Updated treatment guidelines for drug-resistant TB: how safe are clofazimine-based regimens? by E. Pontali, M. Raviglione

“…In June 2024, WHO released ‘Key updates to the treatment of drug-resistant tuberculosis: rapid communication’, after the preliminary publication of results from two clinical trials: ‘BEAT-Tuberculosis’ and ‘endTB’. All proposed regimens include clofazimine (Cfz). …”
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Molecular Basis of Triple Negative Breast Cancer and Implications for Therapy by Parvin F. Peddi, Matthew J. Ellis, Cynthia Ma

“…These findings have implications for therapeutic target identification and the design of future clinical trials for this aggressive group of breast cancer.…”
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Immunotherapy with CAR-Modified T Cells: Toxicities and Overcoming Strategies by Shangjun Sun, He Hao, Ge Yang, Yi Zhang, Yang Fu

“…The adverse events observed in the clinical trials are described in this review, after which, some innovative strategies developed to overcome these unwanted toxicities are outlined, including suicide genes, targeted activation, and other novel strategies.…”
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Myocardial Restoration: Is It the Cell or the Architecture or Both? by Duc Thang Vu, Theo Kofidis

“…Cardiac cell therapy has been introduced to clinical trials for more than ten years but its results are still controversial. …”
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Comparative outcomes of corticosteroids, neuromuscular blocking agents, and inhaled nitric oxide in ARDS: a systematic review and network meta-analysis by Zhiyuan Xu, Xiao Liu, Liang Zhang, Xianliang Yan, Xianliang Yan

“…Therefore, this study aimed to compare and rank these three treatments to identify the most effective option.Data sourcesWe searched PubMed, Embase, Cochrane Library, and Web of Science for clinical trials from the earliest records to 1 May 2024.Study selection and data extractionClinical trials evaluating three interventions compared with the control group for ARDS were included, with restrictions on any language. …”
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Machine learning predicted fast progression after initiation of immune checkpoint inhibitors in advanced non-small cell lung cancer by Martin Stockler, Yu Yang Soon, Chee Khoon Lee, Teng Hwee Tan

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Integrating MAPK pathway inhibition into standard-of-care therapy for pediatric low-grade glioma by Erin E. Crotty, Aimee A. Sato, Aimee A. Sato, Mohamed S. Abdelbaki

“…Additionally, we review important considerations for the off-label use of these agents while contemporaneous clinical trials assessing front-line efficacy are ongoing. …”
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The role of artificial intelligence in pandemic responses: from epidemiological modeling to vaccine development by Mayur Suresh Gawande, Nikita Zade, Praveen Kumar, Swapnil Gundewar, Induni Nayodhara Weerarathna, Prateek Verma

“…The collaborative aspect of AI in vaccine discovery and clinical trials of various vaccines is emphasised, focusing on constructing AI-powered surveillance networks. …”
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Eligibility for sacubitril–valsartan in patients with acute decompensated heart failure by David Carballo, Jérôme Stirnemann, Nicolas Garin, Chistophe Marti, Jacques Serratrice, Sebastian Carballo

“…Abstract Aims Large‐scale clinical trials have demonstrated clinical benefits of sacubitril–valsartan in symptomatic heart failure with reduced ejection fraction patients (PARADIGM‐HF), with potential benefits in patients hospitalized for acute decompensated heart failure (ADHF) (PIONEER‐HF) and fewer benefits in patients with heart failure with preserved ejection fraction (PARAGON‐HF). …”
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Vitamins and Mineral Supplements for Retinitis Pigmentosa by Ying Zhao, Kai Feng, Ruibao Liu, Jinhua Pan, Lailin Zhang, Xuejing Lu

“…Therefore, this study aimed to systematically review data from randomized clinical trials (RCTs) evaluating the safety and efficacy of vitamins and mineral supplements for the treatment of RP. …”
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Determining prognostic factors in the treatment of primary hemifacial spasm: Clinical outcomes and complications. A literature review by Juan Carlos Acevedo-González, Alex Taub-Krivoy, Julian Alfonso Sierra-Peña, Julian Geronimo Lizarazo

“…Each author reviewed abstracts, applying inclusion criteria like systematic reviews, clinical trials, observational studies, and case series, while excluding theoretical or non-English articles. …”
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Hyperthermia and targeting heat shock proteins: innovative approaches for neurodegenerative disorders and Long COVID by David M. Smadja, David M. Smadja, M. Marc Abreu, M. Marc Abreu

