Cadaveric simulation versus standard training for postgraduate trauma and orthopaedic surgical trainees: protocol for the CAD:TRAUMA study multicentre randomised controlled educati... by Damian Griffin, Hannah K James, Giles T R Pattison, Joanne D Fisher

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Title not available by Carlos Sverdloff, Vinícius Marcondes-Rezende, Ligia de Cassia-Val, Ma. Elena Cedano-Limón, Lygia Nerath-Bonanato, Murali Pendela, Mohammad H. Badii, Sreekanth Kakarla, Nelly C. Lemus-Castro

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Artificial intelligence methods applied to longitudinal data from electronic health records for prediction of cancer: a scoping review by Victoria Moglia, Owen Johnson, Gordon Cook, Marc de Kamps, Lesley Smith

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In Silico Evaluation of Algorithm-Based Clinical Decision Support Systems: Protocol for a Scoping Review by Michael Dorosan, Ya-Lin Chen, Qingyuan Zhuang, Shao Wei Sean Lam

“…Such CDS systems are traditionally assessed via controlled but resource-intensive clinical trials. ObjectiveThis paper presents a review protocol for preimplementation in silico evaluation methods to enable broadened impact analysis under simulated environments before clinical trials. …”
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Statistical analysis plan for a pragmatic randomised controlled trial comparing enhanced acceptance and commitment therapy plus ( +) added to usual aftercare versus usual aftercare... by Clare Robinson, Trudie Chalder, Paul McCrone, Olivier Quintin, Evdoxia Gkaintatzi, Imran Khan, Stephanie J. C. Taylor, on behalf of the SURECAN GROUP

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Multi-target gene therapy AUP1602-C to improve healing and quality of life for diabetic foot ulcer patients: a phase I, open-label, dose-finding study by Christoph Schindler, Jacek Mikosiński, Pawel Mikosiński, Hanna-Riikka Kärkkäinen, Mirka Sanio, Jere Kurkipuro, Igor Mierau, Wesley Smith, Aki Vartiainen, Laurent Décory, Dirk Weber, Thomas Wirth, Juha Yrjänheikki, Sebastian Schellong, Haritha Samaranayake

“…Trial registration: The study was registered in ClinicalTrials.gov (NCT04281992) and ClinicalTrialsRegister.eu (2018-003415-22).…”
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Trajectories of Change, Illness Understanding, and Parental Worries in Children and Adolescents Undergoing Internet-Delivered Cognitive-Behavioral Therapy for Functional Abdominal... by Eva Skovslund Nielsen, Karen Kallesøe, Tine Bennedsen Gehrt, Ellen Bjerre-Nielsen, Maria Lalouni, Lisbeth Frostholm, Marianne Bonnert, Charlotte Ulrikka Rask

“…Trial RegistrationClinicalTrials.gov NCT05237882; https://clinicaltrials.gov/study/NCT05237882; ClinicalTrials.gov NCT05486585; https://clinicaltrials.gov/study/NCT05486585; OSF Registries osf.io/c49k7; https://osf.io/c49k7 International Registered Report Identifier (IRRID)DERR1-10.2196/58563…”
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CAR T-cell detection scoping review: an essential biomarker in critical need of standardization by Naomi Taylor, Nirali N Shah, David P Turicek, Victoria M Giordani, Josquin Moraly

“…To evaluate whether subsequent manuscripts from a trial resolved these issues, we analyzed all subsequent manuscripts reporting on the 21 clinical trials, recording all expansion and persistence data. …”
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Protocol for a multicentre randomised controlled trial examining the effects of temporarily pausing Bruton tyrosine kinase inhibitor therapy to coincide with SARS-CoV-2 vaccination... by Abhishek Abhishek, Jonathan A Cook, Helen M Parry, Anne Francis, Lelia Duley, Vicki S Barber, Paul Moss, Nicholas Peckham

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Exact Group Sequential Methods for Estimating a Binomial Proportion by Zhengjia Chen, Xinjia Chen

