Heart–brain microvascular MRI study: protocol for a multicentre, observational, cohort study in the UK assessing associations between small vessel disease of the heart and brain by Colin Berry, Alex McConnachie, Peter Kellman, Terry Quinn, Paul Donnelly, Vanessa Orchard, Robert A Sykes, Gemma McKinley, Conor Patrick Bradley, Jodi Watt, Natasha Fullerton

“…All patients provided written informed consent.Trial registration number ClinicalTrials.gov ID NCT04805814.…”
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Comparative safety of transvenous and leadless pacemakers in patients with cardiovascular diseases: A meta-analysis study by Cedric Mhasseb, Mayassa Kiwan, Marie-Elie Merhi, Nicolas Moussallem, Jana Moussalli, Maroun Abou Zeid, Sarah Abou Daher, Ghassan Nabbout, Sami Azar, Amjad Kanaan, Frederic Harb

“…A comprehensive and systematic search was conducted across PubMed, Embase, Cochrane Library, Web of Science and ClinicalTrials.gov, spanning from inception until just before the final analysis. …”
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Experiences, perceptions and ethical considerations of the malaria infection study in Thailand by Bhensri Naemiratch, Natinee Kulpijit, Supanat Ruangkajorn, Nicholas P. J. Day, Jetsumon Prachumsri, Phaik Yeong Cheah

“…Trial registration This manuscript is part of the clinical trials registered under ClinicalTrials.gov IDs NCT04083508 (MIST1) registered on 5 Sep 2019 and NCT05071079 (MIST2) registered on 28 July 2021. …”
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Randomised, multicentre, placebo-controlled trial of fenofibrate for treatment of diabetic macular oedema with economic evaluation (FORTE study): study protocol for a randomised co... by Gerald Liew, Paul Mitchell, Bamini Gopinath, Helen Nguyen, Richard Kha

“…Trial results will be disseminated to the public in de-identified form through publications in peer-reviewed journals.Trial registry name Australian New Zealand Clinical Trials Registry.Trial registration number ACTRN12618000592246.…”
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Randomised controlled trial comparing intraoperative cell salvage and autotransfusion with standard care in the treatment of hip fractures: a protocol for the WHITE 9 study by Mike Murphy, Nicholas Parsons, James Mason, Juul Achten, Duncan Appelbe, Edward Dickenson, Damian Griffin, Katy Mironov, Matthew Wyse, Amrita Athwal, Xavier Luke Griffin, Heather O'Connor

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Multicomponent rehabilitation to improve independence and functioning in elderly patients with common age-associated diseases: a scoping review by Omar Baritello, Hanna Stein, Heinz Völler, Annett Salzwedel, Theo Taxis, Machteld Luizink-Dogan

“…This review mapped the evidence on MR in elderly patients following hospitalisation for age-related conditions regarding functioning-related outcomes.Design Scoping review.Data sources PubMed, Cochrane Library, International Clinical Trials Registry Platform and ClinicalTrials.gov (searched through 24 June 2024).Eligibility criteria We included randomised controlled trials (RCT) and controlled cohort studies (CCS) comparing centre-based MR with usual care (medical care excluding exercise training) in patients ≥75 years, hospitalised for age-related cardiac, neurological, oncological and orthopaedic diseases. …”
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The effect of mindfulness-based counselling on the anxiety levels and childbirth satisfaction among primiparous pregnant women: a randomized controlled trial by Rozhin Feli, Sousan Heydarpour, Kamran Yazdanbakhsh, Fatemeh Heydarpour

“…Trial registration Clinical Trials Iranian Registery of clinical trials-Beta version, https://en.irct.ir/trial/35390 (IRCT20170305032900N3), registered (2019-02-24).…”
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East Midlands knee pain multiple randomised controlled trial cohort study: cohort establishment and feasibility study protocol by Michael Doherty, Roshan das Nair, Ana Valdes, Reuben Ogollah, Paul Greenhaff, Bonnie Millar, Michelle Hall, Amy Fuller, Polykarpos Angelos Nomikos, David A Walsh, A Abhishek

“…Qualitative interviews will be conducted with a sample of participants from each of the two active intervention arms.Ethics and dissemination This protocol was approved by the East Midlands-Derby Research Ethics Committee (18/EM/0288) and registered at ClinicalTrials.gov (protocol v4.0, 10/02/2020). The study will be reported in accordance with the Consolidated Standards of Reporting Trials guidance and standards. …”
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European ILD registry algorithm for self-assessment in interstitial lung diseases (eurILDreg ASA-ILD). by Ekaterina Krauss, Laurenz H Claas, Silke Tello, Jennifer Naumann, Sandra Wobisch, Stefan Kuhn, Raphael W Majeed, Karen Moor, Maria Molina-Molina, Oisin Byrne, Rebecca Borton, Marlies S Wijsenbeek, Nik Hirani, Carlo Vancheri, Bruno Crestani, Andreas Guenther, eurILDreg investigators

