Testosterone Deficiency, Cardiac Health, and Older Men by G. Hackett, M. Kirby, A. J. Sinclair

“…There are recent data to suggest that testosterone replacement therapy may reduce cardiovascular mortality as well as improving multiple surrogate markers for cardiovascular events. Specific clinical trials of testosterone replacement therapy are needed in selected populations but in the meantime we must treat patients based on the best current evidence.…”
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PEEP or No PEEP: That Is Not the Question by Jesús Villar, Arthur S Slutsky

“…In the absence of controlled clinical trials, the use of PEEP in acute respiratory distress syndrome needs to be guided by physiological principles that balance the beneficial effects of an increase in functional residual capacity, prevention of alveolar closure, redistribution of lung water and improved ventilation of low ventilation-perfusion areas against the potential harm of alveolar rupture (barotrauma and "volutrauma") and reduction in cardiac output.…”
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The Effects of Hypoxia on the Immune-Modulatory Properties of Bone Marrow-Derived Mesenchymal Stromal Cells by Zsolt Fábián

“…Despite the encouraging in vivo data, however, clinical trials delivered ambiguous results. Since one of the typical features of inflamed tissues is decreased oxygenation, the success of cellular therapy in inflammatory pathologies seems to be affected by the impact of oxygen depletion on transplanted cells. …”
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CANDLE syndrome – a narrative review by Aleksandra Snopkowska, Joanna Gołda, Julia Mężyk, Piotr Gacka, Marcin Dołęga

“…Further research and clinical trials are imperative to enhance understanding and optimise treatment strategies for this rare and debilitating condition.…”
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The Evolution of Radiation Therapy in Metastatic Breast Cancer: From Local Therapy to Systemic Agent by Jessica M. S. Jutzy, Jeffrey M. Lemons, Jason J. Luke, Steven J. Chmura

“…In this article, we will review the emerging role of radiation in the treatment of metastatic disease and discuss the current state of the science and clinical trials investigating the combination of radiation and immunotherapy.…”
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Functional Multipotency of Stem Cells: What Do We Need from Them in the Heart? by Pablo Díez Villanueva, Ricardo Sanz-Ruiz, Alberto Núñez García, María Eugenia Fernández Santos, Pedro L. Sánchez, Francisco Fernández-Avilés

“…After more than ten years of human research in the field of cardiac regenerative medicine, application of stem cells in different phases of ischemic heart disease has come to age. Randomized clinical trials have demonstrated that stem cell therapy can improve cardiac recovery after the acute phase of myocardial ischemia and in patients with chronic ischemic heart disease, and several efficacy phase III trials with clinical endpoints are on their way. …”
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Intestinal microbiome as effective regulator of enteral and central nervous system activity by V. T. Ivashkin, K. V. Ivashkin

“…Accumulated data change the current concept on human microbiome and its potential, however further clinical trials required.…”
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Iron Chelation Therapy in Myelodysplastic Syndromes by Emanuela Messa, Daniela Cilloni, Giuseppe Saglio

“…The usefulness of iron chelation in MDS patients is still under debate, mainly because of the lack of solid prospective clinical trials that should take place in the future. …”
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CAR-T cell therapy: developments, challenges and expanded applications from cancer to autoimmunity by Yaojie Kong, Jingyao Li, Xueyao Zhao, Yanwei Wu, Liang Chen

“…We reviewed preclinical experiments and clinical trials involving CAR-T, Car-Treg and CAAR-T cell therapies in various autoimmune diseases. …”
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Recent Advances in Antiviral Therapy for Chronic Hepatitis C by Akihiro Tamori, Masaru Enomoto, Norifumi Kawada

“…This review introduces the characteristics and results of recent clinical trials of several DAAs: NS3/4A protease inhibitors, NS5A inhibitors, and NS5B inhibitors. …”
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Therapeutic Strategies for High-Dose Vasopressor-Dependent Shock by Estevão Bassi, Marcelo Park, Luciano Cesar Pontes Azevedo

“…The use of more than 0.5 mcg/kg/min of norepinephrine or epinephrine to maintain target blood pressure is often used in clinical trials as a threshold. Nearly 6% of critically ill patients will develop refractory shock, which accounts for 18% of deaths in intensive care unit. …”
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Drug Therapy for Non-Alcoholic Steatohepatitis-Induced Liver Fibrosis by D. V. Garbuzenko

