Levosimendan for sepsis-induced myocardial dysfunction: friend or foe? by Xinxin Du, Xinxin Du, Fang Xiong, Yafei Hou, Xiangyou Yu, Pengfei Pan

“…We also analyzed the potential and limitations of levosimendan for the treatment of SIMD to provide ideas for future clinical trials and the clinical application of levosimendan in SIMD.…”
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The Photobiology of Lutein and Zeaxanthin in the Eye by Joan E. Roberts, Jessica Dennison

“…Lutein and zeaxanthin are antioxidants found in the human retina and macula. Recent clinical trials have determined that age- and diet-related loss of lutein and zeaxanthin enhances phototoxic damage to the human eye and that supplementation of these carotenoids has a protective effect against photoinduced damage to the lens and the retina. …”
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Age-Related White Matter Changes by Yun Yun Xiong, Vincent Mok

“…Although the clinical relevance of WMC has been extensively studied, to date, only very few clinical trials have evaluated potential symptomatic or preventive treatments for WMC. …”
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Real-Time fMRI Neurofeedback Modulation of Dopaminergic Midbrain Activity in Young Adults With Elevated Internet Gaming Disorder Risk: Randomized Controlled Trial by Anqi Gu, Cheng Lam Chan, Xiaolei Xu, Joseph P Dexter, Benjamin Becker, Zhiying Zhao

“…We show that, after 2 sessions of neurofeedback training, participants successfully downregulated their brain responses to gaming cues, suggesting the therapeutic potential of rt-fMRI NF for IGD (Trial Registration: ClinicalTrials.gov NCT06063642; https://clinicaltrials.gov/study/NCT06063642).…”
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An Update on the Potential of Mesenchymal Stem Cell Therapy for Cutaneous Diseases by Yanyun Li, Ziyu Ye, Weiqin Yang, Qunzhou Zhang, Jincheng Zeng

“…In this review, we highlight the mechanisms underlying MSC-mediated immunomodulation and tissue repair/regeneration and present the latest development of MSC-based clinical trials on cutaneous diseases.…”
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Patiromer Acetate Induced Hypercalcemia: An Unreported Adverse Effect by Shreeyukta Bhattarai, Stephen Pupillo, Gulshan Man Singh Dangol, Erdal Sarac

“…Hypercalcemia, although a theoretical possibility, has not been reported in any major clinical trials. We present a case of hypercalcemia associated with patiromer acetate used for treatment of hyperkalemia in a stage IV CKD patient. …”
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Warm and humid environment induces gut microbiota dysbiosis and bacterial translocation leading to inflammatory state and promotes proliferation and biofilm formation of certain ba... by Yinrui Guo, Jianlang He, Shaojie Li, Shiqi Zou, Haiting Zhang, Xin Yang, Jian Wang

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Digital Twins of Biological Systems: A Narrative Review by Ghufran A. Alsalloum, Nour M. Al Sawaftah, Kelly M. Percival, Ghaleb A. Husseini

“…The influence of DTs extends beyond healthcare and can revolutionize healthcare management, drug development, clinical trials, and various biomedical research fields…”
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Optimization Manufacture of Virus- and Tumor-Specific T Cells by Natalia Lapteva, Juan F. Vera

“…Although ex vivo expanded T cells are currently widely used in pre-clinical and clinical trials, the complexity of manufacture remains a major impediment for broader application. …”
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Sporadic inclusion body myositis in the rheumatology clinic by Fernando Henrique Carlos de Souza, Gustavo Luiz Behrens Pinto, Jean Marcos de Souza, Pablo Arturo Olivo Pallo, Leonardo Santos Hoff, Samuel Katsuyuki Shinjo

“…Although there have been no robust clinical trials, training exercise/physiotherapy should be prescribed regularly in sIBM patients.…”
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Experimental and Clinical Use of Therapeutic Hypothermia for Ischemic Stroke: Opportunities and Limitations by Tine Zgavc, An-Gaëlle Ceulemans, Sophie Sarre, Yvette Michotte, Said Hachimi-Idrissi

