Do Nonsteroidal Anti-Inflammatory Drugs Affect Bone Healing? A Critical Analysis by Ippokratis Pountos, Theodora Georgouli, Giorgio M. Calori, Peter V. Giannoudis

“…Basic science research defining the exact mechanism with which NSAIDs could interfere with bone cells and also the conduction of well-randomized prospective clinical trials are warranted. In the absence of robust clinical or scientific evidence, clinicians should treat NSAIDs as a risk factor for bone healing impairment, and their administration should be avoided in high-risk patients.…”
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Funicular Myelosis in a Butcher: It Was the Cream Cans by Fabian Wolpert, Krisztina Baráth, Janis Brakowski, Roland Renzel, Michael Linnebank, Andreas R. Gantenbein

“…Nevertheless, there are only a few clinical trials assessing its long-term effects and there is no literature about the role of nutritional vitamin B12 supplementation in the context of nitrous oxide abuse. …”
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A Brief Review on Medicinal Plants-At-Arms against COVID-19 by Shivani Srivastava, Fangzhou He, Yuanding Huang, Meng Niu, Alok Adholeya, Weng Kung Peng

“…Accordingly, this review highlights the unprecedented opportunities offered by medicinal plants and their compounds, candidates as the therapeutic agent, against COVID-19 by acting as viral protein inhibitors and immunomodulator in (32 clinical trials and hundreds of in silico experiments) conjecture with modern science. …”
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Prevention and treatment of cerebral vasospasm following aneurysmal subarachnoid hemorrhage by Kyle McGrath, Grace Hey, Ghaidaa Ebrahim, Noah Gilberstadt, David Mahan, Brandon Lucke-Wold

“…Numerous preclinical investigations highlight novel targets related to the immune response that could prove effective at improving outcomes in clinical trials. Further investigation of the glymphatic system and its role in PHCV pathogenesis could result in novel pharmacologic targets. …”
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Advancements in the Treatment of Mucopolysaccharidoses: From Established Therapies to Gene Therapy by Joanna Wanat, Wojciech Homa, Aleksandra Warunek, Gabriela Gronowicz, Izabela Dzikowska, Agata Siejka, Daria Stefaniak, Weronika Zielińska, Michał Chról

“…State of knowledge Numerous studies and clinical trials suggest that novel therapies could be game-changers in managing MPS. …”
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Serotonin and Its Receptor as a New Antioxidant Therapeutic Target for Diabetic Kidney Disease by Yu Yang, Hui Huang, Zheng Xu, Jun-kai Duan

“…We conclude that 5-HTR is a potential therapeutic target for treating DKD, as it has been successfully applied in animal models and has currently being investigated in randomized and controlled clinical trials.…”
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Electromyographic parameters for treatment of pelvic floor disorders in pregnant and postpartum women: A review protocol. by Alethéa Cury Rabelo Leitão, Silvia Oliveira Ribeiro Lira, Elizabel de Souza Ramalho Viana

“…A systematic review of randomized controlled experimental studies (clinical trials) and quasi-experimental studies in English, Portuguese or Spanish, which used electromyography as an intervention for treatment of pelvic floor disorders in pregnant or postpartum women up to 12 months after delivery will be performed in online databases (Scopus, Medline, Pedro, Scielo and Pubmed),. …”
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Integrins and Their Extracellular Matrix Ligands in Lymphangiogenesis and Lymph Node Metastasis by Jie Chen, J. Steven Alexander, A. Wayne Orr

“…Work over the past 40 years, varying from molecular examination to clinical trials, verified this hypothesis and identified a host of therapeutic targets to limit tumor angiogenesis, including the integrin family of extracellular matrix receptors. …”
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MSCs: Delivery Routes and Engraftment, Cell-Targeting Strategies, and Immune Modulation by Thomas J. Kean, Paul Lin, Arnold I. Caplan, James E. Dennis

“…Mesenchymal stem cells (MSCs) are currently being widely investigated both in the lab and in clinical trials for multiple disease states. The differentiation, trophic, and immunomodulatory characteristics of MSCs contribute to their therapeutic effects. …”
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Platelet count and retinopathy of prematurity, a systematic review and meta-analysis by Qian Zeng, Qian Zeng, Ling Wang, Yurong Li, Yurong Li, Yuanyuan Yue, Yuanyuan Yue, Xin Lv, Xin Lv

