muscle damage and sarcopenia that, in turn, limits the capacity of muscle to remove excess blood-borne ammonia and the cycle continues. Randomized clinical trials and meta-analyses confirm that L-ornithine L-aspartate (LOLA) is an effective ammonia-lowering agent currently employed for the treatment of hepatic encephalopathy (HE) that stimulates both urea synthesis by residual hepatocytes and muscle glutamine synthesis together with putative hepatoprotective actions. …”
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The Dynamicity of the Oxytocin Receptor in the Brain May Trigger Sensory Deficits in Autism Spectrum Disorder by Claudia Camerino

“…The neurohormone oxytocin (Oxt) is involved in the etiology of ASD, and there are several ongoing clinical trials regarding Oxt administration in ASD patients. …”
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Long-Term Use of Ruxolitinib in an AML Patient with Posttransplant Steroid Refractory GVHD by Philip T. Sobash, Achuta K. Guddati, Vamsi Kota

“…The long-term use of ruxolitinib has not been explicitly studied outside the context in the treatment of multiple myeloma. With current clinical trials underway for the use of ruxolitinib in srGVHD, there are still no current guidelines or protocols for long-term clinical use. …”
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LFA-1: A potential key player in microglia-mediated neuroprotection against oxygen-glucose deprivation in vitro. by Robin Jansen, Marc Pawlitzki, Michael Gliem, Sven G Meuth, Stefanie Schreiber, Michael-W Görtler, Jens Neumann

“…For the last 38 years, all neuroprotective agents for patients with ischemic stroke have failed in clinical trials. The innate immune system, particularly microglia, is a much-discussed target for neuroprotective agents. …”
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Pneumocystis carinii Pneumonia in HIV — Investigate or Just Treat? by Steven Kesten

“…This strategy has not been tested in controlled clinical trials although decision analysis models have attempted to evaluated it, it's liekly reasonable to choose empirical antimicrobial therapy in specific clinical settings such as: (a) typical radiographic picture in a person with dyspnea and/or nonproductive cough. presence of HIV and a CD4 count of less than 200 cells/mm3:(b) previous PCP, typical appearance and the patient is known to tolerate standard anti-PCP medications: and (c) high clinical suspicion in a patient who refuses bronchoscopy yet desires treatment or where bronchoscopy cannot he performed. …”
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Contemporary Evaluation and Management of the Diabetic Foot by Bauer E. Sumpio

“…While these, increasingly expensive, therapies have shown promising results in clinical trials, the results have yet to be translated into widespread clinical practice leaving a huge scope for further research in this field.…”
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