“…The eurIPFreg and eurIPFbank are listed in ClinicalTrials.gov (NCT02951416). EurILDreg is registered in German Clinical Trials Register, DRKS 00028968.…”
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Recruiting Young People for Digital Mental Health Research: Lessons From an AI-Driven Adaptive Trial by Wu Yi Zheng, Artur Shvetcov, Aimy Slade, Zoe Jenkins, Leonard Hoon, Alexis Whitton, Rena Logothetis, Smrithi Ravindra, Stefanus Kurniawan, Sunil Gupta, Kit Huckvale, Eileen Stech, Akash Agarwal, Joost Funke Kupper, Stuart Cameron, Jodie Rosenberg, Nicholas Manoglou, Manisha Senadeera, Svetha Venkatesh, Kon Mouzakis, Rajesh Vasa, Helen Christensen, Jill M Newby

“… BackgroundWith increasing adoption of remote clinical trials in digital mental health, identifying cost-effective and time-efficient recruitment methodologies is crucial for the success of such trials. …”
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Combination of Anti-VEGF and Laser Photocoagulation for Diabetic Macular Edema: A Review by Laura N. Distefano, Jose Garcia-Arumi, Vicente Martinez-Castillo, Anna Boixadera

“…Here, we review some of the clinical trials that have assessed the efficacy of macular laser treatment, either as part of the treatment protocol or as rescue therapy.…”
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Diagnostic and Therapeutic Advances of RNAs in Precision Medicine of Gastrointestinal Tumors by Runhan Liu, Jiaxin Zhou, Xiaochen Chen, Jie Zhang, Qunzhi Chen, Xiaoming Liu, Kunhou Yao

“…Many RNA-based therapeutics, such as small interfering RNA (siRNA) and antisense oligonucleotides (ASO), have entered clinical trials or are available on the market. This review provides a narrative examination of the diagnostic and therapeutic potential of RNA in gastrointestinal cancers, with an emphasis on its application in precision medicine. …”
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Recent progress in preventive effect of collagen peptides on photoaging skin and action mechanism by Chongyang Li, Yu Fu, Hongjie Dai, Qiang Wang, Ruichang Gao, Yuhao Zhang

“…More importantly, some clinical trials on the beneficial effect on skin of collagen peptides are also discussed. …”
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Zn(II) and Fe(II) complexes of  2,4-dinitro-N-[(Z)-[(E)-3-(2-nitrophenyl)prop-2-enylidene] amino] aniline: synthesis, characterization and In Silico SARS-CoV-2 inhibition studies by K. O. Eberendu, J. I. Iheanyichukwu, O. M. Mac-kalunta, C. I. Nwankwo, I. E. Otuokere, J. C. Nnaji

“…These results recommend biological, preclinical, and clinical trials take place, with the target being SARS-CoV-2 protease …”
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Proteolysis targeting chimera (PROTAC)-driven antibody internalization of oncogenic cell surface receptors by Ezequiel J. Tolosa, Lin Yang, Jennifer Ayers-Ringler, Shinichiro Suzuki, Jayapal Reddy Mallareddy, Janet Schaefer-Klein, Mitesh Borad, Farhad Kosari, Amarnath Natarajan, Aaron S. Mansfield

“…This application of PROTACs may impact the use of ADCs and provides a rationale to combine these agents in clinical trials.…”
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Corneal Stem Cells as a Source of Regenerative Cell-Based Therapy by Jasmin S. Nurković, Radiša Vojinović, Zana Dolićanin

“…Until now, various approaches and methods for isolation of LESCs and CSSCs and their successful transplantation have been described and tested in several preclinical studies and clinical trials. This review describes in detail phenotypic characteristics of LESCs and CSSCs and discusses their therapeutic potential in corneal regeneration. …”
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FDA’s approval of resmetirom (Rezdiffra): a breakthrough in MASH management by Muhammad Mazhar Azam, Sameen Mukhtar, Muhammad Haris, Fatima Laique, Suhaina Amir, Mubashir Mohiuddin, Bibek Giri

“…This mechanism effectively reduces fibrosis markers, improves liver enzyme levels, and minimizes liver fat buildup. Clinical trials have shown that resmetirom has a favorable safety profile, with manageable side effects like diarrhea and nausea. …”
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Mechanism Design and Analysis of Rehabilitation Training Robot based on Gait Regularity by Liang Qisong, Jiang Lijie, Wang Yong

“…Through the comprehensive analysis,a rehabilitation training robot based on two DOF five-bar metamorphic mechanism is designed,and then a prototype production and clinical trials are carried out. The experimental results show that the proposed design of sitting rehabilitation robot is qualified to meet the demands of personalized training of hemiplegic patients.…”
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Sugar Alcohols, Caries Incidence, and Remineralization of Caries Lesions: A Literature Review by Kauko K. Mäkinen

“…The possible difference between erythritol and xylitol must be confirmed in future clinical trials.…”
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Current Potential of Pantoprazole in Treatment and Prevention of Gastrointestinal Diseases by A. A. Sheptulin, S. S. Kardasheva, A. A. Kurbatova

“…Pantoprazole is considered among optimal PPIs for efficacy, safety and adherence on the basis of clinical trials for treatment and prevention of gastrointestinal diseases, systematic reviews and meta-analyses.…”
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