A randomised controlled implementation trial of the feasibility and effectiveness of school staff delivery of a selective substance use and mental health program during the COVID-1... by Lucinda Grummitt, Kirsty Rowlinson, Joanne Cassar, Chloe Conroy, Louise Birrell, Lexine Stapinski, Emma Louise Barrett, Julia Macauley, Maree Teesson, Nicola C. Newton, Erin V. Kelly

“…The study was prospectively registered with the Australian New Zealand Clinical Trials Registry (ACTRN12620000790943, registration date 6 August 2020). …”
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Efficacy and Safety of Risankizumab in Patients with Psoriasis Showing Suboptimal Response to Secukinumab or Ixekizumab: Results from a Phase 3b, Open-Label, Single-Arm (aIMM) Stud... by Richard B. Warren, Lev Pavlovsky, Antonio Costanzo, Michael Bukhalo, Neil J. Korman, Yu-Huei Huang, Georgios Kokolakis, Andreas Pinter, Nadia Ibrahim, Yanbing Zheng, Leonidas Drogaris, Vassilis Stakias, Ahmed M. Soliman, Simone Rubant, Diamant Thaçi

“…This study supports the efficacy of risankizumab in patients previously treated with biologics, including IL-17 inhibitors, and suggests a direct switch to risankizumab for improved clinical outcomes and QoL. Clinical Trials ClinicalTrials.gov identifier: NCT04102007. …”
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Importance of infarct topography in determination of stroke mechanism and recurrence risk: a post-hoc analysis of the dabigatran acute treatment of stroke trial by Michael D Hill, Ken Butcher, Kelvin Ng, Mukul Sharma, Shelagh B Coutts, Brian H Buck, Thalia Field, Erol Cimen, Laura C Gioia, Jodi Miller, Oscar R Benavente

“…Irrespective of aetiological classification, patients with MRI-defined cryptogenic embolic pattern infarcts are at high risk for recurrent events.Trial registration number Linked to the DATAS II trial. ClinicalTrials.gov ID NCT02295826.…”
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Clinical Effectiveness of Viddha Karma in PCOS: A Case Report by Bhagyashree Jibkate, Akshay S. Pargaonkar, Mayuri Deshpande

“…However, further research and clinical trials are necessary to gain a comprehensive understanding of its effectiveness.…”
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Motion – All Patients with GERD Should Be Offered Once in a Lifetime Endoscopy: Arguments against the Motion by James W Freston

“…The evidence for the recommendation that patients with gastroesophageal reflux disease (GERD) be offered once in a lifetime endoscopy is weak and is not supported by any clinical trials. GERD is a very prevalent condition, yet only 10% of patients with GERD have Barrett’s esophagus (BE). …”
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Prostaglandin-Induced Cystoid Macular Edema Following Routine Cataract Extraction by Negin Agange, Sameh Mosaed

“…Definitive conclusions about causal relationships cannot be made without well-designed, prospective clinical trials addressing this issue.…”
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Effectiveness of Prolotherapy for Chronic Musculoskeletal Conditions by Saurabh Agarwal, Abhishek Nagaich, Nikhil Jain, Arvind Kumar Shah

“…The efficacy of prolotherapy for different musculoskeletal conditions with different injections is different, and the precise mechanism of prolotherapy effect is still not clear, so further studies and clinical trials are recommended.…”
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Interleukin-1, Tumour Necrosis Factor and Treatment of the Septic Shock Syndrome by Charles A Dinarello

“…Soluble TNF and IL-1 surface receptors, which bind their respective cytokines. also ameliorate disease processes. Clinical trials are presently evaluating the safety and efficacy of anticytokine therapies either alone or in combination.…”
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A Comprehensive Review on the Chemical Composition and Pharmacological Activities of Acacia catechu (L.f.) Willd. by Bikash Adhikari, Babita Aryal, Bibek Raj Bhattarai

“…Although the metabolites from the plant are reported with diverse pharmacological applications, there is little information in regards to toxicity and clinical trials on bioactive compounds of this plant. …”
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Optimal Delivery of Pain Management in Schwannomatosis: A Literature Review by Hino U, Tamura R, Toda M

“…The lack of accurate animal models hampers understanding of pain mechanisms and tumor development, necessitating further basic research and clinical trials to improve treatment strategies.Keywords: schwannomatosis, pain, surgery, medication, neuromodulation…”
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Inflammatory Bowel Disease and Statins by V. V. Genkel, I. I. Shaposhnik