“…Given a lack of approved antifibrotic therapies in NASH, several drugs have nevertheless demonstrated an adequate efficacy and safety in phase 3 clinical trials, also in compensated cirrhosis, which allows their practical validation in phase 4.Conclusion. …”
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Mesenchymal Stem/Stromal Cell-Mediated Mitochondrial Transfer and the Therapeutic Potential in Treatment of Neurological Diseases by Deqiang Han, Xin Zheng, Xueyao Wang, Tao Jin, Li Cui, Zhiguo Chen

“…In the end, we summarized recent advances in preclinical research and clinical trials for the treatment of stroke and spinal cord injury, through application of MSCs and/or MSC-derived mitochondria.…”
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The role and therapeutic effectiveness of Plantago ovata seed husk (psyllium husk) in the prevention and non-pharmacological treatment of gastrointestinal diseases. Part 1. Clinica... by Justyna Przybyszewska, Andrzej Kuźmiński, Michał Przybyszewski, Cezary Popławski

“…The outer seed coat of P. ovata, obtained by cleaning the seeds, contains soluble and insoluble fibre in a ratio of 7:3, making products containing P. ovata husk an ideal source of health-beneficial fibre. The results of clinical trials demonstrate the therapeutic efficacy of psyllium husk for various gastrointestinal disorders. …”
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Systemic Role for Vitamin D in the Treatment of Psoriasis and Metabolic Syndrome by Lisa Wenyang Fu, Ronald Vender

“…We propose there is merit in more clinical trials investigating the use of vitamin D to treat both psoriasis and metabolic syndrome through its anti-inflammatory effects. …”
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Effects of Inositol(s) in Women with PCOS: A Systematic Review of Randomized Controlled Trials by Vittorio Unfer, John E. Nestler, Zdravko A. Kamenov, Nikos Prapas, Fabio Facchinetti

“…The purpose of this systematic review is the analysis of recent randomized clinical trials of inositol(s) in PCOS, in particular myo- and D-chiro-inositol, in order to better elucidate their physiological involvement in PCOS and potential therapeutic use, alone and in conjunction with assisted reproductive technologies, in the clinical treatment of women with PCOS.…”
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Update in Noninvasive Home Mechanical Ventilation: A Narrative Review of Indications, Outcomes, and Monitoring by Laura Tregidgo, Prasheena Naran, Eshrina Gosal, Rebecca F. D’Cruz

“…Patients at risk of developing chronic respiratory failure and those with established disease should be referred to a specialist ventilation unit for evaluation and consideration of home noninvasive ventilation (NIV) initiation. Clinical trials demonstrate that, following careful patient selection, home NIV can improve a range of clinical, patient-reported, and physiological outcomes. …”
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The use of oral topically acting glucocorticosteroids in the treatment of inflammatory bowel disease by P. Rutgeerts

“…The first results of clinical trials are promising and budesonide has been shown to have an improved safety with almost comparable efficacy in comparison with prednisolone. …”
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Telomeres, telomerase, and cancer: mechanisms, biomarkers, and therapeutics by Songting Shou, Ayidana Maolan, Di Zhang, Xiaochen Jiang, Fudong Liu, Yi Li, Xiyuan Zhang, En Geer, Zhenqing Pu, Baojin Hua, Qiujun Guo, Xing Zhang, Bo Pang

“…Many candidate drugs remain in the experimental stage, with only a few advancing to clinical trials. This review explores the relationship between telomeres, telomerase, and cancer, synthesizing their roles as biomarkers and reviewing the outcomes of completed trials. …”
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Clinical and Radiographic Success of Selective Caries Removal to Firm Dentin in Primary Teeth: 18-Month Follow-Up by Tássia Carina Stafuzza, Luciana Lourenço Ribeiro Vitor, Daniela Rios, Thiago Cruvinel Silva, Maria Aparecida Andrade Moreira Machado, Thais Marchini Oliveira

“…Notwithstanding, further randomized clinical trials with longer following-up periods are still necessary.…”
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