The protective effect of carnosic acid on dextran sulfate sodium-induced colitis based on metabolomics and gut microbiota analysis by Changhui Du, Zhenjie Li, Jing Zhang, Ni Yin, Lirong Tang, Jie Li, Jingyin Sun, Xiaoqing Yu, Wei Chen, Hang Xiao, Xian Wu, Xuexiang Chen

“…Changes in gut microbiota and the correlated metabolites might partially explain CA’s anti-inflammatory effects against colitis. Future clinical trials are needed to determine the therapeutic effects and mechanisms of CA on IBD in humans.…”
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Stem Cells for Cardiac Repair: Status, Mechanisms, and New Strategies by Ren Mingliang, Zhang Bo, Wang Zhengguo

“…It is expected to replace and repair damaged myocardium. But many clinical trials have shown that the stem cell therapy of heart failure is modest or not effective. …”
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The Unsolved Problem of Surveillance for Colorectal Cancer in Ulcerative Colitis by Fabiola Delco, Amnon Sonnenberg

“…A crude calculation suggests that such a surveillance program would also be cost effective. None of several clinical trials, however, has been able to provide unequivocal evidence in favour of surveillance. …”
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The hypoglycemic potential of phenolics from functional foods and their mechanisms by Oksana Golovinskaia, Chin-Kun Wang

“…Nevertheless, further clinical trials are required to confirm the bioavailability, safety, and efficacy of phenolics, especially the dosage and duration of treatment, to avoid adverse effects and give better dietary recommendations.…”
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In Vitro Activity of Geldanamycin Derivatives against Schistosoma japonicum and Brugia malayi by David Wenkert, Bernadette Ramirez, Yuehai Shen, Michael A. Kron

“…Two of the derivatives, 17-N-allyl-17-demethoxygeldanamycin (17-AAG) and 17-N-(2-dimethylaminoethylamino)-17-demethoxygeldanamycin (DMAG), are currently in human clinical trials as anticancer drugs. Using concentrations considered safe peak plasma concentrations for these two derivatives, all four derivatives were active against both parasites. …”
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COVID-19 residual symptoms and adverse drug reactions after oral antiviral therapy in the Singapore primary care setting by Jia Qi Yeo, Poh Ching Tan, Cheryl Wei Yan Tan, Poay Sian Sabrina Lee

“… The COVID-19 pandemic remains a significant public health threat with over 7 million deaths worldwide (as of 14 January 2024).1 In Singapore, oral antivirals (OAVs) nirmatrelvir/ritonavir and molnupiravir were approved in 2022 for treating mild-to-moderate COVID-19 in adults at risk of progression to severe disease.2,3 Clinical trials in Western populations showed nirmatrelvir/ritonavir having higher efficacy in reducing hospitalisations and mortality by 88% compared to 30% for molnupiravir.2-4 A Singapore study showed nirmatrelvir/ritonavir’s effectiveness in reducing hospitalisation and severe COVID-19.5 However, further research is needed on potential adverse drug reactions (ADRs) and control of COVID-19 symptoms in Asian populations. …”
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Artificial intelligence in rheumatology research: what is it good for? by Diego Benavent, José Miguel Sequí-Sabater

“…Artificial intelligence (AI) is transforming rheumatology research, with a myriad of studies aiming to improve diagnosis, prognosis and treatment prediction, while also showing potential capability to optimise the research workflow, improve drug discovery and clinical trials. Machine learning, a key element of discriminative AI, has demonstrated the ability of accurately classifying rheumatic diseases and predicting therapeutic outcomes by using diverse data types, including structured databases, imaging and text. …”
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Analysis of the Modified Rankin Scale in Randomised Controlled Trials of Acute Ischaemic Stroke: A Systematic Review by Aimie Nunn, Philip M. Bath, Laura J. Gray

“…Historically, most acute stroke clinical trials were neutral statistically, with trials typically dichotomising ordinal scales, such as the modified Rankin Scale. …”
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Carboxylic Acid Bioisosteres in Medicinal Chemistry: Synthesis and Properties by Kato Bredael, Silke Geurs, Dorien Clarisse, Karolien De Bosscher, Matthias D’hooghe

“…Lead optimization represents the tedious process of fine-tuning lead compounds from biologically active hits to suitable drug candidates for clinical trials. By chemically modifying a hit structure, an improved compound can be obtained in terms of activity, selectivity, and pharmacokinetic ADME (absorption, distribution, metabolism, and excretion) properties. …”
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Critical updates on oral insulin drug delivery systems for type 2 diabetes mellitus by Chan Yew Low, Wei Ling Gan, Su Jeat Lai, Rachel Su-May Tam, Jie Fei Tan, Stefanie Dietl, Lay Hong Chuah, Nicolas Voelcker, Athirah Bakhtiar

“…This review examines the advancements of several oral insulin formulations in preclinical and clinical trials, their effectiveness and safety characteristics, and potential implications for future treatment options. …”
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Combined Implant and Tooth Support: An Up-to-Date Comprehensive Overview by Mahmoud K. Al-Omiri, Maher Al-Masri, Mohannad M. Alhijawi, Edward Lynch

“…Due to the shortage in within-subject, long term, randomized, controlled clinical trials regarding the subject a meta-analysis was not possible. …”
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Current status and innovative developments of CAR-T-cell therapy for the treatment of breast cancer by Hany E. Marei, Khaled Bedair, Anwarul Hasan, Layla Al-Mansoori, Sara Caratelli, Giuseppe Sconocchia, Alice Gaiba, Carlo Cenciarelli

