Role of Inflammatory Cell Subtypes in Heart Failure by Derek Strassheim, Edward C. Dempsey, Evgenia Gerasimovskaya, Kurt Stenmark, Vijaya Karoor

“…Various types of immune cells are implicated in myocardial inflammation and include neutrophils, macrophages, eosinophils, mast cells, natural killer cells, T cells, and B cells. Recent clinical trials have targeted inflammatory cascades as therapy for heart failure with limited success. …”
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PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia by Sarawin Harnchoowong, Poonkiat Suchonwanit

“…In this review article, we discuss the pathogenesis of PCA with a focus on PPAR-γ involvement in pathogenesis of lichen planopilaris (LPP), the most common lymphocytic form of PCA. We also discuss clinical trials utilizing PPAR-agonists in PCA treatment.…”
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New Immunotherapeutic Approaches for Glioblastoma by Gustavo Ignacio Vázquez Cervantes, Dinora F. González Esquivel, Saúl Gómez-Manzo, Benjamín Pineda, Verónica Pérez de la Cruz

“…In this review, we summarize and discuss promising immunotherapies for GBM currently under preclinical investigation as well as in clinical trials.…”
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Emerging targeted therapies in oral oncology: Focus on EGFR inhibition by Vishnu Priya Veeraraghavan, Shikhar Daniel, Arun Kumar Dasari, Kaladhar Reddy Aileni, Chaitra patil, Santosh R. Patil

“…Small-molecule tyrosine kinase inhibitors (TKIs) and monoclonal antibodies (mAbs) targeting EGFR have shown promise in preclinical studies and clinical trials. However, challenges, such as the development of resistance mechanisms and treatment-related toxicities, pose obstacles to their clinical utility. …”
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Contemporary Antiviral Drug Regimens for the Prevention and Treatment of Orolabial and Anogenital Herpes Simplex Virus Infection in the Normal Host: Four Approved Indications and 1... by Fred Y Aoki

“…Although these drugs are only approved for four orolabial and anogenital infections in healthy persons, their efficacy and safety for 13 other related uses in this population have been demonstrated in controlled clinical trials, so called off-label uses. In this review, the evidence supporting these 17 uses, the drugs and regimens evaluated, and their current costs, are described.…”
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Extensive Longitudinal Transverse Myelitis Temporally Related to the Use of AZD1222, AstraZeneca COVID-19 Vaccine: Cerebrospinal Fluid Analysis and Recent Data Review by Paulo Diniz da Gama, Tiago Gomes de Alcantara, Rafaela Ramos Smaniotto, Penélope de Lima Petuco, Wammer Alves de Almeida, Rodrigo Assad Diiniz da Gama, Yara Dadalti Fragoso

“…Neurological complications such as transverse myelitis raise concerns as cases were observed in clinical trials. Cerebrospinal fluid analysis is routine in these cases and the characteristics of the abnormalities found are of great help not only in establishing the diagnosis but also in understanding this rare condition. …”
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Harnessing the Effect of Adoptively Transferred Tumor-Reactive T Cells on Endogenous (Host-Derived) Antitumor Immunity by Yolanda Nesbeth, Jose R. Conejo-Garcia

“…However, recent evidence in animal models and clinical trials suggests that host conditioning interventions tailored for some of the most aggressive and frequent epithelial cancers will be needed to maximize the benefit of this approach. …”
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Granulocyte Colony-Stimulating Factor and Its Potential Application for Skeletal Muscle Repair and Regeneration by Craig R. Wright, Alister C. Ward, Aaron P. Russell

“…This has been supported by preclinical studies and clinical trials investigating G-CSF as a potential therapeutic agent in relevant disease states. …”
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Antibody-Drug Conjugates in the Treatment of Metastatic Breast Cancer: The Emerging Questions of Sequence and Resistance by Allan Relecom, Francesco Sciotto, Mathieu Chevallier, José Luis Sandoval

“…This article reviews recent advancements and the efficacy of ADCs in clinical trials and explores the mechanisms of resistance and the implications of ADC sequencing in treatment protocols. …”
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Present Evidence of Determinants to Predict the Efficacy of Renal Denervation by Hao Zhou, Yanping Xu, Weijie Chen, Liang Wang, Huaan Du, Hang Liu, Zhiyu Ling, Yuehui Yin

