Targeted Therapy in Hepatocellular Carcinoma by Clarinda W. L. Chua, Su Pin Choo

“…There have been many targeted drugs that have shown potential in the treatment of HCC. Many clinical trials have been carried out with many more in progress. …”
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Proangiogenic Features of Mesenchymal Stem Cells and Their Therapeutic Applications by Hongyan Tao, Zhibo Han, Zhong Chao Han, Zongjin Li

“…Accordingly, several clinical trials using MSCs have been performed and revealed that MSCs may improve relevant clinical parameters in patients with vascular diseases. …”
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Mesotherapy: From Historical Notes to Scientific Evidence and Future Prospects by Massimo Mammucari, Enrica Maggiori, Domenico Russo, Chiara Giorgio, Gianpaolo Ronconi, Paola E Ferrara, Flora Canzona, Luciano Antonaci, Bartolomeo Violo, Renato Vellucci, Domenico Rocco Mediati, Alberto Migliore, Umberto Massafra, Barbara Bifarini, Fabio Gori, Massimo di Carlo, Stefano Brauneis, Teresa Paolucci, Piergiovanni Rocchi, Anna Cuguttu, Raffaele Di Marzo, Alessandro Bomprezzi, Stefania Santini, Manuela Giardini, Anna Rosa Catizzone, Fiammetta Troili, Dario Dorato, Alessandra Gallo, Costanza Guglielmo, Silvia Natoli

“…Despite the lack of randomized clinical trials in some fields of application, a general consensus is also reached in nonpharmacological mechanism of action, the technique execution modalities, the scientific rationale to apply it in some indications, and the usefulness of the informed consent. …”
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Spices and gastrointestinal health benefits: a state-of-the-art by Pauline Raoul, Campagna Chiara, Gianferrari Elisa, Nicodemo Mirella, Pizzari Ginevra, Marco Cintoni, Emanuele Rinninella, Esmeralda Capristo, Maria Cristina Mele

“…This review presents an overviewof the most common spices highlighting their anti-inflammatory, prebiotic, and anti-tumoral properties. Human clinical trials, specifically randomized controlled trials, are necessary to describe and demonstrate their health benefits to define it as a functional food.…”
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Neoadjuvant pembrolizumab-carboplatin-paclitaxel in locally advanced squamous cell carcinoma of the oral cavity: A case report and literature review by Abdulrahman Hesham, Fawaz AlOtaibi, D. David Kim, Yousef Alshamrani, Joao Hyppolito, Katie Jubala

“…In addition, the patient remains free of locoregional disease nine months after the surgery. Clinical trials are essential to investigate the viability of this potentially less toxic and more convenient combined therapy in patients with advanced squamous cell carcinoma of the oral cavity.…”
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The effectiveness of dexamethasone as a combination therapy for COVID-19 by Namazi Nader

“…Still, there is no effective pharmaceutical agent for the treatment of COVID-19 though several drugs are undergoing clinical trials. Recent studies have shown that dexamethasone, a corticosteroid, can reduce the rate of COVID-19-related mortality in the intensive care unit by 35 % for patients who are on mechanical ventilation. …”
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Recent advances in mesenchymal stem cell therapy for multiple sclerosis: clinical applications and challenges by Kamran Sheikhi, Salah Ghaderi, Hassan Firouzi, Sarvenaz Rahimibarghani, Ehsan Shabani, Hamed Afkhami, Hamed Afkhami, Hamed Afkhami, Aref Yarahmadi

“…It examines preclinical studies and clinical trials evaluating the efficacy, safety, and limitations of MSC therapy in various MS phenotypes. …”
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A Case of Rituximab Use as an Induction and Maintenance of Remission in ANCA-Associated Vasculitis by Neveen Awad, Shahd Hafiz, Abdurahman Albeity, Hani Almoallim

“…There are no randomized clinical trials addressing rituximab effect in induction and remission at the same time. …”
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Understanding cancer predisposition in Singapore: what’s next by Jianbang Chiang, Tarryn Shaw, Joanne Ngeow

“…These include the potential for finding unexpected germline variants through somatic tumour testing, optimal risk management of patients with hereditary conditions involving moderate-penetrance genes, role of polygenic risk score in an under-represented Asian population, management of variants of uncertain significance, clinical trials in patients with germline pathogenic variants and technology in genetic counselling. …”
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Medical Devices Made of Substances: The Need for a Change in Approach in Paediatrics by Stefano Stagi