“…We discuss in detail the role of tumor-associated antigens in breast cancer, current clinical trials, barriers to the intended therapeutic effects of CAR-T cell therapy, and potential ways to increase treatment efficacy. …”
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Women and birth partners’ experiences of cervical ripening at home and in hospital by Cassandra Yuill, Mairi Harkness, Helen Cheyne, Boo Charkin, Monica Ferreira, Eloise Price, Amarnath Bhide, Mairead Black, Kathleen Boyd, Neelam Heera-Shergill, Neena Modi, John Norrie, Dharmintra Pasupathy, Julia Sanders, Sarah J. Stock, Rosemary Townsend, Linda J. Williams, Christine McCourt

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Metrics for Evaluating Telemedicine in Randomized Controlled Trials: Scoping Review by Yuka Sugawara, Yosuke Hirakawa, Masao Iwagami, Ryota Inokuchi, Rie Wakimizu, Masaomi Nangaku

“…Moreover, standardization of the evaluation metrics is desired for future clinical trials and studies. Trial RegistrationOpen Science Forum Registries YH5S7; https://doi.org/10.17605/OSF.IO/YH5S7…”
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Standardized Outcomes for Randomized Controlled Trials Targeting Early Interventions in Patients With Moderate-to-Severe Traumatic Brain Injury: Protocol for the Development of a C... by Raphael Cinotti, Yvan Derouin, Amandine Chenet, Lydia Oujamaa, Bertrand Glize, Yoann Launey, Claire Dahyot-Fizelier, Emmanuelle Cartron, Melodie Renvoise, Benedicte Sautenet, Veronique Sebille

“…In the last 20 years, there has been an increase in clinical trials in neurocritical care, leading mostly to negative results. …”
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Study protocol of a randomised controlled trial on SISU, a software agent providing a brief self-help intervention for adults with low psychological well-being by Harald Baumeister, Ann-Marie Küchler, David Ebert, Natalie Bauereiss, Eileen Bendig, Benjamin Erb, Lena Weger, Echo Meißner

“…Results will be submitted for publication in a peer-reviewed journal and presented at conferences.Trial registration The trial is registered at the WHO International Clinical Trials Registry Platform via the German Clinical Trials Register (DRKS): DRKS00016799 (date of registration: 25 April 2019). …”
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Validation of the Chronic Liver Disease Questionnaire for MASH (CLDQ-MASH) by Zobair M. Younossi, Maria Stepanova, Issah Younossi, Andrei Racila

“…The CLDQ-MASH can be used as a valid disease-specific health-related quality of life instrument for MASH in clinical research and clinical trials.…”
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Cohort profile: Oxford Pain, Activity and Lifestyle (OPAL) Study, a prospective cohort study of older adults in England by Sarah E Lamb, Christian D Mallen, M Watson, Julie Bruce, S Dutton, S Petrou, Lesley Ward, Maria T Sanchez Santos, Esther Williamson, Angela Garrett, Alana Morris, O Conway, F Darton, D Hagan, D Haywood, A Hewitt, I Marian, L Nevay, P Nicolson, M Slark, K Vadher, E Williamson, N Arden, K Barker, G Collins, J Fairbank, J Fitch, D French, F Griffiths, Z Hanson, C Hutchinson

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Randomised controlled trial of topical kanuka honey for the treatment of rosacea by James Fingleton, Mark Weatherall, Richard Beasley, Irene Braithwaite, Janwillem Kocks, Mark Holliday, Andrew Corin, Colin Helm, Davitt Sheahan, Barney Montgomery, Judith Riley, Anna Hunt, Christopher Tofield

“…The VAS-CS at week 2 was 9.1 (95% CI 3.5 to 14.7), p=0.002, and at week 8 was 12.3 (95% CI 5.7 to 18.9)¸ p<0.001 for Honevo compared to control.Conclusions Honevo is an effective treatment for rosacea.Trial registration number This trial was registered in the Australian and New Zealand Clinical Trials Registry ACTRN12614000004662.…”
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Biologics as well as inhaled anti-asthmatic therapy achieve clinical remission: Evidence from the Severe Asthma Network in Italy (SANI) by Giorgio Walter Canonica, MD, Francesco Blasi, PhD, Pierluigi Paggiaro, MD, Enrico Heffler, PhD, Fulvio Braido, MD, Luisa Brussino, PhD, Giulia Scioscia, PhD, Cristina Cardini, MsC, Chiara Oriecuia, MsC, Isabella Sala, MsC, Vincenzo Bagnardi, PhD, Cecilia Calabrese, PhD, Gianna Camiciottoli, MD, Giovanna Elisiana Carpagnano, PhD, Stefano Centanni, PhD, Angelo Guido Corsico, PhD, Maria Teresa Costantino, MD, Claudia Crimi, PhD, Alice D'Adda, MD, Simona D’Alò, MD, Maria D'Amato, PhD, Corrado D'Andria, MD, Stefano Del Giacco, MD, Fabiano Di Marco, PhD, Nicola Cosimo Facciolongo, MD, Alessandro Farsi, MD, Manuela Latorre, PhD, Manlio Milanese, PhD, Eustachio Nettis, MD, Eleonora Nucera, MD, Giovanni Passalacqua, MD, Girolamo Pelaia, MD, Laura Pini, MD, Luisa Ricciardi, PhD, Fabio Luigi Massimo Ricciardolo, PhD, Luca Richeldi, PhD, Erminia Ridolo, PhD, Pierachille Santus, PhD, Nicola Scichilone, PhD, Gianenrico Senna, MD, Giuseppe Spadaro, MD, Antonio Spanevello, MD, Paolo Tarsia, MD

“…Trial registration: ClinicalTrials.gov ID: NCT06625216; Central Ethics Committee: Comitato Etico Area Vasta Nord-Ovest Toscana (study number 1245/2016, protocol number:73714).…”
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