“…ObjectiveThis study aims to investigate the relationship between platelet count (PLT) and retinopathy of prematurity (ROP), with the goal of identifying a straightforward screening method for the early detection of ROP.MethodsA systematic search was conducted in PubMed, EMBASE, Web of Science, Cochrane Library, and ClinicalTrials.gov from January 2005 to 26 September 2023. …”
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Rare epithelial gastric cancers: a review of the current treatment knowledge by Angelica Petrillo, Margaret Ottaviano, Luca Pompella, Emilio Francesco Giunta, Pasquale Pisapia, Gianpaolo Marte, Andrea Tufo, Sara Di Lorenzo, Jessica Orefice, Chiara Miceli, Umberto Malapelle, Bruno Daniele, Ferdinando De Vita

“…Our main aim is to translate the scarce evidence from the literature into daily clinical practice, never forgetting that all the clinicians dedicated to rare GCs should encourage such patients’ enrolment in clinical trials and promote international collaborations. …”
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Behavioral Intervention versus Pharmacotherapy or Their Combinations in the Management of Overactive Bladder Dysfunction by Khanh Tran, Robert M. Levin, Shaker A. Mousa

“…We carried out a comprehensive systematic review of the available literature on the effectiveness of behavioral intervention, anticholinergic drugs, and their combination in the management of adults with overactive bladder, with emphasis on results from clinical trials and primary literature. Each treatment intervention is efficacious, and the choice should be based on the patient's severity of symptoms, tolerability, compliance and satisfaction with the treatment. …”
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Targeting KRAS: from metabolic regulation to cancer treatment by Yanyan Shi, Huiling Zheng, Tianzhen Wang, Shengpu Zhou, Shiqing Zhao, Mo Li, Baoshan Cao

“…We also focus on advances in KRAS inhibitor discovery and related treatment strategies in colorectal, pancreatic, and non-small cell lung cancer, including current clinical trials. Therefore, this review provides an overview of the current understanding of metabolic mechanisms associated with KRAS mutation and related therapeutic strategies, aiming to facilitate the understanding of current challenges in KRAS-driven cancer and to support the investigation of therapeutic strategies.…”
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Nanocurcumin in myocardial infarction therapy: emerging trends and future directions by Mei Lv, Qing Sun, Yilin Yu, Jinwei Bao

“…Micelles composed of polymers have demonstrated high biocompatibility and targeting capabilities with increased cardio-protective effects. Research and clinical trials are essential for comprehensive analysis and efficacy of curcumin-based nano-therapeutics in cardiovascular condition and lowering risk of MI.…”
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Selective Decontamination of the Digestive Tract Reduces Pneumonia and Mortality by Lenneke E. M. Haas, Marcus J. Schultz

“…Selective decontamination of the digestive tract (SDD) has been subject of numerous randomized controlled trials in critically ill patients. Almost all clinical trials showed SDD to prevent pneumonia. Nevertheless, SDD has remained a controversial strategy. …”
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Como as intervenções parentais atuam no desenvolvimento infantil na primeira infância: revisão de literatura by Karine Saraiva da Silva, Virna da Costa e Silva, Roseny Marinho Mesquita Pereira, Renata de B. Bruno Ximenes

“…METHODOLOGY: A search was carried out for randomized clinical trials in two electronic databases: PUBMED and Embase, during the period from 2018 to 2022. …”
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Advances in sodium-glucose transporter protein 2 inhibitors and tumors by Jiaqi Wang, Wenyong Yang

“…The aim of this article is to provide a comprehensive understanding of the research progress of SGLT2i in different tumors by integrating the latest studies and to encourage further exploration of SGLT2i therapies in clinical trials. This could pave the way for more effective management strategies and improved outcomes for tumor patients.…”
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Meditation as an Adjunct to the Management of Multiple Sclerosis by Adam B. Levin, Emily J. Hadgkiss, Tracey J. Weiland, George A. Jelinek

“…Additional rigorous clinical trials are required to validate the existing findings and determine if meditation has an impact on disease course over time.…”
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(Mesenchymal) Stem Cell-Based Therapy in Cisplatin-Induced Acute Kidney Injury Animal Model: Risk of Immunogenicity and Tumorigenicity by Ž. Večerić-Haler, A. Cerar, M. Perše

“…Since the risk of tumorigenicity of particular therapy as well as the immune response to solid or cell grafts is a major issue in clinical trials, the aim of the present paper is to critically summarize the results of MSC transplantation on animal models of AKI, particularly cisplatin-induced animal models, and to expose results and main concerns about immunogenicity and tumorigenicity of transplanted MSCs, two important issues that need to be addressed in future studies.…”
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Detoxification of Implant Surfaces Affected by Peri-Implant Disease: An Overview of Surgical Methods by Pilar Valderrama, Thomas G. Wilson Jr

“…The aim of this review was to summarize in vitro and in vivo studies as well as clinical trials that have evaluated surgical approaches for detoxification of the implant body surfaces. …”
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