“…Despite the absence of robust clinical trials, the therapeutic implications of WBH extend to immune modulation and the restoration of disrupted physiological pathways. …”
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Regional hyperthermia for soft tissue sarcoma – a survey on current practice, controversies and consensus among 12 European centers by Siyer Roohani, Felix Ehret, Marcus Beck, Danai P. Veltsista, Jacek Nadobny, Sebastian Zschaeck, Sultan Abdel-Rahman, Franziska Eckert, Anne Flörcken, Rolf D. Issels, Stephan Klöck, Robert Krempien, Lars H. Lindner, Markus Notter, Oliver J. Ott, Daniel Pink, Vlatko Potkrajcic, Peter Reichardt, Oliver Riesterer, Mateusz Jacek Spałek, Emanuel Stutz, Rüdiger Wessalowski, Thomas Zilli, Daniel Zips, Pirus Ghadjar, David Kaul

“…At the same time, our data has shown that existing guidelines and decades of experience with the technique of RHT have mostly standardized procedural aspects.Conclusions The provided results may serve as a basis for future guidelines and inform future clinical trials for RHT in STS patients.…”
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Rationale and design of the HOVON 170 DLBCL-ANTICIPATE trial: preventing anthracycline-induced cardiac dysfunction with dexrazoxane by Marijke Linschoten, Jesse Geels, Erik van Werkhoven, Heleen Visser-Wisselaar, Martine E. D. Chamuleau, Arco J. Teske, Lourens Robbers, Simone Oerlemans, Heleen Crommelin, Marleen Breems-de Ridder, Astrid Schut, Folkert W. Asselbergs, Anna van Rhenen, on behalf of the HOVON 170 DLBCL – ANTICIPATE consortium

“…The trial is registered at the EU Clinical Trials Register (EU-CT number 2023-505377-32) and ClinicalTrials.gov (NCT06220032). …”
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Effects of Manual Therapy and Strengthening Exercise on Pain in Patients with Knee Osteoarthritis: A Systematic Review and Meta-Analysis by Beatriz Serrano-García, Carmen Belén Martínez-Cepa, Francisco Forriol, Santiago Angulo-Díaz-Parreño, Juan Andrés Mesa-Jiménez, Juan Carlos Zuil-Escobar

“…This systematic review and meta-analysis aimed to determine whether manual therapy (MT) and strengthening exercises (SE) reduce pain in patients with knee osteoarthritis (KO). Clinical trials were identified through a search of PubMed, PEDro, Scopus, and Ovid databases up to April 2024. …”
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Lerociclib plus fulvestrant in patients with HR+/HER2− locally advanced or metastatic breast cancer who have progressed on prior endocrine therapy: LEONARDA-1 a phase III randomize... by Binghe Xu, Qingyuan Zhang, Yang Luo, Zhongsheng Tong, Tao Sun, Changping Shan, Xinlan Liu, Yumin Yao, Bing Zhao, Shusen Wang, Xiaohua Zeng, Changlu Hu, Xi Yan, Xiaojia Wang, Hongyan Jia, Zhendong Chen, Fuming Qiu, Xinhong Wu, Deyong Zhang, Tong Li

“…(Funded by Genor Biopharma; LEONARDA-1 ClinicalTrials.gov identifier, NCT05054751.)…”
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Hepatocellular carcinoma: signaling pathways and therapeutic advances by Jiaojiao Zheng, Siying Wang, Lei Xia, Zhen Sun, Kui Ming Chan, René Bernards, Wenxin Qin, Jinhong Chen, Qiang Xia, Haojie Jin

“…Here, we provide here a comprehensive review of cellular signaling pathways, their therapeutic potential, evidence derived from late-stage clinical trials in HCC and discuss the concepts underlying earlier clinical trials, biomarker identification, and the development of more effective therapeutics for HCC.…”
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Crosstalk between Gut Microbiota and Cancer Immunotherapy: Present Investigations and Future Perspective by Yuhui Tang, Qiaoting Cai, Zhi Tian, Wenkuan Chen, Hailin Tang

“…To better grasp the underlying crosstalk between gut microbiota and immunotherapy, more experimental and clinical trials are indispensable for the customized gut microbiota-based treatments in cancer patients undergoing immunotherapy.…”
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Brain Complete Response to Cabozantinib prior to Radiation Therapy in Metastatic Renal Cell Carcinoma by An Uche, Chad Sila, Tad Tanoura, James Yeh, Neil Bhowmick, Edwin Posadas, Robert Figlin, Jun Gong

“…Its activity in mRCC patients with brain metastases (BMs) has been largely underreported in prospective clinical trials. We present the unique case of a heavily pretreated mRCC patient with BMs who achieved a brain complete response to cabozantinib prior to receiving radiation therapy. …”
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Optical Coherence Tomography in Huntington's Disease—A Potential Future Biomarker for Neurodegeneration? by Clancy Cerejo, Nicolas De Cleene, Elias Mandler, Katarina Schwarzová, Samuel Labrecque, Philipp Mahlknecht, Florian Krismer, Atbin Djamshidian, Klaus Seppi, Beatrice Heim

“…Lately, there have been multiple ongoing clinical trials targeting therapeutic agents for preventing disease onset or slowing disease progression in HD. …”
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