“…Ethical concerns often prevent clinical trials in children, meaning that specific data for the paediatric population can be lacking. …”
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A class of constrained optimal control problems arising in an immunotherapy cancer remission process by Yineng Ouyang, Zhaotao Liang, Zhihui Ma, Lei Wang, Zhaohua Gong, Jun Xie, Kuikui Gao

“…These results provide a theoretical framework that can guide clinical trials in immunotherapy.…”
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Stem Cell-Based Therapies for Liver Diseases: State of the Art and New Perspectives by Anna Chiara Piscaglia, Mariachiara Campanale, Antonio Gasbarrini, Giovanni Gasbarrini

“…Aim of this paper is to critically analyze the possible sources of SCs suitable for liver repopulation and the results of the clinical trials that have been published until now.…”
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Translating Research into Clinical Scale Manufacturing of Mesenchymal Stromal Cells by Karen Bieback, Sven Kinzebach, Marianna Karagianni

“…The challenge relates to managing the expected therapeutic benefits with the potential risks and to balance the fast move to clinical trials with time-consuming cautious risk assessment. …”
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Update on Edoxaban for the Prevention and Treatment of Thromboembolism: Clinical Applications Based on Current Evidence by Ali Zalpour, Thein Hlaing Oo

“…Emerging evidence from the clinical trials has shown that DOACs are noninferior to VKA or low-molecular-weight heparins in the prevention and treatment of thromboembolism. …”
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Update on glasdegib in acute myeloid leukemia – broadening horizons of Hedgehog pathway inhibitors by Fersing Cyril, Mathias Fanny

“…Elements of its routine clinical use and the landscape of ongoing clinical trials are also stated.…”
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TMPRSS2 as a Key Player in Viral Pathogenesis: Influenza and Coronaviruses by Gilmara Barros de Lima, Everton Nencioni, Fábio Thimoteo, Camila Perea, Rafaela Fuzaro Alves Pinto, Sergio Daishi Sasaki

“…This review provides a summary of TMPRSS2 inhibitors currently under study, with some already in clinical trials to test their effectiveness against viral infections. …”
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Exercise and the Cardiovascular System by Saeid Golbidi, Ismail Laher

“…In this paper we review some important exercise-induced changes in cardiac, vascular, and blood tissues and discuss recent clinical trials related to the benefits of exercise. We also discuss the roles of boosting antioxidant levels, consequences of epicardial fat reduction, increases in expression of heat shock proteins and endoplasmic reticulum stress proteins, mitochondrial adaptation, and the role of sarcolemmal and mitochondrial potassium channels in the contributing to the cardioprotection offered by exercise. …”
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Revolutionizing acute myeloid leukemia treatment: a systematic review of immune-based therapies by Ugochi Ebinama, Binsah George

“…This comprehensive review article specifically examines classical unconjugated and toxin-conjugated monoclonal antibodies, which are currently in the preclinical phase or undergoing evaluation in clinical trials. The review delves into the proposed mechanisms through which these monoclonal antibodies elicit anti-tumor activity and identifies the challenges associated with designing targeted immunotherapy. …”
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A SYSTEMATIC REVIEW OF THE USE OF TULATHROMYCIN IN VETERINARY MEDICINE by Carmen (Pop) Moldovan, Alexandra Dreancă, Oana Rotar, Mihai Madru, Ioan Marcus

“…Additionally, the review examines the dosage regimens, administration routes, and potential side effects reported in clinical trials. Data regarding antimicrobial resistance to tulathromycin is discrepant due to several sources that display negative results regarding the sole use of this macrolide and its off-label use. …”
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The Use of Regenerative Medicine in the Management of Invasive Bladder Cancer by Matthew E. Hyndman, Deborah Kaye, Nicholas C. Field, Keith A. Lawson, Norm D. Smith, Gary D. Steinberg, Mark P. Schoenberg, Trinity J. Bivalacqua

“…Therefore, there is a great opportunity to decrease the morbidity of the surgical management of bladder cancer through utilization of novel technologies for creating a urinary diversion without the use of intestine. Clinical trials using neourinary conduits (NUC) seeded with autologous smooth muscle cells are currently in progress and may represent a significant surgical advance, potentially eliminating the complications associated with the use of gastrointestinal segments in the urinary reconstruction, simplifying the surgical procedure, and greatly facilitating recovery from cystectomy.…”
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