Novel Generalized Divergence Measure on Intuitionistic Fuzzy Sets and Its Application by Priya Arora, V. P. Tomar

“…In that case, we have devised a method to choose the best treatment for the patients based on the results of clinical trials.…”
Get full text

Think Stop before Going 'Off-Label' by Gerald Y Minuk

“…Only after careful and extensive review of all available safety and efficacy data derived from preclinical and clinical trials will a regulatory body approve the licensing of a drug for a specific medical condition ('indication'). …”
Get full text

Vedolizumab for inflammatory bowel diseasesI by Igor L. Khalif, M. V. Shapina

“…The results received in clinical trials were confirmed by clinical data in the different countries. …”
Get full text

Novel approaches in myelofibrosis by Steffen Koschmieder

“…Together, the new generations of clinical trials promise to offer substantial improvements in the management of MF patients and long‐term disease control.…”
Get full text

Lymphatic filariasis in Zambia: A scoping review protocol. by Hugh Shirley, Adrienne Orriols, Dylan Hogan, Kingford Chimfwembe, Alinaswe Balya, Kaala Sibbuku, Janelle Lardizabal, Sophie Tillotson, Philip Espinola Coombs, Richard Wamai

“…In consultation with a research librarian, these guidelines will be applied to a literature search of articles from peer-reviewed journals, or government and international regulatory bodies using PubMed, Embase, Web of Science, Cochrane CENTRAL, WHO ICTRP, Pan African Clinical Trials Registry, and ClinicalTrials.gov. Each record will be screened at the abstract and full-text level by two independent reviewers, and results reported via summary statistics.…”
Get full text

Role of phytochemicals in cardiovascular disease management: Insights into mechanisms, efficacy, and clinical application by Esther Ugo Alum

“…The review analyzes findings from clinical trials, epidemiological studies, and preclinical research to explain how these phytochemicals are effective in preventing and treating cardiovascular diseases. …”
Get full text

Apremilast generic for the treatment of active psoriatic arthritis: A single-center real-life experience from India by Sanjiv Amin, Aneesa Kapadia, Dhiraj Dhoot, Hanmant Barkate

“…Its efficacy and safety have been established in the landmark clinical trials; however, there is still a dearth of its real-world experience in the management of PsA in India. …”
Get full text

Personalized Organoid-Based Treatments in Older Patients with Cancer: A Registry Study in Progress by Pirmin Häuptle, Kirsten Mertz, Michèle Voegeli, Robert Rosenberg, Emanuel Burri, Svetozar Subotic, Anna Romanens, Anne Leuppi-Taegtmeyer, Christian Regenbrecht, Lena Wedeken, Marcus Vetter

“…The treatment of older patients with cancer is challenging owing to frailty and the presence of comorbidities, which complicate treatment decisions by impacting tolerance to therapeutic interventions, as well as poor representation of this patient population in clinical trials, leading to a lack of evidence-based data, especially in later lines of therapy. …”
Get full text

Application of Mild Therapeutic Hypothermia on Stroke: A Systematic Review and Meta-Analysis by Shaheen E. Lakhan, Fabricio Pamplona

“…Seven parallel-controlled clinical trials were included in the meta-analysis. Sample sizes ranged from 18 to 62 patients, yielding a total of 288. …”
Get full text

Study protocol for Video Images about Decisions to Improve Ethical Outcomes with Palliative Care Educators (VIDEO-PCE): a pragmatic stepped wedge cluster randomised trial of older... by Joshua R Lakin, Na Wang, Howard J Cabral, Michael K Paasche-Orlow, Charlotta Lindvall, Angelo Volandes, Aretha Delight Davis, Michael R Winter, Edward T Moseley, Lori Henault, Sophia N Zupanc, Sophiya Das, Kate Sciacca, Edith A Burns, Maria T Carney, Jennifer Itty, Santiago Lopez, Kaitlin Emmert, Narda J Martin, Sherene Lambert, Jennifer Polo, Shreya Sanghani, Julianne N Dugas, Michele Gomez, Shira Gabry-Kalikow, Alexandra Dobie, Meredith Amshoff, Traci Cucinotta, Milton Joel, Lisa B Caruso, Ana Maria Ramirez, Kathleen Salerno, Qausarat Ogunneye

“…This trial is registered at ClinicalTrials.gov.Trial registration number NCT04857060; ClinicalTrials.gov…”
Get full text

Prediction of Survival Outcomes in Patients with Glioma Using Magnetic Resonance Imaging (MRI): A Systematic Review and Meta-Analysis by Mingfang Hu, Jinge Li, Zhangyu Li, Jian Shen

“…Methods: Review of the literature included the following databases: WHO International Clinical Trials Registry Platform; Google Scholar; Web of Science; PubMed; SIGLE; NYAM; Scopus; Randomized controlled trial (RCT); Virtual Health Library (VHL); Cochrane Collaboration; EMBASE; and Clinical Trials. …”
Get full text

Protocol for the systematic review of age and sex in preclinical models of age-correlated diseases [version 2; peer review: 2 approved] by Céline Heinl, Ines Schadock, Maximilian Wurm, Paul Lucas Wildner, Daniel Butzke, Bettina Bert, Alexandra Bannach-Brown, Matthias Steinfath, Kai Diederich

“…We compare the results with the age and sex of patients in clinical trials focusing on Alzheimer's disease, stroke, type 2 diabetes mellitus, ischemic heart disease, and chronic obstructive pulmonary disease. …”
Get full text