“…Illustrative examples are given for applications in clinical trials.…”
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Eosinophilic gastroenteritis – a manifestation of an allergic disease in the gastrointestinal tract? Part 2. Treatment by Andrzej Kuźmiński, Tomasz Rosada, Justyna Przybyszewska, Natalia Ukleja-Sokołowska, Zbigniew Bartuzi

“…Unfortunately, there is still a lack of well-designed, prospective. and randomized clinical trials involving large groups of patients with EGE and assessing the effectiveness of individual treatments. …”
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The Impact of Sulforaphane on Sex-Specific Conditions and Hormone Balance: A Comprehensive Review by Jed W. Fahey, Mirran Raphaely

“…SF has been the subject of thousands of studies and over 125 clinical trials. The many mechanisms of action of SF in mammalian systems have been extensively documented. …”
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Control of atropoisomerism: an access to valuable compounds by Choppin, Sabine, Wencel-Delord, Joanna, Colobert, Françoise

“…Atropoisomerism is well-known in biaryls, however this phenomenon is encountered in many pharmaceutically relevant compounds such as heterobiaryl, diarylamines, benzamides and anilides.Currently four FDA-approved drugs are atropostable and many others are in clinical trials. It is also important to note that almost 30% of recent FDA-approved small molecules are “proatropisomeric” and interact with a target in a specific chiral conformation.Given this vivid interest in C–C but also C–N atropisomerically stable compounds, this account will detail the new atropoisomeric strategies we developed and their applications in the synthesis of relevant molecules and ligands.…”
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Application of bone turnover markers in skeletal and extra-skeletal conditions in children and adults by Agnieszka Postępska, Przemysław Sikora

“…Therefore, there is a need for standardized clinical trials on currently available and new BTMs.…”
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Convergence of evolving artificial intelligence and machine learning techniques in precision oncology by Elena Fountzilas, Tillman Pearce, Mehmet A. Baysal, Abhijit Chakraborty, Apostolia M. Tsimberidou

“…., digital twins, in order to provide the necessary information to design or expedite the conduct of clinical trials. Currently, many operational and technical challenges exist related to data technology, engineering, and storage; algorithm development and structures; quality and quantity of the data and the analytical pipeline; data sharing and generalizability; and the incorporation of these technologies into the current clinical workflow and reimbursement models.…”
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Peroxisome Proliferator-Activated Receptors and the Heart: Lessons from the Past and Future Directions by Wang-Soo Lee, Jaetaek Kim

“…We also describe the results and lessons learned from important clinical trials on PPAR agonists and discuss the potential future directions for this class of drugs.…”
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Verteporfin Photodynamic Therapy Combined with Intravitreal Ranibizumab for Polypoidal Choroidal Vasculopathy Controversy Concerning Long-Term Followup by Maribel Fernández, María Gil, Francisco Gomez-Ulla, Pablo Charlón

“…These data need to be confirmed in large, prospective, and controlled clinical trials which are randomized and carried out over a long period.…”
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PPARγ and Its Role in Cardiovascular Diseases by Mini Chandra, Sumitra Miriyala, Manikandan Panchatcharam

“…This review aims to discuss the role of PPARγ in the various cardiovascular diseases and summarize the current knowledge on PPARγ agonists from multiple clinical trials. Finally, we also review the new PPARγ agonists under development as potential therapeutics with reduced or no adverse effects.…”
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Dietary Recommendations for the Prevention of Type 2 diabetes: What Are They Based on? by Patrice Carter, Kamlesh Khunti, Melanie J. Davies

“…In addition we aim to explore the available evidence from both observation studies and clinical trials to determine whether these recommendations are appropriate.…”
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Receptor Tyrosine Kinases and Inhibitors in Lung Cancer by Evan Pisick, Simha Jagadeesh, Ravi Salgia

“…The inhibitors against the specific RTKs are in various preclinical and clinical trials, and this will be detailed.…”
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