“…However, well-planned randomised clinical trials are needed to evaluate the effects of statins in IBD.…”
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Olanzapine for young PEople with aNorexia nervosa (OPEN): results of a feasibility study by Olena Said, Dominic Stringer, Ece Sengun Filiz, Hiba Mutwalli, Sevgi Bektas, Melahat Nur Akkese, Vanessa Kellermann, Katie Ireland, Elizabeth Tyrrell-Bunge, Demelza Beishon-Murley, Joel W. T. Khor, Lee Allman, Joanna Barker, Nicus Kotze, Ben Carter, Mima Simic, Dilveer Singh Sually, Jessica Bentley, Allan H. Young, Sloane Madden, Sarah Byford, Sabine Landau, Vanessa Lawrence, Janet Treasure, Ulrike Schmidt, Dasha Nicholls, Hubertus Himmerich

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Systemic brain dissemination of glioblastoma requires transdifferentiation into endothelial-like cells via TGF-β-ALK1-Smad1/5 signaling by Thomas M.B. Ware, Adilson Fonseca Teixeira, Josephine Iaria, Rodney B. Luwor, Hong-Jian Zhu

“…This is despite the large number of clinical trials that have attempted to replicate the success of therapeutics developed for other cancer types. …”
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Accessible model predicts response in hormone receptor positive HER2 negative breast cancer receiving neoadjuvant chemotherapy by Luca Mastrantoni, Giovanna Garufi, Giulia Giordano, Noemi Maliziola, Elena Di Monte, Giorgia Arcuri, Valentina Frescura, Angelachiara Rotondi, Armando Orlandi, Luisa Carbognin, Antonella Palazzo, Federica Miglietta, Letizia Pontolillo, Alessandra Fabi, Lorenzo Gerratana, Sergio Pannunzio, Ida Paris, Sara Pilotto, Fabio Marazzi, Antonio Franco, Gianluca Franceschini, Maria Vittoria Dieci, Roberta Mazzeo, Fabio Puglisi, Valentina Guarneri, Michele Milella, Giovanni Scambia, Diana Giannarelli, Giampaolo Tortora, Emilio Bria

“…Our model is freely available and can be used to enhance the stratification of BC patients receiving NACT, providing a framework for the development of risk-adapted clinical trials.…”
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Stroke Prevention: Managing Modifiable Risk Factors by Silvia Di Legge, Giacomo Koch, Marina Diomedi, Paolo Stanzione, Fabrizio Sallustio

“…The results of recent clinical trials investigating new anticoagulants (factor Xa inhibitors and direct thrombin inhibitors) clearly indicate alternative strategies in stroke prevention for patients with atrial fibrillation. …”
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Tau-Reactive Endogenous Antibodies: Origin, Functionality, and Implications for the Pathophysiology of Alzheimer’s Disease by Lenka Hromadkova, Saak Victor Ovsepian

“…Multiple anti-tau antibodies inhibiting the formation and propagation of cytotoxic tau or promoting its clearance and degradation have been tested in clinical trials, albeit with the inconclusive outcome. …”
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Pelvic Organ Distribution of Mesenchymal Stem Cells Injected Intravenously after Simulated Childbirth Injury in Female Rats by Michelle Cruz, Charuspong Dissaranan, Anne Cotleur, Matthew Kiedrowski, Marc Penn, Margot Damaser

“…The local route of stem cell administration utilized presently in clinical trials for stress incontinence may not take full advantage of the capabilities of these cells. …”
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Crossroad of Tradition and Innovation – The Application of Lactic Acid Fermentation to Increase the Nutritional and Health-Promoting Potential of Plant-Based Food Products – a Revi... by Anna Maria Ogrodowczyk, Natalia Drabińska

“…However, still more clinical trials evaluating the effect of their consumption on the human health are in demand.…”
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Treating Penile Cancer in the Immunotherapy and Targeted Therapy Era by Gavin Hui, Sanaz N. Ghafouri, John Shen, Sandy Liu, Alexandra Drakaki

“…There were no available clinical trials for penile cancer patients who progressed beyond the standard surgical therapy and chemotherapy.…”
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Advancing Multiple Myeloma Immunotherapy: A Review of Chimeric Antigen Receptor T-Cell and Bispecific T-Cell Engagers Cell Therapies in Revolutionizing Treatment by Rahul Navab, Pragyat Futela, Verkha Kumari, Jayesh Valecha, Ramansh Bandhu Gupta, Rohit Jain

“…These therapies exhibit impressive efficacy in clinical trials, leading to FDA approvals for specific MM patient populations. …”
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