“…Renal denervation (RDN) has been evidenced by series of clinical trials for its efficacy and safety to treat overactivated sympathetic nervous system induced diseases. …”
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The immunological bases of alemtuzumab as induction-therapy in pediatric-onset multiple sclerosis by Marco Puthenparampil, Marco Puthenparampil, Marco Puthenparampil, Marta Gaggiola, Marta Gaggiola, Francesca Rinaldi, M. Nosadini, M. Nosadini, S. Sartori, S. Sartori, Paola Perini, Paolo Gallo, Paolo Gallo

“…Although no data on the use of induction therapies in POMS are available from clinical trials currently, case series or case reports on the effect of alemtuzumab (ALTZ) have been recently published. …”
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To Live or to Die: Prosurvival Activity of PPARγ in Cancers by Y. Lynn Wang, Qi Miao

“…We discuss the following five aspects of the nuclear hormone receptor and its agonists: (1) relative expression of PPARγ in human tumor versus normal tissues; (2) receptor-dependent proneoplastic effects; (3) impact of PPARγ and its agonists on tumors in animal models; (4) clinical trials of thiazolidinediones (TZDs) in human malignancies; (5) TZDs as chemopreventive agents in epidemiology studies. …”
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Upper Gastrointestinal Tract Crohn's Disease by Hugh J Freeman

“…Although upper gastrointestinal involvement is increasingly recognized as a significant cause of morbidity in Crohn's disease, the treatment options are limited , largely anecdotal and need to be the subject of detailed epidemiologic investigation and clinical trials.…”
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Effects of coffee consumption on health by Berlis Gómez Leyva, María Teresa Díaz Armas, Regla Cristina Valdés Cabodevilla, Manuel Alejandro Miguel Cruz

“…Original articles, bibliographic reviews, systematic reviews, meta-analyzes and clinical trials published in the last five years were mainly used. …”
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Therapeutics in paediatric genetic diseases: current and future landscape by Ai Ling Koh, Saumya Shekhar Jamuar

“…Specifically, gene therapy has been shown to be effective in various clinical trials, and indeed, these trials have led to regulatory approvals, paving the way for gene therapies for other types of PGDs. …”
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Radioimmunotherapy: A Specific Treatment Protocol for Cancer by Cytotoxic Radioisotopes Conjugated to Antibodies by Hidekazu Kawashima

“…This review outlines the fundamentals of RIT and current knowledge of the preclinical/clinical trials for cancer treatment.…”
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<i>Galleria mellonella</i> (Greater Wax Moth) as a Reliable Animal Model to Study the Efficacy of Nanomaterials in Fighting Pathogens by Stefania Villani, Matteo Calcagnile, Christian Demitri, Pietro Alifano

“…Evaluating the safety and efficacy of these new antimicrobial strategies requires testing in animal models before being tested in clinical trials. In this context, <i>Galleria mellonella</i> could represent a valid alternative to traditional mammalian and non-mammalian animal models, due to its low cost, ease of handling, and valuable biological properties to investigate host–pathogen interactions. …”
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Selecting the appropriate design in biomedical research: experimental studies. Part II by Raúl Aguilera Eguía, Ángel Roco Videla, Olga Patricia López Soto, Brenda Herrera Serna, Héctor Fuentes Barria, Mariana Melo Lonconao

“…Considerations are issued from the historical evolution and theoretical foundations, to the practical implementation of experimental designs, with a particular focus on randomized clinical trials, for their robustness in demonstrating causal relationships and influence in optimizing clinical decisions. …”
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The Role of Targeted Therapy in Metastatic Renal Cell Carcinoma by Jaya Unnithan, Brian I. Rini

“…This article briefly describes the biological pathways involved in the development of RCC and the results of clinical trials using targeted therapy in metastatic RCC.…”
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The Renoprotective Actions of Peroxisome Proliferator-Activated Receptors Agonists in Diabetes by M. C. Thomas, K. A. Jandeleit-Dahm, C. Tikellis

“…This review will examine these direct and indirect actions of PPAR agonists in the diabetic kidney and explore recent findings of clinical trials of PPAR agonists in patients with diabetes.…”
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