“…Several studies with TH in experimental models and small clinical trials have shown beneficial effects. Despite this, implementation into the clinical setting is still lacking due to methodological considerations as well as hypothermia-related complications. …”
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Single-Cell Transcriptome Analysis of Human Adipose-Derived Stromal Cells Identifies a Contractile Cell Subpopulation by Elize Wolmarans, Juanita Mellet, Chrisna Durandt, Fourie Joubert, Michael S. Pepper

“…The potential for human adipose-derived stromal cells (hASCs) to be used as a therapeutic product is being assessed in multiple clinical trials. However, much is still to be learned about these cells before they can be used with confidence in the clinical setting. …”
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EGFR inhibitors in the treatment of colorectal cancer by M. В. Zabelin, A. D. Kaprin, A. A. Kostin, E. V. Gameeva, S. E. Varlamova

“…A review of current literature data on the use of both approved for clinical use (cetuximab, panitumumab) and an -EGFR an bodies at the stage of clinical trials is presented. EGFR inhibitors are one of the main groups of targeted drugs used to treat pa ents with colorectal cancer. …”
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Probiotics for Alleviating Alcoholic Liver Injury by Zelin Gu, Yanlong Liu, Shumeng Hu, Ying You, Jiaqi Wen, Wancong Li, Yuhua Wang

“…Many animal experiments and clinical trials showed that probiotics are effective for the treatment of alcoholic liver disease. …”
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Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and Survival by K. E. O’Sullivan, E. T. Hurley, J. P. Hurley

“…We undertook to perform a review of the current status of morbidity and mortality associated with oesophagectomy, grading systems determining pathologic response, and data from clinical trials managing patients with definitive chemoradiotherapy to inform a discussion on the topic.…”
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NGcGM3 Ganglioside: A Privileged Target for Cancer Vaccines by Luis E. Fernandez, Mariano R. Gabri, Marcelo D. Guthmann, Roberto E. Gomez, Silvia Gold, Leonardo Fainboim, Daniel E. Gomez, Daniel F. Alonso

“…N-glycolyl (NGc) gangliosides, and particularly NGcGM3, have received attention as a privileged target for cancer therapy. Many clinical trials have been performed with the anti-NGc-containing gangliosides anti-idiotype monoclonal antibody racotumomab (formerly known as 1E10) and the conjugated NGcGM3/VSSP vaccine for immunotherapy of melanoma, breast, and lung cancer. …”
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Where Are We Heading with Noninvasive Clinical Vascular Physiology? Why and How Should We Assess Endothelial Function? by Elizabeth A. Ellins, Julian P. J. Halcox

“…Techniques for endothelial function testing have evolved over time from these invasive methods, which, by their nature, are restricted to small studies in the research laboratory, to more standardized noninvasive methods, which are suitable for use in large prospective cohort studies and clinical trials. This paper describes currently available methods for assessment of endothelial function and their potential application in cardiovascular research and clinical practice.…”
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PPAR Genomics and Pharmacogenomics: Implications for Cardiovascular Disease by Sharon Cresci

“…Numerous pharmacologic studies have assessed the effects of specific PPAR agonists in clinical trials and have provided insight into the clinical effects of these genes while genetic studies have demonstrated clinical associations between PPAR polymorphisms and abnormal cardiovascular phenotypes. …”
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Glucagon like peptide-1 (GLP-1) agonists and cardiometabolic protection: historical development and future challenges by Francisco Westermeier, Enrique Z. Fisman

“…This editorial synthesizes key milestones, from the discovery of GLP-1 to recent clinical trials highlighting the pleiotropic effects of GLP-1RAs in addressing the interconnected spectrum of cardiometabolic conditions, with a focus on cardiovascular, renal, and hepatic benefits. …”
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A Randomized, Double-Masked, Active-Controlled, Crossover Phase III Equivalence Study of Generic Dorzolamide 2% versus Innovator Trusopt® Eye Drop Solution in Subjects with Open-An... by Katharina Bell, Christina Korb, Christina Butsch, Bert Constantin Giers, Anna Beck, Alicja Strzalkowska, Christian Ruckes, Ulrike Klingberg, Norbert Pfeiffer, Katrin Lorenz

“…This trial is registered with (ClinicalTrials.gov (identifier: NCT00878917) on April 9, 2009).…”
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