Non-pharmacological therapies in the treatment of chemotherapy-induced alopecia – a literature review by Izabela Ochonska, Karolina Jaglarz, Maciej Kuca, Marcin Cholewa, Maria Jasiewicz

“…However, most current approaches show only moderate efficacy or are still in clinical trials. …”
Get full text

Clinical Significance of ErbB Receptor Family in Urothelial Carcinoma of the Bladder: A Systematic Review and Meta-Analysis by Yuh-Shyan Tsai, Hong-Lin Cheng, Tzong-Shin Tzai, Nan-Haw Chow

“…Using published evidence, we examined the clinical value and the updated results of clinical trials targeting ErbB receptor family members. …”
Get full text

Expert Consensus on Molecular Tumor Boards in Taiwan: Joint Position Paper by the Taiwan Oncology Society and the Taiwan Society of Pathology by Ming-Huang Chen, Wan-Shan Li, Bin-Chi Liao, Chiao-En Wu, Chien-Feng Li, Chia-Hsun Hsieh, Feng-Che Kuan, Huey-En Tzeng, Jen-Fan Hang, Nai-Jung Chiang, Tse-Ching Chen, Tom Wei-Wu Chen, John Wen-Cheng Chang, Yao-Yu Hsieh, Yen-Lin Chen, Yi-Chen Yeh, Yi-Hsin Liang, Yu-Li Su, Chiung-Ru Lai, James Chih-Hsin Yang

“…Results: The joint statement proposes key recommendations: (1) MTB discussions encompass diverse molecular analyses including next-generation sequencing (NGS), RNA sequencing, whole-exon sequencing, and whole-genomic sequencing addressing relevant genomic changes, tumor mutation burden, microsatellite instability, and specific biomarkers for certain cancers. (2) MTB meetings should involve multidisciplinary participants who receive regular updates on NGS-related clinical trials. (3) Prioritize discussing cases with unique clinical needs, gene alterations lacking treatments, untreatable neoplasms, or oncogenes unresponsive to targeted therapies. (4) Base MTB discussions on comprehensive patient data, including genetics, pathology, timing of specimen collection, and NGS outcomes. (5) MTBs offer treatment recommendations: standard therapies, off-label use, clinical trials, genetic counseling, and multidisciplinary reviews. (6) MTB effectiveness can be gauged by member composition, case reviews, treatment suggestions, and patient outcomes. …”
Get full text

PD-1 Blockade in Advanced Melanoma in Patients with Hepatitis C and/or HIV by Diwakar Davar, Melissa Wilson, Chelsea Pruckner, John M. Kirkwood

“…We argue for the further investigation of checkpoint inhibition in cancer patients with underlying chronic viral infections in the context of carefully designed clinical trials.…”
Get full text

Endoscopic Dilation with Bougies versus Balloon Dilation in Esophageal Benign Strictures: Systematic Review and Meta-Analysis by Iatagan R. Josino, Antônio C. Madruga-Neto, Igor B. Ribeiro, Hugo G. Guedes, Vitor O. Brunaldi, Diogo T. H. de Moura, Wanderley M. Bernardo, Eduardo G. H. de Moura

“…We included 5 randomized clinical trials (RCTs), totalizing 461 patients. Among them, 151 were treated with bougie dilation and 225 underwent balloon dilation. …”
Get full text

The Role of Lactobacillus reuteri DSMZ17648 for Helicobacter pylori eradication therapy (Review of literature and advisory council resolution, February 28, 2018) by V. T. Ivashkin, O. P. Alekseyeva, A. Yu. Baranovsky, Ye. K. Baranskaya, Ye. V. Beloborodova, T. A. Kolesov, N. V. Korochanskaya, K. . Lang, T. L. Lapina, I. V. Mayev, M. V. Mokshina, D. L. Nepomnyashchy, Ye. V. Onuchina, R. G. Sayfutdinov, T. H. Sviridova, V. I. Simanenkov, A. V. Tkachev, A. S. Trukhmanov, L. P. Faizova, I. B. Khlynov, O. B. Khlynova, A. A. Sheptulin

“…Potential of PylopassTM combination to various H. pylori eradication therapy modes is a subject offutnet multicenter randomized clinical trials for assessment of optimal combination to antibiotic drugs, treatment duration and adverse effect rates. …”
Get full text

Targeting the activated allosteric conformation of the endothelin receptor B in melanoma with an antibody-drug conjugate: mechanisms and therapeutic efficacy by Amaury Herbet, Marie Hautière, Frédéric Jean-Alphonse, Delphine Vivier, Christophe Leboeuf, Narciso Costa, Aloïse Mabondzo, Guilhem Bousquet, Franck Denat, Eric Reiter, Didier Boquet

“…Conclusions xiRB49-MMAE is a promising drug candidate for clinical trials in ETB + tumors. RB49 could be used as a diagnostic tool for patient stratification.…”
Get full text

Feasibility study of an experimental social space-oriented rehabilitation concept for people with intellectual and/or multiple disabilities: a study protocol by Kathrin Förster, Judith Gartmann, Andrea Boekel, Thilo Busche, Christoph Egen

“…Widespread implementation: If the project is continued and adequately staffed, the rehabilitative care concept could be implemented nationwide, and the University Hospital could be available as a reference clinic.Trial registration number German Clinical Trials Register (reference number: DRKS00032493).…”
Get full text